15S_RRNA	15S_RRNA_2	Ribosomal RNA of the small mitochondrial ribosomal subunit; MSU1 allele suppresses ochre stop mutations in mitochondrial protein-coding genes				S000007287
21S_RRNA	21S_rRNA_3|21S_rRNA_4	Mitochondrial 21S rRNA; intron encodes the I-SceI DNA endonuclease				S000007288
21S_RRNA_4		Merged rRNA, does not encodes a discrete transcript; 21S_rRNA_4 was merged into 21S_rRNA_3 to produce a single feature named 21S_rRNA (See GenBank AJ011856)				S000007289
9S_RRNA_1		Deleted rRNA, does not encode a discrete transcript; the annotations for 9S_rRNA_1 and 9S_rRNA_5 have been removed and replaced with a single gene, RPM1, which provides the correct annotation of the 9S RNA component of RNase P				S000007285
9S_RRNA_5		Deleted rRNA, does not encode a discrete transcript; the annotations for 9S_rRNA_1 and 9S_rRNA_5 have been removed and replaced with a single gene, RPM1, which provides the correct annotation of the 9S RNA component of RNase P				S000007286
AAC1		Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator	ADP/ATP carrier	Null mutant is viable, shows altered colony morphology	YMR056C	S000004660
AAC3	ANC3	Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Pet9p and Aac1p; has roles in maintenance of viability and in respiration	ADP/ATP carrier	Null mutant is viable; pet9,aac3 double null mutant is inviable under anaerobic conditions	YBR085W	S000000289
AAD10		Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role			YJR155W	S000003916
AAD14		Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role			YNL331C	S000005275
AAD15		Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role			YOL165C	S000005525
AAD16		Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role			YFL057C	S000001837
AAD3		Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role			YCR107W	S000000704
AAD4		Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase, involved in the oxidative stress response		Responds to oxidative stress induced by diamide and di-ethyl maleic acid ester in a YAP1 dependant manner	YDL243C	S000002402
AAD6		Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase, involved in the oxidative stress response		Responds to oxidative stress induced by diamide and di-ethyl maleic acid ester in YAP1 dependant manner	YFL056C	S000001838
AAH1		Adenine deaminase (adenine aminohydrolase), involved in purine salvage and nitrogen catabolism	adenine aminohydrolase|adenine deaminase		YNL141W	S000005085
AAP1	AAP1'	Arginine/alanine aminopeptidase, overproduction stimulates glycogen accumulation	arginine/alanine aminopeptidase	null mutant is viable, decrease in glycogen accumulation	YHR047C	S000001089
AAR2		Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron		growth defect and defect in splicing the pre-mRNA of the MATa1 cistron	YBL074C	S000000170
AAT1		Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis	aspartate aminotransferase	Null mutant is viable; aat1 leu2 double mutant is inviable.	YKL106W	S000001589
AAT2	ASP5	Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells	aspartate aminotransferase		YLR027C	S000004017
ABC1	COQ8	Protein required for ubiquinone (coenzyme Q) biosynthesis and for respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis			YGL119W	S000003087
ABD1		Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA	RNA (guanine-7-)methyltransferase (cap methyltransferase)		YBR236C	S000000440
ABF1	BAF1|OBF1|REB2|SBF1	DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair	transcription factor		YKL112W	S000001595
ABF2		Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation			YMR072W	S000004676
ABM1		Protein of unknown function, required for normal microtubule organization			YJR108W	S000003869
ABP1		Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization	actin binding protein		YCR088W	S000000684
ABP140	YOR240W	Nonessential protein that binds actin filaments and localizes to actin patches and cables, has similarity to S-adenosylmethionine (AdoMet)-dependent methyltransferases	actin filament binding protein		YOR239W	S000005765
ABZ1		Para-aminobenzoate (PABA) synthase, has similarity to Escherichia coli PABA synthase components PabA and PabB	aminodeoxychorismate synthase	Null mutant is viable and PABA auxotroph	YNR033W	S000005316
ABZ2		4-amino-4-deoxychorismate lyase, catalyzes the third step in para-aminobenzoic acid biosynthesis	4-amino-4-deoxychorismate lyase	Null: PABA auxotrophy. Defective in 4-amino-4-deoxychorismate lyase activity.	YMR289W	S000004902
ACA1		Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, may regulate transcription of genes involved in utilization of non-optimal carbon sources			YER045C	S000000847
ACB1		Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes	acyl-CoA-binding protein (ACBP)/diazepam binding inhibitor (DBI)/endozepine (EP)	Null mutant is viable, slightly reduced growth rate on ethanol	YGR037C	S000003269
ACC1	ABP2|FAS3|MTR7	Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids	acetyl CoA carboxylase	acc1 spores fail to enter vegetative growth	YNR016C	S000005299
ACD1						S000029024
ACE2		Transcription factor that activates expression of early G1-specific genes, localizes to daughter cell nuclei after cytokinesis and delays G1 progression in daughters, localization is regulated by phosphorylation; potential Cdc28p substrate	transcription factor	Null mutant is viable, exhibits decreased CUP1 mRNA expression	YLR131C	S000004121
ACF2	ENG2|PCA1	Intracellular beta-1,3-endoglucanase, expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly		Null mutant shows defect in in vitro actin assembly in the permeabilized cell assay	YLR144C	S000004134
ACF4		Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate			YJR083C	S000003843
ACH1		Acetyl-coA hydrolase, primarily localized to mitochondria; required for acetate utilization and for diploid pseudohyphal growth	acetyl CoA hydrolase		YBL015W	S000000111
ACK1		Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria			YDL203C	S000002362
ACM1		Cell cycle regulated protein of unknown function; associated with Cdh1p and may supress the APC/C[Cdh1]-mediated proteolysis of mitotic cyclins			YPL267W	S000006188
ACN9		Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes			YDR511W	S000002919
ACO1	GLU1	Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy	aconitase		YLR304C	S000004295
ACO2		Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol			YJL200C	S000003736
ACP1		Mitochondrial matrix acyl carrier protein, involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p	acyl carrier protein	The null mutant is viable but respiratory-deficient and contains only 5-10% of the wild-type amount of lipoic acid.	YKL192C	S000001675
ACR1		Involved in sensitivity to aculeacin A		Resistant to aculeacin A, echinocandin B, and papulacandin B		S000029025
ACR2		Involved in sensitivity to aculeacin A		Resistant to aculeacin A, echinocandin B, but not papulacandin B		S000029026
ACR3		Involved in sensitivity to aculeacin A		Resistant to aculeacin A, echinocandin B, and papulacandin B		S000029027
ACR4		Involved in sensitivity to aculeacin A		Resistant to aculeacin A, echinocandin B, and papulacandin B		S000029028
ACS1	FUN44	Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions	acetyl CoA synthetase	Null mutant is viable and grows on ethanol or glucose (but not acetate) as sole carbon source (but with long lag-phase); acs1 acs2 double null mutant is inviable	YAL054C	S000000050
ACS2		Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions	acetyl CoA synthetase	Null mutant is viable, and grows on ethanol or acetate as sole carbon source, but is unable to grow on glucose as sole carbon source; acs1 acs2 double null mutant is inviable	YLR153C	S000004143
ACT1	ABY1|END7	Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions	actin		YFL039C	S000001855
ADA2	SWI8	Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes	Ada histone acetyltransferase complex component|transcriptional coactivator	Null mutant is viable, grows poorly on minimal media	YDR448W	S000002856
ADD1						S000029029
ADD37		Protein of unknown function involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene			YMR184W	S000004796
ADD66	PBA2	Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly			YKL206C	S000001689
ADE1		N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine	SAICAR synthase|phosphoribosylaminoimidazolesuccinocarbozamide synthetase	Null mutant is viable and adenine auxotroph; ade1 mutants produce red pigment when grown in media containing low lvels of adenine.	YAR015W	S000000070
ADE12	BRA9	Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence	adenylosuccinate synthetase	Adenine requiring	YNL220W	S000005164
ADE13	BRA1|BRA8	Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency	adenylosuccinate lyase	Unable to grow on complete media with glucose or fructose as a carbon source, but can grow with glycerol or ethanol	YLR359W	S000004351
ADE15				Adenine requiring		S000029030
ADE16		Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade17p; ade16 ade17 mutants require adenine and histidine	5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) transformylase/IMP cyclohydrolase	Null mutant is viable; ade16 ade17 double mutant requires adenine	YLR028C	S000004018
ADE17		Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade16p; ade16 ade17 mutants require adenine and histidine	5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) transformylase/IMP cyclohydrolase	Null mutant is viable; ade16 ade17 double mutants require adenine	YMR120C	S000004727
ADE2		Phosphoribosylaminoimidazole carboxylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; red pigment accumulates in mutant cells deprived of adenine	phosphoribosylaminoimidazole carboxylase	Null mutant is viable and requires adenine. ade2 mutants are blocked at a stage in the adenine biosynthetic pathway that causes an intermediate to accumulate in the vacuole; the intermediate gives the cell a red color.	YOR128C	S000005654
ADE3		Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine	C1-tetrahydrofolate synthase	Null mutant is viable, adenine auxotroph, histidine auxotroph	YGR204W	S000003436
ADE4		Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway	phosphoribosylpyrophosphate amidotransferase	Adenine requiring	YMR300C	S000004915
ADE5,7		Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities	aminoimidazole ribotide synthetase|glycinamide ribotide synthetase	Adenine requiring	YGL234W	S000003203
ADE6		Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway	5'-phosphoribosylformyl glycinamidine synthetase	Adenine requiring	YGR061C	S000003293
ADE8		Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway	glycinamide ribotide transformylase	Adenine requiring	YDR408C	S000002816
ADH1	ADC1	Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway	alcohol dehydrogenase	Null mutant is viable and sensitive to formaldehyde.	YOL086C	S000005446
ADH2	ADR2	Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1	alcohol dehydrogenase II		YMR303C	S000004918
ADH3		Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production	alcohol dehydrogenase isoenzyme III		YMR083W	S000004688
ADH4	NRC465|ZRG5	Alcohol dehydrogenase type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency; alcohol dehydrogenase isoenzyme IV	alcohol dehydrogenase isoenzyme IV		YGL256W	S000003225
ADH5		Alcohol dehydrogenase isoenzyme V; involved in ethanol production	alcohol dehydrogenase isoenzyme V		YBR145W	S000000349
ADH6	ADHVI	NADPH-dependent cinnamyl alcohol dehydrogenase family member with broad substrate specificity; may be involved in fusel alcohol synthesis or in aldehyde tolerance	medium chain alcohol dehydrogenase		YMR318C	S000004937
ADH7	ADHVII	NADPH-dependent cinnamyl alcohol dehydrogenase family member with broad substrate specificity; may be involved in fusel alcohol synthesis	medium chain alcohol dehydrogenase		YCR105W	S000000702
ADI1		Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions	Acireductone Dioxygenease		YMR009W	S000004611
ADK1	AKY1|AKY2	Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence	adenylate kinase		YDR226W	S000002634
ADK2	AKY3|PAK3	Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background	GTP:AMP phosphotransferase|adenylate kinase		YER170W	S000000972
ADO1		Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle	adenosine kinase		YJR105W	S000003866
ADP1		Putative ATP-dependent permease of the ABC transporter family of proteins			YCR011C	S000000604
ADR1		Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization	transcription factor	abolished derepression of ADH2	YDR216W	S000002624
ADY2	ATO1	Acetate transporter required for normal sporulation		Null mutant is viable; forms predominantly asci containing 2 spores (dyads) whensporulated; required for long-term growth on YPD at 37 degrees C; defect in ammonia production in S.cerevisiae colonies	YCR010C	S000000603
ADY3		Protein required for spore wall formation, thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p		Null forms largely asci that contain 2 spores (dyads) when sporulated. Sporulation defect in ady3ady3 cells is due to a failure to synthesize spore wall polymers.	YDL239C	S000002398
ADY4		Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane			YLR227C	S000004217
AEP1	NCA1	Protein required for expression of the mitochondrial OLI1 gene encoding subunit 9 of F1-F0 ATP synthase		permanently respiratory defective; unable to translate OLI1 transcripts	YMR064W	S000004668
AEP2	ATP13	Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader		non-conditional respiratory mutant; unable to express the mitochondrial OLI1 gene; pet mutant	YMR282C	S000004895
AEP3		Peripheral mitochondrial inner membrane protein, located on the matrix face of the membrane; stabilizes the bicistronic AAP1-ATP6 mRNA encoding subunits 6 and 8 of the ATP synthase complex			YPL005W	S000005926
AFG1		Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain			YEL052W	S000000778
AFG2	DRG1	ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; may be involved in degradation of aberrant mRNAs			YLR397C	S000004389
AFG3	YTA10	Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes	ATP dependent metalloprotease	nuclear petite phenotype; loss of repspiratory competence	YER017C	S000000819
AFR1		Alpha-factor pheromone receptor regulator, negatively regulates pheromone receptor signaling; required for normal mating projection (shmoo) formation; required for Spa2p to recruit Mpk1p to shmoo tip during mating; interacts with Cdc12p	cytoskeletal protein	defect in alpha-factor-stimulated morphogenesis	YDR085C	S000002492
AFT1	RCS1	Transcription factor involved in iron utilization and homeostasis; binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availability		Null mutant is viable; mutant cells are larger than normal, since critical size for budding is increased; mutant shows incorrect regulation of expression of genes involved in iron uptake; spores from heterozygous diploid have reduced ability to germinate;	YGL071W	S000003039
AFT2		Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; similar to Aft1p		Null: Deletion of AFT2 exacerates iron deficiency of AFT1 disruption.	YPL202C	S000006123
AGA1		Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds	a-agglutinin anchorage subunit	mating defect in liquid medium	YNR044W	S000005327
AGA2		Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds	a-agglutinin adhesion subunit		YGL032C	S000003000
AGC1		Mitochondrial transporter, acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism, ornithine synthesis, and the malate-aspartate NADH shuttle	amino acid transporter	Null: viable. Other phenotypes: not viable on minimal medium supplemented with acetate or oleate	YPR021C	S000006225
AGE1	SAT1	ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif	ARF GAP with effector function(s)		YDR524C	S000002932
AGE2	SAT2	ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif	ARF GAP with effector function(s)		YIL044C	S000001306
AGP1	YCC5	Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)	uncharged amino acid transporter	Null mutant is viable; resistant to the amino acid analog gamma-hydroxyaspartate, decreased growth on asn, gln and some other amino acids in strains in which Gap1 and Gnp1 are also missing.	YCL025C	S000000530
AGP2		High affinity polyamine permease, preferentially uses spermidine over putrescine; expression is down-regulated by osmotic stress; plasma membrane carnitine transporter, also functions as a low-affinity amino acid permease	carnitine transporter	Null mutant is viable; loss of growth on some amino acids as nitrogen source (leu, thr) in a strain which has no Gap1p or Agp1p function	YBR132C	S000000336
AGP3		Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation		Null mutant is viable; loss of growth on some amino acids as nitrogen source (leu, thr) in a strain which has no Gap1p or Agp1p function	YFL055W	S000001839
AGS1				aminoglycoside antibiotic sensitive		S000029031
AGX1		Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases	alanine:glyoxylate aminotransferase		YFL030W	S000001864
AHA1		Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock	co-chaperone		YDR214W	S000002622
AHC1		Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex	Ada histone acetyltransferase complex component		YOR023C	S000005549
AHC2		Protein of unknown function, putative transcriptional regulator; proposed to be a Ada Histone acetyltransferase complex component; GFP tagged protein is localized to the cytoplasm and nucleus			YCR082W	S000000678
AHP1		Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p	alkyl hydroperoxide reductase|cTPxIII	hypersensitive to tert-butyl hydroperoxide	YLR109W	S000004099
AHT1		Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; multicopy suppressor of glucose transport defects, likely due to the presence of an HXT4 regulatory element in the region			YHR093W	S000001135
AI1		Reverse transcriptase required for splicing of the COX1 pre-mRNA, encoded by a mobile group II intron within the mitochondrial COX1 gene	intron-specific reverse transcriptase	unable to excise adjacent aI2 intron; reduced intron mobility	Q0050	S000007261
AI2		Reverse transcriptase required for splicing of the COX1 pre-mRNA, encoded by a mobile group II intron within the mitochondrial COX1 gene	intron-specific reverse transcriptase	defective in aI1 and aI2 intron mobility	Q0055	S000007262
AI3		Endonuclease I-SceIII, encoded by a mobile group I intron within the mitochondrial COX1 gene	I-SceIII endonuclease	Mutations that block aI3 splicing cause defects in respiration and accumulate I-SceIII endonuclease.	Q0060	S000007263
AI4		Endonuclease I-SceII, encoded by a mobile group I intron within the mitochondrial COX1 gene; intron is normally spliced by the BI4p maturase but AI4p can mutate to acquire the same maturase activity	I-SceII endonuclease	Mutations that block aI4 splicing cause defects in respiration; other mutations affect intron mobility or maturase functions.	Q0065	S000007264
AI5_ALPHA		Endonuclease I-SceIV, involved in intron mobility; encoded by a mobile group I intron within the mitochondrial COX1 gene	DNA endonuclease		Q0070	S000007265
AI5_BETA		Protein of unknown function, encoded within an intron of the mitochondrial COX1 gene; translational initiation codon is predicted to be ATA rather than ATG			Q0075	S000007266
AIF1	CPD1	Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase			YNR074C	S000005357
AIP1		Actin cortical patch component, interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats	actin cortical patch component		YMR092C	S000004698
AIR1		RING finger protein that interacts with the arginine methyltransferase Hmt1p to regulate methylation of Npl3p, which modulates Npl3p function in mRNA processing and export; has similarity to Air2p			YIL079C	S000001341
AIR2		RING finger protein that interacts with the arginine methyltransferase Hmt1p; may regulate methylation of Npl3p, which modulates Npl3p function in mRNA processing and export; has similarity to Air1p			YDL175C	S000002334
AKL1		Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization			YBR059C	S000000263
AKR1		Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats	ankyrin repeat-containing protein	Null mutant is viable, exhibits slow growth, abnormal morphology, and partial activation of pheromone response; defective for endocytosis of Ste2p and Ste3p	YDR264C	S000002672
AKR2		Ankyrin repeat-containing protein similar to Akr1p; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p			YOR034C	S000005560
ALA1	CDC64	Cytoplasmic alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog		null mutant is inviable; allele cdc64-1: arrest of proliferation at the regulatory step Start, inhibition of zygote formation and successful conjugation	YOR335C	S000005862
ALB1		Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p			YJL122W	S000003658
ALD1			aldehyde dehydrogenase			S000029651
ALD2		Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p	aldehyde dehydrogenase		YMR170C	S000004780
ALD3		Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose	aldehyde dehydrogenase		YMR169C	S000004779
ALD4	ALD7	Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed	aldehyde dehydrogenase		YOR374W	S000005901
ALD5		Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed	aldehyde dehydrogenase		YER073W	S000000875
ALD6	ALD1	Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress	aldehyde dehydrogenase	Null mutant is viable, grows at approximately one-third the rate of wild-type, unable to grow on ethanol as a carbon source	YPL061W	S000005982
ALF1		Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance	tubulin folding cofactor B	Null mutant is viable, benomyl super-sensitive, alf1 tub1 mutants are inviable	YNL148C	S000005092
ALG1		Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog	beta-1,4-mannosyltransferase		YBR110W	S000000314
ALG11		Alpha-1,2-mannosyltransferase, catalyzes sequential addition of the two terminal alpha 1,2-mannose residues to the Man5GlcNAc2-PP-dolichol intermediate during asparagine-linked glycosylation in the ER		Null mutant displays poor growth and temperature-sensitive lethality	YNL048W	S000004993
ALG12	ECM39	Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation	dolichyl phosphate-D-mannose:protein O-D-mannosyltransferase		YNR030W	S000005313
ALG13		Catalytic component of UDP-GlcNAc transferase, required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferases	UDP-N-acetylglucosamine transferase		YGL047W	S000003015
ALG14		Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases			YBR070C	S000000274
ALG2		Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol	glycosyltransferase	Null mutant is inviable, mutants accumulate Man1-2GlcNAc2 and arrest at G1	YGL065C	S000003033
ALG3	RHK1	Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins		Null mutant is viable, resistant to Hansenula killer toxin	YBL082C	S000000178
ALG5		UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum	UDP-glucose:dolichyl-phosphate glucosyltransferase	underglycosylation of carboxypeptidase Y	YPL227C	S000006148
ALG6		Glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease	alpha-1,2 glucosyltransferase	Null mutant is viable and defective in protein glycosylation.	YOR002W	S000005528
ALG7	TUR1	UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin	UDP-N-acetylglucosamine-1-P transferase	Asparagine-linked glycosylation deficient; Null mutant is inviable	YBR243C	S000000447
ALG8	YOR29-18	Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p	glycosyl transferase		YOR067C	S000005593
ALG9		Mannosyltransferase, involved in N-linked glycosylation; catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation	mannosyltransferase		YNL219C	S000005163
ALK1		Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; similar to Alk2p and to mammalian haspins	haspin		YGL021W	S000002989
ALK2		Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; similar to Alk1p and to mammalian haspins			YBL009W	S000000105
ALO1		D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of D-erythroascorbic acid, which is protective against oxidative stress	D-arabinono-1,4-lactone oxidase	Null mutant is viable, shows increased sensitivity towards oxidative stress	YML086C	S000004551
ALP1	APL1	Basic amino acid transporter, involved in uptake of cationic amino acids	arginine transporter		YNL270C	S000005214
ALR1	SWC3	Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions		Null mutant is inviable; overexpression increases resistance to aluminum and gallium toxicity	YOL130W	S000005490
ALR2		Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions		Null mutant is viable, overexpression increases resistance to aluminum and gallium toxicity	YFL050C	S000001844
ALT1		Putative alanine transaminase (glutamic pyruvic transaminase); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YLR089C	S000004079
ALT2		Putative alanine transaminase (glutamic pyruvic transaminase)			YDR111C	S000002518
ALY1		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm			YKR021W	S000001729
ALY2		Cytoplasmic protein of unknown function that interacts with the cyclin Pcl7p; phosphorylated in vitro by the cyclin-CDK complex, Pcl7p-Pho85p; identified as a potential Cdc28p substrate; mRNA is cell cycle regulated, peaking in M phase			YJL084C	S000003620
AMA1	SPO70	Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis		Null mutant is viable; homozygous null mutant does not sporulate but does not exhibit any vegetative phenotype.	YGR225W	S000003457
AMC1	CHL6	controls segregation of artificial minichromosomes during mitosis		affects mitotic transmission of natural chromosomes		S000029032
AMD1	AMD3	AMP deaminase, tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; may be involved in regulation of intracellular adenine nucleotide pools	AMP deaminase		YML035C	S000004498
AMD2		Putative amidase			YDR242W	S000002650
AME1	ARP100	Essential kinetochore protein associated with microtubules and spindle pole bodies; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance		Null: Null mutant is inviable; localizes to microtubules and SPB region, ame1-1 arrests in G2/M, mutant rescues benomyl sensitivity of TUB4/ tub4 heterozygote, ame1-4 mutant allele and heterozygous mutant confer benomyl resistance, interacts with APC lid protein by two-hybrid	YBR211C	S000000415
AML1		Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae	N-6 adenine-specific DNA methyltransferase 2		YGR001C	S000003233
AMN1	CST13|ICS4	Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)			YBR158W	S000000362
AMS1		Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway	alpha mannosidase		YGL156W	S000003124
ANB1	HYP1|TIF51B	Translation initiation factor eIF-5A, promotes formation of the first peptide bond; similar to and functionally redundant with Hyp2p; undergoes an essential hypusination modification; expressed under anaerobic conditions	translation initiation factor eIF5A	null mutant is viable; a double mutant containing disruptions of both ANB1 and and the highly homologous HYP2 is inviable	YJR047C	S000003808
ANC4		actin non-complementing mutant				S000029033
ANI1				Anisomycin resistance		S000029034
ANP1	GEM3|MNN8	Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol		Null mutant has altered mannoprotein glycosylation and a defect in N-linked outerchain glycan mannosylation; other mutant phenotypes include aminonitrophenyl propanediol resistance, vanadate resistance, hygromycin B sensitive and a clumpy growth morphology.	YEL036C	S000000762
ANR2						S000114863
ANT1		Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation		Null: growth defect on medium-chain length fatty acids.	YPR128C	S000006332
AOS1	RHC31	Nuclear protein that acts as a heterodimer with Uba2p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability			YPR180W	S000006384
APA1	DTP1	Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase I (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa2p	diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase I		YCL050C	S000000555
APA2		Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa1p	5',5'''-P-1,P-4-tetraphosphate phosphorylase II		YDR530C	S000002938
APC1		Largest subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition	ubiquitin ligase subunit		YNL172W	S000005116
APC11		Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition	anaphase promoting complex (APC) subunit	Null mutant is inviable at 25 C	YDL008W	S000002166
APC2	RSI1	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; similar to cullin Cdc53p	anaphase promoting complex (APC) subunit	Null mutant is inviable at 25 deg. C; ts mutants arrest in metaphase due to defect in the degradation of Pds1; extracts from G1-arrested apc2 mutants are defective in the ubiquitination of mitotic cyclins	YLR127C	S000004117
APC4		Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition	anaphase promoting complex (APC) subunit	Null mutant is inviable at 25 C	YDR118W	S000002525
APC5	RMC1	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition	anaphase promoting complex (APC) subunit	Null mutant is inviable at 25 C	YOR249C	S000005775
APC9		Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition	anaphase promoting complex (APC) subunit	Null mutant is viable at 37 C but show delay in entry into anaphase at 37 C	YLR102C	S000004092
APD1		Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus			YBR151W	S000000355
APE2	LAP1|YKL158W	Zinc-dependent metallopeptidase yscII, may have a role in obtaining leucine from dipeptide substrates; sequence coordinates have changed since RT-PCR analysis showed that the adjacent ORF YKL158W comprises the 5' exon of APE2/YKL157W	aminopeptidase yscII		YKL157W	S000001640
APE3	APY1	Vacuolar aminopeptidase Y, processed to mature form by Prb1p	aminopeptidase yscIII	Null mutant is viable but exhibited reduced vacuolar aminopeptidase activities and could not hydrolyze Lys-Ala-MCA to Lys and Ala-MCA.	YBR286W	S000000490
APG11		Involved in autophagy		defective in protein degradation in the vacuoles induced by nitrogen starvation, homozygous diploids fail to sporulate		S000029035
API2		Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology			YDR525W	S000002933
APJ1		Putative chaperone of the HSP40 (DNAJ) family; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YNL077W	S000005021
APL1	YAP80	Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex	beta-adaptin|clathrin associated protein complex large subunit		YJR005W	S000003765
APL2		Beta-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting	beta-adaptin|clathrin associated protein complex large subunit		YKL135C	S000001618
APL3		Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport	clathrin associated protein complex large subunit		YBL037W	S000000133
APL4		Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport	clathrin associated protein complex large subunit|gamma-adaptin		YPR029C	S000006233
APL5	YKS4	Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function	clathrin assembly complex AP-3 adaptin component delta-like subunit	Null mutant is viable, rescues yck1,yck2 double mutant	YPL195W	S000006116
APL6	YKS5	Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools		Null mutant is viable, null rescues yck1 yck2 double mutant	YGR261C	S000003493
APM1	YAP54	Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting	clathrin associated protein complex medium subunit	Null mutant is viable, enhances the slow growth and late Golgi sorting defects of a chc1-ts mutant	YPL259C	S000006180
APM2		Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport			YHL019C	S000001011
APM3	YKS6	Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway	clathrin associated protein complex medium subunit	Null mutant is viable, even combined with apm1 and apm2	YBR288C	S000000492
APM4	AMP1	Mu2-like subunit of the clathrin associated protein complex (AP-2); involved in vesicle transport	clathrin associated protein complex medium subunit		YOL062C	S000005423
APN1		Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine	major apurinic/apyrimidinic endonuclease/3'-repair diesterase	hypersensitive to both oxidative and alkylating agents that damage DNA; higher rate of spontaneous mutation	YKL114C	S000001597
APN2	ETH1	Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII	AP endonuclease		YBL019W	S000000115
APP1		Protein of unknown function, interacts with Rvs161p and Rvs167p; computational analysis of protein-protein interactions in large-scale studies suggests a possible role in actin filament organization		Null: Viable. Other phenotypes: Unknown	YNL094W	S000005038
APQ12		Protein involved in nucleocytoplasmic transport of mRNA			YIL040W	S000001302
APQ13		Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene NET1; null mutant is sensitive to sorbate			YJL075C	S000003611
APR2						S000029037
APR3						S000029038
APR4						S000029039
APR5						S000029040
APS1	YAP19	Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex	clathrin associated protein complex small subunit	Null mutant is viable; aps1 mutants demonstrate synthetic effects with chc1 alleles	YLR170C	S000004160
APS2	YAP17	Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex	clathrin associated protein complex small subunit	null mutant is viable; slight effect on chc1-ts cell growth	YJR058C	S000003819
APS3	YKS7	Small subunit of the clathrin-associated adaptor complex AP-3, which is involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function		Null mutant is viable, rescues yck1,yck2 double mutant	YJL024C	S000003561
APT1		Adenine phosphoribosyltransferase, catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis	adenine phosphoribosyltransferase		YML022W	S000004484
APT2		Apparent pseudogene, not transcribed or translated under normal conditions; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity			YDR441C	S000002849
AQR1		Plasma membrane transporter of the major facilitator superfamily that confers resistance to short-chain monocarboxylic acids and quinidine	multidrug transporter	Null mutant is viable, but exhibits increased susceptibility to low-chain organic acids (C2-C6), azoles, antimalarial quinoline-ring containing drugs, malachite green and crystal violet	YNL065W	S000005009
AQY1		Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance	aquaporin	Null mutant is viable and exhibits improved viability when grown under hypo-osmolar or hyper-osmolar stress.	YPR192W	S000006396
AQY2		Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains			YLL052C	S000003975
ARA1		NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product	D-arabinose dehydrogenase	Null mutant is viable but cannot produce D-arabinono-1,4-lactone, a precursor of D-erythroascorbic acid	YBR149W	S000000353
ARA2		NAD-dependent arabinose dehydrogenase, involved in biosynthesis of erythroascorbic acid; similar to plant L-galactose dehydrogenase	D-arabinose dehydrogenase		YMR041C	S000004644
ARB1		ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p	Shuttling protein, ATP binding cassette protein		YER036C	S000000838
ARC1		Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids		Null mutant is viable, leads to slow growth and reduced MetRS activity; arc1- mutants are synthetic lethals and are complemented by the genes for methionyl-tRNA and glutamyl-tRNA synthetase.	YGL105W	S000003073
ARC15		Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches		Null mutant exhibits severe growth defects. Cells with mutations in Arp2 and Arc15 are defective in mitochondrial movement.	YIL062C	S000001324
ARC18		Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches			YLR370C	S000004362
ARC19		Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches		Null mutant is viable, but exhibits severe growth defects	YKL013C	S000001496
ARC35	END9	Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin		Null mutant exhibits severe growth defects; synthetic lethal with vma2.	YNR035C	S000005318
ARC40		Essential subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches			YBR234C	S000000438
ARD1		Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing	N alpha-acetyltransferase major subunit		YHR013C	S000001055
ARE1	SAT2	Acyl-CoA:sterol acyltransferase, isozyme of Are2p; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen	acyl-CoA cholesterol acyltransferase (sterol-ester synthetase)	Null mutant is viable, slightly reduces in vivo and in vitro ergosterol esterification. Deletion of both ARE1 and ARE2 completely eliminates of in vivo and in vitro ergosterol esterification	YCR048W	S000000644
ARE2	SAT1	Acyl-CoA:sterol acyltransferase, isozyme of Are1p; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen	acyl-CoA cholesterol acyltransferase (sterol-ester synthetase)	Null mutant is viable; greatly reduces in vivo and in vitro ergosterol esterification (to 15 - 35 % of wild-type). Deletion of both ARE1 and ARE2 completely eliminates in vivo and in vitro ergosterol esterification	YNR019W	S000005302
ARF1		ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; functionally interchangeable with Arf2p	ADP-ribosylation factor	Null mutant is viable and shows slow growth, cold sensitivity and sensitivity to normally sublethal concentrations of fluoride ion in the medium.	YDL192W	S000002351
ARF2		ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; functionally interchangeable with Arf1p	ADP-ribosylation factor 2		YDL137W	S000002296
ARF3	ARL2	Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity	GTP-binding ADP-ribosylation factor		YOR094W	S000005620
ARG1	ARG10	Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate	arginosuccinate synthetase	Arginine requiring	YOL058W	S000005419
ARG2	HRB574	Acetylglutamate synthase (glutamate N-acetyltransferase), mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p	acetylglutamate synthase		YJL071W	S000003607
ARG3		Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine	ornithine carbamoyltransferase	Arginine requiring	YJL088W	S000003624
ARG4		Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway	argininosuccinate lyase	Arginine requiring	YHR018C	S000001060
ARG5,6		Protein that is processed in the mitochondrion to yield acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase, which catalyze the 2nd and 3rd steps in arginine biosynthesis; enzymes form a complex with Arg2p	N-acetyl-gamma-glutamyl-phosphate reductase	Arginine requiring	YER069W	S000000871
ARG8		Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine	acetylornithine aminotransferase	Arginine requiring	YOL140W	S000005500
ARG80	ARGR1	Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p	transcription factor	Arginine requiring	YMR042W	S000004645
ARG81	ARGR2	Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p	transcription factor		YML099C	S000004565
ARG82	ARGR3|IPK2	Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; putative nuclear lipid inositol PI3-kinase; regulates arginine-, phosphate-, and nitrogen-responsive genes	inositol polyphosphate multikinase	Null mutant is viable but requires arginine at 23C; growth defect at 30C; inviable at 37C; null is defective in sporulation, mating, amino acid metabolism (fails to grow on medium in which arginine or ornithine is the sole nitrogen source); null mutants accumulate IP3, I(4,5)P2 and have drastically reduced levels of IP4, IP5 and IP6.	YDR173C	S000002580
ARG84				Arginine requiring		S000029041
ARH1		Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability			YDR376W	S000002784
ARK1		Serine/threonine protein kinase involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis		Null mutant is viable and shows slight delocalisation of actin cytoskeleton	YNL020C	S000004965
ARL1	DLP2	Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor	ADP-ribosylation factor-like protein 1		YBR164C	S000000368
ARL3		GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor		Null mutant is viable, displays cold-sensitive growth	YPL051W	S000005972
ARN1		Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores			YHL040C	S000001032
ARN2	TAF1	Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C	triacetylfusarinine C transporter		YHL047C	S000001039
ARO1		Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids	3-dehydroquinate dehydratase (3-dehydroquinase)|3-dehydroquinate synthase|epsp synthase|shikimate 5-dehydrogenase|shikimate kinase	aromatic amino acid requiring; lack of premeiotic DNA synthesis; blocked sporulation in homozygous mutant	YDR127W	S000002534
ARO10		Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway			YDR380W	S000002788
ARO2		Bifunctional chorismate synthase and flavin reductase, catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids	chorismate synthase	aromatic amino acid requiring; lack of premeiotic DNA synthesis; blocked sporulation in homozygous mutant	YGL148W	S000003116
ARO3		3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase isoenzyme		YDR035W	S000002442
ARO4		3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase isoenzyme		YBR249C	S000000453
ARO7	HGS1|OSM2|TYR7	Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis	chorismate mutase	Aromatic amino acid requiring; Low osmotic pressure sensitive	YPR060C	S000006264
ARO8		Aromatic aminotransferase, expression is regulated by general control of amino acid biosynthesis	aromatic amino acid aminotransferase		YGL202W	S000003170
ARO80		Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids			YDR421W	S000002829
ARO9		Aromatic aminotransferase, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism	aromatic amino acid aminotransferase II		YHR137W	S000001179
ARP1	ACT5	Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin		Null mutant is viable, but both null mutations and overexpression lead to defects in spindle orientation and nuclear migration (during mitosis in arp1 mutants the nucleus fails to move into the neck).	YHR129C	S000001171
ARP10		Component of the dynactin complex, localized to the pointed end of the Arp1p filament; may regulate membrane association of the complex			YDR106W	S000002513
ARP2	ACT2	Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity		cells with mutations in Arp2 and Arc15 are defective in mitochondrial movement.	YDL029W	S000002187
ARP3	ACT4	Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity		Mutations in Arp3 lead to defects in actin-patch motility and a rearrangement of the cortical actin cytoskeleton.	YJR065C	S000003826
ARP4	ACT3	Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes	NuA4 histone acetyltransferase subunit		YJL081C	S000003617
ARP5		Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes			YNL059C	S000005004
ARP6		Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A			YLR085C	S000004075
ARP7	RSC11|SWP61	Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation	chromatin remodeling Snf/Swi complex subunit	Null mutant is viable, exhibits typical swi/snf phenotypes, including growth defects on media containing galactose, glycerol, or sucrose as sole carbon sources. ARP7 is required for expression of an HO-lacZ fusion gene and for full transcriptional enhancement by the GAL4 activator	YPR034W	S000006238
ARP8		Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes			YOR141C	S000005667
ARP9	RSC12|SWP59	Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation	chromatin remodeling Snf/Swi complex subunit	Null mutant is viable, exhibits typical swi/snf phenotypes, including growth defects on media containing galactose, glycerol, or sucrose as sole carbon sources. ARP9 is required for expression of an HO-lacZ fusion gene and for full transcriptional enhancement by the GAL4 activator	YMR033W	S000004636
ARR1	ACR1|YAP8	Transcriptional activator of the bZIP family, required for transcription of genes involved in resistance to arsenic compounds		Null mutant is viable, confers arsenite and arsenate hypersensitivity	YPR199C	S000006403
ARR2	ACR2	Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p		Null mutant is viable but sensitive to arsenate (but not arsenite).	YPR200C	S000006404
ARR3	ACR3	Arsenite transporter of the plasma membrane, required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite		Overexpression confers arsenite but not arsenate resistance	YPR201W	S000006405
ARS1		Early-firing autonomously replicating sequence				S000029652
ARS101	ARSI-160	ARS containing multiple redundant binding sites for the origin recognition complex				S000077372
ARS110	ARSI-176	Autonomously Replicating Sequence, originally referred to as ADE1 ARS				S000114488
ARS1208	ARSXII-151|CEN12 ARS	Autonomously Replicating Sequence				S000114848
ARS1516	ADE2 ARS|ARSXV-567	Autonomously Replicating Sequence				S000114843
ARS2		Autonomously Replicating Sequence				S000029042
ARS209		Autonomously Replicating Sequence, originally referred to as H4 ARS				S000114517
ARS300		Autonomously Replicating Sequence				S000028476
ARS301		Inactive replication origin associated with the silent mating type locus HML, where it functions as a transcriptional silencer				S000028477
ARS302		Inactive replication origin associated with the silent mating type locus HML, where it functions as a transcriptional silencer				S000028478
ARS303		Autonomously Replicating Sequence on Chromosome III				S000028479
ARS304		Autonomously Replicating Sequence on Chromosome III				S000028481
ARS305		Early-firing autonomously replicating sequence on Chromosome III				S000028482
ARS306		Autonomously Replicating Sequence on Chromosome III				S000028483
ARS307		Autonomously Replicating Sequence on Chromosome III				S000028484
ARS308		Autonomously Replicating Sequence on Chromosome III				S000028485
ARS309		Autonomously Replicating Sequence on Chromosome III				S000028486
ARS310		Compound autonomously replicating sequence on Chromosome III				S000028487
ARS313	ARSIII-194	Autonomously Replicating Sequence on Chromosome III				S000028488
ARS314	ARSIII-198	Autonomously Replicating Sequence on Chromosome III, active in <10% of cell cycles				S000028489
ARS315	ARSIII-225	Highly-active autonomously replicating sequence, initiates replication in ~90% of cell cycles				S000028490
ARS316	ARSIII-273	Inefficient autonomously replicating sequence, active in ~25% of cell cycles				S000028491
ARS317	HMR-E ARS	Autonomously replicating sequence active in only a small fraction of cell cycles				S000028492
ARS318	HMR-I ARS	Autonomously replicating sequence active in only a small fraction of cell cycles				S000028493
ARS319		Highly-active subtelomeric autonomously replicating sequence, initiates replication in ~90% of cell cycles				S000028494
ARS320		Autonomously Replicating Sequence on Chromosome III				S000028480
ARS404	HO ARS	Autonomously Replicating Sequence				S000114787
ARS422	ARO1 ARS|ARSIV-703	Autonomously Replicating Sequence				S000114834
ARS600	ARS120	Subtelomeric Autonomously Replicating Sequence; originally published as ARS120				S000029653
ARS601		Autonomously replicating sequence on Chromosome VI, overlaps ARS602, ARS601/ARS602 together appear to be activated during the second half of S phase in ~32% of cell cycles				S000007633
ARS602		Autonomously replicating sequence on Chromosome VI, overlaps ARS601, ARS601/ARS602 together appear to be activated during the second half of S phase in ~32% of cell cycles				S000007634
ARS603		Highly-efficient autonomously replicating sequence on Chromosome VI, activated during the second half of S phase in ~67% of cell cycles				S000007635
ARS603.5		Autonomously replicating sequence on Chromosome VI, activated early in S phase in ~50% of cell cycles				S000007645
ARS604		Extremely inefficient autonomously replicating sequence on Chromosome VI				S000007636
ARS605		Autonomously replicating sequence on Chromosome VI, activated early in S phase in ~27% of cell cycles				S000007637
ARS606		Highly-efficient autonomously replicating sequence on Chromosome VI, activated early in S phase in ~74% of cell cycles				S000007638
ARS607		Highly-efficient autonomously replicating sequence on Chromosome VI, activated very early in S phase in >85% of cell cycles				S000007639
ARS608		Extremely inefficient autonomously replicating sequence on Chromosome VI, activated early in S phase in <10% of cell cycles				S000007640
ARS609		Autonomously replicating sequence on Chromosome VI, activated very late in S phase in ~37% of cell cycles				S000007641
ARS610	ARSVI-270	Autonomously Replicating Sequence				S000121260
ARS706	ARO8 ARS	Autonomously Replicating Sequence				S000114845
ARS805	ARSVIII-64|SPO11 ARS	Autonomously Replicating Sequence				S000114849
ARS901	ARS249|ARSIX-215	Autonomously Replicating Sequence				S000007644
ARV1		Protein required for normal intracellular sterol distribution and for sphingolipid metabolism; similar to Nup120p and C. elegans R05H5.5 protein		temperature sensitive, anaerobically inviable, polyene antibiotic sensitive, inviable in the absence of sterol esterification|Subcellular membrane accumulation of free sterol; Mutations in yeast ARV1 are complemented by expression of human ARV1|Subcellular membrane accumulation of free sterol; arv1 mutations are complemented by human ARV1 and are synthetically lethal with are1 and are2 null mutations; null mutant is temperature sensitive, anaerobically inviable, polyene antibiotic sensitive, and inviable in the absence of sterol esterification	YLR242C	S000004232
ARX1		Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex			YDR101C	S000002508
ASC1	CPC2	WD repeat protein (G-beta like protein) involved in translation regulation; required for repression of Gcn4p activity in the absence of amino-acid starvation; core component of the ribosome; ortholog of mammalian RACK1		Null mutant is viable. Null mutation suppresses the absence of growth of a cyp1- strain in anaerobiosis and also causes delayed growth in aerobic or heme sufficient conditions; trp auxotrophs of the asc1 null allele are cold sensitive for growth; other mutants have increased cell size	YMR116C	S000004722
ASC2		CYP1 absence of growth supressor				S000029043
ASE1	YOR29-09	Mitotic spindle midzone localized microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate	spindle midzone component	Null mutant is viable but temperature sensitive.	YOR058C	S000005584
ASF1	CIA1	Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed			YJL115W	S000003651
ASF2		Anti-silencing protein that causes derepression of silent loci when overexpressed			YDL197C	S000002356
ASG1		Proposed transcriptional activator, member of the Gal4p family of zinc cluster proteins		Null: viable. Other phenotypes: suppressor of gcn5 catalytically inactive mutants	YIL130W	S000001392
ASG7		Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell; specific to a-cells and induced by alpha-factor			YJL170C	S000003706
ASH1		Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate	transcription factor	Mutant ash1 daughters can transcribe HO and switch mating type	YKL185W	S000001668
ASI1		Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals			YMR119W	S000004725
ASI2		Integral inner nuclear membrane protein that acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals			YNL159C	S000005103
ASI3		Putative integral membrane E3 ubiquitin ligase; acts with Asi1p and Asi2p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals			YNL008C	S000004953
ASK1		Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases			YKL052C	S000001535
ASK10		Component of the RNA polymerase II holoenzyme, phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p, which relieves repression of stress-response genes	transcriptional activator		YGR097W	S000003329
ASL1				Null: lethal in combination with apl2. Temperature-sensitive allele confers a secretory block in an apl2 background		S000029044
ASM4	NUP59	Nuclear pore complex subunit, part of a subcomplex also containing Nup53p, Nup170p, and Pse1p	nuclear pore complex subunit	Null mutant is viable in some strain backgrounds (including CEN.PK2); however, in the FY1679 genetic background, it is inviable.	YDL088C	S000002246
ASN1		Asparagine synthetase, isozyme of Asn2p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway	asparagine synthetase	Null mutant is viable; L-asparagine auxotrophy occurs upon mutation of both ASN1 and ASN2	YPR145W	S000006349
ASN2		Asparagine synthetase, isozyme of Asn1p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway	asparagine synthetase	Null mutant is viable; L-asparagine auxotrophy occurs upon mutation of both ASN1 and ASN2	YGR124W	S000003356
ASP1		Cytosolic L-asparaginase, involved in asparagine catabolism	asparaginase I	Aspartic acid requiring	YDR321W	S000002729
ASP3-1	ASP3	Cell-wall L-asparaginase II, involved in asparagine catabolism; expression is induced during nitrogen starvation; four copies of ASP3 are present in the genome reference strain S288C	nitrogen catabolite-regulated cell-wall L-asparaginase II		YLR155C	S000004145
ASP3-2	ASP3	Cell-wall L-asparaginase II, involved in asparagine catabolism; expression is induced during nitrogen starvation; four copies of ASP3 are present in the genome reference strain S288C	nitrogen catabolite-regulated cell-wall L-asparaginase II		YLR157C	S000004147
ASP3-3	ASP3	Cell-wall L-asparaginase II, involved in asparagine catabolism; expression is induced during nitrogen starvation; four copies of ASP3 are present in the genome reference strain S288C	nitrogen catabolite-regulated cell-wall L-asparaginase II		YLR158C	S000004148
ASP3-4	ASP3	Cell-wall L-asparaginase II, involved in asparagine catabolism; expression is induced during nitrogen starvation; four copies of ASP3 are present in the genome reference strain S288C	nitrogen catabolite-regulated cell-wall L-asparaginase II		YLR160C	S000004150
ASR1		Protein involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain			YPR093C	S000006297
AST1		Peripheral membrane protein that interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane, possibly by influencing its incorporation into lipid rafts		multicopy AST1 suppresses pma1 alleles defective for targeting	YBL069W	S000000165
AST2		Protein that may have a role in targeting of plasma membrane [H+]ATPase (Pma1p) to the plasma membrane, as suggested by analysis of genetic interactions		in high copy number, suppresses a pma1 ts mutant that is mis-routed to the vacuole at the restrictive temperature	YER101C	S000000903
ASU9		anti-suppressor that reduces the efficiency of sup45 and sup35		asu9 allele causes sensitivity to paromomycin		S000029045
ATA1		Sporulation-specific gene characterized by ATA sequences				S000029046
ATC1	LIC4	Nuclear protein, possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern			YDR184C	S000002592
ATE1		Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway	arginyl-tRNA-protein transferase	Null mutant is viable, but unable to degrade substrates of the N-end rule pathway that start with residues recognized by the Arg-transferase	YGL017W	S000002985
ATF1		Alcohol acetyltransferase with potential roles in lipid and sterol metabolism; responsible for the major part of volatile acetate ester production during fermentation	alcohol acetyltransferase		YOR377W	S000005904
ATF2		Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important in brewing	alcohol acetyltransferase		YGR177C	S000003409
ATG1	APG1|AUT3|CVT10	Protein serine/threonine kinase, required for autophagy and for the cytoplasm-to-vacuole targeting (Cvt) pathway	serine/threonine protein kinase	Defective in autophagy; loses viability more rapidly than wild type during nitrogen starvation; defective in vacuolar protein degradation during nitrogen starvation; defective in sporulation	YGL180W	S000003148
ATG10	APG10	E2-like conjugating enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy	protein-conjugating enzyme	Defective autophagy, apg10-1 allele shows reduced viablility under starvation conditions	YLL042C	S000003965
ATG11	CVT9	Peripheral membrane protein required for delivery of aminopeptidase I (Lap4p) to the vacuole in the cytoplasm-to-vacuole targeting pathway; also required for peroxisomal degradation (pexophagy)	Oligomeric, coiled-coil, peripheral membrane protein required for stable binding of precursor API to its target membrane.	cvt9 is defective in maturation of the vacuolar protein, aminopeptidase I and exhibits minor defects in autophagy|cvt9 is defective in vacuolar delivery of aminopeptidase I and peroxisome degradation but is not needed for macroautophagy. The null mutant is viable and is relatively starvation-insensitive.	YPR049C	S000006253
ATG12	APG12	Ubiquitin-like modifier, conjugated via an isopeptide bond to a lysine residue of Atg5p by the E1 enzyme, Atg7p, and the E2 enzyme, Atg10p, a step that is essential for autophagy		Null mutant is viable, defective in autophagy	YBR217W	S000000421
ATG13	APG13	Phosphorylated protein that interacts with Vac8p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway and autophagy		Defective in autophagy	YPR185W	S000006389
ATG14	APG14|CVT12	Subunit of an autophagy-specific phosphatidylinositol 3-kinase complex (with Vps34p, Vps15p, and Vps30p) required for organization of a pre-autophagosomal structure; ATG14 transcription is activated by Gln3p during nitrogen starvation		Null mutant is viable but defective in autophagy.	YBR128C	S000000332
ATG15	AUT5|CVT17	Lipase, required for intravacuolar lysis of autophagic bodies; located in the endoplasmic reticulum membrane and targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway		cvt17 is defective in lysis of autophagic vesicles after delivery to the vacuole. Null mutant is starvation-sensitive, accumulates subvacuolar vesicles, defective in maturation of aminopeptidase I and in autophagy.	YCR068W	S000000664
ATG16	APG15|APG16|CVT11|SAP18	Protein that interacts with the Atg12p-Atg5p conjugate during formation of the pre-autophagosomal structure; essential for autophagy		Null mutant is viable, defective in autophagy	YMR159C	S000004769
ATG17	APG17	Scaffold potein responsible for pre-autophagosomal structure organization; interacts with and is required for activation of Apg1p protein kinase; involved in autophagy but not in the Cvt (cytoplasm to vacuole targeting) pathway		required for activation of Apg1 protein kinase|Null mutant is viable and has defect in autophagy	YLR423C	S000004415
ATG18	AUT10|CVT18|NMR1|SVP1	Phosphatidylinositol 3,5-bisphosphate-binding protein of the vacuolar membrane, predicted to fold as a seven-bladed beta-propeller; required for recycling of Atg9p through the pre-autophagosomal structure		(NMR1)Null mutant is viable; arrests with 2C DNA content after shift to sporulation medium.	YFR021W	S000001917
ATG19	CVT19	Protein involved in the cytoplasm-to-vacuole targeting pathway and in autophagy, recognizes cargo proteins and delivers them to the preautophagosomal structure for eventual engulfment by the autophagosome and degradation	Receptor for biosynthetic cytoplasm to vacuole targeting	Null: viable, unable to target vacuolar aminopeptidase I and to vacuoles, both under growing and nitrogen starvation conditions.	YOL082W	S000005442
ATG2	APG2|AUT8|SPO72	Peripheral membrane protein required for the formation of cytosolic sequestering vesicles involved in vacuolar import through both the Cvt pathway and autophagy; interacts with Atg9p and is necessary for its trafficking		The null mutant is viable but blocked in autophagy, pexophagy and import of Ape1 by the cytoplasm to vacuole targeting pathway. Diploids homozygous for the null mutation lack premeitoic DNA synthesis and do not sporulate.	YNL242W	S000005186
ATG20	CVT20|SNX42	Protein required for transport of aminopeptidase I (Lap4p) through the cytoplasm-to-vacuole targeting pathway; binds phosphatidylinositol-3-phosphate, involved in localization of membranes to the preautophagosome, potential Cdc28p substrate		Null: The cvt20 mutant accumulates precursor Ape1 but is normal for autophagy.. Other phenotypes: A mutation of a conserved tyrosine to alanine in the PX domain abolishes binding to PtdIns(3)P.	YDL113C	S000002271
ATG21	HSV1|MAI1	Phosphatidylinositol 3,5-bisphosphate-binding protein required for maturation of pro-aminopeptidase I, predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization		mai1 null is viable; mai1 aut10 ygr223c triple deletion strain does not grow on a specific acetate medium at 15C	YPL100W	S000006021
ATG22	AUT4	Protein required for the breakdown of autophagic vesicles in the vacuole during autophagy, putative integral membrane protein that localizes to vacuolar membranes and punctate structures attached to the vacuole		Null mutant is viable, but exhibits defects in lysis of autophagic vesicles after delivery to the vacuole; vesicles accumulate in the vacuole in the absence of PMSF; maturation of the vacuolar protein, aminopeptidase I is unaffected in aut4	YCL038C	S000000543
ATG23	CVT23	Peripheral membrane protein, required for autophagy and for the cytoplasm-to-vacuole targeting (Cvt) pathway			YLR431C	S000004423
ATG26	UGT51	UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids, involved in autophagy	UDP-glucose:sterol glucosyltransferase	Null mutant is viable and unable to synthesize sterol glucoside	YLR189C	S000004179
ATG27	ETF1	Type II membrane protein involved in autophagy; binds phosphatidylinositol 3-phosphate, required for the cytoplasm-to-vacuole targeting (Cvt) pathway			YJL178C	S000003714
ATG29		Protein specifically required for autophagy; may function in autophagosome formation at the pre-autophagosomal structure in collaboration with other autophagy proteins			YPL166W	S000006087
ATG3	APG3|AUT1	Protein involved in autophagy; E2-like enzyme that plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy		Null mutant is viable, defective in starvation-induced bulk flow transport of cytoplasmic proteins to the vacuole, exhibits decreased survival rates during starvation, defective in protein degradation in the vacuoles induced by nitrogen starvation, homozygous diploids fail to sporulate	YNR007C	S000005290
ATG4	APG4|AUT2	Cysteine protease required for autophagy; cleaves Atg8p to a form required for autophagosome and Cvt vesicle generation; mediates attachment of autophagosomes to microtubules through interactions with Tub1p and Tub2p	mediates attachment of autophagosomes to microtubules	Null mutant is viable but lacks autophagocytosis: i.e. starvation-induced protein transport to the vacuole; homozygous aut2-mutant diploids cannot sporulate	YNL223W	S000005167
ATG5	APG5	Conserved autophagy-related protein that undergoes conjugation with Atg12p and then associates with Atg16p to form a cytosolic complex essential for autophagosome formation		reduced viability upon nutrient starvation; defective in autophagy	YPL149W	S000006070
ATG7	APG7|CVT2	Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation		Null mutant is viable, defective in autophagy	YHR171W	S000001214
ATG8	APG8|AUT7|CVT5	Protein required for autophagy; modified by the serial action of Atg4p, Atg7p, and Atg3p, and conjugated at the C terminus with phosphatidylethanolamine, to become the form essential for generation of autophagosomes		Null mutant is viable but lacks autophagocytosis and is unable to sporulate. AUT7 is a suppressor of mutant phenotypes of aut2-1 cells. Uptake of precursor Aminopeptidase I into the vacuole depends on Aut2p and Aut7p.	YBL078C	S000000174
ATG9	APG9|AUT9|CVT7	Transmembrane protein involved in formation of Cvt and autophagic vesicles; cycles between the pre-autophagosomal structure and other cytosolic punctate structures, not found in autophagosomes		Null mutant is viable but blocked in autophagy and aminopeptidase I import into vacuole. Temperature-sensitive mutant accumulates membrane-associated, protease-sensitive API.	YDL149W	S000002308
ATH1		Acid trehalase required for utilization of extracellular trehalose	acid trehalase	Null mutant is viable; shows lack of vacuolar acid trehalase activity	YPR026W	S000006230
ATI5		acaciae toxin insensitive		Recessives are insensitive to the toxin produced by Pichia acaciae		S000029047
ATM1		Mitochondrial inner membrane transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol; member of the ATP-binding cassette (ABC) transporter family	iron-sulfur cluster transporter	slow growth on rich medium, inviable on minimal medium; unstable mitochondrial genome; have 'white' mitochondria that completely lack cytochromes	YMR301C	S000004916
ATO2	FUN34	Putative transmembrane protein, involved in the export of ammonia, a starvation signal that promotes cell death in the center of aging colonies; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p		Null mutant is viable. Other phenotype: defect in ammonia production in S.cerevisiae colonies	YNR002C	S000005285
ATO3		Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; member of the TC 9.B.33 YaaH family of putative transporters		Null: viable. Other phenotypes: defect in ammonia production in S.cerevisiae colonies	YDR384C	S000002792
ATP1		Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis	F1F0 ATP synthase alpha subunit	null mutant is viable; grows slowly on fermentable carbon sources; exhibits delayed kinetics of protein import for several mitochondrial precursors	YBL099W	S000000195
ATP10		Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6		loss of rutamycin sensitivity in mitochondrial ATPase but no effect on respiratory enzymes	YLR393W	S000004385
ATP11		Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase		greatly reduced ATPase activity; alpha and beta subunits of F1-ATPase accumulate in mitochondria as inactive aggregates	YNL315C	S000005259
ATP12		Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency		greatly reduced ATPase activity; alpha and beta subunits of F1-ATPase accumulate in mitochondria as inactive aggregates	YJL180C	S000003716
ATP14		Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis	F1F0 ATP synthase subunit h	unable to grow on glycerol medium; no detectable oligomycin-sensitive ATPase activity	YLR295C	S000004286
ATP15	ATPEPSILON	Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis	F1F0 ATP synthase epsilon subunit	unable to grow on glycerol medium; no detectable oligomycin-sensitive ATPase activity; oligomycin-sensitive uncoupling of the mitochondrial respiration rate	YPL271W	S000006192
ATP16		Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis	F1F0 ATP synthase delta subunit	cells are entirely cytoplasmic petite	YDL004W	S000002162
ATP17		Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis	F1F0 ATP synthase subunit f	No growth on glycerol	YDR377W	S000002785
ATP18		Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms		Null mutant is viable, deficient in oligomycin-sensitive ATPase activity, and is unable to grow on nonfermentable carbon sources.	YML081C-A	S000007247
ATP19		Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase	F1F0 ATP synthase subunit k		YOL077W-A	S000007339
ATP2		Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis	F1F0 ATP synthase beta subunit	Mutant displays a growth defect on glycerol	YJR121W	S000003882
ATP20		Subunit g of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase	F1F0 ATP synthase subunit g	Null mutant is viable but exhibits a reduced growth rate on respiratory substrates	YPR020W	S000006224
ATP22	TCM10	Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis			YDR350C	S000002758
ATP23		Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex			YNR020C	S000005303
ATP3		Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis	F1F0 ATP synthase gamma subunit		YBR039W	S000000243
ATP4	LPF7	Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis	F1F0 ATP synthase subunit b	Null mutant is viable but is oxidative phosphorylation deficient, is unable to grow on glycerol, shows an F1 loosely bound to mitochondrial membrane, lacks subunit 6 in F0, has a five times lower cytochrome oxidase activity, produces a high percentage of sponteneous rho- mutants, and is oligomycin-insensitive	YPL078C	S000005999
ATP5	OSC1	Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein)	F1F0 ATP synthase subunit 5|oligomycin sensitivity-conferring protein	null mutant is viable, but unable to grow on glycerol; exhibits high level of genetic instability	YDR298C	S000002706
ATP6	OLI2|OLI4|PHO1	Mitochondrially encoded subunit 6 of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis	F1F0 ATP synthase subunit 6	oligomycin resistance	Q0085	S000007268
ATP7		Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis	F1F0 ATP synthase subunit d	glycerol minus phenotype; mitochondria have no detectable oligomycin-sensitive ATPase activity; F1 loosely bound to the membranous portion	YKL016C	S000001499
ATP8	AAP1	Subunit 8 of the F0 sector of mitochondrial inner membrane F1-F0 ATP synthase, encoded on the mitochondrial genome	F1F0 ATP synthase subunit 8	Loss of respiratory function	Q0080	S000007267
ATR1	SNQ1	Multidrug efflux pump of the major facilitator superfamily, required for resistance to aminotriazole and 4-nitroquinoline-N-oxide		Null mutant is viable, but is sensitive to very low (5 mM) levels of aminotriazole and to 4-nitroquinoline-N-oxide (4-NQO); multiple copies of ATR1 confer hyper-resistance to 4-NQO; multiple copies of ATR1 in gcn4 background confer resistance to high (80mM) levels of aminotriazole	YML116W	S000004584
ATS1	FUN28|KTI13	Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle		slow growth	YAL020C	S000000018
ATX1		Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake	copper chaperone	hypersensitive toward paraquat (a generator of superoxide anion)	YNL259C	S000005203
ATX2	YOR29-30	Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation		Null mutant is viable but has reduced levels of intracellular manganese.	YOR079C	S000005605
AUA1	YFL011W-A	Protein required for the negative regulation by ammonia of Gap1p, which is a general amino acid permease			YFL010W-A	S000001955
AUR1		Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance		Null mutant is inviable; mutant exhibits dominant resistance to aureobasidin A. Wild type (sensitive) is recessive.	YKL004W	S000001487
AUS1		Transporter of the ATP-binding cassette family, involved in uptake of sterols and anaerobic growth		Null mutant is viable but exhibits reduced cholesterol accumulation.	YOR011W	S000005537
AUT6		Defective in autophagocytosis		AUT6 was isolated genetically as a mutant defective in autophagy.		S000029048
AVL9		Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms		Transposon insertion allele is synthetically lethal with pho85-delta	YLR114C	S000004104
AVO1		Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth			YOL078W	S000005438
AVO2		Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth			YMR068W	S000004672
AVT1		Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters	neutral amino acid transporter		YJR001W	S000003761
AVT2		Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters			YEL064C	S000000790
AVT3		Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters	neutral amino acid transporter		YKL146W	S000001629
AVT4		Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters	neutral amino acid transporter		YNL101W	S000005045
AVT5		Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters			YBL089W	S000000185
AVT6		Vacuolar transporter, exports aspartate and glutamate from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters	amino acid transporter		YER119C	S000000921
AVT7		Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters			YIL088C	S000001350
AWA1		Putative GPI-anchored protein, localized to the cell wall; involved in foam formation in sake mash by conferring hydrophobicity to the cell surface				S000029703
AXE1		Is very likely an allele of PDR1		Axenomycin resistance		S000029050
AXL1	FUS5|STE22	Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells		Null mutant is viable; exhibits reduced a-factor expresion; haploid mutants show bipolar budding pattern (diploid pattern) rather than the normal axial (spiral) budding pattern	YPR122W	S000006326
AXL2	BUD10|SRO4	Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate			YIL140W	S000001402
AYR1		NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones	1-acyl dihydroxyacetone phosphate reductase	Null mutant is viable. ybr159w/ayr1 double mutant is inviable.	YIL124W	S000001386
AYT1		Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis			YLL063C	S000003986
AZF1		Zinc-finger transcription factor, involved in induction of CLN3 transcription in response to glucose; genetic and physical interactions indicate a possible role in mitochondrial transcription or genome maintenance			YOR113W	S000005639
AZR1		Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole			YGR224W	S000003456
BAG7		Rho GTPase activating protein (RhoGAP), stimulates the intrinsic GTPase activity of Rho1p, which plays a role in actin cytoskeleton organization and control of cell wall synthesis; structurally and functionally related to Sac7p	GTPase activating protein (GAP)	Null mutant is viable; overexpression suppresses sac7 null mutation	YOR134W	S000005660
BAP2		High-affinity leucine permease, functions as a branched-chain amino acid permease involved in the uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains	amino acid transporter	reduced uptake of leucine, isoleucine, and valine	YBR068C	S000000272
BAP3	PAP1	Amino acid permease involved in the uptake of cysteine, leucine, isoleucine and valine	amino acid transporter		YDR046C	S000002453
BAR1	SST1	Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest	metalloprotease	MATa bar1 cells are supersensitive to the G1 arrest induced by alpha factor	YIL015W	S000001277
BAS1		Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes	transcription factor		YKR099W	S000001807
BAT1	ECA39|TWT1	Mitochondrial branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during logarithmic phase and repressed during stationary phase	branched-chain amino acid transaminase	Null mutant is viable; ILV auxotrophy in bat1 bat2 double mutant	YHR208W	S000001251
BAT2	ECA40|TWT2	Cytosolic branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase	branched-chain amino acid transaminase		YJR148W	S000003909
BBC1	MTI1|YJL021C	Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches			YJL020C	S000003557
BBP1		Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p		Null mutant is inviable; cells depleted of Bbp1p are defective in nuclear segregation, bud formation, cytokinesis and nuclear spindle formation; overexpression gives ascus that contains asci instead of spores	YPL255W	S000006176
BCD1		Essential protein required for the accumulation of box C/D snoRNA			YHR040W	S000001082
BCH1		Member of the Chs5p-Arf1p-binding proteins (ChAPs), a group of 4 related, interacting proteins (Bch1p, Fmp50p, Bud7p, Chs6p) that mediate export of specific cargo proteins, including chitin synthase Chs3p; may interact with ribosomes			YMR237W	S000004850
BCH2	FMP50	Member of the Chs5p-Arf1p-binding proteins (ChAPs), a group of 4 related, interacting proteins (Bch1p, Fmp50p, Bud7p, Chs6p) that mediate export of specific cargo proteins, including chitin synthase Chs3p, from the Golgi to plasma membrane			YKR027W	S000001735
BCK1	LAS3|SAP3|SLK1|SSP31	Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p	MAP kinase kinase kinase (MEKK)	Null mutants are temperature-sensitive and exhibit cell lysis, which can be rescued by 1M sorbitol; null mutants grow very poorly even at the permissive temperature. Some dominant alleles suppress a pkc1 null mutant.	YJL095W	S000003631
BCK2	CTR7	Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations			YER167W	S000000969
BCP1		Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport			YDR361C	S000002769
BCS1		Protein of the mitochondrial inner membrane that functions as an ATP-dependent chaperone, required for the incorporation of the Rip1p and Qcr10p subunits into the cytochrome bc(1) complex; member of the CDC48/PAS1/SEC18 ATPase family	ATPase (AAA family)	Gross reduction in the Rieske iron-sulfur subunit	YDR375C	S000002783
BCY1	SRA1	Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA), a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation	cAMP-dependent protein kinase regulatory subunit	Null mutant is viable; sra1 mutants are associated with reduction of glycogen accumulation, temperature sensitivity, reduced growth rate on maltose and sucrose, inability to grow on galactose and nonfermentable carbon sources and nitrogen starvation intolerance. Cells lacking Sra1p are constitutive for cAPK activity resulting in meiotic arrest prior to premeiotic DNA synthesis	YIL033C	S000001295
BDF1		Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p		Null mutant is viable; defect in sporulation and spore formation, reduced rate of vegetative growth, sensitivity to a DNA-damaging agent, defective in snRNA production	YLR399C	S000004391
BDF2		Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p		Null mutant is viable in FY1679, RAY3A-D, and CEN.PK2 backgrounds, and synthetic lethal with bdf1	YDL070W	S000002228
BDH1		NAD-dependent (2R,3R)-2,3-butanediol dehydrogenase, a zinc-containing medium-chain alcohol dehydrogenase, produces 2,3-butanediol from acetoin during fermentation and allows using 2,3-butanediol as a carbon source during aerobic growth	(2R,3R)-2,3-butanediol dehydrogenase		YAL060W	S000000056
BDH2		Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; BDH2 is an essential gene			YAL061W	S000000057
BDP1	TFC5	Essential subunit of RNA polymerase III transcription factor (TFIIIB), which is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs	transcription factor TFIIIB subunit	Null mutant is inviable; tfc5 mutant suppresses mutations in the class III transcription system	YNL039W	S000004984
BDS1		Bacterially-derived sulfatase required for use of alkyl- and aryl-sulfates as sulfur sources	alkyl/aryl-sulfatase		YOL164W	S000005524
BEL3				bel3 bel7 mutations cause enhanced transcription of a gene fusion, consisting of the open reading frame of PHO5 connected to the HIS5 promoter (HIS5p) integrated at the ura3 or leu2 locus in a gcn4 null background		S000029051
BEL4				bel4 mutations cause enhanced transcription of a gene fusion, consisting of the open reading frame of PHO5 connected to the HIS5 promoter (HIS5p) integrated at the ura3 or leu2 locus in a gcn4 null background		S000029052
BEL5				bel5 bel6 mutations cause enhanced transcription of a gene fusion, consisting of the open reading frame of PHO5 connected to the HIS5 promoter (HIS5p) integrated at the ura3 or leu2 locus in a gcn4 null background		S000029053
BEL6				bel6 bel5 mutations cause enhanced transcription of a gene fusion, consisting of the open reading frame of PHO5 connected to the HIS5 promoter (HIS5p) integrated at the ura3 or leu2 locus in a gcn4 null background		S000029054
BEL7				bel7 bel3 mutations cause enhanced transcription of a gene fusion, consisting of the open reading frame of PHO5 connected to the HIS5 promoter (HIS5p) integrated at the ura3 or leu2 locus in a gcn4 null background		S000029055
BEM1	SRO1	Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p		Null mutant is viable; exhibits a defect in polarization in vegetative cells, exhibits decreased expression of FUS1	YBR200W	S000000404
BEM2	IPL2|SUP9|TSL1	Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence	rho GTPase activating protein (GAP)	randomized bud-site selection at 26 degrees C and defective bud emergence and growth at 37 degrees C	YER155C	S000000957
BEM3		Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly	rho GTPase activating protein (GAP)		YPL115C	S000006036
BEM4	ROM7	Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length			YPL161C	S000006082
BER1						S000116954
BET1	SLY12	Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins			YIL004C	S000001266
BET2		Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p	geranylgeranyltransferase type II beta subunit		YPR176C	S000006380
BET3		Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles; component of the TRAPP (transport protein particle) complex	transport protein particle (TRAPP) component		YKR068C	S000001776
BET4		Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p	geranylgeranyltransferase type II alpha subunit (PGGTase-II, alpha subunit)		YJL031C	S000003568
BET5		Component of the TRAPP (transport protein particle) complex, which plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi	TRAPP 18kDa component		YML077W	S000004542
BFA1	IBD1	Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis		Null mutant is viable; mutants are sensitive to microtubule inhibitors, exhibit defects in mitotic checkpoints, and exhibit moderate defects in mating efficiency	YJR053W	S000003814
BFR1		Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity			YOR198C	S000005724
BFR2		Essential protein possibly involved in secretion; multicopy suppressor of sensitivity to Brefeldin A		Null mutant is inviable; BFR2 overexpression can suppress the growth defect of mutants blocked at the step of budding or docking of small vessicles en route to the Golgi	YDR299W	S000002707
BGL2		Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance	cell wall endo-beta-1,3-glucanase		YGR282C	S000003514
BI2		Mitochondrial mRNA maturase with a role in splicing, encoded by both exon and intron sequences of partially processed COB mRNA	mitochondrial mRNA maturase		Q0110	S000007271
BI3		Mitochondrial mRNA maturase, forms a complex with Mrs1p to mediate splicing of the bI3 intron of the COB gene; encoded by both exon and intron sequences of partially processed COB mRNA	mitochondrial mRNA maturase		Q0115	S000007272
BI4		Mitochondrial mRNA maturase, forms a complex with Nam2p to mediate splicing of the bI4 intron of the COB gene; encoded by both exon and intron sequences of partially processed COB mRNA	mitochondrial mRNA maturase		Q0120	S000007273
BIG1		Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall beta-1,6-glucan		Null mutant is viable but shows very slow growth on glucose, cells are big and accumulate increased ploidy; overexpression suppresses rot1 rot2 synthetic lethality	YHR101C	S000001143
BIK1	ARM5|PAC14	Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170		Null mutant is viable, bik1 mutants exhibit bilateral defects in karyogamy	YCL029C	S000000534
BIM1	EB1|YEB1	Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally		Null mutant is viable, causes cold sensitivity, benomyl supersensitivity, aberrant microtubule morphology. During mitosis in bim1 mutants, the nucleus fails to move to the mother-bud neck.	YER016W	S000000818
BIO2		Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant	biotin synthase		YGR286C	S000003518
BIO3		7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis	7,8-diamino-pelargonic acid aminotransferase (DAPA) aminotransferase		YNR058W	S000005341
BIO4		Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels	dethiobiotin synthetase		YNR057C	S000005340
BIO5		Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis			YNR056C	S000005339
BIO6		Biotin biosynthetic enzyme; first identified in sake strains and some lab strains; homologs present in S. bayanus, S. paradoxus, S. mikatae and S. kudriavzevii; disruptants are auxotrophic for biotin				S000029723
BIR1		Essential chromosomal passenger protein involved in coordinating cell cycle events for proper chromosome segregation; C-terminal region binds Sli15p, and the middle region, upon phosphorylation, localizes Cbf2p to the spindle at anaphase			YJR089W	S000003849
BIT2		Hypothetical protein			YBR270C	S000000474
BIT61		Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p-Slm1p-Slm2p), a membrane-associated complex that regulates cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity			YJL058C	S000003594
BLM1		Required for resistance to bleomycin, ionizing radiation and oxidative damage by hydrogen peroxide; mutants display slow growth and abnormal morphology; homozygous mutant has reduced spore viability; bleomycin resistance suppressed by MSH4;				S000119219
BLM10	YFL006W	Proteosome activator subunit; found in association with core particles, with and without the 19S regulatory particle; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200			YFL007W	S000001887
BLM3		Required for resistance to bleomycin				S000086717
BLM5		Required for resistance to bleomycin, ionizing radiation and oxidative damage by hydrogen peroxide, required for sporulation		blm5 mutants arrest in meiosis at the mononucleate stage		S000029056
BLS2				Blasticidin-S resistance		S000029057
BMH1	APR6	14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling		Null mutant is viable; bmh1 bmh2 double mutant is inviable; (in strain Sigma-1278b, required for pseudohyphal development but not for viability)	YER177W	S000000979
BMH2	SCD3	14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling		Null mutant is viable; bmh1 bmh2 double mutant is inviable; (in strain Sigma-1278b, required for pseudohyphal development but not for viability)	YDR099W	S000002506
BMK6						S000029058
BMK7						S000029059
BMK8						S000029060
BMS1		Essential conserved nucleolar GTP-binding protein required for synthesis of 40S ribosomal subunits and for processing of the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, has similarity to Tsr1p		Null mutant is inviable; a temperature-sensitive allele exhibits a synthetic growth defect with bmh1-delta; the temperature-sensitive allele also exhibits diploid specific bud site randomization at the semi-permissive temperature	YPL217C	S000006138
BNA1	HAD1	3-hydroxyanthranilic acid dioxygenase, required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway	3-hydroxyanthranilic acid dioxygenase	Null mutant is viable, nicotinic acid auxotroph. Deletion results in significant rDNA silencing defect only on medium deficient in nicotinic acid, an NAD(+) precursor.	YJR025C	S000003786
BNA2		Tryptophan 2,3-dioxygenase, required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway		Null: Nicotinic acid auxotroph. Other phenotypes: Deletion of the gene is co-lethal with the deletion of NPT1	YJR078W	S000003839
BNA3		Arylformamidase, involved in biosynthesis of nicotinic acid from tryptophan via kynurenine pathway; potential Cdc28p substrate	arylformamidase	Null: none detected	YJL060W	S000003596
BNA4		Kynurenine 3-mono oxygenase, required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway	Kynurenine 3-mono oxygenase	Null: Nicotinic acid auxotroph. Other phenotypes: Deletion of the gene is co-lethal with the deletion of NPT1	YBL098W	S000000194
BNA5		Kynureninase, required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway	Kynureninase	Null: Nicotinic acid auxotroph. Other phenotypes: Deletion of the gene is co-lethal with the deletion of NPT1	YLR231C	S000004221
BNA6	QPT1	Quinolinate phosphoribosyl transferase, required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway	quinolinate phosphoribosyl transferase	Null: Nicotinic acid auxotroph. Other phenotypes: Deletion of the gene is co-lethal with the deletion of NPT1	YFR047C	S000001943
BNI1	PPF3|SHE5	Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1	formin, involved in spindle orientation	Null mutant is viable, bni1 bnr1 double deletion mutants are temperature sensitive and are deficient in bud emergence, exhibit a random distribution of cortical actin patches and often become multinucleate at the restrictive temperature; rho1 bni1 double mutants exhibit synthetic lethality	YNL271C	S000005215
BNI4		Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p		Null mutant is viable, shows delocalized chitin, elongated buds, enlarged bud necks	YNL233W	S000005177
BNI5		Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner		Null: Null mutant is viable, interacts genetically with CDC3, CDC10, CDC11, and CDC12 (septin) genes	YNL166C	S000005110
BNR1		Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1		Null mutant is viable; bni1 bnr1 double mutant exhibits severe temperature sensitive growth	YIL159W	S000001421
BNS1		Protein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosis		Null mutant is viable and exhibits no obvious meiotic defects. When overexpressed, BNS1 can partially suppress the meiotic defect of spo12/spo12 deletion mutants.	YGR230W	S000003462
BOI1	BOB1|GIN7	Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain			YBL085W	S000000181
BOI2	BEB1	Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain		Null boi1 boi2 mutants become large round cells or lysed with buds, display defects in bud formation and in the maintenance of cell polarity	YER114C	S000000916
BOP2		Protein of unknown function, overproduction suppresses a pam1 slv3 double null mutation		Null: Multicopy suppressor of a pam1 slv3 double deletion mutant	YLR267W	S000004257
BOP3		Protein of unknown function, potential Cdc28p substrate; overproduction suppresses a pam1 slv3 double null mutation and confers resistance to methylmercury		Null: Multicopy suppressor of a pam1 slv3 double deletion mutant	YNL042W	S000004987
BOR1		Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1	boron transporter		YNL275W	S000005219
BOS1	SEC32	v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi	v-SNARE		YLR078C	S000004068
BPH1		PProtein homologous to human Chediak-Higashi syndrome and murine Beige proteins, which are implicated in disease syndromes due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting		Null mutant is viable, sensitive to low pH	YCR032W	S000000628
BPL1	ACC2	Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation	biotin:apoprotein ligase		YDL141W	S000002300
BPT1		ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p	highly homologous to human MRP1 and to C. elegans mrp-1	Null mutant is viable but lacks approximately 40% of the trasport activity of unconjugated bilirubin into the vacuolar system of yeast	YLL015W	S000003938
BRE1		E3 ubiquitin ligase for Rad6p, required for the ubiquitination of histone H2B, recruitment of Rad6p to promoter chromatin and subsequent methylation of histone H3 (on K4 and K79), contains RING finger domain		null mutant is sensitive to brefeldin A	YDL074C	S000002232
BRE2	CPS60	Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; involved in telomere maintenance; similar to trithorax-group protein ASH2L	COMPASS (complex proteins associated with Set1p) component	Null: null mutant is sensitive to brefeldin A	YLR015W	S000004005
BRE4		Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport			YDL231C	S000002390
BRE5		Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A			YNR051C	S000005334
BRF1	PCF4|TDS4	TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB	transcription factor TFIIIB subunit		YGR246C	S000003478
BRL1		Essential nuclear envelope integral membrane protein identified as a suppressor of a cold-sensitive mutant of CRM1, a karyopherin; homologous to and interacts with Brr6p, which is a nuclear envelope protein involved in nuclear export			YHR036W	S000001078
BRN1		Essential protein required for chromosome condensation, likely to function as an intrinsic component of the condensation machinery, may influence multiple aspects of chromosome transmission and dynamics			YBL097W	S000000193
BRO1	ASI6|LPF2|NPI3|VPS31	Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes			YPL084W	S000006005
BRP1		Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1			YGL007W	S000002975
BRR1		snRNP protein component of spliceosomal snRNPs, required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed	spliceosomal snRNP component		YPR057W	S000006261
BRR2	PRP44|RSS1|SLT22|SNU246	RNA-dependent ATPase RNA helicase involved in the facilitation and disruption of snRNA interactions, required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis	DEIH-box ATPase	Null mutant is inviable; stabilized splicing intermediates which contain a mutant hammerhead cis-targeted ribozyme, decreased steady-state levels of endogneous mRNAs, increased ratio of pre-mRNA to mRNA of specific message(s); synthetic lethal with U2 mutants	YER172C	S000000974
BRR4				brr4 mutations inhibit splicing before the first step of the reaction		S000029061
BRR6		Essential nuclear envelope integral membrane protein required for nuclear transport; depletion alters nucleoporin distribution and nuclear envelope morphology, suggesting a role in the spatial organization of nuclear pores			YGL247W	S000003216
BRX1		Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif			YOL077C	S000005437
BSC1		Protein of unconfirmed function, similar to cell surface flocculin Muc1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression			YDL037C	S000002195
BSC2		Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression			YDR275W	S000002683
BSC3		Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 100% of YLR465C overlaps the uncharacterized ORF YLR464W and 86% of YLR465C overlaps the verified gene YRF1-4			YLR465C	S000004457
BSC4		Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p			YNL269W	S000005213
BSC5		Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression			YNR069C	S000005352
BSC6		Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression			YOL137W	S000005497
BSD2		Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification			YBR290W	S000000494
BSP1		Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton			YPR171W	S000006375
BST1	PER17	GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules	GPI inositol deacylase		YFL025C	S000001869
BST3		Negatively regulated COPII vesicle formation		Suppress mutations in SEC13; mutation slows secretion of some secretory proteins and causes resident ER proteins Kar2p and Pdi1p to leak more rapidly from the ER		S000029062
BTN2		v-SNARE binding protein that facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase			YGR142W	S000003374
BTS1		Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic	geranylgeranyl diphosphate synthase		YPL069C	S000005990
BTT1		Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex (alpha, beta1, beta3) which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides	nascent polypeptide-associated complex (NAC) beta3 subunit		YDR252W	S000002660
BUB1		Protein kinase that forms a complex with Mad1p and Bub3p that is crucial in the checkpoint mechanism required to prevent cell cycle progression into anaphase in the presence of spindle damage, associates with centromere DNA via Skp1p		Mutants are unable to recover from transient loss of spindle function. Overexpression of BUB1 rescues the cold sensitivity of tub1-729.	YGR188C	S000003420
BUB2	PAC7	Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage		Reduces the cell cycle delay which accompanies activation of a conditionally dicentric chromosome	YMR055C	S000004659
BUB3		Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p			YOR026W	S000005552
BUD11		bud site selection		Recessive mutants have a bud site selection phenotype in a and alpha cells and are sensitive to hydroxyurea.		S000029063
BUD12		bud site selection		Semi-dominant mutants have a bud site selection phenotype in a and alpha cells.		S000029064
BUD13	CWC26	Subunit of the RES complex, which is required for nuclear pre-mRNA retention and splicing; involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern		Null mutant is viable; diploid null mutants exhibit unipolar budding and elongate phenotype.	YGL174W	S000003142
BUD14		Protein involved in bud-site selection, Bud14p-Glc7p complex functions as a cortical regulator of dynein; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern			YAR014C	S000000069
BUD16		Protein involved in bud-site selection and telomere maintenance; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; has similarity to pyridoxal kinases			YEL029C	S000000755
BUD17		Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern			YNR027W	S000005310
BUD19		Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay			YJL188C	S000003724
BUD2	CLA2|ERC25	GTPase activating factor for Rsr1p/Bud1p required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types	GTPase activating protein (GAP) for Rsr1p/Bud1p	Null mutant is viable, with random bud site selection in all cell types	YKL092C	S000001575
BUD20		Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern			YLR074C	S000004064
BUD21	UTP16|YOR29-29	Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern	U3 snoRNP protein	Null mutant is viable; random budding in diploid null mutants; null has both reduced growth and reduced protein synthesis rates	YOR078W	S000005604
BUD22		Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern			YMR014W	S000004616
BUD23		Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern			YCR047C	S000000643
BUD25		Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern			YER014C-A	S000007590
BUD26		Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay			YDR241W	S000002649
BUD27		Protein involved in bud-site selection, nutrient signaling, and gene expression controlled by the TOR kinase; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern			YFL023W	S000001871
BUD28		Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay		Diploid null mutants exhibit random budding	YLR062C	S000004052
BUD3	YCL012W	Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding		Null mutant is viable; bipolar budding pattern in all cell types	YCL014W	S000000520
BUD30		Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay			YDL151C	S000002310
BUD31	CWC14	Protein involved in bud-site selection; analysis of integrated high-throughput datasets predicts an involvement in RNA splicing; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern		Diploid mutants exhibit random budding	YCR063W	S000000659
BUD32	LDB14	Protein kinase proposed to be involved in bud-site selection, telomere uncapping and elongation, and transcription; component of the EKC/KEOPS protein complex with Kae1p, Cgi121p, Pcc1p, and Gon7p		Diploid mutants exhibit random budding	YGR262C	S000003494
BUD4		Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding; potential Cdc28p substrate		Null mutant is viable, haploids have dipolar budding, normally they have axial budding, no effects on diploids	YJR092W	S000003852
BUD5		GTP/GDP exchange factor for Rsr1p (Bud1p) required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types	GTP/GDP exchange factor for Rsr1 protein	bud5 mutants select bud sites randomly	YCR038C	S000000634
BUD6	AIP3	Actin- and formin-interacting protein, involved in actin cable nucleation and polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate		Null mutant is viable; mutants exhibit severe disruption of the actin cytoskeleton; deletion strains have a depolarized cytoskeleton, mitotic delay, and probable cytokinesis defects	YLR319C	S000004311
BUD7		Member of the Chs5p-Arf1p-binding proteins (ChAPs), a group of 4 related, interacting proteins (Bch1p, Fmp50p, Bud7p, Chs6p) that mediate export of specific cargo proteins, including chitin synthase Chs3p, from the Golgi to plasma membrane		Diploid-specific heterogenous bud site selection	YOR299W	S000005825
BUD8		Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole		A bud8 bud9 double mutant buds almost exclusively from the proximal pole	YLR353W	S000004345
BUD9		Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole		In null mutants bipolar-budding cells bud preferentially at distal pole	YGR041W	S000003273
BUG1		Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes			YDL099W	S000002257
BUL1	DAG1|RDS1|SMM2	Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex, functional homolog of Bul2p, disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases			YMR275C	S000004888
BUL2		Component of the Rsp5p E3-ubiquitin ligase complex, involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions, functional homolog of BUL1			YML111W	S000004579
BUR2	CST4	Cyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II		Uncharacterized mutant allele causes increased transcription of SUC2 in the absence of its UAS; Overexpression induces chromosome loss	YLR226W	S000004216
BUR6	NCB1	Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha	transcriptional regulator	Null mutant is viable, but grows very poorly	YER159C	S000000961
BYE1		Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit	negative regulator of transcription elongation	Null: viable, 6-AU resistant	YKL005C	S000001488
BZZ1	LSB7	SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins			YHR114W	S000001156
CAC2		Component of the chromatin assembly complex (with Rlf2p and Msi1p) that assembles newly synthesized histones onto recently replicated DNA, required for building functional kinetochores, conserved from yeast to humans	chromatin assembly factor-I (CAF-I) p60 subunit		YML102W	S000004570
CAD1	YAP2	AP-1-like bZIP transcriptional activator involved in multiple stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins, binds consensus sequence TTACTAA; 5' UTR contains uORFs	transcription factor		YDR423C	S000002831
CAF120		Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation	CCR4-NOT transcriptional complex subunit		YNL278W	S000005222
CAF130		Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation	CCR4-NOT transcriptional complex subunit		YGR134W	S000003366
CAF16		Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation; putative ABC ATPase; interacts with Ssn2p, Ssn3p, and Ssn8p	CCR4-NOT transcriptional complex subunit		YFL028C	S000001866
CAF17		Mitochondrial protein that interacts with Ccr4p in the two-hybrid system; 3'-untranslated region contains a putative mRNA localization element common to genes encoding mitochondrial proteins		Null mutant is viable, shows petite phenotype	YJR122W	S000003883
CAF20	CAF2|CAP20	Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E	p20		YOR276W	S000005802
CAF4		WD40 repeat-containing protein associated with the CCR4-NOT complex, interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission	CCR4-NOT transcriptional complex subunit		YKR036C	S000001744
CAF40		Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p	CCR4-NOT transcriptional complex subunit		YNL288W	S000005232
CAG1		alpha-specific gene involved in the regulation of sex agglutinin synthesis		Constitutively agglutinable at 36 degrees C		S000029065
CAJ1		Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly			YER048C	S000000850
CAK1	CIV1	Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases	cyclin-dependent kinase-activating kinase	Null mutant is inviable; temperature-sensitive mutant confers a G2 delay accompanied by low Cdc28p protein kinase activity	YFL029C	S000001865
CAM1	TEF3	Homolog of translational cofactor elongation factor-1 gamma, participates in the regulation of GTP-binding protein EF-1 alpha, may play a redundant role in the regulation of protein synthesis or another GTP-dependent process	calcium and phospholipid binding protein homologous to translation elongation factor 1-gamma (EF-1gamma)		YPL048W	S000005969
CAN1		Plasma membrane arginine permease, requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance	arginine transporter	Canavanine resistance	YEL063C	S000000789
CAP1		Alpha subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches	capping protein	Null mutant is viable; severe deficit of actin cables and increased number of actin spots in the mother; round, relatively large cells	YKL007W	S000001490
CAP2		Beta subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches	capping protein beta subunit	Null mutant is viable, exhibits abnormal actin distribution (including loss of actin cables); round, large cells with heterogeneous size distribution; slower growing; chitin found over entire mother cell surface rather than restricted to the mother-bud junction	YIL034C	S000001296
CAR1	LPH15|cargA	Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance	arginase	Null mutant is viable but defective in arginine catabolism	YPL111W	S000006032
CAR2	cargB	L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive	ornithine aminotransferase	Catabolism of arginine defective	YLR438W	S000004430
CAT2	YCAT	Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes	carnitine O-acetyltransferase	Null mutant is viable; cat2 cit2 double mutants cannot grow on oleate.	YML042W	S000004506
CAT5	COQ7	Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation		Null mutant is viable, results in complete loss of glucose derepression affecting gluconeogenic key enzymes. Respiration, but not mitochondrial cytochrome c oxidase activity, are also affected; fails to synthesize ubiquinone	YOR125C	S000005651
CAT8	DIL1|MSP8	Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements		Null mutant is viable but unable to grow on non-fermentable carbon sources due to failure to derepress all major gluconeogenic enzymes; overexpression of Cat8p suppress inability of snf1 and snf4 mutants to grow on ethanol	YMR280C	S000004893
CAX4	CWH8	Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation	dolichyl pyrophosphate phosphatase	Null mutant is viable with severely affected growth rate, hypo-N-glycosylation of secretory proteins, and severely reduced levels of dolichol-linked oligosaccharides in the endoplasmic reticulum. Exhibits defective actin organization and calcofluor white hypersensitivity. Synthetically lethal with a temperature sensitve allele of CMD1	YGR036C	S000003268
CBC2	CBP20|MUD13|SAE1	Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif	nuclear cap binding complex subunit	mutants exhibit promiscuous 3'-end formation; sae-1 mutation causes temporary cell cycle arrest in meiotic prophase	YPL178W	S000006099
CBF1	CEP1|CPF1	Helix-loop-helix protein that binds the motif CACRTG, which is present at several sites including MET gene promoters and centromere DNA element I (CDEI); required for nucleosome positioning at this motif; targets Isw1p to DNA	basic helix-loop-helix protein	Null mutant is viable, but grows slowly and causes partial loss of centromere function (increased chromosome loss), benomyl and thiabendazole sensitivity, methionine auxotrophy, and changes in chromatin structure at CENs and some promoters. Null mutation causes precocious sister segregation at MI, and reduced spore viability.	YJR060W	S000003821
CBF2	CBF3A|CEP2|CSL5|CTF14|NDC10	Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo	centromere binding factor CBF3 110 kDa subunit		YGR140W	S000003372
CBF5		Pseudouridine synthase catalytic subunit of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), acts on both large and small rRNAs and on snRNA U2	pseudouridine synthase		YLR175W	S000004165
CBK1		Serine/threonine protein kinase that regulates cell morphogenesis pathways; involved in cell wall biosynthesis, apical growth, proper mating projection morphology, bipolar bud site selection in diploid cells, and cell separation	serine/threonine protein kinase	Null mutation is viable; shows alpha factor resistance; in liquid culture large aggregates of cells are formed	YNL161W	S000005105
CBP1		Mitochondrial protein that interacts with the 5'-untranslated region of the COB mRNA and has a role in its stability and translation; found in a complex at the inner membrane along with Pet309p		Null mutant is viable, unable to respire due to degradation of mitochondrially encoded cytochrome b (cob) RNA	YJL209W	S000003745
CBP2		Mitochondrial protein required for splicing of the group I intron aI5 of the COB pre-mRNA, binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene			YHL038C	S000001030
CBP3		Mitochondrial protein required for assembly of ubiquinol cytochrome-c reductase complex (cytochrome bc1 complex); interacts with Cbp4p and function is partially redundant with that of Cbp4p		reduced levels of a subset of subunit polypeptides of the coenzyme QH2-cytochrome c reductase complex	YPL215W	S000006136
CBP4		Mitochondrial protein required for assembly of ubiquinol cytochrome-c reductase complex (cytochrome bc1 complex); interacts with Cbp3p and function is partially redundant with that of Cbp3p		Inability to respire, pleiotropic reduction in steady state levels of four subunits of ubiquinol-cytochrome c reductase	YGR174C	S000003406
CBP6		Protein required for translation of the mitochondrial COB mRNA	mitochondrial translational activator	Null mutant is viable, repiratory deficiency with concomitant loss of cytochrome b	YBR120C	S000000324
CBR1	CBR5	Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia	cytochrome b reductase		YIL043C	S000001305
CBS1		Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader	mitochondrial translational activator		YDL069C	S000002227
CBS2	CBP7	Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader	mitochondrial translational activator	Null mutant is viable, exhibits a mitochondrial apocytochrome b mRNA translational defect	YDR197W	S000002605
CBT1	SOC1	Protein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p			YKL208W	S000001691
CCA1	TNT1	ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites	tRNA nucleotidyltransferase		YER168C	S000000970
CCB1		cross-complementation of budding defect				S000029066
CCC1		Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation		Wild-type complements csg1 (calcium sensitive-group) mutants when overexpressed. Deletion of CCC1 results in decreased vacuolar iron content and decreased iron stores, which affect cytosolic iron levels and cell growth.	YLR220W	S000004210
CCC2		Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases		Null mutant is viable, exhibits defects in respiration and iron uptake	YDR270W	S000002678
CCE1	MGT1	Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA	cruciform cutting endonuclease	Null mutant is viable, exhibits a higher than normal frequency of appearance of petite cells	YKL011C	S000001494
CCH1		Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together		Null mutant is viable; exhibits reduced growth rate, viability and calcium uptake; exhibits a defect in pheromone-induced Ca2+ uptake; suppressor of cdc1 temperature-sensitive mutant	YGR217W	S000003449
CCL1		Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters	transcription initiation factor TFIIH subunit		YPR025C	S000006229
CCP1		Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress	cytochrome c peroxidase		YKR066C	S000001774
CCR4	FUN27|NUT21	Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening	CCR4-NOT transcriptional complex subunit	reduced levels of ADH2 expression under both glucose and ethanol growth conditions; temperature sensitive growth on nonfermentative medium	YAL021C	S000000019
CCS1	CCS|LYS7	Copper chaperone for superoxide dismutase Sod1p, involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation	copper chaperone	Null mutant is viable, methionine and lysine auxotroph, pH and temperature sensitive; sensitive to superoxide generating drugs and light irradiation, exhibits diminution of calcineurin activity	YMR038C	S000004641
CCT2	BIN3|TCP2	Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo			YIL142W	S000001404
CCT3	BIN2|TCP3	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo	gamma chaperonin subunit	Defects in microtubule and actin assembly in vivo, aberrant chromosome segregation, supersensitivity to benomyl	YJL014W	S000003551
CCT4	ANC2|TCP4	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo			YDL143W	S000002302
CCT5	TCP5	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo	chaperonin subunit epsilon subunit		YJR064W	S000003825
CCT6	HTR3|TCP20|TCP6	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif			YDR188W	S000002596
CCT7	TCP7	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo	chaperonin containing T-complex subunit seven component		YJL111W	S000003647
CCT8		Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo	chaperonin containing T-complex subunit eight component		YJL008C	S000003545
CCW1						S000029067
CCW10						S000029068
CCW12		Cell wall protein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor	cell wall mannoprotein	Null mutant is viable and shows decrease in mating efficiency and defect in agglutination	YLR110C	S000004100
CCW14	SSR1|YLR391W|YLR391W-A	Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall	cell wall mannoprotein	Null mutant is viable but causes increased sensitivities to calcofluor white, Congo red, and zymolyase digestion. Overexpression also causes calcofluor white and Congo red sensitivity. (see Moukadiri et al (1997) J. Bacteriol. 179:2154-62).	YLR390W-A	S000006429
CCW2						S000029069
CCW3						S000029070
CCW4						S000029071
CCW9						S000029073
CCZ1	CVT16	Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway		Null mutant is viable, but is sensitive to caffeine, calcium and zinc; no sporulation in homozygous null diploids	YBR131W	S000000335
CDA1		Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall	chitin deacetylase	Null mutant is viable, mutants spores disrupted for both cda1 and cda2 fail to emit natural fluorescence and are sensitive to hydrolyrtic enzymes, ether, and heat shock	YLR307W	S000004298
CDA2		Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall	chitin deacetylase	Null mutant is viable, mutant spores disrupted for both cda1 and cda2 fail to emit natural fluorescence and are sensitive to hydrolyrtic enzymes, ether, and heat shock	YLR308W	S000004299
CDC1	DSC1|DSR1|ESP2	Putative membrane protein of unknown function involved in Mn2+ homeostasis; mutants display actin and general growth defects, heterogeneous cell cycle arrests, and pleiotropic defects in cell cycle progression and organelle distribution			YDR182W	S000002590
CDC10		Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM	septin	abnormal cell-wall deposition and bud growth, inability to complete cytokinesis, failure to form the ring of 10nm filaments in the neck region of budding cells	YCR002C	S000000595
CDC11	PSL9	Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM	10 nm filament component of mother-bud neck|septin	abnormal cell-wall deposition and bud growth, inability to complete cytokinesis, failure to form the ring of 10nm filaments in the neck region of budding cells	YJR076C	S000003837
CDC12	CLA10|PSL7	Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM	10 nm filament component of mother-bud neck|septin	abnormal cell-wall deposition and bud growth, inability to complete cytokinesis, failure to form the ring of 10nm filaments in the neck region of budding cells	YHR107C	S000001149
CDC123		Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein			YLR215C	S000004205
CDC13	EST4	Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping	single-stranded TG1-3 telomere G-tails binding protein		YDL220C	S000002379
CDC14	OAF3	Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit	protein phosphatase	Null mutant is inviable; ts mutant arrests at late anaphase with phenotypes similar to cdc5 mutants	YFR028C	S000001924
CDC15	LYT1	Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p		Null mutant inviable, arrests in G2; buds at distal instead of axial position, undergoes autolysis when buds reach the size of mother cells; the mitotic, but not meiotic, phenotype is suppressible by overexpressing SPO12.	YAR019C	S000000072
CDC16		Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation		Null mutant is inviable; sensitive to caffeine; cdc16 mutants are unable to progress through the G(sub)2/M transition, cell division cycle blocked at 36 degrees C	YKL022C	S000001505
CDC19	PYK1	Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration	pyruvate kinase	Null mutant is inviable. cdc19 mutants are pyruvate kinase deficient and show cell division cycle blocked at 36 degrees C	YAL038W	S000000036
CDC2	HPR6|POL3|TEX1	Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)	DNA polymerase III catalytic (delta) subunit	Null mutant is inviable. cdc2 mutants arrest at the mononucleate stage with duplicated spindle pole bodies and no complete spindles. mgs1 mutation suppresses the temperature sensitivity of cdc2 mutants.	YDL102W	S000002260
CDC20	PAC5	Cell-cycle regulated activator of anaphase-promoting complex/cyclosome (APC/C), which is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; potential Cdc28p substrate	anaphase promoting complex (APC) subunit	Null mutant is inviable; conditional alleles show cell cycle arrest in G2	YGL116W	S000003084
CDC21	CRT9|TMP1|YOR29-25	Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S	thymidylate synthase	defective in continued replication during S phase of the cell cycle; temperature-sensitive thymidylate auxotroph	YOR074C	S000005600
CDC22	DNA1					S000029074
CDC23		Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition		unable to complete G(sub)2/M transition	YHR166C	S000001209
CDC24	CLS4	Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing	guanine nucleotide exchange factor (a.k.a. GDP-release factor) for cdc42	temperature sensitive mutation affecting bud formation and localized cell surface growth at a restrictive temperature	YAL041W	S000000039
CDC25	CDC25'|CTN1	Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1		Null mutant is inviable; arrests at G(sub)1; low levels cAMP and decreased levels of Mg2+-dependent cyclase activity	YLR310C	S000004301
CDC26	HIT3|SCD26	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition		thermosensitive cell growth (lethal at high temperature)	YFR036W	S000001932
CDC27	APC3|SNB1	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition	anaphase promoting complex (APC) subunit	Null mutant is inviable. Some conditional alleles overreplicate their DNA.	YBL084C	S000000180
CDC28	CDK1|HSL5|SRM5	Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates	cyclin-dependent protein kinase	arrests at G1/S transition <br> arrests at G2/M transition	YBR160W	S000000364
CDC29		Cell division cycle blocked at 36 degree C				S000029075
CDC3		Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM	septin	Null mutant is inviable; other mutants show abnormal cell-wall deposition and bud growth, inability to complete cytokinesis, and failure to form the ring of 10nm filaments in the neck region of budding cells.	YLR314C	S000004306
CDC31	DSK1	Component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; interacts with Kar1p	nuclear pore complex subunit|spindle pole body calcium-binding protein component	Null mutant is inviable. cdc31 mutants form reductional dyads with unduplicated spindle pole bodies	YOR257W	S000005783
CDC33	TIF45	Cytoplasmic mRNA cap binding protein; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with the translation initiation factor eIF4G (Tif4631p or Tif4632p)	eIF-4E|mRNA cap binding protein eIF-4E	Null mutant is inviable. cdc33 mutants arrest at G(sub)1. cdc33 has normal cAMP pools and is not suppressed by cAPK mutants, suggesting sporulation is independent of the cAMP pathway	YOL139C	S000005499
CDC34	DNA6|UBC3	Ubiquitin-conjugating enzyme or E2; together with Skp1p, Rbx1p, Cdc53p, and an F-box protein, forms a ubiquitin-protein ligase called the SCF complex which regulates cell cycle progression by targeting key substrates for degradation	ubiquitin-conjugating enzyme	overexpression confers resistance to xenobiotics (methylmercury, mercuric chloride, and p-chloromercuribenzoate).	YDR054C	S000002461
CDC36	DNA19|NOT2	Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor	CCR4-NOT transcriptional complex subunit	Null mutant is viable, cdc36 mutant arrests in G(sub)1; forms shmoo morphology at restrictive temperature, arrests at pachytene at the mononucleate stage with duplicated spindle pole bodies and no spindles	YDL165W	S000002324
CDC37	SMO1	Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding	co-chaperone	Null mutant is inviable; temperature-sensitive mutants arrest in G1 and form shmoo morphology at the restrictive temperature	YDR168W	S000002575
CDC39	NOT1|ROS1|SMD6	Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor	CCR4-NOT transcriptional complex subunit	Null mutant is inviable; arrests in G(sub)1 at pachytene at the mononucleate stage with duplicated, unseparated spindle pole bodies and no spindles; temperature sensitive mutation which causes increased basal transcription of many genes	YCR093W	S000000689
CDC4		F-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p	ubiquitin ligase subunit	Null mutant is inviable. cdc4 mutants arrest in meiosis at the mononucleate stage with duplicated spindle pole bodies.	YFL009W	S000001885
CDC40	PRP17|SLT15|SLU4	Pre-mRNA splicing factor, important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression; required for DNA synthesis during mitosis and meiosis; has WD repeats		Null mutant is viable, temperature sensitive at 36 degrees celsius, arrests at the mononucleate stage; synthetically lethal with U2 snRNA LSR1; blocks pre-mRNA splicing in vivo and in vitro	YDR364C	S000002772
CDC42		Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins		Null mutant is inviable; temperature sensitive mutations unable to form buds and display delocalized cell-surface deposition at the restrictive temperature	YLR229C	S000004219
CDC43	CAL1	Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis	CAAX geranylgeranyltransferase beta subunit	temperature sensitive mutants unable to form buds and display delocalized cell-surface deposition	YGL155W	S000003123
CDC45	SLD4	DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes	chromosomal DNA replication initiation protein	required for minichromosome maintenance and chromosomal DNA replication	YLR103C	S000004093
CDC46	BOB1|MCM5	Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase		Null mutant is inviable; at nonpermissive temperature cdc46(ts) mutants arrest with a large bud and a single nucleus and exhibit a high rate of recombination	YLR274W	S000004264
CDC47	MCM7	Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase		Null mutant is inviable, at nonpermissive temperature cdc47(ts) mutants arrest with a large bud and a single nucleus	YBR202W	S000000406
CDC48		ATPase in ER, nuclear membrane and cytosol with homology to mammalian p97; in a complex with Npl4p and Ufd1p participates in retrotranslocation of ubiquitinated proteins from the ER into the cytosol for degradation by the proteasome			YDL126C	S000002284
CDC5	MSD2|PKX2	Polo-like kinase with similarity to Xenopus Plx1 and S. pombe Plo1p; found at bud neck, nucleus and SPBs; has multiple functions in mitosis and cytokinesis through phosphorylation of substrates; may be a Cdc28p substrate	serine/threonine protein kinase	Null mutant is inviable. cdc5(ts) mutants form synaptonemal complexes lacking central elements and arrest either at meiosis I with broken spindles or at meiosis II with short spindles. Late shifts to a restrictive temperature result in reductional dyads; each spore contains an entire meiosis II short spindle with unseparated chromatids. In some strains at semi-permissive temperature, chromosomes segregate reductionally or equationally depending upon the centromere.	YMR001C	S000004603
CDC50		Endosomal protein that regulates cell polarity; similar to Ynr048wp and Lem3p		Null mutant is cold-sensitive and sensitive to MMS and HU	YCR094W	S000000690
CDC53		Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation		Cells arrest in G1 with active Cln kinases but no Clb-associated Cdc28p kinase activity	YDL132W	S000002290
CDC54	HCD21|MCM4	Essential helicase component of heterohexameric MCM2-7 complexes which bind pre-replication complexes on DNA and melt the DNA prior to replication; accumulates in the nucleus in G1; homolog of S. pombe Cdc21p		Null mutant is inviable; at nonpermissive temperature cdc54(ts) mutants arrest with a large bud and a single nucleus and exhibit a high rate of recombination	YPR019W	S000006223
CDC55		Non-essential regulatory subunit B of protein phosphatase 2A; has multiple roles in mitosis and protein biosynthesis; found in the nucleus of most cells but also at the bud neck (large-budded cells) and at the bud tip (small-budded cells)	protein phosphatase 2A regulatory subunit B	abnormally elongated buds, delay or partial block of septation and/or cell separation; deletion mutant is cold-sensitive	YGL190C	S000003158
CDC6		Essential ATP-binding protein required for DNA replication, component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p	pre-initiation complex component	arrest at initiation of S phase	YJL194W	S000003730
CDC60		Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA	LeuRS|leucyl-tRNA synthetase	arrest at START point of cell cycle upon shift to restrictive temperature	YPL160W	S000006081
CDC61						S000029076
CDC62		cell division cycle blocked at 36 degree C				S000029077
CDC65	DNA33|SUP70	tRNA-Gln; glutamine tRNA with anticodon CUG	tRNA-Gln	A temperature-sensitive allele inhibits zygote formation and conjugation.		S000006690
CDC67		Regulator of the cell cycle at Start		Arrest of proliferation at the regulatory step Start, inhibition of zygote formation and successful conjugation		S000029078
CDC7	LSD6|SAS1	DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in mitosis through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression	Cdc7p-Dbf4p kinase complex catalytic subunit	Null mutant is inviable. cdc7 mutant arrests at G(sub)1/S phase with duplicated spindle pole bodies and no spindles; the spindle pole bodies eventually enlarge, invaginate from the nuclear envelope into the center of the nucleus, sometimes fragmenting into three or four smaller spindle pole bodies. In heterozygotes, cdc7 spores fail to germinate.	YDL017W	S000002175
CDC73		Constituent of Paf1 complex with RNA polymerase II, Paf1p, Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinct from Srb-containing Pol II complexes; required for expression of certain genes, modification of some histones, and telomere maintenance		Mutations affect cell growth and the abundance of transcripts from a subset of genes	YLR418C	S000004410
CDC77	NDC2	cell division cycle blocked at 36 degree C				S000029079
CDC8		Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p	thymidylate kinase	Null mutant is inviable. cdc8 mutants are defective in continued replication during S phase of the cell cycle. cdc8 arrests at the mononucleate stage with duplicated spindle pole bodies and no spindles.	YJR057W	S000003818
CDC9	MMS8	DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination	DNA ligase	cell division cycle blocked at 36 degrees, increased sensitivity to ultraviolet radiation and bleomycin; temperature sensitive	YDL164C	S000002323
CDD1		Cytidine deaminase; catalyzes the modification of cytidine to uridine in vitro but native RNA substrates have not been identified, localizes to both the nucleus and cytoplasm	cytidine deaminase		YLR245C	S000004235
CDH1	HCT1	Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including CDC20, ASE1, CIN8 and FIN1		Null mutant is viable but defective in Clb2p and Ase1p degradation; deletion of cdh1 causes pheromone resistance and is synthetically lethal with sic1 deletion; overexpression causes ectopic degradation of Clb2p and Ase1p	YGL003C	S000002971
CDL1				some alleles cause lethality in combination with chc1 null mutants		S000029080
CDS1	CDG1	Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids	phosphatidate cytidylyltransferase		YBR029C	S000000233
CEF1	NTC85	Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p		Null mutant is inviable, arrests in G2/M, exhibits abnormal nuclear morphologies. Essential for mRNA splicing.	YMR213W	S000004826
CEG1		Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphophatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide	mRNA capping enzyme alpha subunit|mRNA guanylyltransferase		YGL130W	S000003098
CEM1		Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration		Null mutant is viable; exhibits respiratory-deficient growth	YER061C	S000000863
CEM11						S000029081
CEN1		Chromosome I centromere				S000006463
CEN10		Chromosome X centromere				S000006471
CEN11		Chromosome XI centromere				S000006472
CEN12		Chromosome XII centromere				S000006473
CEN13		Chromosome XIII centromere				S000006474
CEN14		Chromosome XIV centromere				S000006475
CEN15		Chromosome XV centromere				S000006476
CEN16		Chromosome XVI centromere				S000006477
CEN2		Chromosome II centromere				S000006464
CEN3		Chromosome III centromere				S000006465
CEN4		Chromosome IV centromere				S000006466
CEN5		Chromosome V centromere				S000006467
CEN6		Chromosome VI centromere				S000001896
CEN7		Chromosome VII centromere				S000006468
CEN8		Chromosome VIII centromere				S000006469
CEN9		Chromosome IX centromere				S000006470
CEP3	CBF3|CBF3B|CSL1	Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain	Cbf3 kinetochore protein complex subunit b	Null mutant is inviable; mutations within the zinc finger domain result in cells that exhibit a G2-M cell cycle delay and increased chromosome loss in each mitotic cell division; at nonpermissive temperature the cep3 cells arrest with an undivided nucleus and a short mitotic spindle; at permissive temperature cep3 cells are unable to support segregation of minichromosomes with mutations in the central part of element III of yeast centromere DNA	YMR168C	S000004778
CET1	CES5	Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide	RNA 5'-triphosphatase|mRNA capping enzyme beta subunit (80 kDa)		YPL228W	S000006149
CEX1		Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p			YOR112W	S000005638
CFD1	DRE3	Highly conserved, putative P-loop ATPase localized in the cytoplasm; has a potential role in assembly of iron-sulfur clusters in proteins			YIL003W	S000001265
CFT1	YHH1	RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF	cleavage factor II (CF II) component		YDR301W	S000002709
CFT13						S000029082
CFT2	YDH1	Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein.	cleavage factor II (CF II) component		YLR115W	S000004105
CGI121		Protein involved in telomere uncapping and elongation as component of the KEOPS protein complex with Bud32p, Kae1p, Pcc1p, and Gon7p; also shown to be a component of the EKC protein complex; homolog of human CGI-121			YML036W	S000004500
CGR1		Protein involved in nucleolar integrity and processing of the pre-rRNA for the 60S ribosome subunit; transcript is induced in response to cytotoxic stress but not genotoxic stress	coiled-coil protein	Null mutant is inviable; CGR1 expression is down-regulated in the postdiauxic growth phase	YGL029W	S000002997
CHA1		Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine	catabolic serine (threonine) dehydratase	Null mutant is viable and cannot grow on media with L-serine or L-threonine as sole nitrogen source	YCL064C	S000000569
CHA4	SIL2|SIL3	DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain	transcription factor	Unable to grow with serine or threonine as the sole nitrogen source, suppresses ilv1 mutant by causing inducer-independent, constitutive expression of CHA1	YLR098C	S000004088
CHC1	SWA5	Clathrin heavy chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; two heavy chains form the clathrin triskelion structural component; the light chain (CLC1) is thought to regulate function	Clathrin heavy chain	Null mutant is viable, but is slow-growing and shows defects in mating, sporulation and vesicle ultrastructure (however it shows little or no defect in secretion); null mutants easily become inviable due to second site mutations in a number of unlinked genes such as SCD1 and CDL1. Null mutants also exhibit an endocytosis defect, late Golgi protein mislocalization. chc1-5 exhibits delayed vacuolar protein transport.	YGL206C	S000003174
CHD1		Nucleosome remodeling factor that functions in regulation of transcription elongation; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SILK complexes	RNA polymerase II elongation factor	Null mutant is viable, resistant to 6-azauracil	YER164W	S000000966
CHK1		DNA damage checkpoint effector kinase, mediates mitotic cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer kinase Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase	serine/threonine protein kinase	Mutants are defective in the DNA damage checkpoint operating at metaphase	YBR274W	S000000478
CHL1	CTF1|LPA9	Conserved nuclear protein required to establish sister-chromatid pairing during S-phase, probable DNA helicase with similarity to human BACH1, which associates with tumor suppressor BRCA1; associates with acetyltransferase Ctf7p	deah box protein|kinetochore protein	Null mutant is viable, ts mutants mis-segregate chromosomes at permissive temperature leading to increased rate of mitotic chromosome loss, at non-permissive temperature ts mutants transiently arrest as large-budded cells with G(sub)2 DNA content and short spindle	YPL008W	S000005929
CHL2		Involved in controlling mitotic transmission of yeast chromosomes		increase in the rate of mitotic chromosome loss		S000029083
CHL4	CTF17|MCM17	Outer kinetochore protein required for chromosome stability, interacts with kinetochore proteins Ctf19p, Ctf3p, and Iml3p; exhibits a two-hybrid interaction with Mif2p; association with CEN DNA requires Ctf19p		Null mutant is viable. Some authors report a temperature-senstive deletion allele, while others fine no temperature sensitivity in another deletion allele. Fidelity of chromosome transmission and minichromosome nondisjunction in mitosis is decreased at all temperatures.	YDR254W	S000002662
CHL5		Involved in controlling mitotic transmission of yeast chromosomes		increase in the rate of mitotic chromosome loss		S000029084
CHL8	AMC3|CTF12	Identified as a chromosome transmission fidelity mutant that has a high rate of chromosome loss		Increase in the rate of mitotic chromosome loss and temperature sensitivity		S000029085
CHL9	AMC4	Involved in controlling the segregation of natural chromosomes in yeast		Impaired segregation of artificial minichromosomes, affects on the mitotic transmission of natural chromosomes		S000029086
CHO1	PSS1	Phosphatidylserine synthase, functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline	phosphatidylserine synthase	The null mutant is viable but grows slowly on minimal medium. The growth rate of the null mutant on minimal medium can be increased by supplementing the medium with choline or other phospholipid precursors.	YER026C	S000000828
CHO2	PEM1	Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis	phosphatidylethanolamine methyltransferase	Null mutant is viable and accumulates phosphatidylethanolamine and has reduced levels of phosphatidylcholine	YGR157W	S000003389
CHS1	USA4	Chitin synthase I, requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for repairing the chitin septum during cytokinesis; transcription activated by mating factor	chitin synthase		YNL192W	S000005136
CHS2		Chitin synthase II, requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for the synthesis of chitin in the primary septum during cytokinesis	chitin synthase		YBR038W	S000000242
CHS3	CAL1|CSD2|DIT101|KTI2	Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan	chitin synthase		YBR023C	S000000227
CHS5	CAL3	Protein involved in export from the Golgi to plasma membrane; involved in chitin biosynthesis through its role in Chs3p localization; interacts with Arf1p, Bch1p, Fmp50p, Bud7p, and Chs6p			YLR330W	S000004322
CHS6	CSD3	Member of the Chs5p-Arf1p-binding proteins (ChAPs), a group of 4 related, interacting proteins (Bch1p, Fmp50p, Bud7p, Chs6p) that mediate export of specific cargo proteins, including chitin synthase Chs3p, from the Golgi to plasma membrane			YJL099W	S000003635
CHS7		Protein of unknown function, involved in chitin biosynthesis by regulating Chs3p export from the ER			YHR142W	S000001184
CHZ1		Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif	chaperone		YER030W	S000000832
CIA1		Essential protein involved in assembly of cytosolic and nuclear iron-sulfur proteins			YDR267C	S000002675
CIC1	NSA3	Essential protein that interacts with proteasome components and has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles		Null: lethal. Other phenotypes: cic1-2 ts mutant stabilizes F-box proteins.	YHR052W	S000001094
CIK1		Kinesin-associated protein required for both karyogamy and mitotic spindle organization, interacts stably and specifically with Kar3p and may function to target this kinesin to a specific cellular role; has similarity to Vik1p	Kar3-binding protein	Null mutant is viable but is defective in both karyogamy and chromosome maintenance and does not show proper localization of Kar3p to microtubule-associated structures	YMR198W	S000004811
CIN1		Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl	tubulin folding cofactor D	Null mutant is viable, exhibits cold sensitivity for viability; defect in nuclear migration and nuclear fusion, supersensitivity to benomyl and nocodozole	YOR349W	S000005876
CIN2		Tubulin folding factor C (putative) involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl	tubulin folding cofactor C	Null mutant is viable but shows supersensitivity to benomyl and nocodazole, cold sensitivity, defects in karyogamy, and increased rates of chromosome loss; shows genetic interaction with tubulin mutations	YPL241C	S000006162
CIN4	GTP1|UGX1	GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl	GTP-binding protein	Null mutant is viable; supersensitivity to benomyl and nocodozole	YMR138W	S000004746
CIN5	HAL6|YAP4	Basic leucine zipper transcriptional factor of the yAP-1 family that mediates pleiotropic drug resistance and salt tolerance; localizes constitutively to the nucleus	transcriptional activator	Null mutant is viable and suppresses the cold sensitivity of yap1 mutants	YOR028C	S000005554
CIN8	KSL2|SDS15	Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation		Null mutant is viable; cin8 dyn1 and cin8 kip1 double deletion mutants are inviable	YEL061C	S000000787
CIS1	ATG31	Protein required for autophagosome formation in concert with Atg17p; may be involved in microtubule organization; high-copy suppressor of CIK1 deletion			YDR022C	S000002429
CIS3	CCW11|CCW5|PIR4	Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family		Null mutant is viable; CIS3 is a high copy suppressor of cik1 deletion mutants	YJL158C	S000003694
CIT1	CS1|LYS6	Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein	citrate synthase	Null mutant is viable; disruption of both CIT1 and CIT2 result in glutamate auxotrophy and poor growth on rich medium containing lactate	YNR001C	S000005284
CIT2		Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors	citrate synthase		YCR005C	S000000598
CIT3		Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, mitochondrial isozyme involved in the TCA cycle	citrate synthase	Null mutant shows severely reduced growth on the respiratory substrate glycerol in a delta cit1 background	YPR001W	S000006205
CKA1		Alpha catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA2, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases	protein kinase CK2 alpha subunit	Null mutant is viable; however, strains lacking both cka1 and cka2 (the alpha and alpha' subunits of protein kinase CK2, respectively) are inviable.	YIL035C	S000001297
CKA2	YOR29-12	Alpha' catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases	protein kinase CK2 alpha' subunit	Null mutant is viable, cka1 cka2 double deletion mutants are inviable; Cells in which protein kinase CK2 activity is depleted increase substantially in size prior to growth arrest, and a significant fraction of the arrested cells exhibit a pseudomycelial morphology. Disruption of the activity also results in flocculation. Yeast strains lacking both endogenous catalytic subunit genes can be rescued by expression of the alpha and beta subunits of Drosophila protein kinase CK2 or by expression of the Drosophila alpha subunit alone	YOR061W	S000005587
CKB1		Beta regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB2, the many substrates include transcription factors and all RNA polymerases	protein kinase CK2 beta subunit	Null mutant is viable, exhibits salt sensitivity specific to NaCl and LiCl	YGL019W	S000002987
CKB2		Beta' regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB1, the many substrates include transcription factors and all RNA polymerases	protein kinase CK2 beta' subunit		YOR039W	S000005565
CKI1		Choline kinase, catalyzes the first step in the CDP-choline pathway phosphatidylcholine synthesis (Kennedy pathway); mRNA expression is regulated by inositol and choline, enzyme activity is stimulated by phosphorylation by protein kinase	choline kinase		YLR133W	S000004123
CKS1		Subunit of the Cdc28 protein kinase, required for mitotic proteolysis, may also be involved in the proteolysis of the G1 cyclins	cyclin-dependent protein kinase subunit	Null mutant is inviable and arrests in G1.|Null mutant is viable in W303 and BF246-15DU backgrounds	YBR135W	S000000339
CLA4	ERC10	Cdc42p activated signal transducing kinase of the PAK (p21-activated kinase) family, involved in septin ring assembly and cytokinesis; directly phosphorylates septins Cdc3p and Cdc10p; other yeast PAK family members are Ste20p and Skm1p	serine/threonine protein kinase	Null mutant is viable, possesses a cytokinesis defect; cla4 cln1 cln2 strains are inviable; cla4 ste20 double deletion mutants cannot maintain septin rings at the bud neck and and cannot undergo cytokinesis	YNL298W	S000005242
CLB1	SCB1	B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome	B-type cyclin		YGR108W	S000003340
CLB2		B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome	B-type cyclin		YPR119W	S000006323
CLB3		B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation	B-type cyclin		YDL155W	S000002314
CLB4		B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation	B-type cyclin		YLR210W	S000004200
CLB5		B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase	B-type cyclin	Null mutant is viable, but has an extended S phase	YPR120C	S000006324
CLB6		B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1	B-type cyclin		YGR109C	S000003341
CLC1	SCD4	Clathrin light chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function, two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component	clathrin light chain	Null mutant is viable but slow-growing and shows defects in receptor-mediated endocytosis, maturation of alpha factor and levels of clathrin heavy chain (Chc1p); high copy suppresses the inviable double mutant chc1-delete, scd1-i-allele; elevated CHC1 expression suppresses some clc1-delete phenotypes	YGR167W	S000003399
CLF1	NTC77|SYF3	Essential splicesome assembly factor; contains multiple tetratricopeptide repeat (TPR) protein-binding motifs and interacts specifically with many spliceosome components, may serve as a scaffold during splicesome assembly	pre-mRNA splicing factor	Null mutant is inviable; clf1 alleles show synthetic lethality with cdc40/prp17 and are defective in 5' splice site cleavage	YLR117C	S000004107
CLG1		Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2			YGL215W	S000003183
CLN1		G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)	G1 cyclin	Null mutant is viable, exhibits G1 arrest	YMR199W	S000004812
CLN2		G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)	G1 cyclin	Null mutant is viable, exhibits G1 arrest; dominant mutation advances the G(sub)1- to S- phase transition and impairs ability of cells to arrest in G(sub)1 phase in response to external signals	YPL256C	S000006177
CLN3	DAF1|FUN10|WHI1	G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis	G1 cyclin	Null mutant is viable; dominant mutation causes alpha-factor resistance and small cell size; chromosomal deletion increases cell volume	YAL040C	S000000038
CLP1		Subunit of cleavage factor I (CFI), involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation	cleavage and polyadenylation factor CF I component involved in pre-mRNA 3'-end processing		YOR250C	S000005776
CLS1				Calcium-sensitive		S000029088
CLU1	TIF31	eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant		Null mutant is viable, growth is normal, mitochondrial network is collapsed to one side of the cell	YMR012W	S000004614
CLY2				Cell lysis at 36 degree C		S000029089
CLY3				Cell lysis at 36 degree C		S000029090
CLY7				Null phenotype unknown; cly7 mutants lyse at high temperature		S000029091
CLY8				Cell lysis at 36 degree C		S000029092
CLY9						S000029093
CMC1		Putative protein of unknown function; mutation results in growth defect on a non-fermentable (respiratory) carbon source			YKL137W	S000001620
CMD1		Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin	calmodulin		YBR109C	S000000313
CMK1		Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk2p and mammalian Cam Kinase II	calmodulin-dependent protein kinase		YFR014C	S000001910
CMK2		Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk1p and mammalian Cam Kinase II	calmodulin-dependent protein kinase	Null mutant is viable, exhibits slow rate of spore germination	YOL016C	S000005376
CMP2	CNA2	Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1	calcineurin subunit A		YML057W	S000004521
CMS1		centromere mutation suppressor				S000029094
CNA1	CMP1	Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1	calcineurin subunit A		YLR433C	S000004425
CNB1	CRV1|YCN2	Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1	protein phosphatase type 2B	Null mutant is viable, Li+ and Na+ sensitive, cnb1 fks1 and cnb1 vma3 double mutants are inviable	YKL190W	S000001673
CNE1	FUN48	Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast		Null mutant is viable, increase of cell-surface expression of ste2-3p, increase in secretion of heterologously expressed mammalian alpha 1-antitrypsin. ~30% decrease in beta-1,6-glucan upon disruption of CNE1.	YAL058W	S000000054
CNM67		Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration		Null mutant is viable but shows slow growth and a nuclear migration defect	YNL225C	S000005169
CNN1		Kinetochore protein of unknown function; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by both Clb5-Cdk1 and, to a lesser extent, Clb2-Cdk1.	kinetochore protein		YFR046C	S000001942
CNS1		TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion		Null mutant is inviable; overexpression of CNS1 restores normal growth and Hsp90 activity in a cpr7 mutant strain.	YBR155W	S000000359
COA1	FMP35	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant is defective in cytochrome oxidase and is respiratory deficient			YIL157C	S000001419
COB	COB1|CYTB	Cytochrome b, mitochondrially encoded subunit of the ubiquinol-cytochrome c reductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p	cytochrome b|ubiquinol-cytochrome c oxidoreductase complex subunit		Q0105	S000007270
COF1		Cofilin, promotes actin filament depolarization in a pH-dependent manner; binds both actin monomers and filaments and severs filaments , thought to be regulated by phosphorylation at SER4, ubiquitous and essential in eukaryotes	actin binding and severing protein|cofilin		YLL050C	S000003973
COG1	COD3|LDB11|SEC36	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments			YGL223C	S000003191
COG2	SEC35	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments		Null mutant shows severe growth defect at 30 degrees and is inviable at 21 degrees; sec35-1 allele is temperature-sensitive for growth	YGR120C	S000003352
COG3	GRD20|SEC34	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments		Strains carrying the null allele are extremely slow growing; they display a severe growth defect at 25 or 30 degrees, and fail to grow at 14 or 37 degrees. In addition to defects in protein localization and sorting, sec34 mutants exhibit defects in polarization of filamentous actin.	YER157W	S000000959
COG4	COD1|SEC38|SGF1	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments			YPR105C	S000006309
COG5	API4|COD4	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments			YNL051W	S000004996
COG6	COD2|SEC37	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments			YNL041C	S000004986
COG7	COD5	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments			YGL005C	S000002973
COG8	DOR1	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments			YML071C	S000004536
COP1	RET1|SEC33|SOO1	Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway	coatomer complex gamma-alpha-COP alpha subunit	Null mutant is inviable; other cop1 alleles show secretion and protein sorting defects	YDL145C	S000002304
COQ1		Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis	hexaprenyl pyrophosphate synthetase		YBR003W	S000000207
COQ10		Coenzyme Q binding protein, required for function of coenzyme Q in respiration by functioning in the delivery of Q<sub>6</sub> to its proper location for electron transport, START domain protein with homologs in bacteria and eukaryotes			YOL008W	S000005368
COQ2		Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis	para-hydroxybenzoate: polyprenyl diphosphate transferase	Null mutant is viable but is respiratory defective and lacks PHB:polyprenyltransferase activity	YNR041C	S000005324
COQ3		O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex	3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase	Null mutant is viable, fails to grow on H2O2; fails to grow on glycerol	YOL096C	S000005456
COQ4		Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex		Unable to produce ubiquinone, hypersensitivity to polyunsaturated fatty acid treatment	YDR204W	S000002612
COQ5	DBI56	2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes	2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase	Null mutant is viable, respiratory deficient, petite.	YML110C	S000004578
COQ6		Putative flavin-dependent monooxygenase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes	monooxygenase	Unable to produce ubiquinone, hypersensitivity to polyunsaturated fatty acid treatment	YGR255C	S000003487
COQ9	FMP53	Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes			YLR201C	S000004191
COR1	QCR1	Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain	ubiquinol-cytochrome c oxidoreductase complex subunit	deficiency in cytochrome b; slow growth on glycerol	YBL045C	S000000141
COS1		Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins			YNL336W	S000005280
COS10		Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins			YNR075W	S000005358
COS111		Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YBR203W	S000000407
COS12		Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins			YGL263W	S000003232
COS2		Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins			YBR302C	S000000506
COS3		Protein involved in salt resistance; interacts with sodium:hydrogen antiporter Nha1p; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins			YML132W	S000004601
COS4		Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins			YFL062W	S000001832
COS5		Protein of unknown function, member the DUP380 subfamily of conserved, often subtelomerically-encoded proteins			YJR161C	S000003922
COS6		Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins			YGR295C	S000003527
COS7		Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YDL248W	S000002407
COS8		Nuclear membrane protein, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; regulation suggests a potential role in the unfolded protein response			YHL048W	S000001040
COS9		Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins			YKL219W	S000001702
COT1		Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium		Null mutant is viable, yet increased sensitivity to cobalt	YOR316C	S000005843
COX1	OXI3	Subunit I of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits	cytochrome c oxidase subunit I		Q0045	S000007260
COX10		Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders	heme O synthase|hemeA:farnesyltransferase|protoheme IX farnesyltransferase	mutant lacks cytochrome oxidase activity and cytochromes a and a3 and is respiratory-defective	YPL172C	S000006093
COX11	LPI13|PSO7	Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p		deficient in cytochrome oxidase; sensitive to photoactivated 3-carbethoxypsoralen, UV light, radiomimetic mutagens, and oxidative stress	YPL132W	S000006053
COX12		Subunit VIb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of fully active cytochrome c oxidase but not required for activity after assembly	cytochrome c oxidase subunit VIb	Null mutant is viable, grows poorly at room temperature, fails to grow on glycerol/ethanol media at 37 degrees	YLR038C	S000004028
COX13		Subunit VIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP	cytochrome c oxidase subunit VIa	Null mutant is viable, shows slightly reduced growth rate on nonfermentable carbon sources	YGL191W	S000003159
COX14		Mitochondrial membrane protein, required for assembly of cytochrome c oxidase		Nuclear respiration deficient, lack cytochromes a and a3 and detectable cytochrome oxidase activity	YML129C	S000004598
COX15		Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase		fail to synthesize cytochrome oxidase	YER141W	S000000943
COX16		Mitochondrial inner membrane protein, required for assembly of cytochrome c oxidase		Null: viable, respiration deficient	YJL003W	S000003540
COX17		Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase	copper chaperone	Null mutant is viable, respiratory defective, rescued by addition of copper to growth media and/or high copy expression of SCO1 and SCO2 genes	YLL009C	S000003932
COX18	OXA2	Mitochondrial inner membrane protein, required for export of the Cox2p C terminus from the mitochondrial matrix to the intermembrane space during its assembly into cytochrome c oxidase; similar to Oxa2p of N. crassa		Null mutant is viable, respiratory deficient due to inactivity of cytochrome oxidase	YGR062C	S000003294
COX19		Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase			YLL018C-A	S000007245
COX2	OXI1|OXII	Subunit II of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits	cytochrome c oxidase subunit II		Q0250	S000007281
COX20		Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase	required for maturation and assembly of cytochrome oxidase subunit II	Null mutant is respiratory-deficient and has no cytochrome oxidase activity or accumulation of precursor of CoxII	YDR231C	S000002639
COX23		Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p			YHR116W	S000001158
COX3	OXI2	Subunit III of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits	cytochrome c oxidase subunit III		Q0275	S000007283
COX4		Subunit IV of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; N-terminal 25 residues of precursor are cleaved during mitochondrial import	cytochrome c oxidase subunit IV		YGL187C	S000003155
COX5A		Subunit Va of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth	cytochrome c oxidase subunit Va	Null mutant is viable, respires at 10-15% of the wild-type rate due to the presence of COX5B; cox5a cox5b double deletion mutants are completely non-respiratory	YNL052W	S000004997
COX5B		Subunit Vb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth	cytochrome c oxidase subunit Vb		YIL111W	S000001373
COX6		Subunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels	cytochrome c oxidase subunit VI	Null mutant is viable, sensitive to H2O2	YHR051W	S000001093
COX7		Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain	cytochrome c oxidase subunit VII	Null mutant is viable, lacks cytochrome c oxidase activity and haem a/a3 spectra; respiratory deficient	YMR256C	S000004869
COX8		Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain	cytochrome c oxidase subunit VIII	Null mutant is viable, deficient in cellular respiration and cytochrome C oxidase activity	YLR395C	S000004387
COX9		Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain	cytochrome c oxidase subunit VIIa	Lacks functional cytochrome c oxidase holoenzyme	YDL067C	S000002225
COY1		Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function			YKL179C	S000001662
CPA1		Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader	carbamoyl phosphate synthetase small subunit		YOR303W	S000005829
CPA2		Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor	carbamoyl phosphate synthetase large subunit		YJR109C	S000003870
CPD1		Cyclic nucleotide phosphodiesterase, hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; no detectable phenotype is conferred by null mutation or by overexpression	2',3'-cyclic nucleotide 3'-phosphodiesterase	null: viable, no detected growth defects, defective in hydrolysis of ADP-ribose 1'',2''-cyclic phosphate (Appr>p)	YGR247W	S000003479
CPR1	CPH1|CYP1	Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A	PPIase|peptidyl-prolyl cis-trans isomerase		YDR155C	S000002562
CPR2	CYP2	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway	PPIase|peptidyl-prolyl cis-trans isomerase	Null mutant is viable; sensitive to heat	YHR057C	S000001099
CPR3	CYP3	Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria	PPIase|peptidyl-prolyl cis-trans isomerase	Null mutant is viable, unable to grow on L-lactate at 37 degrees C	YML078W	S000004543
CPR4	CYP4|SCC3|YCR070W	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway	PPIase|peptidyl-prolyl cis-trans isomerase	suppressor of cdc65	YCR069W	S000000665
CPR5	CYP5	Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER	PPIase|peptidyl-prolyl cis-trans isomerase		YDR304C	S000002712
CPR6	CYP40	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity	PPIase|peptidyl-prolyl cis-trans isomerase	Null mutant is viable, has normal growth rate	YLR216C	S000004206
CPR7		Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity	PPIase|peptidyl-prolyl cis-trans isomerase		YJR032W	S000003793
CPR8		Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway	PPIase|peptidyl-prolyl cis-trans isomerase		YNR028W	S000005311
CPS1		Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions	carboxypeptidase yscS	Null mutant is viable; leucine auxotroph	YJL172W	S000003708
CPT1		Cholinephosphotransferase, required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription	diacylglycerol cholinephosphotransferase	Null mutant is viable, cpt1 ept1 double deletion mutants are viable	YNL130C	S000005074
CRC1		Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation	carnitine transporter		YOR100C	S000005626
CRD1	CLS1	Cardiolipin synthase; produces cardiolipin, which is an important constituent of mitochondrial membranes; required for normal mitochondrial membrane potential and function	cardiolipin synthase	Null mutant is viable, exhibits growth defects in galactose and glycerol/ethanol media	YDL142C	S000002301
CRF1		Transcriptional corepressor involved in the regulation of ribosomal protein gene transcription via the TOR signaling pathway and protein kinase A, phosphorylated by activated Yak1p which promotes accumulation of Crf1p in the nucleus			YDR223W	S000002631
CRG1		Putative S-adenosylmethionine-dependent methyltransferase; mediates cantharidin resistance			YHR209W	S000001252
CRH1		Cell wall protein that functions in the transfer of chitin to beta(1-6)glucan, putative chitin transglycosidase	cell wall protein	Null mutant is viable and hypersensitive to Congo Red and Calcofluor White	YGR189C	S000003421
CRL1				Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole.		S000029095
CRL10		may be involved in the fidelity of protein translation		Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole.		S000029096
CRL11				Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole.		S000029097
CRL12		may be involved in the fidelity of protein translation		arrest late in the cell cycle after several divisions at the nonpermissive temperature		S000029098
CRL15				Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole.		S000029099
CRL16				Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole.		S000029100
CRL17				Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole.		S000029101
CRL18				Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole.		S000029102
CRL2				Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole.		S000029103
CRL22				Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole.		S000029104
CRL4				Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole.		S000029105
CRL7				Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole.		S000029106
CRL9				Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole.		S000029107
CRM1	KAP124|XPO1	Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus	chromosome region maintenance protein	Null mutant is inviable; a temperature sensitive crm1 allele shows defects in nuclear protein export	YGR218W	S000003450
CRN1		Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity		Overexpression of CRN1 causes growth arrest and redistribution of Arp2p and Crn1p into aberrant actin loops.	YLR429W	S000004421
CRP1		Protein that binds to cruciform DNA structures	Cruciform DNA binding protein	Null: Null mutant is viable and shows no growth defects	YHR146W	S000001189
CRR1		Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation			YLR213C	S000004203
CRS5		Copper-binding metallothionein, required for wild-type copper resistance		Null mutant is viable, exhibits increased sensitivity to copper toxicity	YOR031W	S000005557
CRT10	HUS1	Protein involved in transcriptional regulation of RNR2 and RNR3; expression of the gene is induced by DNA damage and null mutations confer increased resistance to hydroxyurea; N-terminal region has a leucine repeat and a WD40 repeat			YOL063C	S000005424
CRT2				crt2 mutants show a defect in basal level expression of RNR1-lacZ reporter constructs		S000029108
CRZ1	HAL8|TCN1	Transcription factor that activates transcription of genes involved in stress response; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation	transcription factor		YNL027W	S000004972
CSE1	KAP109	Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation			YGL238W	S000003207
CSE2	MED9	Component of the Med9/10 module, which is a subcomplex within the RNA polymerase II Mediator complex; required for regulation of RNA polymerase II activity	mediator complex subunit	Null mutant is viable, accumulates large-budded cells, results in significant increase in chromosome missegregation, slower growth, and defective meiosis	YNR010W	S000005293
CSE4	CSL2	Centromere protein that resembles histones, required for proper kinetochore function; homolog of human CENP-A		Null mutant is inviable; cse4-1 mutant causes increased non-disjunction of chromosome with mutated CEN and t.s. arrest at G2/M boundary with 2N DNA content	YKL049C	S000001532
CSF1		Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YLR087C	S000004077
CSG2	CLS2	Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations		Null mutant is viable but Ca2+-sensitive; a presumed point mutant is sensitive to Ca2+ levels greater than 10 mM (but remains insensitive to 50 mM Sr2+)	YBR036C	S000000240
CSH1		Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p		Null mutant is viable, does not exhibit calcium sensitivity or alter the calcium sensitive phenotype of a sur1 null strain	YBR161W	S000000365
CSI1		Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling	Interactor with COP9 signalosome (CSN) complex		YMR025W	S000004627
CSI2		Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene		Null mutant is viable but shows delocalized chitin deposition	YOL007C	S000005367
CSL4	SKI4	Subunit of the exosome, which is an essential complex present in both nucleus and cytoplasm that mediates RNA processing and degradation		Null mutant is inviable, csl4-1 exhibits double mutant inviability in combination with cbf1(cep1) deletion mutants	YNL232W	S000005176
CSM1		Nucleolar protein that forms a complex with Lrs4p which binds Mam1p at kinetochores during meiosis I to mediate accurate chromosome segregation, may be involved in premeiotic DNA replication; possible role in telomere maintenance			YCR086W	S000000682
CSM2		Protein required for accurate chromosome segregation during meiosis		Null: missegregates chromosomes in meiosis	YIL132C	S000001394
CSM3		Protein required for accurate chromosome segregation during meiosis		Null: missegregates chromosomes in meiosis	YMR048W	S000004651
CSM4		Protein required for accurate chromosome segregation during meiosis		Null: missegregates chromosomes in meiosis	YPL200W	S000006121
CSN12		Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling	COP9 signalosome (CSN) subunit		YJR084W	S000003844
CSN9		Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling	COP9 signalosome (CSN) subunit		YDR179C	S000002586
CSR1	SFH2	Phosphatidylinositol transfer protein with a potential role in lipid turnover; interacts specifically with thioredoxin peroxidase (Tsa2p) and may have a role in oxidative stress resistance			YLR380W	S000004372
CSR2	MRG19	Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate			YPR030W	S000006234
CST14		Chromosome STability		Overexpression of CSTs induces chromosome loss		S000029121
CST18		Chromosome STability		Overexpression of CSTs induces chromosome loss		S000029122
CST21		Chromosome STability		Overexpression of CSTs induces chromosome loss		S000029123
CST26		Protein of unknown function, affects chromosome stability when overexpressed			YBR042C	S000000246
CST3		Chromosome STability		Overexpression of CSTs induces chromosome loss		S000029124
CST6	ACA2|SHF1	Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, activates transcription of genes involved in utilization of non-optimal carbon sources; involved in telomere maintenance	transcription factor	Overexpression of CSTs induces chromosome loss	YIL036W	S000001298
CST9	ZIP3	SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrate		Null mutant is viable, but exhibits delayed sporulation and reduced viability; overexpression of CSTs induces chromosome loss	YLR394W	S000004386
CTA1		Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation	catalase A	Null mutant is viable and heat sensitive	YDR256C	S000002664
CTF13	CBF3C	Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis			YMR094W	S000004700
CTF18	CHL12	Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint		Null mutant is viable, exhibits increased level of spontaneous mitotic recombination, slow growth, and cold sensitivity	YMR078C	S000004683
CTF19	MCM18	Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly	kinetochore protein		YPL018W	S000005939
CTF3	CHL3	Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules			YLR381W	S000004373
CTF4	CHL15|POB1	Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion	DNA polymerase alpha binding protein	Null mutant is viable but shows increase in the rate of mitotic chromosome loss, increased mitotic recombination, shift toward cells with G2 DNA content, and large budded cells with the nucleus in the bud neck; shows synthetic interactions with rad52, pol1, rad9, and esr1	YPR135W	S000006339
CTF8		Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion			YHR191C	S000001234
CTH1		Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis		Null mutant is viable, displays a threefold increase in CTH2 mRNA accumulation. CTH1 overexpression causes delayed entry of cell cultures into exponential growth, and a decrease in final cell density. Removal of the zinc finger domain of Cth1p by truncation or deletion completely reverses the overexpression slow growth phenotype	YDR151C	S000002558
CTI6	RXT1	Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain			YPL181W	S000006102
CTK1		Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing	kinase subunit of RNA polymerase II carboxy-terminal domain kinase I	Null mutations in each of the CTK1, CTK2, and CTK3 genes cause slow growth, cold-sensitivity, flocculence, and enlarged cell size.	YKL139W	S000001622
CTK2		Beta subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing; has similarity to cyclins	RNA polymerase II C-terminal domain kinase beta subunit, similar to cyclin	Null mutations in each of the CTK1, CTK2, and CTK3 genes cause slow growth, cold-sensitivity, flocculence, and enlarged cell size.	YJL006C	S000003543
CTK3		Gamma subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing	RNA polymerase II C-terminal domain kinase gamma subunit, similar to cyclin-dependent kinase	Null mutations in each of the CTK1, CTK2, and CTK3 genes cause slow growth, cold-sensitivity, flocculence, and enlarged cell size.	YML112W	S000004580
CTL1	CTH1	RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm	RNA triphosphatase	Null mutant is viable at 15/30/37C, on media lacking inositol, and on media containing 15nM caffeine. CTL1 shows no genetic interaction with ceg1-250, cet1-4, nor CTD truncation mutants and does not suppress (in high copy) any of these mutants.	YMR180C	S000004792
CTM1		Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth	cytochrome c methyltransferase	lack of trimethylation of cytochrome C Lys72	YHR109W	S000001151
CTP1		Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family	citrate tranporter		YBR291C	S000000495
CTR1		High-affinity copper transporter of the plasma membrane, mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels	copper transporter	Null mutant is viable, deficient in ferrous iron uptake	YPR124W	S000006328
CTR2		Putative low-affinity copper transporter of the vacuolar membrane; mutation confers resistance to toxic copper concentrations, while overexpression confers resistance to copper starvation		ctr2 mutants display a high level of resistance to toxic copper concentrations. CTR2 overexpression provides increased resistance to copper starvation and is also associated with an increased sensitivity to copper toxicity.	YHR175W	S000001218
CTR3		High-affinity copper transporter of the plasma membrane, acts as a trimer; gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae	copper transporter	Null mutant is viable, grows slower than w.t. under conditons of copper limitation on non-fermentable carbon source; strains with a deletion of both CTR1 and CTR3 are unable to grow on nonfermentable carbon sources	YLR411W	S000004403
CTR86		Essential protein of unknown function; upstream region contains a Gcn4p responsive site suggesting a possible role in amino acid biosynthesis			YCR054C	S000000650
CTR9	CDP1	Component of the Paf1p complex, which is a large complex that binds to and modulates the activity of RNA polymerase II and is required for expression of a subset of genes, including cyclin genes; contains TPR repeats		Null mutant is viable, loses chromosomes and shows temperature sensitivity	YOL145C	S000005505
CTS1		Endochitinase, required for cell separation after mitosis; transcriptional activation during late G and early M cell cycle phases is mediated by transcription factor Ace2p	endochitinase		YLR286C	S000004276
CTS2		Sporulation-specific chitinase	Sporulation-specific chitinase	Null mutant fails to form mature asci, synthesis of spore wall surface layers is affected.	YDR371W	S000002779
CTT1	SPS101	Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide	catalase T	Null mutant is viable and heat sensitive	YGR088W	S000003320
CUE1	KIS4	Endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination		Null mutant is viable and shows stabilization of ER degradation substrates	YMR264W	S000004877
CUE2		Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination			YKL090W	S000001573
CUE3		Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination			YGL110C	S000003078
CUE4		Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination			YML101C	S000004568
CUE5		Protein containing a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern			YOR042W	S000005568
CUL3	CULB	Ubiquitin-protein ligase, member of the cullin family with similarity to Cdc53p and human CUL3; required for ubiquitin-dependent degredation of the RNA Polymerase II subunit RPO21	CULLIN B		YGR003W	S000003235
CUP1-1	CUP1	Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C	copper binding metallothionein	Copper resistance	YHR053C	S000001095
CUP1-2	CUP1	Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C	copper binding metallothionein	Copper resistance	YHR055C	S000001097
CUP14		copper homeostasis		Copper resistance		S000029125
CUP2	ACE1	Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations	transcription factor	Null mutant is sensitive to Cu2+	YGL166W	S000003134
CUP3				Copper resistance		S000029126
CUP5	CLS7|GEF2|VMA3	Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis	V-ATPase V0 sector subunit c	Null mutant is viable, petite, copper sensitive	YEL027W	S000000753
CUP9		Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription		Null mutant is viable, associated with loss of copper resistance	YPL177C	S000006098
CUS1		Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p	U2 snRNP protein	suppresses cold sensitivity of a U2 G53A cs mutant	YMR240C	S000004853
CUS2		Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs)		Null mutant is viable, enhances U2 mutations; mutations in this gene suppress the cold sensitive phenotype of U2 RNA mutation G53A	YNL286W	S000005230
CVT14				cvt14 is defective in maturation of the vacuolar protein, aminopeptidase I		S000029127
CVT15				cvt15 is defective in maturation of the vacuolar protein, aminopeptidase I		S000029128
CVT16				cvt16 is defective in maturation of the vacuolar protein, aminopeptidase I		S000029129
CVT3				cvt3 is defective in maturation of the vacuolar protein, aminopeptidase I and exhibits minor defects in autophagy		S000029130
CVT6				cvt6 is defective in maturation of the vacuolar protein, aminopeptidase I and exhibits minor defects in autophagy		S000029131
CWC15		Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p			YDR163W	S000002570
CWC2	NTC40	Protein involved in pre-mRNA splicing, component of a complex containing Cef1p; interacts with Prp19p; contains an RNA recognition motif; has similarity to S. pombe Cwf2p		Null: required for pre-mRNA splicing	YDL209C	S000002368
CWC21		Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; may bind RNA; has similarity to S. pombe Cwf21p			YDR482C	S000002890
CWC22		Essential protein, component of a complex containing Cef1p, has similarity to S. pombe Cwf22p; putative spliceosomal component, based on computational analysis of large-scale protein-protein interaction data			YGR278W	S000003510
CWC23		Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p			YGL128C	S000003096
CWC24		Essential protein, component of a complex containing Cef1p; has similarity to S. pombe Cwf24p			YLR323C	S000004315
CWC25		Component of a complex containing Cef1p, involved in pre-mRNA splicing; has similarity to S. pombe Cwf25p			YNL245C	S000005189
CWC27		Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p			YPL064C	S000005985
CWH41	DER7|GLS1	Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress	glucosidase II catalytic subunit	Null mutant is viable, associated with K1 killer toxin-resistant phenotype and a 50% reduction in the cell wall beta 1,6-glucan level	YGL027C	S000002995
CWH43		Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion			YCR017C	S000000610
CWP1	YJU1	Cell wall mannoprotein, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; involved in cell wall organization	cell wall mannoprotein	Null mutant is viable, has increased sensitivities to calcoflour white and congo red	YKL096W	S000001579
CWP2	LPR1|YKL097W-A	Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored	cell wall mannoprotein	Null mutant is viable, displays increased sensitivity to Congo red, calcofluor white, and Zymolyase	YKL096W-A	S000001956
CYB2		Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions	L-lactate cytochrome c oxidoreductase|cytochrome b2	Null mutant is viable but is deficient in cytochrome b2 and L-lactate dehydrogenase activity and is unable to use L-lactate as a sole carbon source	YML054C	S000004518
CYB5		Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; required for sterol C5-6 and fatty acid desaturation	cytochrome b5	Null mutant is viable, cyb5 mutations suppress ketoconazole hypersensitivity of a P450 reductase deficient strain	YNL111C	S000005055
CYC1		Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration	iso-1-cytochrome c	Cytochrome c deficiency	YJR048W	S000003809
CYC2		Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)		Null mutant is viable. Deletion of CYC2 leads to accumulation of apocytochrome c in the cytoplasm; strains with deletions of CYC2 still import low levels of cytochrome c into mitochondria	YOR037W	S000005563
CYC3		Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-Cyc1p in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)	CCHL|cytochrome c heme lyase	Cytochrome c deficiency	YAL039C	S000000037
CYC7		Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration	iso-2-cytochrome c		YEL039C	S000000765
CYC8	CRT8|SSN6	General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters		Null mutant is viable; high level constitutivity for invertase, clumpiness, temperature-sensitive growth, alpha-specific mating defects and failure of homozygous diploids to sporulate	YBR112C	S000000316
CYH1				Cycloheximide resistance		S000029132
CYH10				Cycloheximide resistance		S000029133
CYH101						S000029134
CYH35						S000029135
CYH4				Cycloheximide resistance		S000029136
CYH5				Cycloheximide resistance		S000029137
CYH82						S000029138
CYH98						S000029139
CYK3		SH3-domain protein located in the mother-bud neck and the cytokinetic actin ring; mutant phenotype and genetic interactions suggest a role in cytokinesis		Null mutant is viable, exhibits slow growth, mild cytokinesis defects, and aberrant mother-bud neck morphology. cyk3/hof1 and cyk3/myo1 double mutants are inviable	YDL117W	S000002275
CYM1	MOP112	Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology	metalloprotease		YDR430C	S000002838
CYR1	CDC35|FIL1|HSR1|SRA4|TSM0185	Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation	adenylate cyclase	Null mutant is inviable. cyr1 transiently arrests in G1 and sporulates precociously. N-terminal domain is dispensable for mitotic G1 arrest after nitrogen starvation, but required for sporulation. When altered, cAMP levels remain high and cells continue to bud with abnormal spindles	YJL005W	S000003542
CYS1				Mutant is a cysteine auxotroph and lacks serine acetyltransferase activity		S000029140
CYS2				cys2 and cys4 mutations are linked together and co-operatively confer cysteine dependence		S000029141
CYS3	CYI1|FUN35|STR1	Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine	cystathionine gamma-lyase	Null mutant is viable, cysteine auxotroph	YAL012W	S000000010
CYS4	NHS5|STR4|VMA41	Cystathionine beta-synthase, catalyzes the synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis	cystathionine beta-synthase	Null exhibits vacuolar acidification defects; cys2 and cys4 mutations are linked together and cooperatively confer cysteine dependence.	YGR155W	S000003387
CYT1	CTC1|YOR29-16	Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex	cytochrome c1|ubiquinol-cytochrome c oxidoreductase complex subunit		YOR065W	S000005591
CYT2		Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1	CC1HL|cytochrome c1 heme lyase		YKL087C	S000001570
DAD1		Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis		Null mutant is inviable; temperature-sensitive mutant arrests with large buds and a short mitotic spindle	YDR016C	S000002423
DAD2	HSK1	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis			YKR083C	S000001791
DAD3		Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis			YBR233W-A	S000007595
DAD4	HSK2	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis			YDR320C-A	S000007604
DAK1		Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation	dihydroxyacetone kinase	Null mutant is viable and shows no growth defect in normal medium; mutant lacking both dak1 and dak2 is sensitive to dihydroxyacetone during saline growth	YML070W	S000004535
DAK2		Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation	dihydroxyacetone kinase	Null mutant is viable and show no growth defect in normal medium; mutant lacking both dak1 and dak2 is sensitive to dihydroxyacetone during saline growth	YFL053W	S000001841
DAL1		Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression	allantoinase	Allantoin degradation deficient	YIR027C	S000001466
DAL2	ALC1	Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation	allantoicase	Allantoin degradation deficient	YIR029W	S000001468
DAL3		Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression	ureidoglycolate hydrolase		YIR032C	S000001471
DAL4		Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation	allantoin permease	Null mutant is viable, lacks allantoin transport capability	YIR028W	S000001467
DAL5	UREP1	Allantoin permease; ureidosuccinate permease; expression is constitutive but sensitive to nitrogen catabolite repression	allantoate permease	Null mutant is viable, unable to transport allontoate or ureidosuccinate	YJR152W	S000003913
DAL7	MLS2|MSL2	Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation	malate synthase		YIR031C	S000001470
DAL80	UGA43	Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Deh1p	transcriptional repressor	Null mutant is viable, deficient in allantoin degradation	YKR034W	S000001742
DAL81	UGA35	Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism	transcriptional activator	Null mutant is viable, unable to degrade allantoin	YIR023W	S000001462
DAL82		Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain	transcriptional activator	loss of induction for allantoin degradation pathways	YNL314W	S000005258
DAM1		Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments			YGR113W	S000003345
DAN1	CCW13	Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth	cell wall mannoprotein		YJR150C	S000003911
DAN2		Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth			YLR037C	S000004027
DAN3		Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth			YBR301W	S000000505
DAN4		Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth	cell wall mannoprotein		YJR151C	S000003912
DAP1		Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis		Null mutant exhibits sensitivity to MMS, elongated telomeres, elevated petite formation, partial arrest in sterol synthesis	YPL170W	S000006091
DAP2	DPP2	Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p	dipeptidyl aminopeptidase B (DPAP B)|dipeptidyl aminopeptidase yscV	Null mutant is viable and lacks dipeptidyl aminopeptidase yscV activity	YHR028C	S000001070
DAT1		DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability	datin|oligo(dA).oligo(dT)-binding protein	Null mutant is viable, but phenotypically distinguishable	YML113W	S000004581
DBF1			kinase required for late nuclear division	Dumbell formation		S000029142
DBF2		Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis	serine/threonine protein kinase	Null mutant is viable, dbf1 dbf20 null mutants are inviable; mutants show dumb-bell phenotype	YGR092W	S000003324
DBF20		Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis	serine/threonine protein kinase	Dumbell formation	YPR111W	S000006315
DBF4	DNA52|LSD7	Regulatory subunit of Cdc7p-Dbf4p kinase complex, required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated	Cdc7p-Dbf4p kinase complex regulatory subunit	Null mutant is inviable; conditional alleles cause cell cycle arrest at the G1/S transition; dumbbell shape	YDR052C	S000002459
DBL1				Alcian blue dye binding deficient		S000029143
DBP1	LPH8	Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs			YPL119C	S000006040
DBP10		Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis			YDL031W	S000002189
DBP2		Essential ATP-dependent RNA helicase of the DEAD-box protein family, involved in nonsense-mediated mRNA decay and rRNA processing	ATP-dependent RNA helicase		YNL112W	S000005056
DBP3		Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis	ATP-dependent RNA helicase		YGL078C	S000003046
DBP5	RAT8	Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family involved in mRNA export from the nucleus; involved in translation termination	RNA helicase	dbp5(ts) strains exhibit rapid, synchronous accumulation of poly(A)+ RNA in nuclei when shifted to the non-permissive temperature	YOR046C	S000005572
DBP6		Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family		Null mutant is inviable; Dbp6p depletion leads to decreased production of the 27S and 7S precursors, resulting in a depletion of the mature 25S and 5.8S rRNAs	YNR038W	S000005321
DBP7		Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis			YKR024C	S000001732
DBP8		Putative ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 40S ribosomal subunit			YHR169W	S000001212
DBP9		ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 60S ribosomal subunit			YLR276C	S000004266
DBR1	PRP26	RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition	RNA lariat debranching enzyme	Null mutant is viable; reduces Ty1 transposition frequency; defective in the process of intron turnover	YKL149C	S000001632
DCC1		Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance		benomyl sensitive and defective in sister chromatid cohesion	YCL016C	S000000521
DCD1		Deoxycytidine monophosphate (dCMP) deaminase required for dCTP and dTTP synthesis; expression is NOT cell cycle regulated	dCMP deaminase	Null mutant is viable, resistant to 5-fluoro-2'-deoxycytidylate	YHR144C	S000001187
DCG1		Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain			YIR030C	S000001469
DCI1	ECI2	Peroxisomal delta(3,5)-delta(2,4)-dienoyl-CoA isomerase, involved in fatty acid metabolism, contains peroxisome targeting signals at amino and carboxy termini	delta(3,5)-delta(2,4)-dienoyl-CoA isomerase		YOR180C	S000005706
DCN1		Putative Nedd8 ligase; binds Nedd8; involved in cullin neddylation; not essential; similar to C.elegans DCN-1; contains UBA-like ubiquitin-binding domain and a DUF298 domain			YLR128W	S000004118
DCP1		Subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p		Null mutant is inviable in the FY1679 background, but viable, though grows slowly, in the CEN.PK141 background.	YOL149W	S000005509
DCP2	PSU1	Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; member of the Nudix hydrolase family			YNL118C	S000005062
DCR2		Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START			YLR361C	S000004353
DCS1	DcpS	Non-essential hydrolase involved in mRNA decapping, may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; interacts with neutral trehalase Nth1p			YLR270W	S000004260
DCS2		Non-essential, stress induced regulatory protein containing a HIT (histidine triad) motif; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway, similar to Dcs1p.			YOR173W	S000005699
DCW1		Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p	mannosidase		YKL046C	S000001529
DDC1		DNA damage checkpoint protein, part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate		Null mutant is viable, sensitive to DNA damage and defective in delaying G1-S and G2-M transistion and in decreasing rate of DNA synthesis when DNA is damaged during G1, G2 or S phase, respectively	YPL194W	S000006115
DDI1	VSM1	DNA damage-inducible v-SNARE binding protein, contains a ubiquitin-associated (UBA) domain, may act as a negative regulator of constitutive exocytosis, may play a role in S-phase checkpoint control			YER143W	S000000945
DDI2		Protein whose expression is induced by DNA damage			YFL061W	S000001833
DDI3		Hypothetical protein			YNL335W	S000005279
DDP1		Diadenosine polyphosphate hydrolase, member of the MutT family of nucleotide hydrolases with high specificity for diadenosine hexa- and pentaphosphates, required for efficient hydrolysis of diphosphorylated inositol polyphosphates	diadenosine 5', 5"'-P1,P6-hexaphosphate hydrolase|diadenosine and diphosphoinositol polyphosphate phosphohydrolase		YOR163W	S000005689
DDR2	DDRA2|YOL053C-A	Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses		Null mutant is viable, shows no defect in heat shock recovery or thermotolerance and appear normal for DNA damage sensitivity and mutagenesis	YOL052C-A	S000005413
DDR48	FSP	DNA damage-responsive protein, expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS		Null mutant is viable, displays reduced spontaneous mutation rate	YMR173W	S000004784
DDS2		Depressed DNA synthesis		Null phenotype unknown; temperature sensitive mutant ceases DNA synthesis at restrictive temperature		S000029144
DED1	SPP81	ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility	ATP-dependent RNA helicase		YOR204W	S000005730
DED81		Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA	asparaginyl-tRNA synthetase		YHR019C	S000001061
DEF1	VID31	RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex		Null: slow growth. Other phenotypes: unable to degrade RNAPII in response to UV-damage. def1delta and def1delta rad26delta cells are not UV-sensitive, but def1delta rad16delta and def1delta rad14delta cells are much more sensitive than the rad16delta and rad14delta single mutants. def1delta and to a much larger degree def1delta dst1delta are sensitive to the elongation inhibitor 6-azauracil.	YKL054C	S000001537
DEG1	PUS3	Non-essential tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm	tRNA-pseudouridine synthase	Null mutant is viable, but demonstrates depressed growth rate	YFL001W	S000001895
DEM1		Protein of unknown function, shows similarity to RNA-processing protein Pta1p			YBR163W	S000000367
DEP1	FUN54	Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation			YAL013W	S000000011
DER1		Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p		Null mutant is viable, but blocks ER-degradation of target proteins	YBR201W	S000000405
DFG10		Protein of unknown function, involved in filamentous growth		Null mutant is viable and defective in filamentous growth	YIL049W	S000001311
DFG16	ECM41|ZRG11	Probable multiple transmembrane protein, involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; required for accumulation of processed Rim101p		Null mutant is viable, a Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white.	YOR030W	S000005556
DFG5		Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p	mannosidase 	Null mutant is viable and defective in filamentous growth	YMR238W	S000004851
DFM1		ER localized derlin-like family member involved in ER stress and homeostasis; not involved in ERAD or substrate retrotranslocation; interacts with CDC48; contains four transmembrane domains and two SHP boxes			YDR411C	S000002819
DFR1		Dihydrofolate reductase, part of the dTTP biosynthetic pathway, involved in folate metabolism, possibly required for mitochondrial function	dihydrofolate reductase		YOR236W	S000005762
DGA1		Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles	Acyl-CoA : diacylglycerol acyltransferase		YOR245C	S000005771
DHH1		Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping, coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation	ATP-dependent RNA helicase	Null mutant is viable, but grows poorly	YDL160C	S000002319
DHR2		Predominantly nucleolar DEAH-box RNA helicase, required for 18S rRNA synthesis	ATP-dependent RNA helicase	Null: essential	YKL078W	S000001561
DIA1		Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern		Null mutant is viable and causes invasive growth in haploids and pseudohyphal growth in diploids	YMR316W	S000004935
DIA2	YOR29-31	Origin-binding F-box protein that forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication, involved in invasive and pseudohyphal growth		Enhanced invasive growth in haploids; haploid budding pattern becomes polar.	YOR080W	S000005606
DIA3		Protein of unknown function, involved in invasive and pseudohyphal growth		Null mutant is viable and causes invasive growth in haploids and pseudohyphal growth in diploids	YDL024C	S000002182
DIA4		Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth		Null mutant is viable and causes agar invasion in haploids, pseudohyphal growth in diploids; unable to grow on glycerol	YHR011W	S000001053
DIB1	SNU16	17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein			YPR082C	S000006286
DIC1		Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix	dicarboxylate transporter		YLR348C	S000004340
DID2	CHM1|FTI1|VPS46	Class E protein of the vacuolar protein-sorting (Vps) pathway, associates reversibly with the late endosome, has human ortholog that may be altered in breast tumors	class E vacuolar-protein sorting and endocytosis factor	Overexpression causes growth inhibition and G2 arrest in rad52 and cdc9 mutants; null mutants are canavanine-hypersensitive, temperature sensitive, and suppress defects associated with loss of DOA4	YKR035W-A	S000006435
DID4	CHM2|GRD7|REN1|VPL2|VPS2|VPT14	Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis	class E vacuolar-protein sorting and endocytosis factor		YKL002W	S000001485
DIE2	ALG10	Dolichyl-phosphoglucose-dependent glucosyltransferase of the ER, functions in the dolichol pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1	alpha-1,2 glucosyltransferase		YGR227W	S000003459
DIE3		De-repression of ITR1 Expression				S000029145
DIG1	RST1	Regulatory protein of unknown function, constitutively-expressed, involved in the regulation of mating-specific genes and the invasive growth pathway, required for MAP-kinase imposed repression, inhibits pheromone-responsive transcription		Null mutant is viable, shows abnormal bud morphology; dig1 dig2 double mutants show constitutive mating defect and invasive growth; overexpression causes pheromone resistance	YPL049C	S000005970
DIG2	RST2	Regulatory protein of unknown function, pheromone-inducible, involved in the regulation of mating-specific genes and the invasive growth pathway, required for MAP-kinase imposed repression, inhibits pheromone-responsive transcription		Null mutant is viable; dig1 dig2 double mutants show constitutive mating pheromone specific gene expression and invasive growth	YDR480W	S000002888
DIM1	CDH1	Essential 18S rRNA dimethylase, responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18 S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing	dimethyladenosine transferase		YPL266W	S000006187
DIN7	DIN3	Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination			YDR263C	S000002671
DIP2	UTP12	Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex	U3 snoRNP protein		YLR129W	S000004119
DIP5		Dicarboxylic amino acid permease, mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly	amino acid transporter	Null mutant is viable, exhibits loss of L-aspartate and L-glutamate uptake	YPL265W	S000006186
DIS1		Required for mitotic segregation, meiosis I segregation, and spore viability		mutants cause mitotic and meiotic nondisjunction		S000029146
DIS3	RRP44	Catalytic component of the exosome, involved in RNA processing and degradation; binds Gsp1p/Ran and enhances the GEF activity of Srm1p; implicated in mitotic control; homologous to the E. coli RNase R of the RNase II family	3'-5' exoribonuclease complex subunit		YOL021C	S000005381
DIT1		Sporulation-specific enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure	first enzyme in dityrosine synthesis in the outer layer of the spore wall pathway, converting L-tyrosine to N-formyl-L-tyrosine	lack outermost layer of spore wall	YDR403W	S000002811
DIT2	CYP56	N-formyltyrosine oxidase, sporulation-specific microsomal enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall, homologous to cytochrome P-450s	catalyzes oxidation of N-formyl tyrosine to N,N-bisformyl dityrosine in vitro|cytochrome P450 56	lack outermost layer of spore wall	YDR402C	S000002810
DJP1	ICS1|PAS22	Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ		Null mutant is viable but shows partial mislocalisation of peroxisomal matrix proteins to the cytosol	YIR004W	S000001443
DLD1		D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane	D-lactate ferricytochrome c oxidoreductase	Null mutant is viable and cannot grow on media containing lactate as the sole carbon source	YDL174C	S000002333
DLD2	AIP2	D-lactate dehydrogenase, located in the mitochondrial matrix	D-lactate ferricytochrome c oxidoreductase		YDL178W	S000002337
DLD3		D-lactate dehydrogenase, part of the retrograde regulon which consists of genes whose expression is stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source, located in the cytoplasm	D-lactate dehydrogenase		YEL071W	S000000797
DLP1		Delayed loss of proliferation activity				S000029147
DLS1		Subunit of ISW2/yCHRAC chromatin accessibility complex along with Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing			YJL065C	S000003601
DLT1		Protein of unknown function, deletion causes sensitivity to thermal stress		Null: Poor growth at 15 degrees; phenotype is less apparent in prototrophic strains. Other phenotypes: Sensitive to heat shock and hydrogen peroxide	YMR126C	S000004733
DMA1	CHF1	Protein involved in regulating spindle position and orientation, functionally redundant with Dma2p; homolog of S. pombe Dma1 and H. sapiens Chfr			YHR115C	S000001157
DMA2	CHF2	Protein involved in regulating spindle position and orientation, functionally redundant with Dma1p; homolog of S. pombe Dma1 and H. sapiens Chfr			YNL116W	S000005060
DMC1	ISC2	Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein			YER179W	S000000981
DML1		Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family		Null: inviable. Other phenotypes: Meiotic progeny DML1 cells of the DML1/dml1Delta heterozygote are completely devoid of mtDNA ([rho0]). In addition, meiotic transmission of centromeric plasmids also appears to be impaired.	YMR211W	S000004824
DNA1	MAK1-3			Deficient in the initiation step of DNA synthesis		S000029148
DNA2	WEB2	Essential tripartite DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair pathways; potential Cdc28p substrate	DNA helicase		YHR164C	S000001207
DNF1		Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase		viable. drs2 dnf1 mutant grows slowly, massively accumulates intracellular membranes, and exhibits a substantial defect in the transport of alkaline phosphatase to the vacuole.	YER166W	S000000968
DNF2		Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase			YDR093W	S000002500
DNF3		Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vessicles; localizes to the trans-Golgi network; likely involved in protein transport; type 4 P-type ATPase			YMR162C	S000004772
DNL4	LIG4	DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, catalyzes DNA ligation as part of a complex with Lif1p and Nej1p; involved in meiosis, not essential for vegetative growth	ATP-dependent DNA ligase	Null mutant is viable, deficient in non-homologous double-strand end joining	YOR005C	S000005531
DNM1		Dynamin-related GTPase required for mitochondrial fission and the maintenance of mitochondrial morphology, assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis		Null mutant is viable, shows mating defects consistent with a delay in receptor-mediated endocytosis	YLL001W	S000003924
DOA1	UFD3|ZZZ4	WD repeat protein required for ubiquitin-mediated protein degradation, forms complex with Cdc48p, plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase		Null mutant is viable and defective in degradation of ubiquitinated proteins; homozygous null diploid shows sporulation defect	YKL213C	S000001696
DOA4	DOS1|MUT4|NPI2|SSV7|UBP4	Ubiquitin hydrolase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole	ubiquitin isopeptidase	Null mutant is viable, but exhibits uncoordinated DNA replication|A nonsense mutation in the doa4-10 mutant eliminates the catalytic residues of the deubiquitinating enzyme while keeping the rhodanase domain intact. At 36 degrees C, this doa4-10 mutant exhibits increased sensitivity to camptothecin (CPT), osmotic stress, and hydroxyurea, and a reversible petite phenotype.	YDR069C	S000002476
DOC1	APC10	Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis			YGL240W	S000003209
DOG1		2-deoxyglucose-6-phosphate phosphatase, similar to Dog2p, member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified	2-deoxyglucose-6-phosphate phosphatase		YHR044C	S000001086
DOG2		2-deoxyglucose-6-phosphate phosphatase, member of a family of low molecular weight phosphatases, similar to Dog1p, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed	2-deoxyglucose-6-phosphate phosphatase		YHR043C	S000001085
DOM34		Probable RNA-binding protein, functions in protein translation to promote G1 progression and differentiation, required for meiotic cell division			YNL001W	S000004946
DON1		Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II			YDR273W	S000002681
DOP1		Protein of unknown function, essential for viability, involved in establishing cellular polarity and morphogenesis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies		essential gene	YDR141C	S000002548
DOS2		Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm			YDR068W	S000002475
DOT1	PCH1	Nucleosomal histone H3-Lys79 methylase, associates with transcriptionally active genes, functions in gene silencing at telomeres, most likely by directly modulating chromatin structure and Sir protein localization	histone methyltransferase	Null mutant is viable, bypasses meiotic arrest of zip1 mutant, and shows decreased silencing at telomeres, HML, and HMR. Overexpression causes loss of silencing at telomeres, HML, HMR, and slightly at rDNA	YDR440W	S000002848
DOT5		Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth	thioredoxin peroxidase		YIL010W	S000001272
DOT6		Protein of unknown function, involved in telomeric gene silencing and filamentation			YER088C	S000000890
DPB11		Essential BRCT repeat protein, required on the prereplicative complex at replication origins for loading DNA polymerases to initiate DNA synthesis, also required for S/M checkpoint control	DNA polymerase II complex	Null mutant is inviable; conditional allele demonstrates defective S-phase progression	YJL090C	S000003626
DPB2		Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for normal yeast chromosomal replication; expression peaks at the G1/S phase boundary; potential Cdc28p substrate	DNA polymerase epsilon subunit B	Null mutant is inviable; conditional mutant shows defects in DNA replication	YPR175W	S000006379
DPB3		Third-largest subunit of DNA polymerase II (DNA polymerase epsilon), required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; mRNA abundance peaks at the G1/S boundary of the cell cycle	DNA polymerase II C and C' subunits	Null mutant is viable, shows increased spontaneous mutation rate	YBR278W	S000000482
DPB4		Shared subunit of DNA polymerase epsilon and of ISW2/yCHRAC chromatin accessibility complex; involved in both chromosomal DNA replication and in inheritance of telomeric silencing	DNA polymerase II (epsilon) 4th subunit		YDR121W	S000002528
DPD1						S000029150
DPH1	KIF48	Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11p			YIL103W	S000001365
DPH2		Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p			YKL191W	S000001674
DPH5		Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm	diphthine synthase		YLR172C	S000004162
DPL1	BST1	Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate	dihydrosphingosine phosphate lyase		YDR294C	S000002702
DPM1	SED3	Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation	dolichol phosphate mannose synthase		YPR183W	S000006387
DPP1	ZRG1	Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism	diacylglycerol pyrophosphate phosphatase		YDR284C	S000002692
DPS1		Cytoplasmic aspartyl-tRNA synthetase, homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation	AspRS|aspartyl-tRNA synthetase		YLL018C	S000003941
DRE2		Protein of unknown function; mutation displays synthetic lethal interaction with the pol3-13 allele of CDC2			YKR071C	S000001779
DRS1		Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles			YLL008W	S000003931
DRS2	FUN38|SWA3	Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vessicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease	aminophospholipid translocase	Null mutant is viable, cold sensitive with perturbed late Golgi function; drs2 arf1 double mutants are inviable. drs2 dnf1 mutants grow slowly, accumulate intracellular membranes, exhibit substantial defect in transport of alkaline phosphatase to vacuole.	YAL026C	S000000024
DRS3				defective in assembly of ribosomes		S000029151
DSE1		Daughter cell-specific protein, may participate in pathways regulating cell wall metabolism; deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall			YER124C	S000000926
DSE2		Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP			YHR143W	S000001186
DSE3		Daughter cell-specific protein, may help establish daughter fate			YOR264W	S000005790
DSE4	ENG1	Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother			YNR067C	S000005350
DSF1		Deletion suppressor of mpt5 mutation			YEL070W	S000000796
DSF2		Deletion suppressor of mpt5 mutation			YBR007C	S000000211
DSK2		Nuclear-enriched ubiquitin-like polyubiquitin-binding protein, required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle, involved in proteolysis, interacts with the proteasome			YMR276W	S000004889
DSL1		Endoplasmic reticulum (ER)-localized peripheral membrane protein required for Golgi-to-ER retrograde traffic; component of the ER target site that interacts with coatomer, the major component of the COPI vesicle protein coat			YNL258C	S000005202
DSM1				Premeiotic DNA synthesis deficient. Semi-dominant ts allele partially suppresses spo8-1 ts. Restores premeioticDNA synthesis, intragenic recombination, but not reciprocal recombination or ascus formation to spo8-1 at a restrictive temperature. DSM1 alone is dispensable for sporulation.		S000029152
DSN1		Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation			YIR010W	S000001449
DSS1	MSU1	RNase, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs	3'-5' exonuclease complex component		YMR287C	S000004900
DSS4		Nucleotide release factor functioning in the post-Golgi secretory pathway, required for ER-to-Golgi transport, binds zinc, found both on membranes and in the cytosol; guanine nucleotide dissociation stimulator	GDP dissociation factor for Sec4p		YPR017C	S000006221
DST1	PPR2	General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites	RNA polymerase II elongation factor	Null mutant is viable; reduced induction of DNA strand transfer; sensitivity to 6-azauracil	YGL043W	S000003011
DTD1		D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes	D-tyrosyl-tRNA(Tyr) deacylase		YDL219W	S000002378
DTR1		Multidrug resistance dityrosine transporter of the major facilitator superfamily, essential for spore wall synthesis, facilitates the translocation of bisformyl dityrosine through the prospore membrane	dityrosine transporter	Null: Null mutant is viable; bisformyl dityrosine accumulates in cytoplasm of spores; spore wall dityrosine is significantly reduced	YBR180W	S000000384
DUG1		Probable di- and tri-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)	Metallopeptidase M20		YFR044C	S000001940
DUG2		Probable di- and tri-peptidase; forms a complex with Dug1p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)			YBR281C	S000000485
DUG3		Probable glutamine amidotransferase, forms a complex with Dug1p and Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)			YNL191W	S000005135
DUN1		Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair	protein serine-threonine kinase	Null mutant is viable, defective in DNA damage repair and DNA damage-resposive induction of RNR genes, and sensitive to DNA damaging agents. dun1pan2 and dun1pan3 double mutants are hypersensitive to replicational stress.	YDL101C	S000002259
DUO1		Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis		Null mutant is inviable; overexpression arrests cells at large budded stage	YGL061C	S000003029
DUR1,2	DUR80	Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation	urea amidolyase|urea carboxylase	Null mutant is viable; urea degradation deficient	YBR208C	S000000412
DUR3		Plasma membrane urea transporter, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway	polyamine transporter	Null mutant is viable; urea degradation deficient	YHL016C	S000001008
DUR4				Urea degradation deficient		S000029153
DUS1		Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17	tRNA dihydrouridine synthase		YML080W	S000004545
DUS3		Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region	dihydrouridine synthase		YLR401C	S000004393
DUS4		Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p	dihydrouridine synthase		YLR405W	S000004397
DUT1		dUTPase, catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability	dUTP pyrophosphatase		YBR252W	S000000456
DYN1	DHC1|PAC6	Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p	heavy chain of cytoplasmic dynein	Null mutant is viable, demonstrates misalignment of the spindle relative to the bud neck during cell division and abnormal distribution of the dividing nuclei between the mother cell and the bud	YKR054C	S000001762
DYN2	SLC1	Cytoplasmic light chain dynein, microtubule motor protein			YDR424C	S000002832
DYN3		Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration	Light intermediate chain of dynein		YMR299C	S000004914
DYS1		Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric	deoxyhypusine synthase		YHR068W	S000001110
EAF3		Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3	NuA4 histone acetyltransferase subunit		YPR023C	S000006227
EAF5		Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex			YEL018W	S000000744
EAF6		Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3			YJR082C	S000003842
EAF7		Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A			YNL136W	S000005080
EAM1		endogenous ethanolamine biosynthesis		Null phenotype unknown; a recessive allele suppresses ethanolamine requirement in cho1 mutants		S000029154
EAM2		endogenous ethanolamine biosynthesis		Null phenotype unknown; a recessive allele suppresses ethanolamine requirement in cho1 mutants		S000029155
EAM6						S000029156
EAP1		eIF4E-associated protein, binds eIF4E and inhibits cap-dependent translation, also functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade		Mutant is temperature sensitive and partially resistant to rapamycin	YKL204W	S000001687
EBP2		Essential protein required for the maturation of 25S rRNA and 60S ribosomal subunit assembly, localizes to the nucleolus; constituent of 66S pre-ribosomal particles			YKL172W	S000001655
EBS1		Cytoplasmic protein of unknown function, involved in inhibition of translation; interacts with cap binding protein Cdc33; contains an RNA recognition motif and similarity to Est1p; mRNA abundance regulated by mRNA decay factors			YDR206W	S000002614
ECI1		Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced	delta3,delta2-enoyl-CoA isomerase	Null mutant is viable but fails to metabolize unsaturated fatty acids	YLR284C	S000004274
ECM1		Protein of unknown function, localized in the nucleoplasm and the nucleolus, genetically interacts with MTR2 in 60S ribosomal protein subunit export			YAL059W	S000000055
ECM10	SSC3	Heat shock protein of the Hsp70 family, localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner; overexpression induces extensive mitochondrial DNA aggregations		A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white.	YEL030W	S000000756
ECM11		Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure		A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white.	YDR446W	S000002854
ECM12		Non-essential protein of unknown function		A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white.	YHR021W-A	S000003531
ECM13		Non-essential protein of unknown function		A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white.	YBL043W	S000000139
ECM14		Putative metalloprotease with similarity to the zinc carboxypeptidase family, required for normal cell wall assembly		A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white.	YHR132C	S000001174
ECM15		Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis		A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white.	YBL001C	S000000097
ECM16	DHR1	Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis	U3 snoRNP protein	A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white.	YMR128W	S000004735
ECM17	MET5	Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine	sulfite reductase beta subunit	loss of function mutants are methionine requiring and sensitive to the cell wall perturbing agent calcoflour white.	YJR137C	S000003898
ECM18		Protein of unknown function, similar to Rlp24p		A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white.	YDR125C	S000002532
ECM19		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies		A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white.	YLR390W	S000004382
ECM2	SLT11	Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p		Synthetic lethal with U2 snRNA (LSR1); temperature-sensitive; blocks pre-mRNA splicing in vivo and in vitro; a Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white.	YBR065C	S000000269
ECM21		Non-essential protein of unknown function; promoter contains several Gcn4p binding elements		A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white.	YBL101C	S000000197
ECM22		Sterol regulatory element binding protein, regulates transcription of the sterol biosynthetic genes ERG2 and ERG3; member of the fungus-specific Zn[2]-Cys[6] binuclear cluster family of transcription factors; homologous to Upc2p			YLR228C	S000004218
ECM23	SRD2	Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p			YPL021W	S000005942
ECM25		Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p			YJL201W	S000003737
ECM27		Non-essential protein of unknown function		A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white.	YJR106W	S000003867
ECM29		Major component of the proteasome; tethers the proteasome core particle to the regulatory particle, and enhances the stability of the proteasome			YHL030W	S000001022
ECM3	YOR3165W	Non-essential protein of unknown function		A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white.	YOR092W	S000005618
ECM30		Non-essential protein of unknown function			YLR436C	S000004428
ECM31		Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate			YBR176W	S000000380
ECM32	HEL1|MTT1	DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes	DNA helicase		YER176W	S000000978
ECM33		GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; similar to Sps2p and Pst1p			YBR078W	S000000282
ECM34		Putative protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins			YHL043W	S000001035
ECM37		Non-essential protein of unknown function			YIL146C	S000001408
ECM38	CIS2	Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; expression induced mainly by nitrogen starvation			YLR299W	S000004290
ECM4	GTO2	Omega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm		A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white.	YKR076W	S000001784
ECM40	ARG7	Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine	acetylornithine acetyltransferase		YMR062C	S000004666
ECM5		Non-essential protein of unknown function, contains ATP/GTP-binding site motif A; null mutant exhibits cellular volume up to four times greater than wild-type, also large drooping buds with elongated necks			YMR176W	S000004788
ECM7	ZRG15	Non-essential protein of unknown function			YLR443W	S000004435
ECM8		Non-essential protein of unknown function			YBR076W	S000000280
ECM9	YKR004C-A	Non-essential protein of unknown function			YKR004C	S000001712
ECO1	CTF7	Acetyltransferase required for the establishment of sister chromatid cohesion during DNA replication, but not for its maintenance during G2 and M phases; also required for postreplicative double-strand break repair; interacts with Chl1p			YFR027W	S000001923
EDC1		RNA-binding protein, activates mRNA decapping directly by binding to the mRNA substrate and enhancing the activity of the decapping proteins Dcp1p and Dcp2p			YGL222C	S000003190
EDC2		RNA-binding protein, activates mRNA decapping directly by binding to the mRNA substrate and enhancing the activity of the decapping proteins Dcp1p and Dcp2p			YER035W	S000000837
EDC3	DCP3|LSM16	Non-essential conserved protein of unknown function, plays a role in mRNA decapping by specifically affecting the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies			YEL015W	S000000741
EDE1	BUD15	Key endocytic protein involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins			YBL047C	S000000143
EDS1		Putative zinc cluster protein; YBR033W is not an essential gene		Null: calcofluor resistant.. Other phenotypes: Deletion suppresses lysis defect of a swi4 deletion.	YBR033W	S000000237
EEB1		Acyl-coenzymeA:ethanol O-acyltransferase responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short chain esterase activity; may be involved in lipid metabolism and detoxification	Acyl-coenzymeA:ethanol O-acyltransferase		YPL095C	S000006016
EFB1	TEF5	Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site	translation elongation factor EF-1 beta		YAL003W	S000000003
EFR3		Non-essential protein of unknown function; exhibits synthetic lethal genetic interactions with PHO85; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YMR212C	S000004825
EFT1		Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin	translation elongation factor 2 (EF-2)		YOR133W	S000005659
EFT2		Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin	translation elongation factor 2 (EF-2)		YDR385W	S000002793
EGD1		Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b	nascent polypeptide-associated complex (NAC) beta1 subunit		YPL037C	S000005958
EGD2		Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes	nascent polypeptide-associated complex (NAC) alpha subunit		YHR193C	S000001236
EGT2		Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner			YNL327W	S000005271
EHD3	MRP5	Protein of unconfirmed function, plays an indirect role in endocytic membrane trafficking, member of a family of enoyl-CoA hydratase/isomerases; the non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YDR036C	S000002443
EHT1		Acyl-coenzymeA:ethanol O-acyltransferase that plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; contains esterase activity; localizes to lipid particles and the mitochondrial outer membrane	Acyl-coenzymeA:ethanol O-acyltransferase	Null mutant is viable, temperature sensitive, and contains higher amounts of phosphatidylinositol, phosphatidic acid, and ergosteryl esters	YBR177C	S000000381
EIP1						S000029157
EKI1		Ethanolamine kinase, primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; also exhibits choline kinase activity	ethanolamine kinase		YDR147W	S000002554
ELA1		Elongin A, F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degredation of the RNA Polymerase II subunit RPO21; subunit of the Elongin-Cullin-Socs (ECS) ligase complex	elongin A subunit		YNL230C	S000005174
ELC1		Elongin C, forms heterodimer with Ela1p that participates in transcription elongation; required for ubiquitin-dependent degradation of the RNA Polymerase II subunit RPO21; expression dramatically upregulated during sporulation	elongin C subunit	The deletion mutant is not sensitive to UV damage, however the elc1 rad23 double mutant is more UV sensitive than the rad23 mutant alone.	YPL046C	S000005967
ELF1		Transcription elongation factor that contains a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression			YKL160W	S000001643
ELG1	RTT110	Protein required for S phase progression and telomere homeostasis, forms an alternative replication factor C complex important for DNA replication and genome integrity; involved in homologous recombination-mediated DNA repair			YOR144C	S000005670
ELM1	LDB9	Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases; forms part of the bud neck ring	serine/threonine protein kinase		YKL048C	S000001531
ELO1		Elongase I, medium-chain acyl elongase, catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids	elongase	Null mutant is viable, but shows no growth on media supplemented with less than 16-C saturated fatty acid in a fatty acid synthase minus background	YJL196C	S000003732
ELP2	TOT2	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin	RNA polymerase II Elongator subunit		YGR200C	S000003432
ELP3	HPA1|TOT3	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin	RNA polymerase II Elongator subunit|histone acetyltransferase		YPL086C	S000006007
ELP4	HAP1|TOT7	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity	RNA polymerase II Elongator protein subunit		YPL101W	S000006022
ELP6	HAP3|TOT6	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity	RNA polymerase II Elongator protein subunit		YMR312W	S000004929
EMG1	NEP1	Protein required for the maturation of the 18S rRNA and for 40S ribosome production; associated with spindle/microtubules; nuclear localization depends on physical interaction with Nop14p; may bind snoRNAs			YLR186W	S000004176
EMI1		Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation			YDR512C	S000002920
EMI2		Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression is regulated by glucose-repression transcription factors Mig1/2p			YDR516C	S000002924
EMI5		Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation			YOL071W	S000005432
EMP24	BST2	Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport			YGL200C	S000003168
EMP46		Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport			YLR080W	S000004070
EMP47		Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport			YFL048C	S000001846
EMP70	p24a	Protein whose 24kDa cleavage product is found in endosome-enriched membrane fractions, predicted to be a transmembrane protein			YLR083C	S000004073
EMT1		tRNA-Met; tRNA that accepts methionine, functions in translational elongation but not translational initiation	tRNA-Met	Anticodon mutation (CAT->CAG) confers defects in pre-mRNA processing.		S000006659
EMT2		tRNA-Met; tRNA that accepts methionine, functions in translational elongation but not translational initiation	tRNA-Met			S000006666
EMT3		tRNA-Met; tRNA that accepts methionine, functions in translational elongation but not translational initiation	tRNA-Met			S000006662
EMT4		tRNA-Met; tRNA that accepts methionine, functions in translational elongation but not translational initiation	tRNA-Met			S000006664
EMT5		tRNA-Met; tRNA that accepts methionine, functions in translational elongation but not translational initiation	tRNA-Met			S000006661
ENA1	HOR6|PMR2	P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance	P-type ATPase Na+ pump|plasma membrane ATPase	Null mutant is sensitive to Na+	YDR040C	S000002447
ENA2		P-type ATPase sodium pump, involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux	P-type ATPase Na+ pump|plasma membrane ATPase	Null mutant is viable and sensitive to Na+, Li+, and alkaline pH	YDR039C	S000002446
ENA5		Protein with similarity to P-type ATPase sodium pumps	Na+ ATPase		YDR038C	S000002445
ENB1	ARN4	Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment	enterobactin transporter		YOL158C	S000005518
END10				end10 mutants are synthetically lethal with vat2/vma2 mutants		S000029158
END3		EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p		Null mutant is viable and defective in endocytosis	YNL084C	S000005028
ENO1	HSP48	Enolase I, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose	enolase		YGR254W	S000003486
ENO2		Enolase II, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is induced in response to glucose	enolase		YHR174W	S000001217
ENP1	MEG1	Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus			YBR247C	S000000451
ENP2		Essential nucleolar protein of unknown function; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p			YGR145W	S000003377
ENS2	Endo.SceI|RF3	50-kD mitochondrially-encoded subunit of Endo.SceI, a dimeric multi-site-specific endonuclease that introduces double-stranded breaks at a number of well-defined sites on the mitochondrial DNA, inducing homologous recombination	endonuclease SceI small subunit			S000029698
ENT1		Epsin-like protein involved in endocytosis and actin patch assembly and functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus		Null mutant is viable, synthetically lethal with ent2 (YLR206w). ent1/2 double mutants have endocytosis and actin cytoskeleton defects.	YDL161W	S000002320
ENT2		Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus		Null mutant is viable; synthetically lethal with ent1 (YDL161w). ent2/1 double mutants have endocytosis and actin cytoskeleton defects.	YLR206W	S000004196
ENT3		Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p			YJR125C	S000003886
ENT4		Protein of unknown function, contains an N-terminal epsin-like domain			YLL038C	S000003961
ENT5		Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin			YDR153C	S000002560
EOS1		Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene			YNL080C	S000005024
EPL1		Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb	NuA4 histone acetyltransferase subunit		YFL024C	S000001870
EPS1		Pdi1p (protein disulfide isomerase)-related protein involved in endoplasmic reticulum retention of resident ER proteins			YIL005W	S000001267
EPT1		sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability	diacylglycerol cholinephosphotransferase|diacylglycerol ethanolaminephosphotransferase		YHR123W	S000001165
ERB1		Protein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1			YMR049C	S000004652
ERD1	LDB2	Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)		disruption of the retention system for ER proteins; defects in the Golgi-dependent modification of glycoproteins|exhibits defects in N-glycosylation of proteins	YDR414C	S000002822
ERD2		Integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins	HDEL receptor		YBL040C	S000000136
ERF2		Subunit of a palmitoyltransferase, composed of Erf2p and Shr5p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole	Ras palmitoyltransferase	Null mutant is viable, but has a synthetic growth defect in the absence of RAS2; Deletion of ERF2 results in the reduction of steady-state levels of Ras2p palmitoylation.	YLR246W	S000004236
ERG1		Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine	squalene monooxygenase	Null mutant is inviable when cells are grown under aerobic conditions; erg1 null mutants are viable under anaerobic conditions during which ergosterol is taken up by the cells	YGR175C	S000003407
ERG10	LPB3|TSM0115	Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis	acetoacetyl CoA thiolase	Nul mutant is inviable; other mutants are ergosterol biosynthesis defective or nystatin resistant	YPL028W	S000005949
ERG11	CYP51	Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family	lanosterol 14-alpha demethylase	Null mutant is inviable, erg11 null inviability is suppressed by deletion of ERG3; erg11 mutants are ergosterol biosynthesis defective; many are also nystatin resistant	YHR007C	S000001049
ERG12	RAR1	Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate	mevalonate kinase	Null mutant is inviable and unable to grow vegetatively or germinate spores; mutants exhibit increased mitotic stability of plasmids with weak ARS elements.	YMR208W	S000004821
ERG13	HMGS	3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis	3-hydroxy-3-methylglutaryl coenzyme A synthase		YML126C	S000004595
ERG2	END11	C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis	C-8 sterol isomerase	synthetic lethal with vma2.	YMR202W	S000004815
ERG20	BOT3|FDS1|FPP1	Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis	FPP synthetase|farnesyl diphosphate synthetase		YJL167W	S000003703
ERG201						S000029159
ERG24		C-14 sterol reductase, acts in ergosterol biosynthesis; mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions	sterol C-14 reductase	Null mutant appears to be inviable in some genetic backgrounds and conditionally lethal in others; erg24 mutations are suppessed by fen1 and fen2 mutations	YNL280C	S000005224
ERG25		C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol	C-4 sterol methyl oxidase		YGR060W	S000003292
ERG26		C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis	C-3 sterol dehydrogenase		YGL001C	S000002969
ERG27		3-keto sterol reductase, catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs	3-keto sterol reductase		YLR100W	S000004090
ERG28	BUD18	Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p		Null mutant is viable; random budding in diploid null mutants; null cells have an unusual sterol content.	YER044C	S000000846
ERG3	PSO6|SYR1	C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources	C-5 sterol desaturase	Null mutant is inviable; suppresses syringomycin resistant mutant; sensitive to photoactivated 3-carbethoxypsoralen, UV light, radiomimetic mutagens, and oxidative stress	YLR056W	S000004046
ERG4		C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol	sterol C-24 reductase		YGL012W	S000002980
ERG5	CYP61	C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs	C-22 sterol desaturase		YMR015C	S000004617
ERG6	ISE1|LIS1|SED6	Delta(24)-sterol C-methyltransferase, converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24; localized to both lipid particles and mitochondrial outer membrane	delta(24)-sterol C-methyltransferase	The null mutant is viable, cannot methylate ergosterol precursors at C-24, and lacks ergosterol. The null mutant shows defective conjugation, diminished capacity for transformation, and defective tryptophan uptake. The null mutant is hypersensitive to cycloheximide, Li+, and Na+, sensitive to anthracyclines, dactinomycin, and bretfeldin A, and resistant to nystatin.	YML008C	S000004467
ERG7		Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis	2,3-oxidosqualene-lanosterol cyclase		YHR072W	S000001114
ERG8		Phosphomevalonate kinase, an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate	phosphomevalonate kinase		YMR220W	S000004833
ERG9		Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway	farnesyl-diphosphate farnesyl transferase|squalene synthetase		YHR190W	S000001233
ERI1	RIN1	Endoplasmic reticulum membrane protein that binds to and inhibits GTP-bound Ras2p at the ER; component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein			YPL096C-A	S000028423
ERJ5		Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response			YFR041C	S000001937
ERO1		Thiol oxidase required for oxidative protein folding in the endoplasmic reticulum		Null mutant is inviable; in ero1-1(ts) mutants newly synthesized carboxypeptidase Y is retained in the ER and lacks disulfide bonds; ero1 mutants are hypersensitive to to the reductant DTT, whereas overexpression of ERO1 confers resistance to DTT, the oxidant diamide can restore growth and secretion in ero1 mutants	YML130C	S000004599
ERP1		Protein that forms a heterotrimeric complex with Erp2p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles		null mutant is viable; delayed transport of Gas1p and invertase	YAR002C-A	S000002129
ERP2		Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles		null mutant is viable; delayed transport of Gas1p	YAL007C	S000000005
ERP3		Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport			YDL018C	S000002176
ERP4		Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport			YOR016C	S000005542
ERP5		Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport			YHR110W	S000001152
ERP6		Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YGL002W	S000002970
ERR1		Protein of unknown function, has similarity to enolases			YOR393W	S000005920
ERR2		Protein of unknown function, has similarity to enolases			YPL281C	S000006202
ERR3		Protein of unknown function, has similarity to enolases			YMR323W	S000004942
ERS1		Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains			YCR075C	S000000671
ERV1		Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins; ortholog of human hepatopoietin (ALR)	sulfhydryl oxidase	Null mutant is inviable; mutants demonstrate defects in mitochondrial biogenesis	YGR029W	S000003261
ERV14		Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon		Null mutant is viable but exhibits defects in sporulation (diploids) and bud site selection (haploids). Null mutants also retain the bud site selection marker, Axl2p, in the ER and exhibit slow recovery from selective to rich media.	YGL054C	S000003022
ERV15		Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p			YBR210W	S000000414
ERV2		Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER	sulfhydryl oxidase	Deletion of ERV2 or depletion of Erv2p by regulated gene expression is not associated with any detectable growth defects.	YPR037C	S000006241
ERV25		Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport	vesicle coat component	Null mutant is viable, displays a selective defect in transport of secretory proteins from the ER to Golgi complex.	YML012W	S000004473
ERV29		Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo			YGR284C	S000003516
ERV41		Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein			YML067C	S000004532
ERV46	FUN9	Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport			YAL042W	S000000040
ESA1	TAS1	Histone acetyltransferase catalytic subunit of the native multisubunit complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail; required for cell cycle progression	NuA4 histone acetyltransferase subunit		YOR244W	S000005770
ESBP6	MCH3	Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane			YNL125C	S000005069
ESC1		Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p			YMR219W	S000004832
ESC2		Protein involved in mating-type locus silencing, interacts with Sir2p; probably functions to recruit or stabilize Sir proteins			YDR363W	S000002771
ESC3		escape of sugars control				S000029160
ESC8		Protein involved in telomeric and mating-type locus silencing, interacts with Sir2p and also interacts with the Gal11p, which is a component of the RNA pol II mediator complex		Null: Viable, HMR silencing defect	YOL017W	S000005377
ESF1		Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels			YDR365C	S000002773
ESF2	ABT1	Essential nucleolar protein involved in pre-18S rRNA processing; component of the small subunit (SSU) processome; has sequence similarity to mABT1, a mouse transcription activator			YNR054C	S000005337
ESP1		Separase with cysteine protease activity (related to caspases) that promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibited by Pds1p	cysteine protease|separin	Null mutant is inviable, produces extra spindle pole bodies, shows disrupted cell cycle control	YGR098C	S000003330
ESS1	PIN1|PTF1	Peptidylprolyl-cis/trans-isomerase (PPIase) specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNA polymerase II large subunit (Rpo21p) C-terminal domain	PPIase|peptidyl-prolyl cis-trans isomerase	Null mutant is inviable; arrest phenotype of mitotic arrest and nuclear fragmentation	YJR017C	S000003778
EST1		TLC1 RNA-associated factor involved in telomere length regulation as the recruitment subunit of the telomerase holoenzyme, has a possible role in activating Est2p-TLC1-RNA bound to the telomere	Telomere elongation protein		YLR233C	S000004223
EST2	TERT	Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia	telomerase reverse transcriptase	Null mutant is viable, exhibits progressively shorter telomeres, cellular senescence and a telomerase-minus defect; est2 rad52 mutants are inviable	YLR318W	S000004310
EST3		Component of the telomerase holoenzyme, involved in telomere replication		Null mutant shows progressively shorter telomeres and cellular senescence; telomerase activity is still present in est3-* extracts	YIL009C-A	S000006432
ETC1		Locus of unknown function that is associated with the TFIIIC component Tfc4p, located between the two divergently transcribed genes ADE8 and SIZ1				S000077072
ETC2		Locus of unknown function that is associated with the TFIIIC component Tfc4p, located upstream of ARG8				S000077073
ETC3		Locus of unknown function that is associated with the TFIIIC component Tfc4p, located upstream of BCK1				S000077074
ETC4		Locus of unknown function that is associated with the TFIIIC component Tfc4p, located upstream of RAD2				S000077075
ETC5		Locus of unknown function that is associated with the TFIIIC component Tfc4p, located upstream of RAD14				S000077076
ETC6		Locus of unknown function that is associated with the TFIIIC component Tfc4p, located between the two divergently transcribed genes TFC6 and ESC2				S000077077
ETC7		Locus of unknown function that is associated with the TFIIIC component Tfc4p, located between the two divergently transcribed genes WTM2 and YOR228C				S000077078
ETC8		Locus of unknown function that is associated with the TFIIIC component Tfc4p, located between the two divergently transcribed genes RPB5 and CNS1				S000077079
ETH3		affects methionine biosynthesis		Ethionine resistant		S000029161
ETR1	MRF1|MRF1'	2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis	2-enoyl thioester reductase, E.C. 1.3.1.-		YBR026C	S000000230
ETS1-1	5' ETS	Non-coding region located immediately upstream of RDN18, that is transcribed as part of the 35S rRNA precursor transcript; contains an essential U3 snoRNA binding site required for maturation of 18S rRNA				S000029717
ETS1-2	5' ETS	Non-coding region located immediately upstream of RDN18, transcribed as part of the 35S rRNA precursor transcript; contains an essential U3 snoRNA binding site required for maturation of 18S rRNA				S000029707
ETS2-1	3' ETS	Non-coding region located adjacent to and downstream of RDN25, transcribed as part of the 35S rRNA precursor transcript; contains the primary rRNA transcription termination site at +93 and a secondary termination site between +211 and +250				S000029718
ETS2-2	3' ETS	Non-coding region located adjacent to and downstream of RDN25, transcribed as part of the 35S rRNA precursor transcript; contains the primary rRNA transcription termination site at +93 and a secondary termination site between +211 and +250; Non-coding region located adjacent to and downstream of RDN25, transcribed as part of the 35S rRNA precursor transcript; excision during transcript maturation is coupled with processing of ITS1 (internal transcribed spacer 1)				S000029713
EUG1		Protein disulfide isomerase of the endoplasmic reticulum lumen, function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER			YDR518W	S000002926
EXA2		extragenic suppressor of hsp70 subfamily A		affect regulation of the stress response		S000029162
EXG1	BGL1	Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes	exo-1,3-beta-glucanase	Null mutant is viable, displays modest increase in killer toxin sensitivity and beta 1,6-glucan levels	YLR300W	S000004291
EXG2		Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor	exo-1,3-beta-glucanase		YDR261C	S000002669
EXO1	DHS1	5'-3' exonuclease and flap-endonuclease involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains	5'-3' exonuclease|flap endonuclease	Mutants demonstrate sensitivity to cycloheximide, bleomycin, actinomycin D, 5-fluorouracil, and several other antibiotics, as well as irregular shapes and sensitivity to zymolase digestion	YOR033C	S000005559
EXO70		Essential 70kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis	exocyst complex component		YJL085W	S000003621
EXO84	USA3	Essential protein with dual roles in spliceosome assembly and exocytosis; the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p) mediates polarized targeting of secretory vesicles to active sites of exocytosis	exocyst complex component|spliceosome assembly protein	Null mutant is inviable, defective in secretion	YBR102C	S000000306
FAA1		Long chain fatty acyl-CoA synthetase with a preference for C12:0-C16:0 fatty acids; involved in the activation of imported fatty acids; localized to both lipid particles and mitochondrial outer membrane; essential for stationary phase	long chain fatty acyl-CoA synthetase	Null mutant is viable as long as fatty acid synthase (fas) complex is active	YOR317W	S000005844
FAA2	FAM1	Long chain fatty acyl-CoA synthetase; accepts a wider range of acyl chain lengths than Faa1p, preferring C9:0-C13:0; involved in the activation of endogenous pools of fatty acids	long chain fatty acyl-CoA synthetase	Not essential for vegetative growth when fatty acid synthase (fas) is active	YER015W	S000000817
FAA3		Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	long chain fatty acyl-CoA synthetase	Not essential for vegetative growth when fatty acid synthase (fas) is active	YIL009W	S000001271
FAA4		Long chain fatty acyl-CoA synthetase, regulates protein modification during growth in the presence of ethanol, functions to incorporate palmitic acid into phospholipids and neutral lipids	long chain fatty acyl-CoA synthetase	Not essential for vegetative growth when fatty acid synthase (fas) is active	YMR246W	S000004860
FAB1	SVL7	1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis	1-phosphatidylinositol-3-phosphate 5-kinase	Null mutant is temperature-sensitive. Mutation causes pleiotropic effects on nuclear migration and orientation, and separation of mitotic chromosomes (forms aploid and binucleate cells); has defects in vacuolar function and morphology.	YFR019W	S000001915
FAD1		Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin	FAD synthetase		YDL045C	S000002203
FAF1		Protein required for pre-rRNA processing and 40S ribosomal subunit assembly			YIL019W	S000001281
FAL1		Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases		Null mutant is inviable; when Fal1p is depleted, either in a temperature-sensitive fal1-1 mutant or in glucose medium when Fal1p is under a gal promoter, there is a decrease in 40S ribosomal subunits, and those strains are sensitive to paromomycin and neomycin	YDR021W	S000002428
FAP1		Protein that binds to Fpr1p (FKBP12), conferring rapamycin resistance by competing with rapamycin for Fpr1p binding; has similarity to putative transcription factors, including D. melanogaster shuttle craft and human NFX1		Null mutant is viable and shows no phenotype; overexpression confers rapamycin resistance	YNL023C	S000004968
FAP7		Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D			YDL166C	S000002325
FAR1		Cyclin-dependent kinase inhibitor that mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate	cyclin-dependent protein kinase inhibitor		YJL157C	S000003693
FAR10		Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate		Null: Defective for pheromone-induced G1 arrest	YLR238W	S000004228
FAR11		Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p		Null: Defective for pheromone-induced G1 arrest	YNL127W	S000005071
FAR3		Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p		Null mutant does not arrest in G1 in response to pheromone but does have an intact signal transduction pathway leading to FAR1 transcriptional induction	YMR052W	S000004656
FAR7		Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p		Null: Defective for pheromone-induced G1 arrest	YFR008W	S000001904
FAR8		Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p		Null: Defective for pheromone-induced G1 arrest	YMR029C	S000004631
FAS1		Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities	acetyl transferase|dehydratase|enoyl reductase|malonyl/palmityl transferase		YKL182W	S000001665
FAS2		Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains beta-ketoacyl reductase and beta-ketoacyl synthase activities	fatty acid synthase alpha subunit	Fatty acid synthetase deficient	YPL231W	S000006152
FAT1		Fatty acid transporter and very long-chain fatty acyl-CoA synthetase, may form a complex with Faa1p or Faa4p that imports and activates exogenous fatty acids	long-chain fatty acid transporter	Null mutant is viable, but is Ole- in presence of cerulenin (i.e., unable to grow on YPD supplemented with oleic acid and cerulenin)	YBR041W	S000000245
FAU1		5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis	5,10-methenyltetrahydrofolate synthetase	Null mutant is viable, but is unable to utilize folinic acid in place of folic acid.	YER183C	S000000985
FBA1	LOT1	Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress	aldolase	Null mutant is viable, lacks aldolase enzymatic activity and fails to grow in media containing as a carbon source metabolites of only one side of the aldolase reaction	YKL060C	S000001543
FBP1	ACN8	Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism	fructose-1,6-bisphosphatase	unable to grow with ethanol	YLR377C	S000004369
FBP26		Fructose-2,6-bisphosphatase, required for glucose metabolism	fructose-2,6-bisphosphatase	Null mutant lacks fructose-2,6-biphosphatase activity but can grow on glucose, fructose, galactose, pyruvate, glycerol and lactate	YJL155C	S000003691
FCF1	UTP24	Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in the pre-rRNA processing steps of 40S ribosomal subunit biogenesis; contains a PINc domain; copurifies with Faf1p			YDR339C	S000002747
FCF2		Essential nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon			YLR051C	S000004041
FCP1		Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p)	protein phosphatase		YMR277W	S000004890
FCY1	yCD	Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)	cytosine deaminase		YPR062W	S000006266
FCY2	BRA7	Purine-cytosine permease, mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation	purine-cytosine permease		YER056C	S000000858
FCY21		Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function	purine-cytosine permease		YER060W	S000000862
FCY22		Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function	purine-cytosine permease		YER060W-A	S000002958
FDH1		NAD(+)-dependent formate dehydrogenase, may protect cells from exogenous formate			YOR388C	S000005915
FDH2		NAD(+)-dependent formate dehydrogenase, may protect cells from exogenous formate; YPL275W and YPL276W comprise a continuous open reading frame in some S. cerevisiae strains but not in the genomic reference strain S288C				S000006196
FEN1	ELO2|GNS1|VBM2	Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway		Null mutant is viable; slow growth; fenpropimorph resistant; resistant to a pneumocandin B0 analog (L-733,560); mating and sporulation defects; synthetic lethality with ELO3	YCR034W	S000000630
FEN2		Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph	H(+)-pantothenate symporter		YCR028C	S000000623
FES1		Hsp70 (Ssa1p) nucleotide exchange factor, cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum	Hsp70 nucleotide exchange factor	Null mutant is thermosensitive. Other phenotypes: cycloheximide sensitive.	YBR101C	S000000305
FET1						S000029163
FET3		Ferro-O2-oxidoreductase required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases	ferro-O2-oxidoreductase|multicopper oxidase	The null mutant is viable but defective for high affinity Fe(II) uptake. The null mutant is inviable when environmental iron is limiting.	YMR058W	S000004662
FET4		Low-affinity Fe(II) transporter of the plasma membrane	metal ion transporter	Mutant lacks low affinity Fe(II) transport but has more active high affinity Fe(II) transport activity	YMR319C	S000004938
FET5		Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport	multicopper oxidase	overexpression of FET5 suppresses a fet3 null mutant.	YFL041W	S000001853
FHL1		Putative transcriptional regulator with similarity to DNA-binding domain of Drosophila forkhead; required for rRNA processing	forkhead protein	Null mutant shows reduced growth rate and lower rRNA content	YPR104C	S000006308
FIG1		Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating		Null mutant is viable, deficient in mating	YBR040W	S000000244
FIG2		Cell wall adhesin, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating		Null mutant is viable, deficient in mating under non-optimal conditions	YCR089W	S000000685
FIG4		Protein that forms a complex with Vac14p and is involved in turnover of PI3,5P2 (phosphatidylinositol 3,5-bisphosphate) after hyperosmotic shock; required for efficient mating; member of a protein family with a domain homologous to Sac1p		Null mutant is viable, mating defective	YNL325C	S000005269
FIM1						S000029164
FIN1		Spindle pole body-related intermediate filament protein, forms cell cycle-specific filaments between spindle pole bodies in mother and daughter cells, able to self-assemble, expression induced during S/G2, localization cell-cycle dependent			YDR130C	S000002537
FIP1		Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity	polyadenylation factor I (PF I)	Null mutant is inviable. At restrictive temperature, a temperature-sensitive mutant shows shortening of poly(A) tails	YJR093C	S000003853
FIR1	PIP1	Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate		Null mutant is viable, shows slow growth in all media	YER032W	S000000834
FIS1	MDV2	Mitochondrial outer membrane protein involved in membrane fission, required for localization of Dnm1p and Mdv1p during mitochondrial division		Null mutant is viable, mitochondrial fission blocked, mitochondrial membranes form nets	YIL065C	S000001327
FIT1		Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall		Impaired siderophore-iron uptake, activation of the major iron-dependent transcription factor AFT1.	YDR534C	S000002942
FIT2		Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall			YOR382W	S000005909
FIT3		Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall			YOR383C	S000005910
FKH1		Forkhead family transcription factor with a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; regulates donor preference during switching	forkhead protein		YIL131C	S000001393
FKH2		Forkhead family transcription factor with a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase	forkhead protein		YNL068C	S000005012
FKR1		FK506 resistant		resistant to FK506		S000029165
FKR2		FK506 resistant		resistant to FK506		S000029166
FKR3		FK506 resistant		resistant to FK506		S000029167
FKS1	CND1|CWH53|ETG1|GSC1|PBR1	Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling	1,3-beta-D-glucan synthase	Null mutant is viable, demonstrates slow growth, hypersensitivity to FK506 and cyclosporin A, sensitivity to echinocandin and a reduction in 1,3-beta-D-glucan synthase activity in vitro; sensitivity to papulacandin B	YLR342W	S000004334
FKS3		Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YMR306W	S000004923
FLC1	BOP1|HUF1	Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance			YPL221W	S000006142
FLC2	HUF2	Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance			YAL053W	S000000049
FLC3	HUF3	Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER			YGL139W	S000003107
FLO1	FLO2|FLO4	Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p		Flocculation	YAR050W	S000000084
FLO10		Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation			YKR102W	S000001810
FLO5		Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p	flocculin	Mutations in FLO5 appear to have no effect on filamentous growth.	YHR211W	S000001254
FLO8	PHD5|YER108C	Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene		Null mutant is viable; wild-type gene is required for flocculation and for pseudo-hyphal growth	YER109C	S000000911
FLO9		Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation			YAL063C	S000000059
FLP1		Site-specific recombinase encoded on the 2-micron plasmid, required for 2-micron plasmid propagation as part of a plasmid amplification system that compensates for any copy number decreases caused by missegregation events	2-micron circle recombinase		R0010W	S000029654
FLR1		Plasma membrane multidrug transporter, member of the major facilitator superfamily; involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs	major facilitator transporter	Null mutant is viable; overexpression confers resistance to fluconazole, cycloheximide, 4-nitroquinoline N-oxide	YBR008C	S000000212
FLS1				fails to grow in the presence of 30 mg of fluphenazine per ml		S000029168
FLX1		Protein required for transport of flavin adenine dinucleotide (FAD), a synthesis product of riboflavin, across the mitochondrial membrane	flavin adenine dinucleotide transporter		YIL134W	S000001396
FMC1		Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p		Null mutant is viable and shows growth deficiency on non-fermentable carbon sources at 37 degrees C	YIL098C	S000001360
FMN1		Riboflavin kinase, phosphorylates riboflavin to form riboflavin monophosphate (FMN), which is a necessary cofactor for many enzymes; localizes to microsomes and to the mitochondrial inner membrane	riboflavin kinase		YDR236C	S000002644
FMO1		Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins	monooxygenase		YHR176W	S000001219
FMP10		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YER182W	S000000984
FMP12		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YHL021C	S000001013
FMP13		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YKR016W	S000001724
FMP14		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YPL099C	S000006020
FMP16		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YDR070C	S000002477
FMP21		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YBR269C	S000000473
FMP22		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YHR198C	S000001241
FMP23		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YBR047W	S000000251
FMP24		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YMR115W	S000004721
FMP25		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YLR077W	S000004067
FMP26		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YJR080C	S000003841
FMP27		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YLR454W	S000004446
FMP29		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YER080W	S000000882
FMP30		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YPL103C	S000006024
FMP31		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YOR286W	S000005812
FMP32		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YFL046W	S000001848
FMP33		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YJL161W	S000003697
FMP34		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YHR199C	S000001242
FMP36		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YDR493W	S000002901
FMP37		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YGL080W	S000003048
FMP38		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YOR205C	S000005731
FMP39		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YMR157C	S000004766
FMP40		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YPL222W	S000006143
FMP41		Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YNL168C	S000005112
FMP42		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YMR221C	S000004834
FMP43		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YGR243W	S000003475
FMP45		Integral membrane protein localized to mitochondria (untagged protein) and eisosomes, immobile patches at the cortex associated with endocytosis; sporulation and sphingolipid content are altered in mutants; has homologs SUR7 and YNL194C			YDL222C	S000002381
FMP46		Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YKR049C	S000001757
FMP48		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YGR052W	S000003284
FMP49		Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria			YER038W-A	S000028746
FMP51		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YBR262C	S000000466
FMP52		Protein of unknown function, localized to the mitochondrial outer membrane			YER004W	S000000806
FMS1		Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis	polyamine oxidase		YMR020W	S000004622
FMT1		Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate	methionyl-tRNA transformylase	Null mutant is viable and lacks mitochondrial formyl-Met-tRNA	YBL013W	S000000109
FOB1	HRM1	Nucleolar protein required for DNA replication fork blocking and recombinational hotspot activities; binds to the replication fork barrier site in the rDNA region; related to retroviral integrases	DNA replication fork blocking protein	Loss of replication fork blocking and recombinational hotspot activities.	YDR110W	S000002517
FOL1		Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities	dihydro-6-hydroxymethylpterin pyrophosphokinase|dihydroneopterin aldolase|dihydropteroate synthetase	essential, induces pseudohyphal growth	YNL256W	S000005200
FOL2		GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway	GTP-cyclohydrolase I	Folinic acid requiring	YGR267C	S000003499
FOL3		Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis	dihydrofolate synthetase	Null mutant is viable; requires folinic acid for growth	YMR113W	S000004719
FOX2	POX2	Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities	multifunctional beta-oxidation protein	mutant lacks 2-enoyl-CoA hydratase and D-3-hydroxyacyl-CoA dehydrogenase activities	YKR009C	S000001717
FPR1	FKB1|RBP1	Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function	PPIase|peptidyl-prolyl cis-trans isomerase		YNL135C	S000005079
FPR2	FKB2	Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking	PPIase|peptidyl-prolyl cis-trans isomerase		YDR519W	S000002927
FPR3	NPI46	Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p	PPIase|peptidyl-prolyl cis-trans isomerase	Null mutant is viable; overexpression gives no phenotype except is growth inhibitory in fpr1 mutant; both null mutant and over-expressor show wild-type sensitivity to FK506 and rapamycin; npi46 fpr1 fpr2 triple mutant is viable	YML074C	S000004539
FPR4		Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones			YLR449W	S000004441
FPS1		Plasma membrane glycerol channel, member of the major intrinsic protein (MIP) family of channel proteins; involved in efflux of glycerol and in uptake of the trivalent metalloids arsenite and antimonite	glycerol channel		YLL043W	S000003966
FRE1		Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels	cupric reductase|ferric reductase	Null mutant is viable, fre1-1 mutants are deficient in the uptake of ferric iron and are extremely sensitive to iron deprivation	YLR214W	S000004204
FRE2		Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels	ferric reductase		YKL220C	S000001703
FRE3		Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels	ferric reductase transmembrane component		YOR381W	S000005908
FRE4		Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels			YNR060W	S000005343
FRE5		Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YOR384W	S000005911
FRE6		Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels			YLL051C	S000003974
FRE7		Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels			YOL152W	S000005512
FRE8		Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p			YLR047C	S000004037
FRM2	YCLX08C	Protein of unknown function, involved in the integration of lipid signaling pathways with cellular homeostasis; similar to bacterial nitroreductases		Null mutant is viable and sensitive to arachidonic acid	YCL026C-A	S000000589
FRO1				Frothing		S000029169
FRO2				Frothing		S000029170
FRQ1		N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily			YDR373W	S000002781
FRS1		Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; sequence is evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase (Msf1p), but substrate binding is similar	mitochondrial phenylalanyl-tRNA synthetase beta subunit		YLR060W	S000004050
FRS2		Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar	mitochondrial phenylalanyl-tRNA synthetase alpha subunit		YFL022C	S000001872
FRT1	HPH1	Tail-anchored endoplasmic reticulum membrane protein that is a substrate of the phosphatase calcineurin, interacts with homolog Frt2p, promotes cell growth in conditions of high Na+, alkaline pH, and cell wall stress			YOR324C	S000005851
FRT2	HPH2	Tail-anchored endoplasmic reticulum membrane protein, interacts with homolog Frt1p but is not a substrate of calcineurin (unlike Frt1p), promotes growth in conditions of high Na+, alkaline pH, or cell wall stress; potential Cdc28p substrate			YAL028W	S000000026
FSF1		Putative protein, predicted by computational methods to be an alpha-isopropylmalate carrier; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YOR271C	S000005797
FSH1		Serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to Fsh2p and Fsh3p			YHR049W	S000001091
FSH2		Serine hydrolase that localizes to the cytoplasm; sequence is similar to Fsh1p and Fsh3p			YMR222C	S000004835
FSH3		Serine hydrolase; sequence is similar to Fsh1p and Fsh2p			YOR280C	S000005806
FSP2		Protein of unknown function, expression is induced during nitrogen limitation			YJL221C	S000003757
FSR1				growth arrested at 35 degrees after nuclear division		S000029171
FSR2				Fluphenazine-resistant; arrests in G2 at 35 degrees in Ca2+-poor medium		S000029172
FTH1		Putative high affinity iron transporter involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis			YBR207W	S000000411
FTR1		High affinity iron permease involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron	iron permease	Lacks high affinity iron uptake	YER145C	S000000947
FUI1		High affinity uridine permease, localized to the plasma membrane; not involved in uracil transport	uridine permease		YBL042C	S000000138
FUM1		Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation	fumarase|fumarate hydralase		YPL262W	S000006183
FUN12	yIF2	GTPase, required for general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; homolog of bacterial IF2	eIF5B		YAL035W	S000000033
FUN14		Mitochondrial protein of unknown function			YAL008W	S000000006
FUN19		Non-essential protein of unknown function			YAL034C	S000002134
FUN26		Nucleoside transporter with broad nucleoside selectivity; localized to intracellular membranes			YAL022C	S000000020
FUN30		Protein whose overexpression affects chromosome stability, potential Cdc28p substrate; homolog of Snf2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YAL019W	S000000017
FUR1		Uracil phosphoribosyltransferase, synthesizes UMP from uracil; involved in the pyrimidine salvage pathway	UPRTase		YHR128W	S000001170
FUR4		Uracil permease, localized to the plasma membrane; expression is tightly regulated by uracil levels and environmental cues	uracil permease		YBR021W	S000000225
FUS1		Membrane protein localized to the shmoo tip, required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate		Null mutant is viable; in fus1 x fus1 matings there is an interruption of the mating process just before cytoplasmic fusion	YCL027W	S000000532
FUS2		Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during mating		Null mutant is viable, fus2 mutants have strong defects in karyogamy and fail to orient microtubules between parental nuclei in zygotes	YMR232W	S000004845
FUS3	DAC2	Mitogen-activated protein kinase involved in mating pheromone response; activated by phosphorylation by Ste7p; provides specificity during the mating vs. filamentous growth response by phosphorylating transcriptional and cytoplasmic targets	serine/threonine protein kinase	sterile; divide continuously in the presence of pheromones; form prezygotes with wild-type cells of opposite mating type but cannot undergo cell fusion	YBL016W	S000000112
FYV1		Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin		Null phenotype is K1 killer toxin hypersensitive	YDR024W	S000002431
FYV10	GID9	Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains CTLH domain		Null mutant is viable but exhibits K1 killer toxin hypersensitivity.	YIL097W	S000001359
FYV12		Protein of unknown function, required for survival upon exposure to K1 killer toxin		Null mutant is viable but exhibits K1 killer toxin hypersensitivity.	YOR183W	S000005709
FYV4		Protein of unknown function, required for survival upon exposure to K1 killer toxin		Null phenotype is K1 killer toxin hypersensitive	YHR059W	S000001101
FYV5		Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in ion homeostasis		Null mutant is viable but exhibits K1 killer toxin hypersensitivity.	YCL058C	S000000563
FYV6		Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining		Null mutant is K1 killer toxin hypersensitive	YNL133C	S000005077
FYV7		Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in processing the 35S rRNA primary transcript to generate the 20S and 27SA2 pre-rRNA transcripts			YLR068W	S000004058
FYV8		Protein of unknown function, required for survival upon exposure to K1 killer toxin		Null phenotype is K1 killer toxin hypersensitive	YGR196C	S000003428
FZF1	NRC299|RSU1|SUL1	Transcription factor involved in sulfite metabolism, sole identified regulatory target is SSU1, overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers	transcription factor		YGL254W	S000003223
FZO1		Mitochondrial integral membrane protein involved in mitochondrial fusion and maintenance of the mitochondrial genome; contains N-terminal GTPase domain		Null mutant is viable, exhibits a petite phenotype and fragmented mitochondrial morphology	YBR179C	S000000383
GAA1	END2	Subunit of the GPI (glycosylphosphatidylinositol):protein transamidase complex, removes the GPI-anchoring signal and attaches GPI to proteins in the ER			YLR088W	S000004078
GAB1	CDC91	GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI			YLR459W	S000004451
GAC1		Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock	Glc7p regulatory subunit		YOR178C	S000005704
GAD1		Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress	glutamate decarboxylase		YMR250W	S000004862
GAL1		Galactokinase, phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p	galactokinase	Null mutant is viable and cannot utilize galactose.	YBR020W	S000000224
GAL10		UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers	UDP-glucose 4-epimerase	Null mutant is viable and cannot utilize galactose.	YBR019C	S000000223
GAL11	ABE1|MED15|RAR3|SDS4|SPT13	Component of the Mediator complex; interacts with RNA polymerase II and the general transcription factors to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors	mediator complex subunit	Null mutant is viable, exhibits reduced expression of Gal4 regulated genes	YOL051W	S000005411
GAL2		Galactose permease, required for utilization of galactose; also able to transport glucose	galactose transporter	Galactose non-utilizer	YLR081W	S000004071
GAL3		Transcriptional regulator involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity		Galactose non-utilizer	YDR009W	S000002416
GAL4	GAL81	DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p	transcription factor	Null mutant is viable, cannot utilize galactose as sole carbon source	YPL248C	S000006169
GAL7		Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism	galactose-1-phosphate uridyl transferase	Null mutant is viable and cannot utilize galactose.	YBR018C	S000000222
GAL80		Transcriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding	transcriptional regulator	Null mutant is viable but has constitutive expression of the GAL genes.	YML051W	S000004515
GAL83	SPM1	One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain			YER027C	S000000829
GAP1		General amino acid permease; localization to the plasma membrane is regulated by nitrogen source	amino acid transporter	abolished activity of the general amino acid transport system	YKR039W	S000001747
GAR1		Protein component of the H/ACA snoRNP pseudouridylase complex, involved in the modification and cleavage of the 18S pre-rRNA	small nucleolar RNP protein		YHR089C	S000001131
GAS1	CWH52|GGP1	Beta-1,3-glucanosyltransferase, required for cell wall assembly; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor			YMR307W	S000004924
GAS2		1,3-beta-glucanosyltransferase, involved with Gas4p in spore wall assembly; has similarity to Gas1p			YLR343W	S000004335
GAS3		Putative 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall			YMR215W	S000004828
GAS4		1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall			YOL132W	S000005492
GAS5		1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall			YOL030W	S000005390
GAT1	MEP80|NIL1	Transcriptional activator of genes involved in nitrogen catabolite repression, member of the GATA family of DNA binding proteins; activity and localization regulated by nitrogen limitation and Ure2p	transcriptional activator with GATA-1-type Zn finger DNA-binding motif		YFL021W	S000001873
GAT2		Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine			YMR136W	S000004744
GAT3		Protein containing GATA family zinc finger motifs			YLR013W	S000004003
GAT4		Protein containing GATA family zinc finger motifs		being investigated	YIR013C	S000001452
GBP2	RLF6	Poly(A+) RNA-binding protein, involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Hrb1p and Npl3p; also binds single-stranded telomeric repeat sequence in vitro		Mutation alters the distribution of Rap1p, a telomere-associated protein, but has no effect on telomere length or telomere position	YCL011C	S000000517
GCD1	TRA3	Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression	translation initiation factor eIF2B gamma subunit	affect growth rate under nonstarvation conditions	YOR260W	S000005786
GCD10	TRM6	Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression	1-methyladenosine tRNA methyltransferase subunit	Null mutant is inviable. There are mutants available that show constitutive HIS4 transcription and slow growth	YNL062C	S000005006
GCD11	SUI4	Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met	translational initiation factor eIF-2 gamma subunit	Null mutant is inviable, gcd11 mutants have slower growth rate under nonstarvation conditions	YER025W	S000000827
GCD13		Negative regulator of GCN4 expression		Slow growth; constitutive expression of GCN4		S000029173
GCD14	TRM61	Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression	1-methyladenosine tRNA methyltransferase subunit	3-Aminotriazole resistance; unconditional slow growth	YJL125C	S000003661
GCD2	GCD12	Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression	translation initiation factor eIF2B subunit	Null mutant is inviable; resistance to 5-methyltryptophan, 5-fluorotryptophan and canavanine; override requirement for GCN2 and GCN3 gene products for derepression of GCN4 constitutive derepression and slow growth; temperature sensitive for growth	YGR083C	S000003315
GCD3		Negative regulator gene in general amino acid biosynthetic pathway, possibly upstream of GCN4		Resistant to 5-methyltrytophan, 5-fluorotryptophan and canavanine; slow growth; elevated mRNA levels of genes in amino acid biosynthesis		S000029174
GCD4		Negative regulatory gene in general amino acid biosynthetic pathway; upstream of GCN4		Resistant to 5-methyltrytophan, 5-fluorotryptophan and canavanine; slow growth; elevated mRNA levels of genes in amino acid biosynthesis		S000029175
GCD6		Catalytic epsilon subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression	translation initiation factor eIF2B subunit	Null mutant is inviable; non-null mutations increase GCN4 translation	YDR211W	S000002619
GCD7		Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression	translation initiation factor eIF2B subunit	Null mutant is inviable; non-null mutants exhibit an increase in GCN4 translation	YLR291C	S000004282
GCDX						S000029176
GCN1		Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn20p; proposed to stimulate Gcn2p activation by an uncharged tRNA	translational activator	Null mutant is viable and sensitive to 3-aminotriazole	YGL195W	S000003163
GCN2	AAS1	Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex	translation initiation factor eIF2 alpha kinase	Null mutant is viable, unable to grow on medium containing 3-aminotriazole (3-AT), a competitive inhibitor of histidine biosynthesis, because it cannot derepress GCN4 and its target genes in the histidine biosynthetic pathway	YDR283C	S000002691
GCN20		Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA		Null mutant is viable and shows impaired derepression of GCN4 translation and reduced levels of eIF-2 alpha phosphorylation	YFR009W	S000001905
GCN3	AAS2	Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression	translation initiation factor eIF2B alpha subunit	null mutants fail to derepress amino acid-regulated genes under conditions of amino acid starvation	YKR026C	S000001734
GCN4	AAS3|ARG9	Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels	transcriptional activator of amino acid biosynthetic genes	The null mutant is viable but requires arginine on minimal medium and issensitive to 3-amino-1,2,4-triazole. General control of amino acid synthesis non-derepressible in the null mutant.	YEL009C	S000000735
GCN5	ADA4|SWI9	Histone acetyltransferase, acetylates N-terminal lysines on histones H2B and H3; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; founding member of the Gcn5p-related N-acetyltransferase superfamily	Ada histone acetyltransferase complex component	Null mutant is viable, sensitive to intra-S-phase DNA damage, and grows poorly on minimal media.	YGR252W	S000003484
GCN6		Positive regulator of GCN4 transcription		Sensitivity to amino acid analogs; decreased mRNA levels of genes under general control of amino acid biosynthesis		S000029177
GCN7		Positive regulator of GCN4 transcription		Sensitivity to amino acid analogs; decreased mRNA levels of genes under general control of amino acid biosynthesis		S000029178
GCN8				Sensitivity to amino acid analogs; decreased mRNA levels of genes under general control of amino acid biosynthesis		S000029179
GCN9				Sensitivity to amino acid analogs; decreased mRNA levels of genes under general control of amino acid biosynthesis		S000029180
GCR1	LPF10	Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p	trans-acting positive regulator of the enolase and glyceraldehyde-3-phosphate dehydrogenase gene families	Null mutant has a severe growth defect when grown in the presence of glucose, but grows quite well on medium with non-fermentable carbon sources; on permissive medium, the null mutant principally affects the expression of glycolytic enzyme genes and transcripts encoded by Ty elements. Mutant exhibits reduction in the intracellular concentration of enolase and glyceraldehyde-3-phosphate dehydrogenase polypeptides	YPL075W	S000005996
GCR2		Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p	transcription factor	Null mutant is viable and has partial growth defect on glucose-containing media	YNL199C	S000005143
GCS1		ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p	ADP-ribosylation factor GTPase-activating protein (ARF GAP)		YDL226C	S000002385
GCV1	GSD1	T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm	glycine decarboxylase complex T subunit	Null mutant is viable but cannot use glycine as sole nitrogen source	YDR019C	S000002426
GCV2	GSD2	P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm	glycine cleavage system P subunit|glycine decarboxylase complex P subunit|glycine synthase P subunit	Inability to convert glycine to serine (ser1 background); Inability to utilize glycine as a nitogen source.	YMR189W	S000004801
GCV3		H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm	glycine cleavage system H-protein subunit	Null mutant is viable but does not grow if glycine is the sole nitrogen source	YAL044C	S000000042
GCY1	GCY	Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family	aldo-keto reductase		YOR120W	S000005646
GDA1		Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate	guanosine diphosphatase		YEL042W	S000000768
GDB1		Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation		Null mutant is viable but unable to degrade glycogen.	YPR184W	S000006388
GDE1		Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes			YPL110C	S000006031
GDH1	GDH-A|GDHA|URE1	NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources	NADP-dependent glutamate dehydrogenase		YOR375C	S000005902
GDH2	GDH-B|GDHB	NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels	NAD-dependent glutamate dehydrogenase	Null mutant is viable, grows very poorly on glutamate as a nitrogen source	YDL215C	S000002374
GDH3	FUN51	NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources	NADP-dependent glutamate dehydrogenase		YAL062W	S000000058
GDI1	SEC19	GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins	GDP dissociation inhibitor		YER136W	S000000938
GDR1				Mutation alters nutritional control of germination		S000029181
GDR2				Mutation alters nutritional control of germination		S000029182
GDS1		Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies		Null mutant is viable, shows partial impairment of growth on medium containing glycerol as the carbon source. Overexpxression suppresses NAM9-1 glycerol deficient phenotype	YOR355W	S000005882
GDT1		Putative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesis			YBR187W	S000000391
GEA1		Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; similar to but not functionally redundant with Gea2p	GDP/GTP exchange factor		YJR031C	S000003792
GEA2		Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; similar to but not functionally redundant with Gea1p	ARF GTP/GDP exchange factor	Null mutant is viable, synthetically lethal with gea1 null mutant	YEL022W	S000000748
GEF1	CLC	Chloride channel localized to late- or post-Golgi vesicles, involved in iron metabolism; highly homologous to voltage-gated chloride channels in vertebrates			YJR040W	S000003801
GEM1	GON1	Evolutionarily-conserved tail-anchored outer mitochondrial membrane GTPase which regulates mitochondrial morphology; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; not required for pheromone-induced cell death		Null mutant is viable but exhibits slightly reduced secretion of over-produced PrA. Null mutants also grow slowly in the presence of high concentrations of calcium. Overexpression enhances secretion of overexpressed PrA.	YAL048C	S000000046
GET1	MDM39	Subunit of the GET complex; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance		Null: Required for spore wall formation, but not IME1 induction or nuclear division	YGL020C	S000002988
GET2	HUR2|RMD7	Subunit of the GET complex; required for meiotic nuclear division and for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion; may be involved in cell wall function		null is hypersensitive to calcofluor white suffer an increased spheroplast lysis rate	YER083C	S000000885
GET3	ARR4	ATPase, subunit of the GET complex; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion; involved in resistance to heat and metal stress		Null: YDL100c gene disruption results in sensitivity to As(III), As(V), Co(II) and Cu(II).	YDL100C	S000002258
GFA1		Glutamine-fructose-6-phosphate amidotransferase, catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis	glucosamine-6-phosphate synthase|glutamine-fructose-6-phosphate amidotransferase	Null mutant is viable, glucosamine auxotroph	YKL104C	S000001587
GFD1		Coiled-coiled protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation		Null mutant is viable; high copy suppressor of rat8-2	YMR255W	S000004868
GFD2		Protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation		Null: Identified as high copy suppressor of a ts mutation affecting Dbp5p/Rat8p.	YCL036W	S000000541
GGA1		Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi	ARF-binding protein	Single and double knockouts are viable at both 30 C and 37 C. Cells lacking GGA1, GGA2 exhibit defects in invertase processing, vacuolar morphology, maturation of alpha-factor, and sorting of CPY, proteinase A to the vacuole, but not endocytosis.	YDR358W	S000002766
GGA2		Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi	ARF-binding protein	Single and double knockouts are viable at both 30 C and 37 C. Cells lacking GGA1, GGA2 exhibit defects in invertase processing, vacuolar morphology, maturation of alpha-factor, and sorting of CPY, proteinase A to the vacuole, but not endocytosis.	YHR108W	S000001150
GGC1	YHM1	Mitochondrial GTP/GDP transporter, essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family		Null mutant is viable; shm1 abf2 double deletion cannot grow on glycerol	YDL198C	S000002357
GIC1		Protein of unknown function involved in initiation of budding and cellular polarization, interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain		Null mutant is viable; gic1 gic2 double null is temperature sensitive at 33 degrees C	YHR061C	S000001103
GIC2		Protein of unknown function involved in initiation of budding and cellular polarization, interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain		Null mutant is viable and temperature sensitive at 37 degrees C; gic1 gic2 double null is temperature sensitive at 33 degrees C	YDR309C	S000002717
GID7	MOH2	Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions			YCL039W	S000000544
GID8	DCR1	Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START			YMR135C	S000004742
GIM3	PFD4	Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it			YNL153C	S000005097
GIM4	PFD2	Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it		Null mutant is viable, sensitive to anti-microtubule drugs benomyl and nocadazole; synthetically lethal with tub4-1 mutations	YEL003W	S000000729
GIM5	PFD5	Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it		Null mutant is viable, cold sensitive, benomyl and nocadazole sensitive and fails to grow on YPD+1.2M KCl or YPD+1.8M sorbitol; synthetically lethal with tub4-1 mutations	YML094W	S000004559
GIN4	ERC47	Protein kinase involved in bud growth and assembly of the septin ring, proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Kcc4p and Hsl1p		Null mutant is viable, exhibits a mild elongated bud phenotype and some cell clumping	YDR507C	S000002915
GIP1		Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p	Glc7p regulatory subunit		YBR045C	S000000249
GIP2		Putative regulatory subunit of the protein phosphatase Glc7p, involved in glycogen metabolism; contains a conserved motif (GVNK motif) that is also found in Gac1p, Pig1p, and Pig2p			YER054C	S000000856
GIP3		Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments	protein phosphatase 1 (Glc7p) regulator		YPL137C	S000006058
GIP4	FUN21	Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate	protein phosphatase 1 (Glc7p) regulator		YAL031C	S000000029
GIR2		Highly-acidic cytoplasmic RWD domain-containing protein of unknown function, sensitive to proteolysis, N-terminal region has high content of acidic amino acid residues, putative IUP (intrinsically unstructured protein)			YDR152W	S000002559
GIS1		JmjC domain-containing histone demethylase; transcription factor involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1		Null mutant is viable and shows enhanced basal level expression of PHR1	YDR096W	S000002503
GIS2		Protein with seven cysteine-rich CCHC zinc-finger motifs, similar to human CNBP, proposed to be involved in the RAS/cAMP signaling pathway			YNL255C	S000005199
GIS3		Protein of unknown function			YLR094C	S000004084
GIS4		CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway	CAAX box containing protein		YML006C	S000004465
GIT1		Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability	glycerophosphoinositol (GroPIns) permease	Null mutant is viable, exhibits decreased GroPIns transport	YCR098C	S000000695
GLC3	GHA1	Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	1,4-glucan-6-(1,4-glucano)-transferase	Null mutant is viable, glycogen deficient	YEL011W	S000000737
GLC7	CID1|DIS2|DIS2S1|PP1	Catalytic subunit of type 1 serine/threonine protein phosphatase, involved in many processes including glycogen metabolism, sporulation, and mitosis; interacts with multiple regulatory subunits; predominantly isolated with Sds22p	protein phosphatase type I		YER133W	S000000935
GLC8		Regulatory subunit of protein phosphatase 1 (Glc7p), involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2	protein phosphatase 1 regulatory subunit		YMR311C	S000004928
GLE1	BRR3|RSS1	Cytoplasmic nucleoporin required for polyadenylated RNA export but not for protein import; component of Nup82p nuclear pore subcomplex; contains a nuclear export signal	nuclear pore complex subunit		YDL207W	S000002366
GLE2	RAE1	Component of the nuclear pore complex required for polyadenylated RNA export but not for protein import, homologous to S. pombe Rae1p	nuclear pore complex subunit		YER107C	S000000909
GLG1		Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin	glycogenin glucosyltransferase	Null mutant is viable; disruption of both GLG1 and GLG2 renders cells unable to synthesize glycogen	YKR058W	S000001766
GLG2		Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin	glycogenin glucosyltransferase	Null mutant is viable; disruption of both GLG2 and GLG2 renders cells unable to synthesize glycogen	YJL137C	S000003673
GLK1	HOR3	Glucokinase, catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources	glucokinase		YCL040W	S000000545
GLN1		Glutamine synthetase (GS), synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation	glutamine synthetase	Glutamine synthetase non-derepressible	YPR035W	S000006239
GLN3		Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source	transcriptional activator of nitrogen-regulated genes		YER040W	S000000842
GLN4		Glutamine tRNA synthetase, monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu); N-terminal domain proposed to be involved in enzyme-tRNA interactions	glutamyl-tRNA synthetase		YOR168W	S000005694
GLO1		Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress	glyoxalase I|lactoylglutathione lyase		YML004C	S000004463
GLO2		Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate	glyoxylase II		YDR272W	S000002680
GLO3		ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p			YER122C	S000000924
GLO4		Mitochondrial glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate	glyoxylase II		YOR040W	S000005566
GLR1	LPG17	Cytosolic and mitochondrial glutathione oxidoreductase, converts oxidized glutathione to reduced glutathione	glutathione oxidoreductase		YPL091W	S000006012
GLT1		NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source	glutamate synthase (NADH)		YDL171C	S000002330
GLU3				glutamate auxotroph; unable to grow on nonfermentable carbon sources		S000029184
GLY1		Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis	threonine aldolase	Null mutant is viable, glycine auxotroph, gly1 null mutants are not glycine auxotrophs on ethanol media	YEL046C	S000000772
GMH1	MSG1	Golgi membrane protein of unknown function, interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting			YKR030W	S000001738
GNA1	PAT1	Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA	glucosamine-phosphate N-acetyltransferase		YFL017C	S000001877
GND1		6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress	6-phosphogluconate dehydrogenase		YHR183W	S000001226
GND2		6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone	6-phosphogluconate dehydrogenase		YGR256W	S000003488
GNP1		High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids	glutamine transporter	Null mutant is viable but shows reduced glutamine transport and is therefore resistant to the glutamine analog L-glutamic acid gamma-monohydroxamate; overexpression induces sensitivity to heat shock	YDR508C	S000002916
GNT1		N-acetylglucosaminyltransferase capable of modification of N-linked glycans in the Golgi apparatus	N-acetylglucosaminyltransferase		YOR320C	S000005847
GON7	LDB6|PCC2	Protein proposed to be involved in the modification of N-linked oligosaccharides, osmotic stress response, telomere uncapping and elongation, transcription; component of the EKC/KEOPS protein complex with Kae1p, Cgi121p, Pcc1p, and Bud32p			YJL184W	S000003720
GOR1		Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YNL274C	S000005218
GOS1		v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28			YHL031C	S000001023
GOT1		Evolutionarily conserved non-essential protein present in early Golgi cisternae that may be involved in ER-Golgi transport at a step after vesicle tethering to Golgi membranes, exhibits membrane topology similar to that of Sft2p		Null mutant is viable but exhibits ER to Golgi transport defects in vitro. got1 is synthetically lethal with mutations in sft2; the got1 sft2 double mutant exhibits defects in transport to the Golgi complex.	YMR292W	S000004906
GPA1	CDC70|DAC1|SCG1	GTP-binding alpha subunit of the heterotrimeric G protein that couples to pheromone receptors; negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response; activates Vps34p at the endosome	G protein alpha subunit	The null mutation is inviable in haploids but not diploids. Gpa1 mutants exhibit specific defects in the pheromone responsiveness of both a and alpha cells.	YHR005C	S000001047
GPA2	SSP101	Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	nucleotide binding regulatory protein		YER020W	S000000822
GPB1	KRH2	Proposed beta subunit of the heterotrimeric G protein; interacts with the receptor Grp1p, affects signaling by altering the level of phosphorylation of PKS substrates; regulates pseudohyphal growth through cAMP levels; homolog of Gpb2p			YOR371C	S000005898
GPB2	KRH1	Proposed beta subunit of the heterotrimeric G protein; interacts with the receptor Grp1p, affects signaling by altering the level of phosphorylation of PKS substrates; regulates pseudohyphal growth through cAMP levels; homolog of Gpb1p		Deletion causes a high PKA phenotype.	YAL056W	S000000052
GPD1	DAR1|HOR1|OSG1|OSR5	NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p	glycerol-3-phosphate dehydrogenase		YDL022W	S000002180
GPD2	GPD3	NAD-dependent glycerol 3-phosphate dehydrogenase, homolog of Gpd1p, expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria	glycerol-3-phosphate dehydrogenase (NAD+)		YOL059W	S000005420
GPG1		Proposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Grp1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p	Heterotrimeric G protein gamma subunit mimic	Null: A modest reduction in pseudohyphal differentiation, invasive growth, and FLO11 expression	YGL121C	S000003089
GPH1		Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway	glycogen phosphorylase	Null mutant is viable; haploid cells contain higher levels of intracellular glycogen	YPR160W	S000006364
GPI1		Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs		Null mutant is viable but is temperature-sensitive for growth, for [3H]inositol incorporation into protein, and for GPI anchor-dependent processing of the Gas1/Ggp1 protein and lacks in vitro N-acetylglucosaminylphosphatidylinositol synthetic activity|Null mutant displays hyperactive Ras Signaling and invasive growth.	YGR216C	S000003448
GPI10		Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the GPI core structure; human PIG-Bp is a functional homolog		Null mutant is inviable but can be complemented by the homologous cDNA from humans that encodes the PIG-B protein; a mutant with conditional expression of GPI10 is defective in GPI anchor synthesis and GPI-anchored protein transport when GPI10 expression is turned off	YGL142C	S000003110
GPI11		ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog			YDR302W	S000002710
GPI12		ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp	N-acetylglucosaminylphosphatidylinositol deacetylase		YMR281W	S000004894
GPI13	MPC1	ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein		Null mutant is inviable; Gpi13p-depleted strains accumulate a GPI precursor whose glycan headgroup contains 4 mannoses and a phosphoethanolamine side-branch on the first mannose	YLL031C	S000003954
GPI14	PMH1	Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M			YJR013W	S000003774
GPI15		Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein		Null mutant is inviable; required for N-acetylglucosaminyl phosphatidylinositol synthesis.	YNL038W	S000004983
GPI16		Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog	GPI transamidase component, human PIG-T homologue		YHR188C	S000001231
GPI17		Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Sp homolog	GPI transamidase component, human PIG-S homologue		YDR434W	S000002842
GPI18	FMP44	Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria	mannosyltransferase		YBR004C	S000000208
GPI19		Subunit of GPI-GlcNAc transferase involved in synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), which is the first intermediate in glycosylphosphatidylinositol (GPI) anchor synthesis, shares similarity with mammalian PIG-P	subunit of the GPI-GlcNAc transferase		YDR437W	S000002845
GPI2	GCR4	Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein			YPL076W	S000005997
GPI4		involved in the attachment of glycosylphosphatidylinositol (GPI) anchors to proteins		defective in GPI anchor synthesis; sensitive to calcofluor white and hygromycin B		S000029185
GPI5		involved in the attachment of glycosylphosphatidylinositol (GPI) anchors to proteins		defective in GPI anchor synthesis; sensitive to calcofluor white and hygromycin B		S000029186
GPI6		involved in the attachment of glycosylphosphatidylinositol (GPI) anchors to proteins		defective in GPI anchor synthesis; sensitive to calcofluor white and hygromycin B		S000029187
GPI8		ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog			YDR331W	S000002739
GPI9		involved in the attachment of glycosylphosphatidylinositol (GPI) anchors to proteins		defective in GPI anchor synthesis; sensitive to calcofluor white and hygromycin B		S000029188
GPM1		Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis	phosphoglycerate mutase	Required for sporulation	YKL152C	S000001635
GPM2		Homolog of Gpm1p phosphoglycerate mutase which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event		Null mutant is viable, gpm2 gpm3 double deletion mutants exhibit no synthetic phenotypes	YDL021W	S000002179
GPM3		Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event		Null mutant is viable, gpm3 gpm2 double deletion mutants exhibit no synthetic phenotypes	YOL056W	S000005417
GPR1		Plasma membrane G protein coupled receptor (GPCR) that interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis	G protein coupled receptor (GPCR)		YDL035C	S000002193
GPT2	GAT1	Glycerol-3-phosphate acyltransferase located in both lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone, which are intermediate steps in lipid biosynthesis	glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase		YKR067W	S000001775
GPX1		Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress			YKL026C	S000001509
GPX2	AMI1	Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress			YBR244W	S000000448
GRC3		Protein of unknown function, required for cell growth and possibly involved in rRNA processing; mRNA is cell cycle regulated			YLL035W	S000003958
GRD10				mutant is deficient in retention (in the Golgi) of proteins normally residing in the trans-Golgi compartment		S000029189
GRD14				mutant is deficient in retention (in the Golgi) of proteins normally residing in the trans-Golgi compartment		S000029190
GRD15				mutant is deficient in retention (in the Golgi) of proteins normally residing in the trans-Golgi compartment		S000029191
GRD16				mutant is deficient in retention (in the Golgi) of proteins normally residing in the trans-Golgi compartment		S000029192
GRD17				mutant is deficient in retention (in the Golgi) of proteins normally residing in the trans-Golgi compartment		S000029193
GRD18				mutant is deficient in retention (in the Golgi) of proteins normally residing in the trans-Golgi compartment		S000029194
GRD3				mutant is deficient in retention (in the Golgi) of proteins normally residing in the trans-Golgi compartment		S000029195
GRD4				mutant is deficient in retention (in the Golgi) of proteins normally residing in the trans-Golgi compartment		S000029196
GRD5				mutant is deficient in retention (in the Golgi) of proteins normally residing in the trans-Golgi compartment		S000029197
GRE1		Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway		Null mutant is viable and shows no phenotype in osmotic, ionic or oxidative stress	YPL223C	S000006144
GRE2		NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway			YOL151W	S000005511
GRE3		Aldose reductase involved in methylglyoxal, d-xylose and arabinose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway	aldose reductase		YHR104W	S000001146
GRH1		Acetylated, cis-golgi localized protein involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes		Null: Null mutation is viable, exhibits defects in spindle checkpoint	YDR517W	S000002925
GRR1	CAT80|COT2|SDC1|SSU2	F-box protein component of the SCF ubiquitin-ligase complex, required for Cln1p and Cln2p degradation; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, and morphogenesis		Null mutant is viable, resistant to high levels of divalent cations, sensitive to sulfite, and defective in high affinity glucose transport and glucose repression; null mutant also exibits an elongated cell morphology	YJR090C	S000003850
GRS1		Cytoplasmic and mitochondrial glycyl-tRNA synthase that ligates glycine to the cognate anticodon bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation	glycyl-tRNA synthetase		YBR121C	S000000325
GRS2		Protein with sequence similarity to Grs1p, which is a glycyl-tRNA synthetase; cannot substitute for Grs1p; possible pseudogene that is expressed at very low levels			YPR081C	S000006285
GRX1		Hydroperoxide and superoxide-radical responsive heat-stable glutathione-dependent disulfide oxidoreductase with active site cysteine pair; protects cells from oxidative damage	glutaredoxin	Null mutant is viable but sensitive to oxidative stress. grx1 grx2 null mutants are viable but lack heat-stable oxidoreductase activity.	YCL035C	S000000540
GRX2	TTR1	Cytoplasmic glutaredoxin, thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress	glutaredoxin|glutathione reductase|thioltransferase		YDR513W	S000002921
GRX3		Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage	glutaredoxin	Null mutant is viable and shows moderate sensitivity to oxidative stress and increased oxidation levels of cell proteins	YDR098C	S000002505
GRX4		Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage	glutaredoxin	Null mutant is viable and shows moderate sensitivity to oxidative stress and increased oxidation levels of cell proteins	YER174C	S000000976
GRX5		Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; mitochondrial matrix protein involved in the synthesis/assembly of iron-sulfur centers; monothiol glutaredoxin subfamily member along with Grx3p and Grx4p	glutaredoxin	Null mutant is viable and shows high sensitivity to oxidative stress and increased sensitivity to osmotic stress, and increased oxidation levels of cell proteins; grx5 is synthetically lethal with grx2.	YPL059W	S000005980
GSC2	FKS2	Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)	1,3-beta-D-glucan synthase	Null mutant is viable and shows partially reduced 1,3-beta-glucan synthase activity	YGR032W	S000003264
GSD3				exhibits defects in conversion of glycine to serine; unable to grow on glycine as a sole nitrogen source		S000029198
GSD4				exhibits defects in conversion of glycine to serine		S000029199
GSD5				exhibits defects in conversion of glycine to serine		S000029200
GSD6				exhibits defects in conversion of glycine to serine		S000029201
GSF1		Glucose Signaling Factor		defective in glucose repression		S000029202
GSF2	ECM6	ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression		A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white; Defective in glucose repression; mutants decrease transcriptional repression by MIG1; alter glucose-regulated subunit interactions within the Snf1 protein kinase complex; the effects of eff1 and eff2 on SUC2 repression are strongly synergistic.	YML048W	S000004511
GSF3				defective in glucose repression.		S000029203
GSG1	MUM1|TRS85	Subunit of TRAPP (transport protein particle), a multi-subunit complex involved in targeting and/or fusion of ER-to-Golgi transport vesicles with their acceptor compartment; protein has late meiotic role, following DNA replication			YDR108W	S000002515
GSH1		Gamma glutamylcysteine synthetase, catalyzes the first step in the gamma-glutamyl cycle for glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury	gamma-glutamylcysteine synthetase	Null mutant is viable, exhibits alteration of glutathione content and reduction in growth rate	YJL101C	S000003637
GSH2		Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock	glutathione synthetase	Null mutant is viable, growth was poor under aerobic conditions in minimum medium	YOL049W	S000005409
GSM1		Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis			YJL103C	S000003639
GSP1	CNR1|CST17	GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; regulated by Prp20p, Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p and Kap95p; yeast Gsp2p homolog	GTP-binding protein		YLR293C	S000004284
GSP2	CNR2	GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability	GTP-binding protein		YOR185C	S000005711
GSY1		Glycogen synthase with similarity to Gsy2p, the more highly expressed yeast homolog; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase	UDP-glucose-starch glucosyltransferase|glycogen synthase	Null mutant is viable. Mutant lacking both GSY1 and GSY2 is viable but lacks glycogen synthase activity and glycogen deposition	YFR015C	S000001911
GSY2		Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase	UDP-glucose-starch glucosyltransferase|glycogen synthase	Null mutant is viable. Mutant lacking both GSY1 and GSY2 is viable but lacks glycogen synthase activity and glycogen deposition	YLR258W	S000004248
GTB1		Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p, involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER			YDR221W	S000002629
GTO1		Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization			YGR154C	S000003386
GTO3		Omega class glutathione transferase; putative cytosolic localization			YMR251W	S000004863
GTR1		Cytoplasmic GTP binding protein and negative regulator, with homolog Gtr2p, of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport; has homology to human RagA and RagB		Null mutant is viable but grows slowly, is cold-sensitive, and has defects in phosphate uptake	YML121W	S000004590
GTR2		Cytoplasmic GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; subunit of EGO complex, which is involved in microautophagy regulation, and of GSE complex, required for sorting of Gap1p; homolog of human RagC and RagD			YGR163W	S000003395
GTS1	FHT1|LSR1	Protein containing a zinc-finger in the N-terminus and a long Gln-rich region in the C-terminus; regulates ultradian rhythm, cell size, cell cycle, lifespan, sporulation, heat tolerance, and multidrug transport		Null mutant is viable; shows reduced lag phase	YGL181W	S000003149
GTT1		ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p	glutathione S-transferase	heat shock sensitive at stationary phase	YIR038C	S000001477
GTT2		Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p	glutathione S-transferase		YLL060C	S000003983
GTT3		Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery			YEL017W	S000000743
GUA1		GMP synthase, an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation	GMP synthase	Null mutant is viable but is a guanine auxotroph	YMR217W	S000004830
GUD1		Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures	guanine deaminase		YDL238C	S000002397
GUF1		Mitochondrial GTPase of unknown function, similar to E. coli elongation factor-type GTP-binding protein LepA and to LK1236.1 from Caenorhabditis elegans	GTPase		YLR289W	S000004280
GUK1	PUR5	Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins	guanylate kinase		YDR454C	S000002862
GUP1		Plasma membrane protein with a possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases			YGL084C	S000003052
GUP2		Probable membrane protein with a possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases; Gup1p homolog			YPL189W	S000006110
GUS1	GSN1	Glutamyl-tRNA synthetase (GluRS), forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm	GluRS		YGL245W	S000003214
GUT1		Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p	glycerol kinase	Null mutant is viable but is unable to grow on glycerol	YHL032C	S000001024
GUT2		Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner	glycerol-3-phosphate dehydrogenase	Null mutant is viable, unable to utilize glycerol as a carbon source	YIL155C	S000001417
GVP36		Golgi vesicle protein of unknown function; localizes to both early and late Golgi vesicles; may interact with ribosomes, based on co-purification experiments		Null: no notable phenotype	YIL041W	S000001303
GWT1		Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors		overexpression confers 1-[4-butylbenzyl]isoquinoline (BIQ)-resistant growth in S. cerevisiae.	YJL091C	S000003627
GYL1	APP2	Putative GTPase activating protein (GAP) that may have a role in polarized exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p			YMR192W	S000004804
GYP1	YOR29-21	Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion	GTPase activating protein (GAP)	Null mutant is viable and shows no phenotype	YOR070C	S000005596
GYP5		GTPase-activating protein (GAP) for yeast Rab family members, involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p	GTPase-activating protein		YPL249C	S000006170
GYP6		GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transport	GTPase activating protein (GAP)  for Ypt6		YJL044C	S000003580
GYP7		GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking	GTPase activating protein (GAP)		YDL234C	S000002393
GYP8		GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport	GTPase-activating protein		YFL027C	S000001867
GZF3	DEH1|NIL2	GATA zinc finger protein and Dal80p homolog that negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p	GATA zinc finger protein 3 homologous to Dal80 in structure and function	Null mutant is partially NCR-insensitive	YJL110C	S000003646
HAA1		Transcriptional activator involved in the transcription of TPO2, HSP30 and other genes encoding membrane stress proteins; despite sequence similarity with the transcription factor Ace1p, it is not subject to metalloregulation			YPR008W	S000006212
HAC1	ERN4|IRE15	bZIP transcription factor (ATF/CREB1 homolog) that regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway utilizing Ire1p, Trl1p and Ada5p facilitates efficient Hac1p synthesis		Null mutant is viable but is sensitive to caffeine (suppressed by high-copy SRA5) and stresses that produce unfolded proteins. High-copy HAC1 suppresses S. pombe cdc10-129	YFL031W	S000001863
HAF2				haf2 mutants exhibit defects in STA2 transcription, are pleiotropically defective in utilization of alternative carbon sources and resemble snf (sucrose non-fermenting) mutants identified previously as unable to derepress the expression of the SUC2 gene encoding invertase		S000029205
HAL1		Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p		Null mutant is viable, shows decreased salt tolerance	YPR005C	S000006209
HAL5		Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters			YJL165C	S000003701
HAL9		Putative transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression		Null mutant is viable, exhibits decreased salt tolerance and ENA1 expression; HAL9 overexpression increases sodium and lithium tolerance	YOL089C	S000005449
HAM1		Conserved protein with deoxyribonucleoside triphosphate pyrophosphohydrolase activity, mediates exclusion of noncanonical purines from deoxyribonucleoside triphosphate pools; mutant is sensitive to the base analog 6-N-hydroxylaminopurine		Null mutant is viable but is sensitive to 6-N-hydroxylaminopurine (HAP), a mutagen; however, mutant does not show higher spontaneous mutation rate	YJR069C	S000003830
HAP1	CYP1	Zinc finger transcription factor involved in the complex regulation of gene expression in response to levels of heme and oxygen; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus	transcription factor	Essential for anaerobic or heme deficient growth; Null mutant is viable, deficient in expression of CYC1 and CYC7	YLR256W	S000004246
HAP2		Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding	transcriptional activator protein of CYC1 (component of HAP2/HAP3 heteromer)		YGL237C	S000003206
HAP3		Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding	transcriptional activator protein of CYC1 (component of HAP2/HAP3 heteromer)		YBL021C	S000000117
HAP4		Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex	transcriptional activator protein of CYC1 (component of HAP2/HAP3 heteromer)	hap4 point mutants or disruptions are unable to grow on non-fermentable carbon sources	YKL109W	S000001592
HAP5		Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex	CCAAT-binding transcription factor component (along with Hap2p and Hap3p)		YOR358W	S000005885
HAS1		ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles			YMR290C	S000004903
HAT1		Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair	histone acetyltransferase		YPL001W	S000005922
HAT2		Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing	histone acetyltransferase subunit		YEL056W	S000000782
HBN1	YCL027C-A	Putative protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus			YCL026C-B	S000007548
HBO10						S000029206
HBS1		GTP binding protein with sequence similarity to the elongation factor class of G proteins, EF-1alpha and Sup35p; associates with Dom34p, and shares a similar genetic relationship with genes that encode ribosomal protein components			YKR084C	S000001792
HBT1		Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis			YDL223C	S000002382
HCA4	DBP4|ECM24	Putative nucleolar DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis			YJL033W	S000003570
HCH1		Heat shock protein regulator that binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; GFP-fusion protein localizes to the cytoplasm and nucleus		Null mutant is viable; when overexpressed, HCH1 is an allele-specific suppressor of hsp82 ts mutants	YNL281W	S000005225
HCM1		Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role	forkhead protein	Null mutant is viable; exacerbates temperature-sensitivity of a cmd1-1 (calmodulin) mutant	YCR065W	S000000661
HCR1		Dual function protein involved in translation initiation as a substoichiometric component of eukaryotic translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA	translation initiation factor eIF3 subunit		YLR192C	S000004182
HCS1	DIP1	Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities	DNA helicase A		YKL017C	S000001500
HDA1		Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation	histone deacetylase		YNL021W	S000004966
HDA2	PLO2	Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance			YDR295C	S000002703
HDA3	PLO1	Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex that contains an Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; has similarity to Hda2p			YPR179C	S000006383
HED1		Meiosis-specific protein that down-regulates Rad51p-mediated mitotic recombination when the meiotic recombination machinery is impaired; early meiotic gene, transcribed specifically during meiotic prophase			YDR014W-A	S000113613
HEF3	ZRG7	Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells	translation elongation factor 3 (EF-3)		YNL014W	S000004959
HEH2		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery	Inner nuclear membrane protein of unknown function		YDR458C	S000002866
HEK2	KHD1	RNA binding protein with similarity to hnRNP-K that localizes to the cytoplasm and to subtelomeric DNA; required for the proper localization of ASH1 mRNA; involved in the regulation of telomere position effect and telomere length		Null: ASH1 mRNA is partially delocalized	YBL032W	S000000128
HEM1	CYD1	5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p	5-aminolevulinate synthase	Null mutant is viable; auxotroph for heme and methionine	YDR232W	S000002640
HEM10				Heme synthesis deficient		S000029207
HEM11		Involved in heme biosynthesis		Null mutant is viable; auxotroph for heme and methionine		S000029208
HEM12	HEM6	Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; activity inhibited by Cu2+, Zn2+, Fe2+, Fe3+ and sulfhydryl-specific reagents	uroporphyrinogen decarboxylase		YDR047W	S000002454
HEM13		Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)	coproporphyrinogen III oxidase		YDR044W	S000002451
HEM14		Protoporphyrinogen oxidase, a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX	protoporphyrinogen oxidase	Null mutant is viable but is protoporphyrinogen oxidase deficient (heme deficiency and accumlation of heme precursors)	YER014W	S000000816
HEM15		Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway	ferrochelatase|protoheme ferrolyase	Null mutant is inviable in certain genetic backgrounds	YOR176W	S000005702
HEM2	SLU1	Delta-aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen, the second step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus	delta-aminolevulinate dehydratase|porphobilinogen synthase	Null mutant is viable; auxotroph for heme and methionine	YGL040C	S000003008
HEM3		Phorphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p	phorphobilinogen deaminase	auxotroph for heme and methionine	YDL205C	S000002364
HEM4	SLU2	Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in the heme biosynthetic pathway	uroporphyrinogen III synthase	respiratory deficiency, accumulation of porphyrins, and heme auxotrophy	YOR278W	S000005804
HEM5				hem5 mutants accumulate protoporphyrin IX		S000029209
HES1	OSH5	Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP)		pleiotropic sterol-related phenotypes	YOR237W	S000005763
HEX3	SLX5	Protein containing a RING finger domain that interacts with Slx8p; mutant phenotypes and genetic interactions suggest a role in sumoylation and in genome stability		null is synthetically lethal with sgs1 null	YDL013W	S000002171
HFA1		Mitochondrial acetyl-coenzyme A carboxylase, catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis			YMR207C	S000004820
HFD1		Putative fatty aldehyde dehydrogenase, located in the mitochondrial outer membrane and also in lipid particles; has similarity to human fatty aldehyde dehydrogenase (FALDH) which is implicated in Sjogren-Larsson syndrome			YMR110C	S000004716
HFI1	ADA1|GAN1|SRM12|SUP110	Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions	Ada histone acetyltransferase complex component	Null mutant phenotypes similar to spt20/ada5 and spt7 mutants. Null mutant is viable, elongated cells, hyperpolarized actin cytoskeleton, heat sensitive, non-respiratory, inositol auxotroph, exhibits suppression of Ty insertion mutations; hfi1 hta1 double mutant is inviable.	YPL254W	S000006175
HFM1	MER3	Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity			YGL251C	S000003220
HGH1		Protein of unknown function with similarity to human HMG1 and HMG2; localizes to the cytoplasm			YGR187C	S000003419
HHF1		One of two identical histone H4 proteins (see also HHF2); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity	histone H4 (HHF1 and HHF2 code for identical proteins)		YBR009C	S000000213
HHF2		One of two identical histone H4 proteins (see also HHF1); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity	histone H4 (HHF1 and HHF2 code for identical proteins)		YNL030W	S000004975
HHO1		Histone H1, a linker histone required for nucleosome packaging at restricted sites; suppresses DNA repair involving homologous recombination; not required for telomeric silencing, basal transcriptional repression, or efficient sporulation	histone H1	Null mutant is viable; other phenotype: Increased basal expression of a CYC1-lacz reporter gene; nuclear localization of a Hho1-GFP fusion protein	YPL127C	S000006048
HHT1	BUR5|SIN2	One of two identical histone H3 proteins (see also HHT2); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation	histone H3 (HHT1 and HHT2 code for identical proteins)		YBR010W	S000000214
HHT2		One of two identical histone H3 proteins (see also HHT1); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation	histone H3 (HHT1 and HHT2 code for identical proteins)		YNL031C	S000004976
HIF1		Non-essential component of the HAT-B histone acetyltransferase complex (Hat1p-Hat2p-Hif1p), localized to the nucleus; has a role in telomeric silencing		Null mutant is viable and does not show any obvious phenotypes	YLL022C	S000003945
HIM1		Protein of unknown function involved in DNA repair			YDR317W	S000002725
HIP1		High-affinity histidine permease, also involved in the transport of manganese ions	histidine permease	requires supplementation with large amounts of histidine for growth	YGR191W	S000003423
HIR1		Non-essential transcriptional corepressor involved in the cell cycle-regulated transcription of histone H2A, H2B, H3 and H4 genes; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores		Null mutant is viable, but HTA1-HTB1 transcription is derepressed and is no longer cell-cycle regulated; other mutations in this gene give 'spt' gene-class phenotype	YBL008W	S000000104
HIR2	SPT1	Non-essential transcriptional corepressor involved in the cell cycle-regulated transcription of histone H2A, H2B, H3, and H4 genes; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p		Null mutant is viable, but HTA1-HTB1 transcription is derepressed and is no longer cell-cycle regulated; other mutations in this gene give 'spt' gene-class phenotype	YOR038C	S000005564
HIR3	HPC1	Transcriptional corepressor involved in the cell cycle-regulated transcription of histone genes HTA1, HTB1, HHT1, and HHT2; involved in position-dependent gene silencing and nucleosome reassembly		HTA1-HTB1 transcription is derepressed and is no longer cell-cycle regulated	YJR140C	S000003901
HIR4		Involved in cell-cycle regulation of histone transcription		Dominant mutant is available that lacks proper cell cycle-dependent regulation of HTA1-HTB1 transcription		S000029211
HIS1		ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control	ATP phosphoribosyltransferase	Null mutant is viable and requires histidine	YER055C	S000000857
HIS2		Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control	histidinolphosphatase	Null mutant is viable and requires histidine	YFR025C	S000001921
HIS3	HIS10	Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p	imidazoleglycerol-phosphate dehydratase	Null mutant is viable and requires histidine	YOR202W	S000005728
HIS4		Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis	histidinol dehydrogenase|phosphoribosyl-AMP cyclohydrolase|phosphoribosyl-ATP pyrophosphatase	Null mutant is viable and requires histidine	YCL030C	S000000535
HIS5		Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts	histidinol-phosphate aminotransferase	Null mutant is viable and requires histidine	YIL116W	S000001378
HIS6		Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts	phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase	Null mutant is viable and requires histidine	YIL020C	S000001282
HIS7		Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth and sixth steps of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor	imidazole glycerol phosphate synthase	Null mutant is viable and requires histidine	YBR248C	S000000452
HIS8						S000029212
HIT1		Protein of unknown function, required for growth at high temperature		no growth at high temperature; confers pet phenotype	YJR055W	S000003816
HIT4				Mutant available that is temperature-sensitive		S000029213
HKR1		Serine/threonine rich cell surface protein that contains an EF hand motif; involved in the regulation of cell wall beta-1,3 glucan synthesis and bud site selection; overexpression confers resistance to Hansenula mrakii killer toxin, HM-1		Null mutant is inviable; overexpression confers resistance to Hanenula mrakii killer toxin	YDR420W	S000002828
HLJ1		Co-chaperone for Hsp40p, anchored in the ER membrane; with its homolog Hdj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ			YMR161W	S000004771
HLR1		Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A			YDR528W	S000002936
HMF1	HIG1	Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro		Null mutant grows faster than wild-type cells and has higher survival rate at 42.5c; overexpression inhibits cell growth	YER057C	S000000859
HMG1		One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae	3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase isozyme	Null mutant is viable, sensitive to compactin, a competitive inhibitor of HMG-CoA reductase; hmg1 hmg2 double deletion mutants are inviable	YML075C	S000004540
HMG2		One of two isozymes of HMG-CoA reductase that convert HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks	3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase isozyme	Null mutant is viable, sensitive to compactin, a competitive inhibitor of HMG-CoA reductase; hmg1 hmg2 double deletion mutants are inviable	YLR450W	S000004442
HMI1		Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD			YOL095C	S000005455
HML		Mating type cassette - left				S000029214
HMLALPHA1	ALPHA1	Silenced copy of ALPHA1 at HML, encoding a transcriptional coactivator involved in the regulation of mating-type alpha-specific gene expression	transcription factor		YCL066W	S000000571
HMLALPHA2	ALPHA2	Silenced copy of ALPHA2 at HML; homeobox-domain protein that associates with Mcm1p in haploid cells to repress a-specific gene expression and interacts with a1p in diploid cells to repress haploid-specific gene expression			YCL067C	S000000572
HMO1	HSM2	Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase		Null mutant is viable, but grows slowly and shows higher than normal plasmid loss rate	YDR174W	S000002581
HMR		Mating type cassette - right				S000029655
HMRA1	YCR097WB	Silenced copy of a1 at HMR; homeobox corepressor that interacts with Alpha2p to repress haploid-specific gene transcription in diploid cells	homeobox transcription factor	Null mutant is viable; deletion of the expressed copy of A1 causes mating defect; diploids in which the expressed copy of a1 is mutated cannot undergo meiosis and sporulation	YCR097W	S000000694
HMRA2	A2	Silenced copy of a2 at HMR; similarity to Alpha2p; required along with a1p for inhibiting expression of the HO endonuclease in a/alpha HO/HO diploid cells with an active mating-type interconversion system			YCR096C	S000000692
HMS1		Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant		Null mutant is viable; multicopy expression suppresses the pseudohyphal defect of mep2/mep2 strains	YOR032C	S000005558
HMS2		Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant		Null mutant is viable; multicopy expression suppresses the pseudohyphal defect of mep2/mep2 strains	YJR147W	S000003908
HMT1	HCP1|ODP1|RMT1	Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, thus facilitating nuclear export of these proteins; required for viability of npl3 mutants	arginine methyltransferase	Null mutant is viable, hmt1 npl3-1 mutants are inviable	YBR034C	S000000238
HMX1		ER localized, heme-binding peroxidase involved in the degradation of heme; does not exhibit heme oxygenase activity despite similarity to heme oxygenases; expression regulated by AFT1			YLR205C	S000004195
HNM1		Choline transporter (permease) that also controls the uptake of nitrogen mustard; expression is co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol	choline transporter	Null mutant is viable, but hyper-resistant to nitrogen mustard; ctr1,cho1 double null is inviable	YGL077C	S000003045
HNT1		Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint			YDL125C	S000002283
HNT2	APH1	Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins			YDR305C	S000002713
HNT3		Member of the third branch of the histidine triad (HIT) superfamily of nucleotide-binding proteins; similar to Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia			YOR258W	S000005784
HO		Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p	homothallic switching endonuclease	Null mutant is viable and cannot undergo mating type switching	YDL227C	S000002386
HOC1		Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele		Null mutant is viable but is hypersensitive to calcofluor white and hygromycin B and has lowered restrictive temperature in a pkc1-371 background; high copy suppressor of pkc1-371	YJR075W	S000003836
HOF1	CYK2	Bud neck-localized, SH3 domain-containing protein required for cytokinesis; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p		Null mutant is defective in cytokinesis	YMR032W	S000004635
HOG1	SSK3	Mitogen-activated protein kinase involved in osmoregulation via three independent osmosensors; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p	MAP kinase kinase (MEK)	Null mutant is viable and unable to grow in high osmolarity media	YLR113W	S000004103
HOL1		Putative ion transporter similar to the major facilitator superfamily of transporters; mutations in membrane-spanning domains permit nonselective cation uptake		Null mutant is viable, unable to uptake histidinol or Na+. Gain-of-function mutations confer non-selective cation transport and abolish translational repression by a small upstream open reading frame	YNR055C	S000005338
HOM2		Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis	aspartic beta semi-aldehyde dehydrogenase	Homoserine requiring	YDR158W	S000002565
HOM3	BOR1|SIL4	Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis	aspartate kinase (L-aspartate 4-P-transferase) (EC 2.7.2.4)	Homoserine requiring; Borrelidin resistance	YER052C	S000000854
HOM6		Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions	L-homoserine:NADP oxidoreductase|homoserine dehydrogenase	Homoserine requiring	YJR139C	S000003900
HOP1		Meiosis-specific DNA binding protein that displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for homologous chromosome synapsis and chiasma formation	DNA binding protein	decreased levels of meiotic crossing over and intragenic recombination between markers on homologous chromosomes	YIL072W	S000001334
HOP2		Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair		Null mutant is viable; homozygous hop2 null diploids arrest in meiotic prophase prior to the first meiotic division	YGL033W	S000003001
HOR2	GPP2	One of two redundant DL-glycerol-3-phosphatases (RHR2/GPP1 encodes the other) involved in glycerol biosynthesis; induced in response to hyperosmotic stress and oxidative stress, and during the diauxic transition		Mutants lacking both RHR2 and HOR2 are devoid of glycerol 3-phosphatase activity and produce only a small amount of glycerol. Overproduction of both genes does not significantly enhance glycerol production.	YER062C	S000000864
HOR7		Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor			YMR251W-A	S000004864
HOS1		Putative class I histone deacetylase (HDAC) with sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; deletion results in increased histone acetylation at rDNA repeats; interacts with the Tup1p-Ssn6p corepressor complex			YPR068C	S000006272
HOS2	RTL1	Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity			YGL194C	S000003162
HOS3		Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats			YPL116W	S000006037
HOS4		Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate			YIL112W	S000001374
HOT1		Transcription factor required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p		osmostress hypersensitivity	YMR172W	S000004783
HOT13		Mitochondrial intermembrane space protein, first component of a pathway mediating assembly of small TIM (Translocase of the Inner Membrane) complexes which escort hydrophobic inner membrane proteins en route to the TIM22 complex			YKL084W	S000001567
HPA2		Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity	histone acetyltransferase	Null mutant is viable and does not show any detectable phenotype	YPR193C	S000006397
HPA3		D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro	D-Amino acid N-acetyltransferase	Null mutant is viable and does not show any detectable phenotype	YEL066W	S000000792
HPC2		Highly charged, basic protein required for normal cell-cycle regulation of histone gene transcription; mutants display strong synthetic defects with subunits of FACT, a complex that allows RNA Pol II to elongate through nucleosomes		altered cell cycle regulation of histone gene transcription; suppresses delta insertion mutations in the HIS4 and LYS2 loci	YBR215W	S000000419
HPC3				altered cell cycle regulation of histone gene transcription		S000029215
HPC4				altered cell cycle regulation of histone gene transcription		S000029216
HPC5				altered cell cycle regulation of histone gene transcription; derepression occurs only in the presence of hydroxyurea but not alpha-factor		S000029217
HPF1		Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines			YOL155C	S000005515
HPR1	TRF1	Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p		Increased intrachromosomal recombination	YDR138W	S000002545
HPR2		Involved in mitotic intrachromosomal recombination		hpr2 mutations increase intrachromosomal gene conversion between repeated sequences and increase loss of a marker between duplicated genes		S000029218
HPR4		Involved in mitotic intrachromosomal recombination		hpr4 mutations increase intrachromosomal gene conversion between repeated sequences		S000029219
HPR5	RADH|RADH1|SRS2	DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; affects genome stability by suppressing unscheduled homologous recombination	DNA helicase	Null mutant is viable, radiation (ultraviolet or ionizing sensitive), loss of function results in RAD52-dependent hyperrecombination suggesting recombination suppression occurs by antagonizing the Rad52 recombinational repair pathway; wild-type suppresses mitotic recombination; some mutant alleles have lower spore viability which is not rescued by spo13, suggesting they affect a late recombination function; hpr5 mutations are rad6 suppressors. Growth defects of mgs1 rad18 double mutants are suppressed by a mutation in HPR5.	YJL092W	S000003628
HPR7		Involved in mitotic intrachromosomal recombination		hpr7 mutations increase intrachromosomal gene conversion between repeated sequences and increase loss of a marker between duplicated genes		S000029220
HPR8		Involved in mitotic intrachromosomal recombination		hpr8 mutations increase intrachromosomal gene conversion between repeated sequences		S000029221
HPT1	BRA6|HPRT	Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate; mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome	HGPRTase|hypoxanthine guanine phosphoribosyltransferase		YDR399W	S000002807
HRA1		non coding RNA, substrate of RNase P, possibly involved in rRNA processing, specifically maturation of 20S precursor into the mature 18S rRNA				S000119380
HRB1	TOM34	Poly(A+) RNA-binding protein, involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Gbp2p and Npl3p			YNL004W	S000004949
HRD1	DER3	Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger		Null mutant is viable, slows degradation of Hmg2p	YOL013C	S000005373
HRD3		Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD), forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events		Null mutant is viable, slows degradation of Hmg2p	YLR207W	S000004197
HRK1		Protein kinase implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis	serine/threonine protein kinase		YOR267C	S000005793
HRP1	NAB4|NAB5	Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences	cleavage and polyadenylation factor CF I component involved in pre-mRNA 3'-end processing	Null mutant is inviable; mutants can suppress temperature-sensitive alleles of npl3 (but not npl3 null mutants)	YOL123W	S000005483
HRQ1		Putative DNA helicase	DNA helicase		YDR291W	S000002699
HRR25		Protein kinase involved in regulating diverse events including vesicular trafficking, gene expression, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta)	casein kinase I	Null mutant is viable but shows slow growth; hrr25-1 mutation results in sensitivity to continuous expression of HO endonuclease, to methylmethanesulfonate, and to x-irradiation; homozygous hrr25-1 mutants are unable to sporulate	YPL204W	S000006125
HRS3				Suppresses hyper-deletion phenotype of hpr1 null mutant		S000029222
HRS4				Suppresses hyper-deletion phenotype of hpr1 null mutant; also has hyper-mutator phenotype		S000029223
HRS5				Suppresses hyper-deletion phenotype of hpr1 null mutant		S000029224
HRT1	HRT2|RBX1|ROC1	RING finger containing subunit of Skp1-Cullin-F-box ubiquitin protein ligases (SCF); required for Gic2p, Far1p, Sic1p and Cln2p degradation; may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF	Skp1-Cullin-F-box ubiquitin protein ligase (SCF) subunit		YOL133W	S000005493
HRT3		Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies			YLR097C	S000004087
HSC82	HSP90	Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels that HSP82 and induced 2-3 fold by heat shock	chaperonin	Null mutant is viable at 25 degrees C; ability to grow at higher temperatures varies with gene copy number	YMR186W	S000004798
HSD1		Endoplasmic reticulum (ER)-resident membrane protein, overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation			YOR311C	S000005838
HSE1		Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes		Null: accumulates enlarged prevacuolar/endosomal compartment. Fails to sort proteins into the vacuolar lumen.. Other phenotypes: secretes CPY	YHL002W	S000000994
HSF1	EXA3|MAS3	Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated	heat shock transcription factor		YGL073W	S000003041
HSH155		U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155			YMR288W	S000004901
HSH49		U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM)			YOR319W	S000005846
HSK3		Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis			YKL138C-A	S000028421
HSL1	NIK1	Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p	serine/threonine protein kinase	Null mutant is viable; synthetically lethal with histone H3 mutations; G2 delay	YKL101W	S000001584
HSL7		Protein arginine N-methyltransferase that exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p		Null mutant is viable; synthetically lethal with histone H3 mutations; G2 delay	YBR133C	S000000337
HSM3		Protein of unknown function, involved in DNA mismatch repair during slow growth; has weak similarity to Msh1p		Null mutant is viable, hsm3 null mutants exhibit enhanced rates of spontaneous mutation to canavanine resistance and reversions of lys1-1 and his1-7, increased rate of intragenic mitotic recombination at the ADE2 gene, and reduced ability to correct DNA heteroduplexes	YBR272C	S000000476
HSP10	CPN10	Mitochondrial matrix co-chaperonin that inhibits the ATPase activity of Hsp60p, a mitochondrial chaperonin; involved in protein folding and sorting in the mitochondria; 10 kD heat shock protein with similarity to E. coli groES	heat shock protein 10	Null mutant is inviable; temperature-sensitive mutants are available	YOR020C	S000005546
HSP104		Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation	heat shock protein 104	Null mutant is viable and defective in induced thermotolerance	YLL026W	S000003949
HSP12	GLP1|HOR5	Plasma membrane localized protein that protects membranes from desiccation; induced by heat shock, oxidative stress, osmostress, stationary phase entry, glucose depletion, oleate and alcohol; regulated by the HOG and Ras-Pka pathways	heat shock protein 12	Null mutant is viable, but shows induction of heat shock response under conditions normally associated with low-level HSP12 expression	YFL014W	S000001880
HSP150	CCW7|ORE1|PIR2	O-mannosylated heat shock protein that is secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation	heat shock protein|secretory glycoprotein		YJL159W	S000003695
HSP26		Small heat shock protein with chaperone activity that is regulated by a heat induced transition from an inactive oligomeric (24-mer) complex to an active dimer; induced by heat, upon entry into stationary phase, and during sporulation		Null mutant is viable; hsp26 hsp42 double deletion mutants are viable	YBR072W	S000000276
HSP30	YRO1	Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase			YCR021C	S000000615
HSP31		Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp32p, Hsp33p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer			YDR533C	S000002941
HSP32		Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp33p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease			YPL280W	S000006201
HSP33		Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease			YOR391C	S000005918
HSP42		Small cytosolic stress-induced chaperone that forms barrel-shaped oligomers and suppresses the aggregation of non-native proteins; oligomer dissociation is not required for function; involved in cytoskeleton reorganization after heat shock		Null mutant is viable; hsp42 hsp26 double deletion mutants are viable; hsp42 null mutants subjected to moderate thermal stress reorganize the actin cytoskeleton more slowly than wild-type	YDR171W	S000002578
HSP60	CPN60|MIF4	Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; similarity to groEL	chaperonin		YLR259C	S000004249
HSP78		Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; prevents the aggregation of misfolded matrix proteins; component of the mitochondrial proteolysis system	heat shock protein 78	Null mutant is viable but in ssc1 mutant background gives rho- phenotype	YDR258C	S000002666
HSP82	HSP90	Cytoplasmic chaperone (Hsp90 family) required for pheromone signaling and negative regulation of Hsf1p; docks with the mitochondrial import receptor Tom70p for preprotein delivery; interacts with co-chaperones Cns1p, Cpr6p, Cpr7p, and Sti1p	heat shock protein 90	Null mutant is viable at 25 degrees C; ability to grow at higher temperatures varies with gene copy number	YPL240C	S000006161
HST1		NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and mitotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance		Overexpression restores transcriptional silencing in a sir2 mutant	YOL068C	S000005429
HST2		Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro			YPL015C	S000005936
HST3		Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism			YOR025W	S000005551
HST4		Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism			YDR191W	S000002599
HSV2		Phosphatidylinositol 3,5-bisphosphate-binding protein, predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization			YGR223C	S000003455
HSX1		tRNA-Arg of low abundance; required for growth on nonfermentable carbon sources at high temperatures, for synthesis of heat shock protein Ssc1p, and for Ty1 retrotransposition through the regulation of translational frameshifting	tRNA-Arg	Null mutant is viable, HSX1 is required for growth at 37 degrees on a nonfermentable carbon source, synthesis of the Ssc1 heat shock protein, and normal Ty1 retrotransposition		S000006707
HTA1	H2A1|SPT11	One of two nearly identical (see also HTA2) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p	histone H2A (HTA1 and HTA2 code for nearly identical proteins)		YDR225W	S000002633
HTA2	H2A2	One of two nearly identical (see also HTA1) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p	histone H2A (HTA1 and HTA2 code for nearly identical proteins)	Null mutant is viable. Deletion of the HTA2-HTB2 (TRT2) locus has no reported observable phenotypes, presumably because HTA1-HTB1 (TRT1) expression is upregulated and can compensate in the absence of TRT2. Overexpression of TRT2 can suppress Ty insertion mutations	YBL003C	S000000099
HTB1	SPT12	One of two nearly identical (see HTB2) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation	histone H2B (HTB1 and HTB2 code for nearly identical proteins)		YDR224C	S000002632
HTB2		One of two nearly identical (see HTB1) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation	histone H2B (HTB1 and HTB2 code for nearly identical proteins)	Null mutant is viable. Deletion of the HTA2-HTB2 (TRT2) locus has no reported observable phenotypes, presumably because HTA1-HTB1 (TRT1) expression is upregulated and can compensate in the absence of TRT2	YBL002W	S000000098
HTD2	RMD12	Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology			YHR067W	S000001109
HTL1		Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance		Null mutant is viable but shows temperature-sensitive lethality	YCR020W-B	S000006439
HTS1	TSM4572	Cytoplasmic and mitochondrial histidine tRNA synthetase; encoded by a single nuclear gene that specifies two messages; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence	histidyl-tRNA synthetase	Certain mutations can be made to disrupt either cytoplasmic or mitochondrial form of Hts1p; loss of mitochondrial synthetase gives Pet- phenotype; loss of cytoplasmic synthetase can result in lethality or respiratory deficiency	YPR033C	S000006237
HTZ1	HTA3	Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin	H2A.F/Z|H2AZ	Null mutant is viable at 28C; high copy suppressor of histone H4 point mutant affecting nucleosome structure	YOL012C	S000005372
HUA1		Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly			YGR268C	S000003500
HUA2		Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly			YOR284W	S000005810
HUB1		Ubiquitin-like protein modifier, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear			YNR032C-A	S000007251
HUG1		Protein involved in the Mec1p-mediated checkpoint pathway that responds to DNA damage or replication arrest, transcription is induced by DNA damage		Null mutant is viable and shows suppression of dun1 delta HU sensitivity.	YML058W-A	S000007472
HUL4		Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability	ubiquitin ligase (E3)		YJR036C	S000003797
HUL5		Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability	ubiquitin ligase (E3)		YGL141W	S000003109
HUR1		Protein required for hydroxyurea resistance; has possible roles in DNA replication and maintenance of proper telomere length		Null mutant is viable but sensitive to HU	YGL168W	S000003136
HUT1		Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1			YPL244C	S000006165
HVG1	YEM9	Protein of unknown function, has homology to Vrg4p			YER039C	S000000841
HXK1		Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p	hexokinase I (PI) (also called hexokinase A)	Null mutant is viable, is able to ferment fructose, and has little or no effect on glucose repression; hxk1, hxk2 double null mutant cannot ferment fructose and fails to show glucose repression at SUC2, CYC1, GAL10	YFR053C	S000001949
HXK2	HEX1|HKB|SCI2	Hexokinase isoenzyme 2 that catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene	hexokinase II (PII) (also called hexokinase B)	Null mutant is viable and can ferment fructose, but fails to show glucose repression at SUC2, CYC1, GAL10. hxk1, hxk2 double null mutant cannot ferment fructose	YGL253W	S000003222
HXT1	HOR4	Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting	hexose transporter		YHR094C	S000001136
HXT10		Putative hexose transporter, expressed at low levels and expression is repressed by glucose	hexose transporter		YFL011W	S000001883
HXT11	LGT3	Putative hexose transporter that is nearly identical to Hxt9p, has similarity to major facilitator superfamily (MFS) transporters and is involved in pleiotropic drug resistance	hexose transporter	Other phenotypes: Shortens the G1 phase of the cell cycle when present in high-copy|Null mutant is viable, cycloheximide, sulfomethuron methyl, and 4-NQO (4-nitroquinoline-N-oxide) resistant	YOL156W	S000005516
HXT12		Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family	putative hexose permease			S000001432
HXT13		Hexose transporter, induced in the presence of non-fermentable carbon sources, induced by low levels of glucose, repressed by high levels of glucose	hexose transporter		YEL069C	S000000795
HXT14		Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	hexose transporter		YNL318C	S000005262
HXT15		Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose	hexose transporter		YDL245C	S000002404
HXT16		Protein of unknown function with similarity to hexose transporter family members, expression is repressed by high levels of glucose	hexose permease		YJR158W	S000003919
HXT17		Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose	hexose transporter		YNR072W	S000005355
HXT2		High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose	hexose transporter		YMR011W	S000004613
HXT3		Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions	hexose transporter	Null mutant is viable but grows slowly on galactose; some mutant alleles confer sodium hypersensitivity.	YDR345C	S000002753
HXT4	LGT1|RAG1	High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose	hexose transporter		YHR092C	S000001134
HXT5		Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs	hexose transporter		YHR096C	S000001138
HXT6		High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3	hexose transporter	Null mutant is viable; snf3 hxt1 hxt2 hxt3 hxt4 hxt6 hxt7 mutant cannot grow on media containing glucose as sole carbon source	YDR343C	S000002751
HXT7		High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels	hexose transporter	Null mutant is viable; snf3 hxt1 hxt2 hxt3 hxt4 HXT7 hxt7 mutant cannot grow on media containing glucose as sole carbon source	YDR342C	S000002750
HXT8		Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose	hexose permease		YJL214W	S000003750
HXT9		Putative hexose transporter that is nearly identical to Hxt11p, has similarity to major facilitator superfamily (MFS) transporters, expression of HXT9 is regulated by transcription factors Pdr1p and Pdr3p	hexose permease	Null mutant is viable, cycloheximide, sulfomethuron methyl, and 4-NQO (4-nitroquinoline-N-oxide) resistant	YJL219W	S000003755
HYG4				Hygromycin resitance		S000029225
HYM1		Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response			YKL189W	S000001672
HYP2	TIF51A	Translation initiation factor eIF-5A, promotes formation of the first peptide bond; similar to and functionally redundant with Anb1p; possible role in translation elongation; undergoes an essential hypusination modification	translation initiation factor eIF5A	Null mutant is viable; a double mutant containing disruptions of both HYP2 and and the highly homologous ANB1 is inviable	YEL034W	S000000760
HYR1	GPX3|ORP1	Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor		Null mutant is hypersensitive to oxidative stress	YIR037W	S000001476
HYS2	HUS2|POL31|SDP5	DNA polymerase III (delta) subunit, essential for cell viability; involved in DNA replication and DNA repair	DNA polymerase delta subunit		YJR006W	S000003766
IAH1		Isoamyl acetate-hydrolyzing esterase, required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing	isoamyl acetate-hydrolyzing esterase	The null mutant is viable but cannot hydrolyze isoamyl acetate.	YOR126C	S000005652
IAR1		Involved in regulating invertase (SUC5) activity and may be in part responsible for low levels of invertase activity observed in diploids		Mutants allow higher levels of invertase expression		S000029226
IBD2		Component of the BUB2-dependent spindle checkpoint pathway, interacts with Bfa1p and functions upstream of Bub2p and Bfa1p		Null: viable, sensitive to benomyl	YNL164C	S000005108
ICE2		Integral ER membrane protein with type-III transmembrane domains; mutations cause defects in cortical ER morphology in both the mother and daughter cells			YIL090W	S000001352
ICK1		found as an extragenic suppressor of ctf13-30				S000029227
ICL1		Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose	isocitrate lyase	Null mutant is viable, fails to grow on ethanol as a carbon source	YER065C	S000000867
ICL2		2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol	2-methylisocitrate lyase		YPR006C	S000006210
ICS2		Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization			YBR157C	S000000361
ICS3		Protein of unknown function			YJL077C	S000003613
ICT1		Protein of unknown function, null mutation leads to an increase in sensitivity to Calcofluor white; expression of the gene is induced in the presence of isooctane			YLR099C	S000004089
ICY1		Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation			YMR195W	S000004808
ICY2		Protein of unknown function; potential Cdc28p substrate			YPL250C	S000006171
IDH1		Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle	isocitrate dehydrogenase 1 alpha-4-beta-4 subunit	Null mutant is viable, grows at a reduced rate on glycerol, lactate, and acetate	YNL037C	S000004982
IDH2		Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle	NAD-dependent isocitrate dehydrogenase		YOR136W	S000005662
IDI1	BOT2|LPH10	Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase), catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability	isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase)		YPL117C	S000006038
IDP1		Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes	NADP-dependent isocitrate dehydrogenase		YDL066W	S000002224
IDP2		Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose	NADP-dependent isocitrate dehydrogenase		YLR174W	S000004164
IDP3		Peroxisomal NADP-dependent isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids	NADP-dependent isocitrate dehydrogenase	Null mutant is viable but is unable to grow on polyunsaturated fatty acids as sole carbon source	YNL009W	S000004954
IDS2		Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation		Null mutations reduce or abolish the ability of IME2p to activate expression of early, middle, and late meiotic genes. Recessive and null ids2 mutants prevent toxicity of Ime2p expression in rad52 haploids, but do not affect Ime2p polypeptide accumulation.	YJL146W	S000003682
IES1		Subunit of the INO80 chromatin remodeling complex			YFL013C	S000001881
IES2		Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions			YNL215W	S000005159
IES3		Subunit of the INO80 chromatin remodeling complex			YLR052W	S000004042
IES4		Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions		Null: non essential.	YOR189W	S000005715
IES5		Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions		Null: non essential.	YER092W	S000000894
IES6		Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions		Null: non essential.	YEL044W	S000000770
IFA38		Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides			YBR159W	S000000363
IFH1		Essential protein with a highly acidic N-terminal domain; IFH1 exhibits genetic interactions with FHL1, overexpression interferes with silencing at telomeres and HM loci; potential Cdc28p substrate		Null mutant is inviable, ifh1 fhl1 double deletion mutant is viable	YLR223C	S000004213
IFM1		Mitochondrial translation initiation factor 2	mitochondrial translation initiation factor	Null mutant is viable but is respiratory-deficient and has defects in mitochondrial protein synthesis	YOL023W	S000005383
IGO1		Hypothetical protein			YNL157W	S000005101
IGO2		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus			YHR132W-A	S000007496
IKI1	ELP5|HAP2|TOT5	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin		Null mutant is viable but is insensitive to pGLK killer toxin; zymotoxin resistant; slow growth; thermo-sensitive above 38 0C; caffeine, Calcofluor White and 6-azauracil sensitive; G1 cell cycle delay	YHR187W	S000001230
IKI2				insensitive to killer toxin		S000029228
IKI3	ELP1|TOT1	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)		Null mutant is viable; insensitive to pGKL killer toxin; zymotoxin resistant; slow growth; thermo-sensitive above 38 0C; caffeine, Calcofluor White and 6-azauracil sensitive; G1 cell cycle delay	YLR384C	S000004376
IKI4				insensitive to killer toxin		S000029229
IKI5				insensitive to killer toxin		S000029230
IKS1		Putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p		Null mutant is heat shock sensitive	YJL057C	S000003593
ILM1		Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth			YJR118C	S000003879
ILP1						S000029231
ILS1		Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A	isoleucyl-tRNA synthetase	Arrests in early G1 at nonpermissive temperature of 36 degrees C	YBL076C	S000000172
ILV1	ISO1	Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation	threonine deaminase		YER086W	S000000888
ILV2	SMR1|THI1	Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control	acetolactate synthase	Isoleucine-plus-valine requiring; Sulfometuron methyl resistance	YMR108W	S000004714
ILV3		Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids	dihydroxyacid dehydratase	Null mutant is viable and requires isoleucine and valine	YJR016C	S000003777
ILV5		Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA	acetohydroxyacid reductoisomerase	Isoleucine-plus-valine requiring	YLR355C	S000004347
ILV6		Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria			YCL009C	S000000515
IMD1		Nonfunctional protein with homology to IMP dehydrogenase; probable pseudogene, located close to the telomere; is not expressed at detectable levels; YAR073W and YAR075W comprise a continuous reading frame in some strains of S. cerevisiae			YAR073W	S000000095
IMD2	PUR5	Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation			YHR216W	S000001259
IMD3		Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed			YLR432W	S000004424
IMD4		Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed			YML056C	S000004520
IME1		Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p		The null mutant is viable. Diploids homozygous for the null mutation lack premeiotic DNA synthesis and do not sporulate; these phenotypes are recessive.	YJR094C	S000003854
IME2	SME1	Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p		Null mutant is viable, homozygous null mutants are sporulation defective. High copy IME2 stimulates meiotic recombination without starvation and permits meiosis in an ime1 null background	YJL106W	S000003642
IME4	SPO8	Probable mRNA N6-adenosine methyltransferase that is required for IME1 transcript accumulation and for sporulation; expression is induced in starved MATa/MAT alpha diploid cells	methyltransferase	Homozygous mutant diploid cannot accumulate IME1 mRNA during early stages of meiosis and cannot sporulate	YGL192W	S000003160
IMG1		Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome	mitochondrial ribosomal large subunit component	Null mutant is viable; respiration deficient	YCR046C	S000000642
IMG2		Mitochondrial ribosomal protein of the small subunit		Null mutant is viable but shows respiratory deficiency and loss of wild-type mtDNA: conversion to rho- and rho zero petites	YCR071C	S000000667
IMH1	SYS3	Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi		Null mutant is viable; imh1 ypt6 double disruption causes growth inhibition	YLR309C	S000004300
IML1		Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane			YJR138W	S000003899
IML2		Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YJL082W	S000003618
IML3	MCM19	Protein with a role in kinetochore function, localizes to the outer kinetochore in a Ctf19p-dependent manner, interacts with Chl4p and Ctf19p		Null mutant is viable, but exhibits chromosome loss and abnormal chromosomal segregation	YBR107C	S000000311
IMP1	PET-TS2858	Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p	inner membrane protease	petite; unable to grow on non-fermentable carbon sources	YMR150C	S000004758
IMP2		Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p	protease		YMR035W	S000004638
IMP2'	IMP2	Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat	transcription factor	Null mutant is viable, Inability to grow on maltose, galactose and raffinose in respiratory-deficient conditions or in the presence of ethidium bromide and erythromycin; leaky phenotype on oxidizable carbon sources: sensitivity to heat shock and sporulation deficiency	YIL154C	S000001416
IMP3		Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA	U3 snoRNP protein	Null mutant is inviable. Depletion of Imp3p prevents the synthesis of mature 18S rRNA.	YHR148W	S000001191
IMP4		Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs	U3 snoRNP protein		YNL075W	S000005019
IMT1		tRNA-IMet; one of four initiator methionine tRNAs in yeast that are functional for translation				S000006665
IMT2		tRNA-IMet; one of four initiator methionine tRNAs in yeast that are functional for translation				S000006667
IMT3		tRNA-IMet; one of four initiator methionine tRNAs in yeast that are functional for translation				S000006663
IMT4		tRNA-IMet; one of four initiator methionine tRNAs in yeast that are functional for translation				S000006660
INH1		Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase, inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has similarity to Stf1p and both Inh1p and Stf1p exhibit the potential to form coiled-coil structures	F1F0 ATP synthase inhibitor	Null mutant is viable; exhibits marked ATP hydrolysis in response to the uncoupler carbonylcyanide-m-chlorophenylhydrazone	YDL181W	S000002340
INM1		Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate			YHR046C	S000001088
INO1	APR1	Inositol 1-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element	L-myo-inositol-1-phosphate synthase	Null mutant is viable, inositol auxotroph	YJL153C	S000003689
INO2	DIE1|SCS1	Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion	helix-loop-helix protein	The null mutant is viable but auxotrophic for inositol and choline. The null mutant can also display aberant cell shape and defects in nuclear segregation. Homozygous mutant ino2 delta-1 diploids fail to sporulate. Other mutant alleles show pleiotropic defects in phospholipid metabolism.	YDR123C	S000002530
INO4		Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain	basic helix-loop-helix (bHLH) protein	The null mutant is viable but auxotrophic for inositol and choline. The null mutant expresses repressed levels of inositol-1-phosphate synthase (INO1) mRNA and exhibits reduced phosphatidylcholine biosynthesis.	YOL108C	S000005468
INO80		ATPase that forms a large complex, containing actin and several actin-related proteins, that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; shows similarity to the Snf2p family of ATPases			YGL150C	S000003118
INP1		Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance			YMR204C	S000004817
INP2		Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene	receptor		YMR163C	S000004773
INP51	SJL1	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth	phosphatidylinositol 4,5-bisphosphate 5-phosphatase	Null mutant is viable, has abnormal vacuoles	YIL002C	S000001264
INP52	SJL2	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in endocytosis; hyperosmotic stress causes translocation to actin patches	inositol polyphosphate 5-phosphatase	Null mutant is viable, has abnormal vacuoles	YNL106C	S000005050
INP53	SJL3|SOP2	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in a TGN (trans Golgi network)-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches	inositol polyphosphate 5-phosphatase	Null mutant is viable but has abnormal vacuoles	YOR109W	S000005635
INP54		Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins	inositol polyphosphate 5-phosphatase		YOL065C	S000005426
IOC2		Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif			YLR095C	S000004085
IOC3		Member of a complex (Isw1a) with Isw1p that has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; has homology to Esc8p, which is involved in silencing			YFR013W	S000001909
IOC4		Member of a complex (Isw1b) with Isw1p and Ioc2p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PWWP motif			YMR044W	S000004647
IPA1				ipa1 mutant has no phenotype, but ipa1 udt1 double mutant accumulates more porphyrin than udt1 mutant		S000029232
IPA2				ipa2 mutant has no phenotype, but ipa2 udt1 double mutant accumulates more porphyrin than udt1 mutant		S000029233
IPA3				ipa3 mutant has no phenotype, but ipa3 udt1 double mutant accumulates more porphyrin than udt1 mutant		S000029234
IPI1		Essential component of the Rix1 complex (with Rix1p and Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles			YHR085W	S000001127
IPI3		Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; highly conserved and contains WD40 motifs; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles			YNL182C	S000005126
IPK1	GSL1	Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable	inositol 1,3,4,5,6-pentakisphosphate 2-kinase	Null mutant is viable but is severely compromised in ability to produce IP6 (100x decrease); null has 100x greater amounts of IP5 and PP-IP4; null also has increased IP3 and IP4; synthetic lethal with gle1-4 (GSL); null has mRNA export defects, fails to grow at 37C after 10 generations	YDR315C	S000002723
IPL1	PAC15	Aurora kinase involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; associates with Sli15p, which promotes Ipl1p association with mitotic spindle	serine/threonine protein kinase	temperature-sensitive mutant lacks proper chromosome segregation at non-permissive temperature	YPL209C	S000006130
IPP1	PPA1	Cytoplasmic inorganic pyrophosphatase (PPase), catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase	inorganic pyrophosphatase		YBR011C	S000000215
IPT1	KTI6|SYR4	Inositolphosphotransferase 1, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), which is the most abundant sphingolipid in cells, mutation confers resistance to the antifungals syringomycin E and DmAMP1 in some growth media	inositolphosphotransferase 1	Null mutant is viable but cannot synthesize M(IP)2C, instead accumulates the precursor, mannose-inositol-P-ceramide, and is slightly resistant to calcium	YDR072C	S000002479
IQG1	CYK1	Essential protein required for determination of budding pattern, promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family		Null mutant is inviable (spores germinate, divide several times and lyse); cells are multinucleate and have defects in cytokinesis, morphology, actin, and tubulin	YPL242C	S000006163
IRA1	GLC1|PPD1	GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase	GTPase activating protein (GAP)	Null mutant is viable, exhibits constitutive activation of the Ras/cyclic AMP (cAMP) pathway, heat shock sensitivity, nitrogen starvation sensitivity, sporulation deficiency, suppresses lethality of cdc25, but not cyr1, ras1, or ras2 mutants	YBR140C	S000000344
IRA2	CCS1|GLC4	GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin	GTPase activating protein (GAP)	Null mutant is viable, exhibits increased sensitivity to heat shock and nitrogen starvation, sporulation defects, and suppression of the lethality of a cdc25 mutants	YOL081W	S000005441
IRC10		Hypothetical protein; null mutant displays increased levels of spontaneous Rad52 foci			YOL015W	S000005375
IRC11		Hypothetical protein; null mutant displays increased levels of spontaneous Rad52 foci			YOR013W	S000005539
IRC12		Hypothetical protein; null mutant displays increased levels of spontaneous Rad52 foci			YOR024W	S000005550
IRC13		Hypothetical protein; null mutant displays increased levels of spontaneous Rad52 foci			YOR235W	S000005761
IRC14		Hypothetical protein; null mutant displays increased levels of spontaneous Rad52 foci			YOR135C	S000005661
IRC15		Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; null mutant displays increased levels of spontaneous Rad52 foci			YPL017C	S000005938
IRC16		Hypothetical protein; null mutant displays increased levels of spontaneous Rad52 foci			YPR038W	S000006242
IRC18		Putative protein of unknown function; expression induced in respiratory-deficient petite cells, in carbon-limited chemostat cultures, during meiosis, sporulation and after alpha factor treatment; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52 foci			YJL037W	S000003574
IRC19	GON2	Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52 foci			YLL033W	S000003956
IRC2		Hypothetical protein, null mutant displays increased levels of spontaneous Rad52 foci			YDR112W	S000002519
IRC20		Putative helicase; localized to mitochondria and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52 foci			YLR247C	S000004237
IRC21		Putative protein of unknown function; proposed to be involved in resistance to carboplatin and cisplatin; shares similarity to a human cytochrome oxidoreductase; null mutant displays increased levels of spontaneous Rad52 foci			YMR073C	S000004677
IRC22		Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52 foci			YEL001C	S000000727
IRC23		Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52 foci			YOR044W	S000005570
IRC24		Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52 foci			YIR036C	S000001475
IRC25		Putative protein of unknown function; mutant accumulates unusually high amounts of dityrosine in the soluble fraction though spores appear wild-type; YLR021W is not an essential gene; null mutant displays increased levels of spontaneous Rad52 foci			YLR021W	S000004011
IRC3		Hypothetical protein; null mutant displays increased levels of spontaneous Rad52 foci			YDR332W	S000002740
IRC4		Hypothetical protein; null mutant displays increased levels of spontaneous Rad52 foci			YDR540C	S000002948
IRC5		Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52 foci			YFR038W	S000001934
IRC6		Hypothetical protein; null mutant displays increased levels of spontaneous Rad52 foci			YFR043C	S000001939
IRC7		Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52 foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner			YFR055W	S000001952
IRC8		Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52 foci			YJL051W	S000003587
IRC9		Hypothetical protein; null mutant displays increased levels of spontaneous Rad52 foci			YJL142C	S000003678
IRE1	ERN1	Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress	serine/threonine protein kinase	Null mutant is viable, myo-inositol auxotroph; IRE1 is essential for viability under stress conditions that cause unfolded proteins to accumulate in the ER	YHR079C	S000001121
IRR1	SCC3	Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability	cohesin complex subunit	Null mutant is inviable; decreased transcription of mutant causes irregularity of zygotes, colonies, decreased adhesion to solid supports	YIL026C	S000001288
IRS4		Protein involved in regulation of phosphatidylinositol 4,5-bisphosphate concentrations; Irs4p and Tax4p bind and activate the phosphatase Inp51p; mutation confers an increase in rDNA silencing		Null mutant is viable and shows increased rDNA silencing	YKR019C	S000001727
ISA1		Mitochondrial matrix protein involved in biogenesis of the iron-sulfur (Fe/S) cluster of Fe/S proteins, isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources			YLL027W	S000003950
ISA2		Protein required for maturation of mitochondrial and cytosolic Fe/S proteins, localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations		null mutant is viable; exhibits dependency on lysine and glutamate for growth, an increase in mitochondrial iron concentration, and a respiratory deficiency due to accumulation of mutations in mitochondrial DNA	YPR067W	S000006271
ISC1		Inositol phosphosphingolipid phospholipase C, hydrolyzes inositolphosphosphingolipids, activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol, mediates Na+ and Li+ halotolerance, contains a P loop-like domain	ISC1 encodes phospholipase C type enzyme which hydrolyzes inositolphosphosphingolipids (IPC, MIPC, M(IP)2C) as well as sphingomyelin.	Null mutant is viable and contains more inositolphosphosphingolipids.	YER019W	S000000821
ISC10		Protein required for sporulation, transcript is induced 7.5 hours after induction of meiosis, expected to play significant role in the formation of reproductive cells		Mutant shows greatly reduced ability to sporulate	YER180C	S000000982
ISD11		Protein required for mitochondrial iron-sulfur cluster biosynthesis			YER048W-A	S000007237
ISF1	MBR3	Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant		Null mutant is viable; overexpression suppresses defects in hap2, hap3, and hap3 mutants; isf1 mbr1 double mutant has synthetic phenotypes	YMR081C	S000004686
ISM1		Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth	mitochondrial isoleucyl-tRNA synthetase	Null mutant is viable but is petite with defects in mitochondrial protein synthesis	YPL040C	S000005961
ISN1		Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms	IMP 5'-Nucleotidase		YOR155C	S000005681
ISR1		Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C	serine/threonine protein kinase	The null mutant is viable but exacerbates the phenotypes of a temperature-sensitive allele (stt1-1) of PKC1.	YPR106W	S000006310
IST1		Putative translation initiation factor, as suggested by computational analysis of large-scale protein-protein interaction data			YNL265C	S000005209
IST2		Plasma membrane protein that may be involved in osmotolerance, localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process			YBR086C	S000000290
IST3	SNU17	Component of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing		Null mutant is viable but exhibits slow growth and a pre-mRNA splicing defect in vivo and in vitro. Deletion caused an immediate and exclusive accumulation of a particle consistent with a pre-mRNA/penta-snRNP complex.	YIR005W	S000001444
ISU1	NUA1	Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable		Null mutant is viable on YPD at 30 degrees C, and is synthetically lethal with isu2 null.	YPL135W	S000006056
ISU2	NUA2	Conserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly; isu1 isu2 double mutant is inviable		Null mutant is viable on YPD at 30 degrees C, and is synthetically lethal with isu1 null.	YOR226C	S000005752
ISW1	SGN2	Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase that forms a complex with Ioc2p and Ioc4p to regulate transcription elongation, and a complex with Ioc3p to repress transcription initiation	ATPase component of a four subunit chromatin remodeling complex	Null mutant is viable, isw1 isw2 chd1 triple deletion mutants are synthetically temperature and formamide sensitive	YBR245C	S000000449
ISW2		Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth	ATPase component of a two subunit chromatin remodeling complex	Null mutant is viable, isw1 isw2 chd1 triple deletion mutants are synthetically temperature and formamide sensitive	YOR304W	S000005831
ISY1	NTC30|UTR3	Component of the spliceosome complex involved in pre-mRNA splicing, auxiliary splicing factor that may modulate Syf1p activity and help optimize splicing; isy1 syf2 double mutation activates the spindle checkpoint, causing cell cycle arrest			YJR050W	S000003811
ITC1		Component of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1		Null mutant is viable, but shows abnormal morphology and reduced mating efficiency when the disruption is in a MATalpha background.	YGL133W	S000003101
ITR1		Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p	myo-inositol transporter		YDR497C	S000002905
ITR2	HRB612	Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively	myo-inositol transporter		YOL103W	S000005463
ITS1-1	ITS1	Non-coding region between RDN58 and RDN18, that is transcribed as part of the 35S rRNA precursor transcript; excision during transcript maturation is coupled with processing of the 3' external transcribed spacer (3'ETS)				S000029715
ITS1-2	ITS1	Non-coding region between RDN58 and RDN18, transcribed as part of the 35S rRNA precursor transcript; excision during transcript maturation is coupled with processing of the 3' external transcribed spacer (3' ETS)				S000029709
ITS2-1	ITS2	Non-coding region between RDN58 and RDN25, that is transcribed as part of the 35S rRNA precursor transcript; forms a stem-loop structure that is required for processing of the precursor transcript				S000029716
ITS2-2	ITS2	Non-coding region between RDN58 and RDN25, transcribed as part of the 35S rRNA precursor transcript; forms a stem-loop structure required for processing of the precursor transcript				S000029712
ITT1		Protein that modulates the efficiency of translation termination, interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins			YML068W	S000004533
IVY1		Phospholipid-binding protein that interacts with both Ypt7p and Vps33p, may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phase			YDR229W	S000002637
IWR1		Protein of unknown function, deletion causes hypersensitivity to the K1 killer toxin			YDL115C	S000002273
IXR1	ORD1	Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b	intrastrand crosslink recognition protein		YKL032C	S000001515
IZH1		Membrane protein involved in zinc metabolism, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc			YDR492W	S000002900
IZH2	PHO36	Plasma membrane protein involved in zinc metabolism and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc			YOL002C	S000005362
IZH3		Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity			YLR023C	S000004013
IZH4		Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism			YOL101C	S000005461
JAC1		Specialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria, involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix		Null mutant is inviable; the jac1-1 mutation caused by a single amino acid deletion of Asp32 can suppress the endogenous oxygen toxicity (methionine and lysine auxotrophies) of sod1 null mutants; jac1-1 exhibits diminished rates of respiratory oxygen consumption and reduced mitochondrial aconitase and succinate dehydrogenase activities	YGL018C	S000002986
JEM1	KAR8	DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2		Null mutant is viable but has karyogamy defect; jem1 scj1 double mutant is temperature sensitive	YJL073W	S000003609
JEN1		Lactate transporter, required for uptake of lactate and pyruvate; expression is derepressed by transcriptional activator Cat8p under nonfermentative growth conditions, and repressed in the presence of glucose, fructose, and mannose		deletion results in slow growth of yeast in synthetic medium supplemented with L-lactate and synergistic with cpr3 null mutation; essential for lactate uptake in yeast	YKL217W	S000001700
JHD1		JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe	JHDM1|histone H3-K36 demethylase		YER051W	S000000853
JHD2		JmjC domain family histone demethylase specific for H3-K4 (lysine at position 4 of the histone H3 protein); removes methyl groups specifically added by Set1p methyltransferase			YJR119C	S000003880
JID1		Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae			YPR061C	S000006265
JIP3		Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2			YLR331C	S000004323
JIP4	YDR474C	Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence			YDR475C	S000002883
JIP5		Nucleolar protein of unknown function, exhibits a physical interaction with Bre1p			YPR169W	S000006373
JJJ1		Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis			YNL227C	S000005171
JJJ2		Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein			YJL162C	S000003698
JJJ3	DPH4	Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein			YJR097W	S000003858
JLP1		Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)			YLL057C	S000003980
JLP2		Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)			YMR132C	S000004739
JNM1	INS1|PAC3	Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B			YMR294W	S000004908
JSN1	PUF1	Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; overexpression suppresses a tub2-150 mutation and causes increased sensitivity to benomyl in wild-type cells		Overexpression suppresses some tub2 alleles and confers greater benomyl sensitivity	YJR091C	S000003851
KAE1		Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex	Putative O-sialo-glycoprotein-endopeptidase A1	Null: gene disruption is lethal	YKR038C	S000001746
KAP104		Transportin, cytosolic karyopherin beta 2 involved in delivery of heterogeneous nuclear ribonucleoproteins to the nucleoplasm, binds rg-nuclear localization signals on Nab2p and Hrp1p, plays a role in cell-cycle progression	karyopherin beta 2	Null mutant is viable at 23 degrees C, but fails to germinate and dies at 30 C, shows severe nuclear envelope defects	YBR017C	S000000221
KAP114		Karyopherin, responsible for nuclear import of Spt15p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear			YGL241W	S000003210
KAP120		Karyopherin with a role in the assembly or export of 60S ribosomal subunits	karyopherin		YPL125W	S000006046
KAP122	PDR6	Karyopherin beta, responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance			YGL016W	S000002984
KAP123	YRB4	Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1	karyopherin beta 4		YER110C	S000000912
KAP95	RSL1	Karyopherin beta, forms a dimeric complex with Srp1p (Kap60p) that mediates nuclear import of cargo proteins via a nuclear localization signal (NLS), interacts with nucleoporins to guide transport across the nuclear pore complex		essential, ts mutant shows nuclear import defect	YLR347C	S000004339
KAR1		Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p		Null mutant is inviable, kar1 mutants are karyogamy defective; defects in KAR1 block spindle pole body duplication; the temperature sensitivity of a kar1 mutant defective for localization to the spindle pole body can be suppressed by CDC31 overexpression or by dominant-acting CDC31 alleles	YNL188W	S000005132
KAR2	GRP78	ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p	BIP	null mutants are inviable; other mutants block karyogamy (nuclear fusion) during mating	YJL034W	S000003571
KAR3	OSR11	Minus-end-directed microtubule motor that functions in mitosis and meiosis, localizes to the spindle pole body and localization is dependent on functional Cik1p, required for nuclear fusion during mating; potential Cdc28p substrate	kinesin-like nuclear fusion protein	Null mutant is viable. Mutations in KAR3 are semidominant and cause pleiotropic effects affecting both mitosis and meiosis. kar3 mutations prevent karyogamy (nuclear fusion).	YPR141C	S000006345
KAR4		Transcription factor required for gene regulation in repsonse to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone	transcription factor	Defective in pheromone-induced expression of KAR3 and CIK1; therefore, defective in nuclear fusion because of defect in microtubule-dependent movement of nuclei; also required for meiosis	YCL055W	S000000560
KAR5	FIG3	Protein required for nuclear membrane fusion during karyogamy, localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; expression of the gene is regulated by pheromone		Null mutant is viable, mating defective, nuclear fusion defective	YMR065W	S000004669
KAR9		Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase		Null mutant is viable; cytoplasmic microtubule orientation defects, nuclear migration defects, benomyl sensitive	YPL269W	S000006190
KCC4		Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p	serine/threonine protein kinase	Null mutant is viable. Deletion of KCC4 causes moderate defects in bud formation at stationary phase; overexpression of KCC4 inhibits cell growth.	YCL024W	S000000529
KCS1		Inositol hexakisphosphate (IP6) kinase, also has inositol heptakisphosphate (IP7) kinase activity, required for proper vacuole morphology and involved in salt stress response; contains two leucine heptad repeats	Inositol polyphosphate kinase	Null mutant is viable; kcs1 ptc1 double mutant is inviable; isolated as a suppressor of a hyper-recombination mutant of PKC1	YDR017C	S000002424
KEG1		Protein of unknown function required for cell viability; localizes to the endoplasmic reticulum membrane			YFR042W	S000001938
KEL1		Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate		The null mutant is viable but shows a moderate defect in cell fusion during mating.	YHR158C	S000001201
KEL2		Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate			YGR238C	S000003470
KEL3		Cytoplasmic protein of unknown function	kelch-repeat protein		YPL263C	S000006184
KEM1	DST2|RAR5|SEP1|SKI1|XRN1	Evolutionarily-conserved 5'-3' exonuclease component of cytoplasmic processing (P) bodies involved in mRNA decay; plays a role in microtubule-mediated processes, filamentous growth, ribosomal RNA maturation, and telomere maintenance	5'-3' exonuclease	<u>K</u>ar1-1 nuclear-fusion-defect <u>E</u>nhancing <u>M</u>utation. Null mutant grows poorly. mutants exhibit aberrant mRNA turnover, are thought to be pleiotropic as a result; elongated morphology, defective in spindle-pole-body duplication/separation and telomere maintenance, benomyl hypersensitive, 10-20-fold elevation in chromosome loss, decreased mitotic recombination, inviable upon N starvation.	YGL173C	S000003141
KEM2				Mutation enhances nuclear fusion defect of kar1-1 yeast during conjugation		S000029235
KEM3				enhance nuclear fusion defect of kar1-1 during conjugation		S000029236
KES1	BSR3|LPI3|OSH4	Member of the oxysterol binding protein family, which includes seven yeast homologs; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex			YPL145C	S000006066
KEX1		Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins	protease	Null mutant is viable and defective in killer expression	YGL203C	S000003171
KEX2	QDS1|SRB1|VMA45	Subtilisin-like protease (proprotein convertase), a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway	Ca2+-dependent serine protease|kexin|yscF	Null mutant is viable and defective in killer expression	YNL238W	S000005182
KGD1	OGD1	Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA	alpha-ketoglutarate dehydrogenase	Null mutant is viable but is deficient in alpha-ketoglutarate dehydrogenase, is therefore respiratory deficient, cannot grow on glycerol, and produces increased amount of organic acids during growth on glucose	YIL125W	S000001387
KGD2		Dihydrolipoyl transsuccinylase, a component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA	alpha-ketoglutarate dehydrogenase complex dihydrolipoyl transsuccinylase component	Null mutant is viable but is respiratory deficient (pet-), and its mitochondria are unable to catalyze the reduction of NAD+ by alpha-ketoglutarate	YDR148C	S000002555
KHA1		Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies			YJL094C	S000003630
KHR1			killer toxin			S000029237
KIC1	NRK1	Protein kinase of the PAK/Ste20 kinase family, required for cell integrity possibly through regulating 1,6-beta-glucan levels in the wall; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body			YHR102W	S000001144
KIN1		Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p		Null mutant is viable and shows no obvious phenotypes	YDR122W	S000002529
KIN2		Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin1p			YLR096W	S000004086
KIN28		Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters	transcription initiation factor TFIIH subunit		YDL108W	S000002266
KIN3	FUN52|NPK1	Nonessential protein kinase with unknown cellular role	serine/threonine protein kinase		YAR018C	S000000071
KIN4	KIN3|KIN31	Kinase that acts by inhibiting the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck	serine/threonine protein kinase		YOR233W	S000005759
KIN82		Putative serine/threonine protein kinase, most similar to cyclic nucleotide-dependent protein kinase subfamily and the protein kinase C subfamily			YCR091W	S000000687
KIP1	CIN9	Kinesin-related motor protein required for mitotic spindle assembly and chromosome segregation; functionally redundant with Cin8p		Null mutant is viable; kip1 cin8 double deletion mutants are inviable	YBL063W	S000000159
KIP2		Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle			YPL155C	S000006076
KIP3		Kinesin-related motor protein involved in mitotic spindle positioning		defective in pre-anaphase nuclear migration	YGL216W	S000003184
KIT12						S000029238
KKQ8		Putative serine/threonine protein kinase with unknown cellular role			YKL168C	S000001651
KNH1		Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant		Null mutant is viable; overexpression suppresses kre9 mutation; knh1 kre9 double mutant is inviable	YDL049C	S000002207
KNS1	L124	Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues			YLL019C	S000003942
KOG1	LAS24	Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors			YHR186C	S000001229
KRE1		Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor		Null mutant is viable, exhibits reduction in cell wall (1--6)-beta-glucan	YNL322C	S000005266
KRE10				recessive mutation leading to killer toxin resistance		S000029239
KRE11	TRS65	Protein involved in biosynthesis of cell wall beta-glucans; subunit of the TRAPP (transport protein particle) complex, which is involved in the late steps of endoplasmic reticulum to Golgi transport		Null mutant is viable; killer toxin resistant; reduced levels of 1,6-beta-glucan in cell wall	YGR166W	S000003398
KRE2	MNT1	Alpha1,2-mannosyltransferase of the Golgi involved in protein mannosylation	alpha-1,2-mannosyltransferase		YDR483W	S000002891
KRE27		Protein of unknown function; null mutant shows K1 killer toxin resistance		K1 killer toxin resistance	YIL027C	S000001289
KRE29		Essential subunit of the Mms21-Smc5-Smc6 complex; protein of unknown function; required for growth and DNA repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance			YER038C	S000000840
KRE33		Essential protein of unknown function; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance		Heterozygous diploid mutant exhibit haploinsufficiency K1 killer toxin resistance	YNL132W	S000005076
KRE5		Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects		Null mutant is viable but has aberrant morphology, reduced levels of cell wall (1,6)-beta-glucan, and extremely compromised growth	YOR336W	S000005863
KRE6	CWH48	Protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; appears functionally redundant with Skn1p		Null mutant is viable, slow growing, killer toxin-resistant, possesses half the normal level of wild-type cell wall (1-->6) beta-glucan)	YPR159W	S000006363
KRE9		Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects		Null mutant is viable, associated with growth defects, altered cell wall, aberrant multiply budded morphology, mating defects; exhibits double mutant lethality in combination with knh1, kre1, kre6, or kre11 mutants; killer toxin resistant; reduction in cell wall (1----6)-beta-glucan	YJL174W	S000003710
KRI1		Essential nucleolar protein required for 40S ribosome biogenesis; physically and functionally interacts with Krr1p			YNL308C	S000005252
KRR1		Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit			YCL059C	S000000564
KRS1	GCD5	Lysyl-tRNA synthetase; also identified as a negative regulator of general control of amino acid biosynthesis	lysyl-tRNA synthetase	Null mutant is inviable; mutants can show resistance to 5-methyltryptophan, 5-fluorotryptophan and canavanine; constitutive derepression and slow growth; posttranscriptional increase in histidine biosynthetic enzyme activity	YDR037W	S000002444
KSL1				Kinetochore synthetic lethal of CTF13		S000029240
KSP1		Nonessential putative serine/threonine protein kinase of unknown cellular role; overproduction causes allele-specific suppression of the prp20-10 mutation			YHR082C	S000001124
KSS1		Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response	MAP kinase kinase (MEK)		YGR040W	S000003272
KTI11	DPH3	Protein required for synthesis of diphthamide, a modified histidine residue of translation elongation factor 2; functions with Dph1p, Dph2p, Jjj3p, and Dph5p; required, with Elongator complex, for modification of wobble nucleosides in tRNA			YBL071W-A	S000007587
KTI12	TOT4	Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p		resistant to Kluyveromyces lactis toxin; over expression also results in resistance to Kluyveromyces lactis toxin; zymotoxin resistant; slow growth; thermo-sensitive above 38C; caffeine; Calcofluor White and 6-azauracil sensitive; G1 cell cycle delay	YKL110C	S000001593
KTR1		Alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family	type II transmembrane protein		YOR099W	S000005625
KTR2		Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family		Null mutant is viable, with partial resistance to killer toxin	YKR061W	S000001769
KTR3		Putative alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family			YBR205W	S000000409
KTR4		Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family			YBR199W	S000000403
KTR5		Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family			YNL029C	S000004974
KTR6	MNN6	Probable mannosylphosphate transferase involved in the synthesis of core oligosaccharides in protein glycosylation pathway; member of the KRE2/MNT1 mannosyltransferase family	mannosylphosphate transferase	Null mutant is viable, hypersensitive to Calcofluor White and hygromycin B; shows less binding to Alcian blue, and diminished mannosylphosphate transferase activity toward the ER core oligosaccharide acceptors, displays a decrease in polymannose outer chain phosphorylation. mnn4, ktr6 mutations affect mannosylphosphorylation of O-linked oligosaccharide, together with that of N-linked oligosaccharide.	YPL053C	S000005974
KTR7		Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family			YIL085C	S000001347
LAA1		AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene			YJL207C	S000003743
LAC1	DGT1	Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p		Null mutant is viable but exhibits synthetic lethality with mutations in lag1.	YKL008C	S000001491
LAG1		Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p			YHL003C	S000000995
LAG2	ECM36	Protein involved in determination of longevity; LAG2 gene is preferentially expressed in young cells; overexpression extends the mean and maximum life span of cells		A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white; Null mutant is viable but shows 50% reduction in mean and maximum life span; overexpression increases mean and maximum life span	YOL025W	S000005385
LAI1		L-A Independant		A growth advantage on ethanol at high temperature, which can be complimented by the presence of the L-A virus.		S000029241
LAI2		L-A Independant		A growth advantage on ethanol at high temperature, which can be complimented by the presence of the L-A virus.		S000029242
LAP3	BLH1|GAL6|YCP1	Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH	aminopeptidase of cysteine protease family	Null mutant is viable with no obvious growth defects but is leucine aminopeptidase deficient and hypersensitive to bleomycin; overexpression confers resistance to bleomycin	YNL239W	S000005183
LAP4	APE1|API|YSC1	Vacuolar aminopeptidase, often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway	vacuolar aminopeptidase ysc1	Leucine aminopeptidase deficient	YKL103C	S000001586
LAR1		Lead Acetate Responsive		Other phenotypes: deletion of gene results in altered response to lead acetate		S000029243
LAS1		Essential nuclear protein possibly involved in bud formation and morphogenesis; mutants require the SSD1-v allele for viability			YKR063C	S000001771
LAS17	BEE1	Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP)	actin assembly factor	Null mutant is viable, demonstrates impaired budding and cytokenesis and severely disrupted cortical actin; other mutants accumulate secretory vesicles in the bud	YOR181W	S000005707
LAS21	GPI7	Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity		Null mutant is viable but is temperature-sensitive. The las21-1 strain is sensitive to tetracaine, but the null las21 mutant is no longer sensitive to tetracaine. Defective in GPI anchor synthesis; sensitive to calcofluor white and hygromycin B	YJL062W	S000003598
LAT1	ODP2|PDA2	Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase component (E2)		YNL071W	S000005015
LCB1	END8|TSC2	Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine	serine palmitoyltransferase component	Null mutant is auxotrophic for long-chain component of sphingolipids; homozygous lcb1 diploids fail to sporulate	YMR296C	S000004911
LCB2	SCS1|TSC1	Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine	serine palmitoyltransferase component	Auxotrophic for long-chain component of sphingolipids; some mutations can suppress the Ca2+-sensitive mutant csg2	YDR062W	S000002469
LCB3	LBP1|YSR2	Long-chain base-1-phosphate phosphatase, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids	dihydrosphingosine-1-phosphate phophatase	Null mutant is viable, has reduced rate of exogenous long chain base incorporation into sphingolipids, increased resistance to growth inhibition by long chain bases	YJL134W	S000003670
LCB4		Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes	sphingoid long chain base (LCB) kinase	Null mutant is viable, exhibts 2-3% of wild-type LCB kinase activity; lcb4 is an extragenic suppressor of the sphingosine-sensitive phenotype of a dpl1 deletion mutation; lcb4 lcb5 double deletion mutants exhibit no LCB kinase activity	YOR171C	S000005697
LCB5		Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules	sphingoid long chain base (LCB) kinase	Null mutant is viable, exhibits ~97% of wild-type LCB kinase activity; lcb4 lcb5 deletion mutants exhibit no LCB kinase activity. Cells lacking Lcb5p are two-fold less resistant to killing when log-phase cells are induced for thermotolerance.	YLR260W	S000004250
LCD1	DDC2|PIE1	Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP		Null mutant is inviable. Null mutant is rescued by deletion of SML1, but deletion of SML1 does not suppress the hypersensitivity to DNA damaging agents caused by the absence of DDC2.	YDR499W	S000002907
LCP1		synthetic lethal with pap1-7				S000029244
LCP2		synthetic lethal with pap1-7				S000029245
LCP3		synthetic lethal with pap1-7				S000029246
LCP4		synthetic lethal with pap1-7				S000029247
LCP5		Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus		Null mutant is inviable; there is also a temperature sensitive mutant defective in rRNA processing and translation	YER127W	S000000929
LDB16		Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria			YCL005W	S000000511
LDB17		Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; null mutant shows a reduced affinity for the alcian blue dye suggesting a decreased net negative charge of the cell surface			YDL146W	S000002305
LDB18		Protein of unknown function; null mutant shows a reduced affinity for the alcian blue dye suggesting a decreased net negative charge of the cell surface			YLL049W	S000003972
LDB19		Protein of unknown function involved in maintenance of proper telomere length; null mutant shows a reduced affinity for the alcian blue dye suggesting a decreased net negative charge of the cell surface			YOR322C	S000005849
LDB7	RSC14	Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions		Null: The mutant shows reduced affinity by the alcian blue dye which indicates a decrease in the negative charge of the cell surface.	YBL006C	S000000102
LDR1		Identified in a screen for mutants that fail to localize the soluble Mnn1p lumenal domain to the Golgi				S000029248
LEA1		Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; invovled in telomere maintenance; putative homolog of human U2A' snRNP protein		Null mutant is viable but grows slowly and is temperature sensitive. Null mutant also exhibits defects in spliceosome formation.	YPL213W	S000006134
LEE1		Zinc-finger protein of unknown function			YPL054W	S000005975
LEM3	BRE3|ROS3	Membrane protein of the plasma membrane and ER, involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane		Null mutant sensitive to brefeldin A, shows increased glucocorticoid receptor activity in response to dexamethasone. Disruption showed marked decrease in internalization of phosphatidylethanolamine and phosphatidylcholine.	YNL323W	S000005267
LEO1		Component of the Paf1 complex, which associates with RNA polymerase II and is involved in histone methylation			YOR123C	S000005649
LET1				let1 mutations completely inactivate the high-affinity leucine transport system		S000029249
LET1M				lethal		S000029250
LET2				let1 let2 mutants are trifluoroleucine-resistant; the let2 mutation causes a marked decrease in the Jmax of the low-affinity transport system of leucine		S000029251
LET3				lethal		S000029252
LET5				lethal		S000029253
LET6				lethal		S000029254
LEU1		Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway	isopropylmalate isomerase	Leucine requiring	YGL009C	S000002977
LEU2		Beta-isopropylmalate dehydrogenase, catalyzes the third step in the leucine biosynthesis pathway	beta-IPM (isopropylmalate) dehydrogenase	Null mutant is viable, leucine auxotroph	YCL018W	S000000523
LEU3		Zinc-finger transcription factor that regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; positively regulated by alpha-isopropylmalate, an intermediate in leucine biosynthesis	transcription factor	Null mutant is viable, leaky leucine auxotroph	YLR451W	S000004443
LEU4		Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway	alpha-isopropylmalate synthase (2-isopropylmalate synthase)	Null mutant is viable, Leu+	YNL104C	S000005048
LEU5		Mitochondrial carrier protein involved in the accumulation of CoA in the mitochondrial matrix; homolog of human Graves disease protein; does not encode an isozyme of Leu4p, as first hypothesized		Null mutant is viable; leu5 mutant is not a leucine auxotroph unless in a leu4 background; glycerol auxotrophy	YHR002W	S000001044
LEU6				leu4 leu6 double mutant show leucine auxotrophy		S000029255
LEU7				leu4 leu7 double mutant show leucine auxotrophy		S000029256
LEU8				leu4 leu8 double mutant show leucine auxotrophy		S000029257
LEU9		Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant	alpha-isopropylmalate synthase (2-isopropylmalate synthase)		YOR108W	S000005634
LGE1		Protein of unknown function; null mutant forms abnormally large cells		Null: large cell size. Other phenotypes: synthetic lethal with swi4	YPL055C	S000005976
LGN1				lgn1 mutants are unable to significantly derepress high- affinity (low-Km) glucose uptake		S000029258
LGN2				lgn2 mutants exhibit elevated repressed levels of high-affinity glucose uptake that either derepress to normal or near normal levels of high-affinity uptake with loss of low-affinity transport		S000029259
LGN3				lgn3 mutants exhibit elevated repressed levels of high-affinity glucose uptake that either derepress to normal or near normal levels of high-affinity uptake with loss of low-affinity transport		S000029260
LGN5				lgn5 mutants are unable to significantly derepress high-affinity (low-Km) glucose uptake		S000029261
LGN6				lgn6 mutants exhibit elevated repressed levels of high-affinity glucose uptake and derepress only slightly, appearing to have an intermediate yet constitutive level of high-affinity transport		S000029262
LGN7				lgn7 mutants are unable to significantly derepress high-affinity (low-Km) glucose uptake		S000029263
LGN8				lgn8 mutants are unable to significantly derepress high-affinity (low-Km) glucose uptake		S000029264
LGN9				lgn9 mutants exhibit elevated repressed levels of high-affinity glucose uptake and derepress only slightly, appearing to have an intermediate yet constitutive level of high-affinity transport		S000029265
LHP1	LAH1|YLA1	RNA binding protein required for maturation of tRNA and snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen	La protein		YDL051W	S000002209
LHS1	CER1|SSI1	Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; member of the Hsp70 family; localizes to the lumen of the ER; regulated by the unfolded protein response pathway			YKL073W	S000001556
LIA1	MMD1	Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyses hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning			YJR070C	S000003831
LIF1		Protein involved in DNA double-strand break repair; physically interacts with DNA ligase 4 (Lig4p); homologous to mammalian XRCC4 protein		Null mutant is viable but is deficient in non-homologous double-strand break repair; inefficient in sporulation; LIG4 protein destabilization	YGL090W	S000003058
LIN1	SNU40	Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication			YHR156C	S000001199
LIP1		Ceramide synthase subunit; single-span ER membrane protein associated with Lag1p and Lac1p and required for ceramide synthase activity, null mutant grows extremely slowly and is defective in ceramide synthesis			YMR298W	S000004913
LIP2		Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups	Lipoyl ligase	Slow growth with glycine as a sole nitrogen source; Slow growth with glycerol as a sole carbon source, rescued by addition of ethanol	YLR239C	S000004229
LIP5		Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase	lipoic acid synthase	Null mutant is viable; cannot synthesize lipoic acid; grows slowly on ethanol-rich media; barely grows on glyerol-rich media; undergoes a high frequency of mitochondrial DNA deletions	YOR196C	S000005722
LOC1		Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles		Mutant exhibits slow growth at 30C	YFR001W	S000001897
LOS1		Nuclear pore protein involved in nuclear export of pre-tRNA	exportin-t	Null mutant is viable but is defective in pre-tRNA splicing at 37 degrees	YKL205W	S000001688
LOT5		Protein of unknown function; gene expression increases in cultures shifted to a lower temperature			YKL183W	S000001666
LOT6		FMN-dependent NAD(P)H:quinone reductase that may be involved in quinone detoxification; gene expression increases in cultures shifted to a lower temperature			YLR011W	S000004001
LPD1	HPD1	Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes	dihydrolipoamide dehydrogenase precursor (mature protein is the E3 component of alpha-ketoacid dehydrogenase complexes)	unable to utilize glycine as sole nitrogen source	YFL018C	S000001876
LPE10		Mitochondrial inner membrane magnesium transporter, involved in maintenance of magnesium concentrations inside mitochondria; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p			YPL060W	S000005981
LPP1		Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA	lipid phosphate phosphatase		YDR503C	S000002911
LRE1		Protein involved in control of cell wall structure and stress response; inhibits Cbk1p protein kinase activity; overproduction confers resistance to cell-wall degrading enzymes		Null mutant is viable; overexpression of both LRE1 and PBN1 confers resistance to laminarinase, which specifically degrades cell wall beta(1,3) glucan linkages	YCL051W	S000000556
LRG1		Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis			YDL240W	S000002399
LRO1		Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase	phospholipid:diacylglycerol acyltransferase		YNR008W	S000005291
LRP1	RRP47|YC1D	Substrate-specific nuclear cofactor for exosome activity in the processing of stable RNAs; required for telomere length maintenance; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination			YHR081W	S000001123
LRS4		Protein involved in rDNA silencing; positively charged coiled-coil protein with limited similarity to myosin		loses rDNA silencing	YDR439W	S000002847
LSB1		Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization			YGR136W	S000003368
LSB3	YFR024C	Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization			YFR024C-A	S000002968
LSB5		Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization			YCL034W	S000000539
LSB6		Phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization			YJL100W	S000003636
LSC1		Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate		Null mutant is viable but grows slowly on minimal glycerol or pyruvate; mutant suppresses idh2 null mutants for growth on glycerol	YOR142W	S000005668
LSC2		Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate		Null mutant is viable but grows slowly on minimal glycerol or pyruvate; mutant suppresses idh2 null mutants for growth on glycerol	YGR244C	S000003476
LSG1	KRE35	Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm			YGL099W	S000003067
LSM1	SPB8	Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs		absence of LSM1p leads to the accumulation of deadenylated capped mRNAs and also suppresses a PAB1 deletion.	YJL124C	S000003660
LSM12		Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS			YHR121W	S000001163
LSM2	SMX5|SNP3	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA	snRNA-associated protein, Sm class		YBL026W	S000000122
LSM3	SMX4|USS2	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA	snRNP protein		YLR438C-A	S000006434
LSM4	SDB23|USS1	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA		Null mutant is inviable. LSM4p depleted cells have reduced levels of U6 snRNA	YER112W	S000000914
LSM5		Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA	snRNP protein		YER146W	S000000948
LSM6		Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA	snRNP protein		YDR378C	S000002786
LSM7		Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA	snRNP protein		YNL147W	S000005091
LSM8		Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA	snRNP protein		YJR022W	S000003783
LSP1		Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways			YPL004C	S000005925
LSR1	snR20	U2 snRNA, component of the spliceosome; pairs with the branchpoint sequence; functionally equivalent to mammalian U2 snRNA	U2 snRNA			S000006478
LST4		Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface		very low activity of the nitrogen-regulated permeases Gap1p and Put4p on poor nitrogen sources; lst4-1 behaves as a complete kanMX knockout for the phenotypes tested so far	YKL176C	S000001659
LST7		Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface		Reduced activity of the nitrogen-regulated permeases Gap1p and Put4p	YGR057C	S000003289
LST8		Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat		Reduced activity of a broad set of amino acid permeases	YNL006W	S000004951
LTE1	MSI2	Putative GDP/GTP exchange factor required for mitotic exit at low temperatures; acts as a guanine nucleotide exchange factor (GEF) for Tem1p, which is a key regulator of mitotic exit; physically associates with Ras2p-GTP		lethal at low temperature (8 degrees C)	YAL024C	S000000022
LTP1		Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine	protein tyrosine phosphatase		YPR073C	S000006277
LTS1				Low temperature sensitive		S000029266
LTS10				Low temperature sensitive		S000029267
LTS3				Low temperature sensitive		S000029268
LTS4				Low temperature sensitive		S000029269
LTV1	YKL2	Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature			YKL143W	S000001626
LUC7	EPE1|EXM2	Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site		Null mutant is inviable; luc7 mutants exhibit synthetic lethality with the Cap-Binding Complex	YDL087C	S000002245
LUG1		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene			YCR087C-A	S000007223
LUP1		Possible regulatory component of an ammonium-regulated hydrophobic amino acid uptake system		leu2-3, 112 lup1 cells are able to grow on meda containing limited leucine		S000029270
LYP1		Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids	lysine permease		YNL268W	S000005212
LYS1		Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway		Lysine requiring	YIR034C	S000001473
LYS12	LYS10|LYS11	Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate	homo-isocitrate dehydrogenase	Null mutant is viable but shows decreased growth in the absence of lysine	YIL094C	S000001356
LYS14		Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer		Lysine requiring	YDR034C	S000002441
LYS15						S000029271
LYS2		Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p	alpha aminoadipate reductase	Null mutant is viable, lysine auxotroph	YBR115C	S000000319
LYS20		Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys21p	homocitrate synthase	Null mutant is viable, is able to grow on minimal media, and exhibits reduced but significant homocitrate synthase activity	YDL182W	S000002341
LYS21		Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys20p	homocitrate synthase		YDL131W	S000002289
LYS4	LYS3	Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway	homoaconitase	Lysine requiring	YDR234W	S000002642
LYS5		Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine	alpha aminoadipate reductase phosphopantetheinyl transferase	Lysine requiring	YGL154C	S000003122
LYS9	LYS13	Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, which is the seventh step in lysine biosynthesis pathway		lysine auxotroph	YNR050C	S000005333
MAB1		Maintenance of bromovirus functions		An uncharacterized mutant allele inhibits Brome mosaic virus (BMV) gene expression.		S000029272
MAB2		Maintenance of bromovirus functions		An uncharacterized mutant allele inhibits Brome mosaic virus (BMV) gene expression.		S000029273
MAB3		Maintenance of bromovirus functions		An uncharacterized mutant allele inhibits Brome mosaic virus (BMV) gene expression.		S000029274
MAC1	CUA1	Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport	metal-binding transcriptional activator	Null mutant is viable, has a defect in the plasma membrane Cu(II) and Fe(III) reductase activity, ais slow growing, respiratory deficient, and hypersensitive to heat and exposure to cadmium, zinc, lead and H2O2	YMR021C	S000004623
MAD1		Coiled-coil protein involved in the spindle-assembly checkpoint; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p			YGL086W	S000003054
MAD2		Component of the spindle-assembly checkpoint complex, which delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p	spindle checkpoint complex subunit		YJL030W	S000003567
MAD3		Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover	spindle checkpoint complex subunit	Null mutant is viable, benomyl/nocodazole sensitive	YJL013C	S000003550
MAE1		Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids	malic enzyme	null mutant exhibits no malic enzyme activity and synthetic phenotypes with pyk1 and pyk2 mutations	YKL029C	S000001512
MAF1		Negative regulator of RNA polymerase III; component of several signaling pathways that repress polymerase III transcription in response to changes in cellular environment; targets the initiation factor TFIIIB		Mislocalizes Mod5p to the nucleus. tRNA levels are elevated in maf1 mutant cells.	YDR005C	S000002412
MAG1	MMS5	3-methyl-adenine DNA glycosylase involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired	3-methyladenine DNA glycosylase	Null mutant is viable, deficient in 3-methyladenine DNA glycosylase activity and shows enhanced sensitivity to several monofunctional alkylating agents	YER142C	S000000944
MAG2		Cytoplasmic protein of unknown function predicted to encode a DNA-3-methyladenine glycosidase II that catalyzes the hydrolysis of alkylated DNA			YLR427W	S000004419
MAH1						S000122554
MAK10		Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible			YEL053C	S000000779
MAK11		Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats		Null mutant is inviable, mak11-1 mutants result in specific loss of M1 double stranded RNA	YKL021C	S000001504
MAK12				deficient in maintenance of killer		S000029275
MAK13				deficient in maintenance of killer		S000029276
MAK14				deficient in maintenance of killer		S000029277
MAK15				deficient in maintenance of killer		S000029278
MAK16		Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus		Null mutant is inviable, conditional mutants arrest at G(sub)1, are deficient in maintenance of killer M1 double-stranded RNA	YAL025C	S000000023
MAK19				deficient in maintenance of killer		S000029279
MAK20				deficient in maintenance of killer		S000029280
MAK21	NOC1	Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein		deficient in maintenance of killer	YDR060W	S000002467
MAK22				deficient in maintenance of killer		S000029281
MAK24				deficient in maintenance of killer		S000029282
MAK26				deficient in maintenance of killer		S000029283
MAK27				deficient in maintenance of killer		S000029284
MAK3		Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus	N-acetyltransferase	deficient in maintenance of killer	YPR051W	S000006255
MAK31	LSM9|SMX1	Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family		Mutant exhibits defects in the structural stability of L-A family of dsRNA-containing viral particles.	YCR020C-A	S000000614
MAK32		Protein necessary for structural stability of L-A double-stranded RNA-containing particles			YCR019W	S000000612
MAK4				deficient in maintenance of killer		S000029285
MAK5		Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits		deficient in maintenance of killer	YBR142W	S000000346
MAK6	LTS5			deficient in maintenance of killer		S000029286
MAK9				deficient in maintenance of killer		S000029287
MAL1				Defective maltose fermentation		S000029680
MAL11	AGT1	Maltose permease, inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters	hexose transporter|maltose permease	Mutant is defective in maltose fermentation.	YGR289C	S000003521
MAL12		Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus	maltase	Defective maltose fermentation	YGR292W	S000003524
MAL13		MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C	MAL-activator protein	defective maltose fermentation	YGR288W	S000003520
MAL2				Defective maltose fermentation		S000029656
MAL21		Part of the complex locus MAL2	maltose permease	Defective maltose fermentation		S000029681
MAL22		Part of the complex locus MAL2	maltase	Defective maltose fermentation		S000029682
MAL23		Part of the complex locus MAL2	MAL-activator protein	Defective maltose fermentation		S000029657
MAL3		Multigene complex that encodes the MAL33 trans-acting MAL-activator, MAL31 maltose permease, and MAL32 maltase		defective maltose fermentation		S000029683
MAL31	MAL3T	Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C	maltose permease	Defective maltose fermentation	YBR298C	S000000502
MAL32	MAL3S	Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C	maltase	Defective maltose fermentation	YBR299W	S000000503
MAL33	MAL3R	MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C	MAL-activator protein	Defective maltose fermentation	YBR297W	S000000501
MAL34				Defective maltose fermentation		S000029684
MAL4				defective maltose fermentation		S000029685
MAL41		Part of the complex locus MAL4	maltose permease	defective maltose fermentation		S000029686
MAL42		Part of the complex locus MAL4	maltase	defective maltose fermentation		S000029687
MAL43		Part of the complex locus MAL4	MAL-activator protein	defective maltose fermentation		S000029688
MAL6				Defective maltose fermentation		S000029689
MAL61		Part of the complex locus MAL6	maltose permease	Defective maltose fermentation		S000029658
MAL62		Part of the complex locus MAL6	alpha-glucosidase|maltase	Defective maltose fermentation		S000029690
MAL63		Part of the complex locus MAL6	MAL-activator protein|transcription factor	Null mutant is viable, unable to ferment maltose		S000029659
MAL64		MAL64 is a nonfunctional homolog of MAL63				S000029691
MAM1		Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle	Monopolin	Null: Null mutant is viable; sister kinetochores orient towards opposite spindle poles in meiosis I (as opposed to wt where homologous kinetochores orient towards the opposite spindle poles and sister kinetochores orient towards the same spindle pole)	YER106W	S000000908
MAM3		Protein required for normal mitochondrial morphology, has similarity to hemolysins			YOL060C	S000005421
MAM33		Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R			YIL070C	S000001332
MAP1		Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p	methionine aminopeptidase		YLR244C	S000004234
MAP2		Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p	methionine aminopeptidase 2	Null mutant is viable, map1 map2 double null mutant is inviable	YBL091C	S000000187
MAS1	MIF1	Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins	mitochondrial processing protease beta subunit	Null mutant is inviable; Elevated mitotic recombination and chromosomal missegregation when overproduced	YLR163C	S000004153
MAS2	MIF2	Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins	mitochondrial processing protease alpha subunit		YHR024C	S000001066
MAS6	MIM23|MPI3|TIM23	Essential protein of the mitochondrial inner membrane, component of the mitochondrial import system		Null mutant is inviable; conditional mutants accumulate mitochondrial precursor proteins at restrictive temperature	YNR017W	S000005300
MAT		Mating type locus; note that the systematic sequence in SGD contains MATalpha sequences				S000029699
MATA1	A1	Expressed copy (at MATa) of a1; homeobox-domain protein that, along with alpha2, represses transcription of haploid-specific genes in diploid cells; a1 sequence is not present in SGD because the sequenced S288C strain is MATalpha, not MATa	homeobox transcription factor	Null mutant is viable and shows mating defect (in MATa strains); diploids in which a1 is mutated at MAT cannot undergo meiosis and sporulation		S000029660
MATA2	A2	Protein of unknown function, identical to the C-terminal 119 amino acid residues of the MATalpha2 protein; a2 sequence is not present in SGD because the sequenced S288C strain is MATalpha, not MATa				S000029661
MATALPHA1	ALPHA1	Transcriptional co-activator involved in regulation of mating-type-specific gene expression; targets the transcription factor Mcm1p to the promoters of alpha-specific genes; one of two genes encoded by the MATalpha mating type cassette	transcription factor		YCR040W	S000000636
MATALPHA2	ALPHA2	Homeobox-domain protein that, with Mcm1p, represses a-specific genes in haploids; acts with A1p to repress transcription of haploid-specific genes in diploids; one of two genes encoded by the MATalpha mating type cassette			YCR039C	S000000635
MBA1		Protein involved in assembly of mitochondrial respiratory complexes; may act as a receptor for proteins destined for export from the mitochondrial matrix to the inner membrane		Null mutant is viable, conditionally defective in the assembly of mitochondrial respiratory complexes	YBR185C	S000000389
MBB1		Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies			YJL199C	S000003735
MBF1	SUF13	Transcriptional coactivator that bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations		Null mutant is viable, shows reduced transcription of HIS3<br> suppresses frameshift mutation	YOR298C-A	S000007253
MBP1		Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes	transcription factor		YDL056W	S000002214
MBR1		Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants		Null mutant is viable, shows defective growth on glycerol	YKL093W	S000001576
MCA1	YCA1	Putative cysteine protease similar to mammalian caspases, involved in regulation of apoptosis upon hydrogen peroxide treatment			YOR197W	S000005723
MCD1	PDS3|RHC21|SCC1	Essential protein required for sister chromatid cohesion in mitosis and meiosis; subunit of the cohesin complex; expression is cell cycle regulated and peaks in S phase		Null mutant is inviable; temperature sensitive mutants are defective in mitotic sister chromatid cohesion and mitotic chromosome condensation; multicopy suppressor of smc1-2 mutation	YDL003W	S000002161
MCD4	FSR2|SSU21|ZRG16	Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes		Null mutant is inviable; viability dependent on a functionnal morphogenesis checkpoint. Mutation affects transport and incorporation into cell wall of the major non-GPI yeast cross-linker--endoglucanaseglucanosyltransferase Bgl2p.	YKL165C	S000001648
MCH1		Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport			YDL054C	S000002212
MCH2		Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport			YKL221W	S000001704
MCH4		Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport			YOL119C	S000005479
MCH5		Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport			YOR306C	S000005833
MCK1	YPK1	Protein serine/threonine/tyrosine (dual-specificity) kinase involved in control of chromosome segregation and in regulating entry into meiosis; related to mammalian glycogen synthase kinases of the GSK-3 family	serine/threonine/tyrosine protein kinase		YNL307C	S000005251
MCM1	FUN80	Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes	transcription factor	Null mutant is inviable, Pro97Leu mutant is sterile, exhibits defects in minichromosome maintenance	YMR043W	S000004646
MCM10	DNA43	Essential chromatin-associated protein involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication origins			YIL150C	S000001412
MCM16		Protein involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA		Null mutant is viable, exhibits increased sensitivity to the anitmitotic drugs benomyl and thiabenzadole; exhibits a high rate of chromosome III loss without a significant increase in recombination frequency, may exhibit altered kinetochore assembly	YPR046W	S000006250
MCM2		Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex		Null mutant is inviable, at nonpermissive temperature mcm2(ts) mutants arrest with a large bud and a single nucleus, with < 2N DNA content, and exhibit a high rate of recombination; mcm2 mutants are defective in minichromosome maintenance; mcm2-1 cdc45-1 mutants are synthetically lethal	YBL023C	S000000119
MCM21	CTF5	Protein involved in minichromosome maintenance; component of the COMA complex (Ctf19p, Okp1p, Mcm21p, Ame1p) that bridges kinetochore subunits that are in contact with centromeric DNA and the subunits bound to microtubules		Null mutant is viable but exhibits defects in the stability of minichromosomes. Mutants also exhibit elevated rates of chromosome loss (but not those of recombination) and are hypersensitive to the anti-mitotic drug benomyl.	YDR318W	S000002726
MCM22		Protein involved in minichromosome maintenance; component of the kinetochore; binds to centromeric DNA in a Ctf19p-dependent manner			YJR135C	S000003896
MCM3		Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex		Null mutant is inviable, at nonpermissive temperature mcm3(ts) mutants arrest with a large bud and a single nucleus and exhibit a high rate of recombination; mcm3 mutants are defective in minichromosome maintenance; mcm3-1 cdc45-1 mutants are synthetically lethal	YEL032W	S000000758
MCM6		Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex			YGL201C	S000003169
MCR1		Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis	NADH-cytochrome b5 reductase		YKL150W	S000001633
MCS2						S000029288
MCS3						S000029289
MCS4						S000029290
MCT1		Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling	malonyl-CoA:ACP transferase	Null mutant is viable, respiratory deficient	YOR221C	S000005747
MCX1		Mitochondrial ATP-binding protein, possibly a mitochondrial chaperone with non-proteolytic function; similar to bacterial ClpX proteins	ATP-binding protein		YBR227C	S000000431
MDC1		Modifier of DCP1		Cause temperature sensitive growth in combination with dcp1-1		S000029291
MDG1		Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations		Null mutant is viable. Deletion of MDG1 causes sterility in cells in which the wild-type G beta has been replaced by partly defective G beta derivatives	YNL173C	S000005117
MDH1		Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle	malate dehydrogenase		YKL085W	S000001568
MDH2		Cytoplasmic malate dehydrogenase, one of the three isozymes that catalyze interconversion of malate and oxaloacetate; involved in gluconeogenesis during growth on ethanol or acetate as carbon source; interacts with Pck1p and Fbp1p	malate dehydrogenase	Null mutant is viable; fails to grow on minimal medium with acetate or ethanol as carbon source	YOL126C	S000005486
MDH3		Cytoplasmic malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle	malate dehydrogenase	Null mutant is viable, does not grow on oleate and grows slowly on acetate	YDL078C	S000002236
MDJ1		Protein involved in folding of mitochondrially synthesized proteins in the mitochondrial matrix; localizes to the mitochondrial inner membrane; member of the DnaJ family of molecular chaperones		Null mutant is viable, displays a petite phenotype, loss of mitochondrial DNA, and inviability at 37 degrees C	YFL016C	S000001878
MDJ2		Constituent of the mitochondrial import motor associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain	chaperonin	Null mutant is viable, mdj1 mdj2 double mutants display severe grwoth defects at high temperature	YNL328C	S000005272
MDL1		Half-type ATP-binding cassette (ABC) transporter of the inner mitochondrial membrane, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress			YLR188W	S000004178
MDL2		Half-type ATP-binding cassette (ABC) transporter of the inner mitochondrial membrane			YPL270W	S000006191
MDM1		Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)	intermediate filament protein	Null mutant is inviable; temperature sensitive mutants display defective transfer of nuclei and mitochondria into developing buds at the non-permissive temperature	YML104C	S000004572
MDM10	FUN37	Subunit of the mitochondrial sorting and assembly machinery (SAM complex); has a role in assembly of the TOM complex, which mediates protein import through the outer membrane; required for normal mitochondrial morphology and inheritance	SAM complex subunit	Null mutant has short actin cables. Point mutants exhibit giant, spherical mitochondria and are defective for mitochondrial inheritance.	YAL010C	S000000008
MDM12		Mitochondrial outer membrane protein, required for transmission of mitochondria to daughter cells; exists in a complex with Mmm1p and Mdm10p		Null mutant is viable, temperature sensitive, and possesses abnormally large, round mitochondria that are defective for inheritance by daughter buds	YOL009C	S000005369
MDM20	DEC1	Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met; involved in mitochondrial inheritance and actin assembly		Null mutant is viable; some alleles demonstrate temperature sensitive growth at 37C	YOL076W	S000005436
MDM30	DSG1	F-box protein; physically associates with mitochondria and is required for normal mitochondrial fusion in rich medium, during sporulation, and in mating cells; promotes ubiquitin-mediated degradation of Gal4p in some strains		Null: high rate of petite formation	YLR368W	S000004360
MDM31		Mitochondrial inner membrane protein with similarity to Mdm32p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34			YHR194W	S000001237
MDM32		Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34			YOR147W	S000005673
MDM34	MMM2	Mitochondrial outer membrane protein, required for normal mitochondrial morphology and inheritance; localizes to dots on the mitochondrial surface near mtDNA nucleoids; interacts genetically with MDM31 and MDM32		Null: often petite, increased rate of mtDNA loss	YGL219C	S000003187
MDM35		Mitochondrial intermembrane space cysteine motif protein; mutation affects mitochondrial distribution and morphology			YKL053C-A	S000007243
MDM36		Protein required for normal mitochondrial morphology and inheritance			YPR083W	S000006287
MDM38	MKH1	Mitochondrial inner membrane protein, involved in membrane integration of a subset of mitochondrial proteins; required for K+/H+ exchange; associates with mitochondrial ribosomes; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome			YOL027C	S000005387
MDN1	REA1	Huge dynein-related AAA-type ATPase (midasin), forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p), may mediate ATP-dependent remodeling of 60S subunits and subsequent export from nucleoplasm to cytoplasm	midasin		YLR106C	S000004096
MDR1	GYP2|MIC1	Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function	GTPase activating protein (GAP)  for Ypt6		YGR100W	S000003332
MDS3		Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions		Null mutant is viable; mds3 pmd1 double deletion mutants exhibit starvation-independent expression of early sporulation-specific genes; mds3 is a suppressor of mck1 sporulation defects; amino terminal truncation generates a dominant negative allele	YGL197W	S000003165
MDV1	FIS2|GAG3|NET2	Peripheral protein of the cytosolic face of the mitochondrial outer membrane, required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats		Null mutant is viable, mitochondrial fission blocked, mitochondrial membranes form nets	YJL112W	S000003648
MDY2	TMA24	Protein required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes and interacts with YOR164C; contains a ubiquitin-like (UBL) domain			YOL111C	S000005471
MEC1	ESR1|SAD3	Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; monitors and participates in meiotic recombination		Null mutant is inviable; overproduction of Rad53p rescues some esr1 alleles	YBR136W	S000000340
MEC3	PIP3	DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1			YLR288C	S000004279
MED1		Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation	mediator complex subunit	Defects in both repression and induction of GAL genes; supresses loss of the Snf1 kinase	YPR070W	S000006274
MED11		Essential subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme	mediator complex subunit		YMR112C	S000004718
MED2		Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation	mediator complex subunit	Null mutant is viable, unable to grow on galactose	YDL005C	S000002163
MED4		Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation	mediator complex subunit		YOR174W	S000005700
MED6		Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation	mediator complex subunit		YHR058C	S000001100
MED7		Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation	mediator complex subunit		YOL135C	S000005495
MED8		Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation	mediator complex subunit		YBR193C	S000000397
MEF1		Mitochondrial elongation factor involved in translational elongation		Null mutant is viable, respiratory defective, displays pleiotropic deficiency in cytochromes a, a3 and b; limited ability to incorporate labeled methionine; loss of mitochondrial DNA	YLR069C	S000004059
MEF2		Mitochondrial elongation factor involved in translational elongation			YJL102W	S000003638
MEH1	EGO1|GSE2	Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification			YKR007W	S000001715
MEI4		Meiosis-specific protein involved in recombination; required for chromosome synapsis; required for production of viable spores		Loss of full chromosome pairing, heteroduplex DNA, synaptonemal complexes, meiotic intra- and interchromosomal gene conversion, reciprocal recombination and viable spores. mei4 executes both divisions with a delay in meiosis II, is rescued by spo13 and is epiststic to rad52	YER044C-A	S000001954
MEI5	LPH6	Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p			YPL121C	S000006042
MEK1	MRE4	Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, phosphorylates Red1p, interacts with Hop1p; required for meiotic recombination and normal spore viability	serine/threonine protein kinase	Null mutant is viable, however diploids homozygous for a mek1 null mutation produce only low percentages of viable spores, reduced spore viability is rescued by spo13 mutations	YOR351C	S000005878
MEL1		Required for the catabolism of melibiose and regulated by several GAL genes.	alpha-galactosidase|melibiase	The null mutant is viable but unable to ferment melibiose.		S000029662
MEL10			alpha-galactosidase|melibiase	lack of melibiose fermentation		S000029692
MEL2			alpha-galactosidase|melibiase	lack of melibiose fermentation		S000029663
MEL3			alpha-galactosidase|melibiase	lack of melibiose fermentation		S000029693
MEL4			alpha-galactosidase|melibiase	lack of melibiose fermentation		S000029694
MEL5			alpha-galactosidase|melibiase	lack of melibiose fermentation		S000029664
MEL6			alpha-galactosidase|melibiase	lack of melibiose fermentation		S000029665
MEL7			alpha-galactosidase|melibiase	lack of melibiose fermentation		S000029695
MEL8			alpha-galactosidase|melibiase	lack of melibiose fermentation		S000029696
MEL9			alpha-galactosidase|melibiase	lack of melibiose fermentation		S000029697
MEP1	AMT1	Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation	ammonium transporter		YGR121C	S000003353
MEP2		Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation	ammonium transporter		YNL142W	S000005086
MEP3		Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease	ammonium transporter	Null mutant is viable. mep1 mep2 mep3 triple mutants cannot grow on media containing less than 5mM NH4+ as the sole nitrogen source	YPR138C	S000006342
MER1		Protein with RNA-binding motifs required for meiosis-specific mRNA splicing; required for chromosome pairing and meiotic recombination	RNA-binding motif protein required for MRE2-dependent mRNA splicing	Null mutant is viable, associated with decreased levels of inter-and intrachromosomal meiotic recombination; production of inviable spores, multicopy REC107 restores gene conversion and syntaptonemal complexes to mer1 mutants, but not reciprocal recombination of viability	YNL210W	S000005154
MES1	MESI	Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs	MetRS|methionyl-tRNA synthetase	no growth at 36 degrees C	YGR264C	S000003496
MET1	MET20	S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis		Null mutant is viable, and is a methionine auxotroph	YKR069W	S000001777
MET10		Subunit alpha of assimilatory sulfite reductase, which is responsible for the conversion of sulfite into sulfide	sulfite reductase alpha subunit		YFR030W	S000001926
MET12		Isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway		Null mutant is viable and shows no phenotypes; double disruption of MET12 and MET13 (the two putative mthfr genes) confers methionine auxotrophy, but has no other known phenotype at this time	YPL023C	S000005944
MET13	MET11|MRPL45	Isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway		Null mutant is viable and shows methionine auxotrophy; double disruption of MET12 and MET13 (the two putative mthfr genes) also confers methionine auxotrophy, but has no other known phenotype at this time.	YGL125W	S000003093
MET14		Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism	adenylylsulfate kinase	Null mutant is viable, and is a methionine auxotroph	YKL001C	S000001484
MET16		3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism	3'phosphoadenylylsulfate reductase	Null mutant is viable, and is a methionine auxotroph	YPR167C	S000006371
MET17	MET15|MET25	O-acetyl homoserine-O-acetyl serine sulfhydrylase, required for sulfur amino acid synthesis	O-acetylhomoserine (thiol)-lyase		YLR303W	S000004294
MET18	MMS19	DNA repair and TFIIH regulator, required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription; involved in telomere maintenance	TFIIH regulator	Null mutant is viable but is temperature-sensitive, defective in ability to remove UV_induced dimers from nuclear DNA, and shows enhanced UV-induced mutations; extracts from mutant exhibit thermolabile defect in RNA Pol II transcription; methionine auxotroph	YIL128W	S000001390
MET2		L-homoserine-O-acetyltransferase, catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway	homoserine O-trans-acetylase	Null mutant is viable, and is a methionine auxotroph	YNL277W	S000005221
MET22	HAL2	Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway	3'(2')5'-bisphosphate nucleotidase	Methionine requiring; lacks 3'-phosphoadenylylsulfate (PAPS) reductase activity; unable to grow on sulfate as sole sulfur source; overexpression confers lithium resistance; pAp accumulation in met22 mutants (or under MET22 inhibition) inhibits the 5'->3' exoribonucleases Xrn1p and Rat1p.	YOL064C	S000005425
MET28		Transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism	transcriptional activator in the Cbf1p-Met4p-Met28p complex	Null mutant is viable but is a methionine-auxotroph and resistant to toxic analogs of sulfate.	YIR017C	S000001456
MET3		ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism	ATP sulfurylase		YJR010W	S000003771
MET30	ZRG11	F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus	F-box protein		YIL046W	S000001308
MET31		Zinc-finger DNA-binding protein, involved in regulating expression of the methionine biosynthetic genes, similar to Met32p	transcriptional regulator of sulfur amino acid metabolism		YPL038W	S000005959
MET32		Zinc-finger DNA-binding protein, involved in regulating expression of the methionine biosynthetic genes, similar to Met31p	transcriptional regulator of sulfur amino acid metabolism		YDR253C	S000002661
MET4		Lecine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p	transcriptional activator		YNL103W	S000005047
MET6		Cobalamin-independent methionine synthase, involved in amino acid biosynthesis; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs	5-methyltetrahydropteroyl triglutamate homocysteine methyltransferase|N5-methyltetrahydrofolate homocysteine methyltransferase|vitamin B12-(cobalamin)-independent methionine synthase	Null mutant is viable, and is a methionine auxotroph	YER091C	S000000893
MET7	MET23	Folylpolyglutamate synthetase, catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA	folylpolyglutamate synthetase	Null mutant is viable, requires methionine for growth, and is respiration-deficient	YOR241W	S000005767
MET8		Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis		Null mutant is viable, and is a methionine auxotroph	YBR213W	S000000417
MEU1		Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression		Null mutant is viable, displays reduced ADH2 expression	YLR017W	S000004007
MEX67		Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP	a poly(A)+RNA binding protein		YPL169C	S000006090
MF(ALPHA)1		Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor	mating factor alpha		YPL187W	S000006108
MF(ALPHA)2		Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2	alpha mating factor		YGL089C	S000003057
MFA1		Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA2	a-factor mating pheromone precursor		YDR461W	S000002869
MFA2		Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA1	a-factor mating pheromone precursor	MATa cells having deletions of the a-factor structural genes (mfa1 mfa2 mutants) are capable of mating w/wild-type MAT alpha cells in the presence of exogenous a-factor, indicating that it is not absolutely essential for MATa cells to actively produce a-factor in order to mate.	YNL145W	S000005089
MFB1		Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding			YDR219C	S000002627
MFT1	MFT52	Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance	mitochondrial targeting protein		YML062C	S000004527
MGA1		Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants			YGR249W	S000003481
MGA2		ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting		Null mutant is viable, shows subtle effects on growth, UV sensitivity, and galactose utilization; mga2 spt23 double deletion mutants are inviable	YIR033W	S000001472
MGE1	GRPE|YGE1	Protein of the mitochondrial matrix involved in protein import into mitochondria; acts as a cochaperone and a nucleotide release factor for Ssc1p; homolog of E. coli GrpE			YOR232W	S000005758
MGL2				a-Methylglucoside fermentation		S000029292
MGM1	MNA1	Mitochondrial GTPase related to dynamin, present in a complex containing Ugo1p and Fzo1p; required for normal morphology of cristae and for stability of Tim11p; homolog of human OPA1 involved in autosomal dominant optic atrophy	GTP-binding domain protein related to dynamin	Null mutant is viable, has a reduced number of copies of the mitochondrial chromosome per cell at each cell division, grows slowly on rich media, fails to grow on non-fermentable carbon sources	YOR211C	S000005737
MGM101	MGM9	Protein involved in mitochondrial genome maintenance; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage		Null mutant is viable. Meiotic segregants with a disrupted mgm101 allele cannot undergo more than 10 divisions on glycerol medium.	YJR144W	S000003905
MGM104				mgm104-1 mutants are associated with slow growth on glucose media, temperature sensitivity, and loss of mitochondrial DNA phenotypes		S000029293
MGR1		Subunit, with Yme1p, of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; required for growth of cells lacking the mitochondrial genome			YCL044C	S000000549
MGR2		Protein required for growth of cells lacking the mitochondrial genome			YPL098C	S000006019
MGS1		Protein with DNA-dependent ATPase and ssDNA annealing activities involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP)		mgs1 is synthetic lethal with rad6 and exhibits a synergistic growth defect with rad18 and rad5. mgs1 mutant is not sensitive to DNA-damaging agents, but mgs1 rad5 double mutant has increased sensitivity to hydroxyurea and a greatly increased spontaneous mutation rate. Growth defects of mgs1 rad18 double mutants are suppressed by a mutation in SRS2 or by overexpression of Rad52. mgs1 mutation suppresses temperature sensitivity of POL3 mutants.	YNL218W	S000005162
MGT1	MGMT	DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage	6-O-methylguanine-DNA methylase	Null mutant is viable, sensitive to alkylation induced killing and mutation	YDL200C	S000002359
MHP1		Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins		Null mutant is inviable; overexpression of the MHP1 C-terminus results in short spindles	YJL042W	S000003578
MHR1	XTC1	Protein involved in homologous recombination in mitochondria and in transcription regulation in nucleus; binds to activation domains of acidic activators; required for recombination-dependent mtDNA partitioning		Temperature sensitive in the maintenance of mitochondrial DNA	YDR296W	S000002704
MHT1		S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio	S-Methylmethionine Homocysteine methylTransferase	Does not use S-methylmethionine as a sulfur source	YLL062C	S000003985
MIA40	FMP15|TIM40	Essential protein of the mitochondrial intermembrane space (IMS); promotes retention of newly imported proteins; may do so by stabilizing client protein folding as part of a disulfide relay system or transferring metal to client proteins			YKL195W	S000001678
MIC14		Mitochondrial intermembrane space cysteine motif protein of 14 kDa			YDR031W	S000002438
MIC17		Mitochondrial intermembrane space cysteine motif protein; MIC17 is not an essential gene			YMR002W	S000004604
MIC2		mannosyl-diinositolphosphorylceramide, M(IP)2C		Null mutant is viable, grows like wild-type on complex and minimal media, under osmotic conditions, at low pH, and in the presence of high ionic strength, shows markedly reduced levels of negatively charged phospholipids in the plasma membrane, is resistant to nystatin		S000029294
MID1		N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer		Null mutant is viable; Ca2+ influx and mating defective	YNL291C	S000005235
MID2	KAI1	O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p		Null mutant is viable, dies when exposed to mating pheromone	YLR332W	S000004324
MIF1		Involved in chromosome transmission fidelity				S000029295
MIF2		Kinetochore protein with homology to human CENP-C, required for structural integrity of the spindle during anaphase spindle elongation, interacts with histones H2A, H2B, and H4, phosphorylated by Ipl1p		Null mutant is inviable, temperature sensitive mutants accumulate large budded cells and broken spindles at the restricitive temperature	YKL089W	S000001572
MIG1	CAT4|SSN1|TDS22	Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase	transcription factor	Null mutant is viable, exhibits partial derepression of numerous glucose regulated transcripts; MIG1 overexpression and deletion studies suggest that other repressors such as MIG2 may act in a redundant fashion with MIG1	YGL035C	S000003003
MIG2	MLZ1	Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter		Null mutant is viable; a strain that contains a double disruption of MIG1 and MIG2 is defective in glucose repression of SUC2 expression	YGL209W	S000003177
MIG3		Probable transcriptional repressor involved in response to toxic agents such as hydroxyurea that inhibit ribonucleotide reductase; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes	DNA binding transcription co-repressor	Multicopy inhibitor of growth during genotoxic stress in snf1 mutants	YER028C	S000000830
MIH1		Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25	protein tyrosine phosphatase	Null mutant is viable <br> Short G2 delay	YMR036C	S000004639
MIM1	TOM13	Mitochondrial outer membrane protein, required for assembly of the translocase of the outer membrane (TOM) complex and thereby for mitochondrial protein import; N terminus is exposed to the cytosol: transmembrane segment is highly conserved			YOL026C	S000005386
MIN1				methionine inhibited		S000029296
MIP1		Catalytic subunit of the mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome.	mitochondrial DNA polymerase catalytic subunit	Null mutant is viable, associated with total loss of mitochondrial DNA and mitochondrial DNA polymerase activity	YOR330C	S000005857
MIP6		Putative RNA-binding protein, interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export			YHR015W	S000001057
MIR1		Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2 under normal conditions		Null mutant is viable on glucose containing media, but is unable to grow on a non-fermentable carbon source, shows reduced levels of mitochondrial proteins	YJR077C	S000003838
MIS1		Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase	C1-tetrahydrofolate synthase	Null mutant is viable, exhibits no apparent defects in cell growth	YBR084W	S000000288
MIS11						S000029297
MKC7	YPS2	GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p	aspartyl protease|yapsin 2	Null mutant is viable, mkc7 yap3 double mutants are temperature sensitive, and mkc7 yap3 kex2 triple mutants are temperaturea nd cold-sensitive	YDR144C	S000002551
MKK1	SSP32	Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p	MAP kinase kinase (MEK)	Null mutant is viable but cannot grow on glycerol, is sensitive to nitrogen starvation, and cannot grow at elevated temperatures unless supplemented with sorbitol.	YOR231W	S000005757
MKK2	LPI6|SSP33	Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p	serine/threonine protein kinase	Null mutant is viable and shows no obvious phenotypes; mkk1 mkk2 double mutant is caffeine-sensitive and shows a temperature-sensitive cell lysis defect remediated by osmotic stabilizers	YPL140C	S000006061
MKS1	LYS80	Pleiotropic regulatory factor involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling	negative transcriptional regulator	Null mutant is viable, fails to grow on galactose media containing ethidium bromide at 25 degrees and on YPglycerol media at 37 degrees	YNL076W	S000005020
MKT1		Protein that forms a complex with Pbp1p that may mediate posttranscriptional regulation of HO endonuclease; involved in propagation of M2 dsRNA satellite of L-A virus	retroviral protease signature protein		YNL085W	S000005029
MLC1		Essential light chain for Myo1p, light chain for Myo2p; stabilizes Myo2p by binding to the neck region; interacts with Myo1p, Iqg1p, and Myo2p to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition	myosin Myo2p light chain	Null mutant is inviable; MLC1 is halploinsufficient, the haploinsufficiency exhibited by MLC1 is suppressed by reduced copies of MYO2; a diploid strain hemizygous for both MYO2 and MLC1 is viable	YGL106W	S000003074
MLC2		Regulatory light chain for the type II myosin, Myo1p; binds to an IQ motif of Myo1p, localization to the bud neck depends on Myo1p; involved in the disassembly of the Myo1p ring	light chain for Myo1p		YPR188C	S000006392
MLF3	YMK1	Serine-rich protein of unknown function; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide		Null mutant is viable and hypersensitive to leflunomide	YNL074C	S000005018
MLH1	PMS2	Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer		Null mutant is viable; displays a dramatic increase in the instability of simple sequence repeats, disruption of the MLH1 gene in diploid strains causes increased spore lethality; mlh1 delta pms1 delta double mutant are indistinguishable from those of the mlh1 delta and pms1 delta single mutants	YMR167W	S000004777
MLH2		Protein involved in the mismatch repair of certain frameshift intermediates and involved in meiotic recombination; forms a complex with Mlh1p		Null mutant is viable but non-Mendelian segregation is elevated and parity is altered during meiosis.	YLR035C	S000004025
MLH3		Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability		Null mutant is viable. Null mutant exhibits reduced (70%) rate of meiotic cross over.	YPL164C	S000006085
MLP1	MPL1	Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs			YKR095W	S000001803
MLP2		Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length			YIL149C	S000001411
MLS1		Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium	carbon-catabolite sensitive malate synthase		YNL117W	S000005061
MMF1	IBM1	Mitochondrial protein involved in maintenance of the mitochondrial genome		Null mutant is viable but cannot utilize glycerol as a carbon source; the mitochondrial DNA is deleted and the number of mitochondria is reduced in the null mutant	YIL051C	S000001313
MMM1	YME6	Mitochondrial outer membrane protein required for normal mitochondrial morphology and mtDNA stability; involved in tethering mitochondria to the actin cytoskeleton and in anchoring mtDNA nucleoids		Null mutant is viable, fails to grow on nonfermentable carbon sources, demonstrates abnormal mitochondrial morphology, fails to segregate mitochondria into daughter cells	YLL006W	S000003929
MMP1		High-affinity S-methylmethionine permease, required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p	S-methylmethionine permease	Null mutant is viable but is unable to use S-methylmethionine as a sulfur source	YLL061W	S000003984
MMR1		Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p			YLR190W	S000004180
MMS1	RTT108|SLM6	Protein likely involved in protection against replication-dependent DNA damage; mutants are sensitive to methyl methanesulfonate (MMS); implicated in regulation of Ty1 transposition		insertion at amino acid 166 is dead on 0.005% diepoxybutane	YPR164W	S000006368
MMS2		Protein involved in error-free postreplication DNA repair; forms a heteromeric complex with Ubc13p that has a ubiquitin-conjugating activity; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p		Null mutant is viable and is sensitive to MMS and UV	YGL087C	S000003055
MMS21		SUMO ligase involved in chromosomal organization and DNA repair; essential subunit of the Mms21-Smc5-Smc6 complex; mutants are sensitive to methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination		mms21-1 mutant is sensitive to MMS, X rays and UV and increases the rate of mitotic segregation 23-fold	YEL019C	S000000745
MMS22	SLM2	Protein involved in resistance to ionizing radiation; acts with Mms1p in a repair pathway that may be involved in resolving replication intermediates or preventing the damage caused by blocked replication forks		Null: Null phenotype in haploids of either mating type and diploid is extreme sensitivity to MMS or hydroxyurea, moderate sensitivity to gamma or UV irradiation. Diploid is very sensitive to camtothecin. Diploid is also sensitive to bleomycin..	YLR320W	S000004312
MMS3				mms3 mutations confer sensitivity to UV and methyl methane sulfonate in both haploids and diploids		S000029298
MMS4	SLX2|YBR100W	Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination and DNA repair		null is synthetically lethal with sgs1 null	YBR098W	S000000302
MMT1		Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p		Null mutant is viable, mmt1 mmt2 double deletion mutants exhibit a growth defect on low iron medium	YMR177W	S000004789
MMT2	MFT2	Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p		Null mutant is viable, mmt1 mmt2 double deletion mutants exhibit a growth defect on low iron medium	YPL224C	S000006145
MND1		Protein required for recombination and meiotic nuclear division; forms a complex with Hop2p, which is involved in chromosome pairing and repair of meiotic double-strand breaks		Null mutant is viable; arrests after DNA-replication but before nuclear divisions after shift to sporulation medium.	YGL183C	S000003151
MND2		Subunit of the anaphase-promoting complex (APC); needed for meiotic nuclear division		arrests after DNA-replication but before nuclear divisions after shift to sporulation medium	YIR025W	S000001464
MNE1		Mitochondrial protein similar to Lucilia illustris mitochondrial cytochrome oxidase			YOR350C	S000005877
MNI1		Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; deletion mutant exhibits a weak vacuolar protein sorting defect, enhanced resistance to caspofungin, and is synthetically lethal with MEN mutants	unknown		YIL110W	S000001372
MNI2		Deletion mutant is synthetically lethal with MEN mutants	unknown		YPR045C	S000006249
MNL1	HTM1	Alpha mannosidase-like protein of the endoplasmic reticulum required for degradation of glycoproteins but not for processing of N-linked oligosaccharides			YHR204W	S000001247
MNN1		Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family	alpha-1,3-mannosyltransferase		YER001W	S000000803
MNN10	BED1|REC41|SLC2	Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family	galactosyltransferase	Null mutant is viable, is larger than wild-type cells, is deficient in bud emergence, and depends upon an intact morphogenesis checkpoint control to survive	YDR245W	S000002653
MNN11		Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p	mannosyltransferase complex component	Null mutant is viable, exhibits defects in mannan synthesis	YJL183W	S000003719
MNN2	CRV4|LDB8|TTP1	Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment		Null mutant is viable. Mannan lacks the main alpha-1,2-linked branches	YBR015C	S000000219
MNN4	YKL200C	Putative positive regulator of mannosylphosphate transferase (Mnn6p), involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases		mannan synthesis defective. mnn4 and ktr6 mutations affect the mannosylphosphorylation of O-linked oligosaccharide, together with that of N-linked oligosaccharide.	YKL201C	S000001684
MNN5		Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment		Null mutant is viable but defective in addition of the alpha-1,3-linked mannose branch to the mannan structure found on N-linked glycans.	YJL186W	S000003722
MNN9		Subunit of Golgi mannosyltransferase complex also containing Anp1p, Mnn10p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; forms a separate complex with Van1p that is also involved in backbone elongation		mnn9 is lethal in combination with chs3.	YPL050C	S000005971
MNP1		Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth			YGL068W	S000003036
MNR2		Putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations		overexpression overcomes manganese toxicity	YKL064W	S000001547
MNS1		Alpha-1,2-mannosidase involved in ER quality control; catalyzes the removal of one mannose residue from Man9GlcNAc to produce a single isomer of Man8GlcNAc in N-linked oligosaccharide biosynthesis; integral to ER membrane	alpha-mannosidase		YJR131W	S000003892
MNT2		Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans	alpha-1,3-mannosyltransferase	MNT2 null mutants are viable. The length of O-linked oligosaccharides is diminished in MNT2 null mutants.	YGL257C	S000003226
MNT3		Alpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation	alpha-1,3-mannosyltransferase		YIL014W	S000001276
MNT4		Putative alpha-1,3-mannosyltransferase, not required for protein O-glycosylation			YNR059W	S000005342
MOB1		Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex		Null mutant is inviable; conditional mutants arrest in late mitosis	YIL106W	S000001368
MOB2	YFL035C|YFL035C-A	Component of the RAM signaling network, localizes and activates the Ace2p in the daughter cell nucleus to direct daughter cell-specific transcription of several genes involved in cell separation; Mob1p-like protein		Null is viable; other mutants have synthetic interactions with MPS1	YFL034C-B	S000001859
MOD5		Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase, required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms	tRNA isopentenyltransferase	Null mutant is viable but temperature sensitive and cannot grow on nonfermentable carbon sources.	YOR274W	S000005800
MOF1				The mof1-1 allele cannot maintain viral M1 dsRNA at 30 degrees.		S000029299
MOF3				An uncharacterized allele increases the efficiency of frameshifting of the gag open reading frame from the L-A dsRNA virus.		S000029300
MOF5		Maintenance Of Frame		temperature sensitive, cold sensitive and pet-		S000029301
MOF7				An uncharacterized allele increases the efficiency of frameshifting of the gag open reading frame from the L-A dsRNA virus.		S000029302
MOF8				An uncharacterized allele increases the efficiency of frameshifting of the gag open reading frame from the L-A dsRNA virus.		S000029303
MOF9				increased efficiency of -1 ribosomal frameshifting but no effect on readthrough of UAG or UAA termination codons; mof9 is complemented by both single and multi-copy 5 S rDNA clones		S000029304
MOG1		Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p		Null mutant is viable, temperature sensitive, exhibits defects in nuclear-protein import; MOG1 overexpression supresses the temperature sensitivity of gsp1 strains; overexpression of NTF2 or GSP1 can suppress the ts phenotype of mog1	YJR074W	S000003835
MOH1		Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase			YBL049W	S000000145
MON1	AUT12	Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate		null mutant is sensitive to monensin and brefeldin A	YGL124C	S000003092
MON2	YSL2	Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins			YNL297C	S000005241
MOS1				modifier of ochre suppressors		S000029305
MOS3				modifier of ochre suppressors		S000029306
MOT1	BTAF1|BUR3|LPF4	Essential abundant protein involved in regulation of transcription, removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity			YPL082C	S000006003
MOT2	NOT4|SIG1	Component of the CCR4-NOT complex, which has multiple roles in transcription regulation, mRNA degradation, and post-transcriptional modifications; with Ubc4p, ubiquitylates subunits of the nascent polypeptide-associated complex (NAC)	CCR4-NOT transcriptional complex subunit	Null mutant is viable, exhibits a modest increase in basal transcription of several pheromone-responsive genes; exhibits a conditional cell lysis phenotype	YER068W	S000000870
MOT3	ROX7	Nuclear transcription factor with two Cys2-His2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes		Null mutant is viable, displays modest increase in Ty mRNA levels; mot3 deletion can partially suppress mutations in mot1 and spt3. mot3Delta mutants have impaired homotypic vacuole fusion and increased sterol levels.	YMR070W	S000004674
MPA43		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies		Null mutant is viable with no specific phenotype and normal expression of PDC1; but overexpression causes higher basal levels of PDC1	YNL249C	S000005193
MPC54		Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate		Null: viable. Other phenotypes: sporulation deficient.	YOR177C	S000005703
MPD1		Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation		Null mutant is viable. MPD1 overexpression can suppress the maturation defect of carboxypeptidase Y caused by PDI1 deletion	YOR288C	S000005814
MPD2		Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p		Null mutant is viable; overproduction of Mpd2p suppresses lethality and carboxypeptidase Y maturation defect caused by pdi1 deletion -- this suppression depends on the CXXC sequence of Mpd2p	YOL088C	S000005448
MPE1		Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif			YKL059C	S000001542
MPH1		Member of the DEAH family of helicases, functions in an error-free DNA damage bypass pathway that involves homologous recombination, mutations confer a mutator phenotype			YIR002C	S000001441
MPH2		Alpha-glucoside permease, transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph3p; encoded in a subtelomeric position in a region likely to have undergone duplication	alpha-glucoside transporter		YDL247W	S000002406
MPH3		Alpha-glucoside permease, transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph2p; encoded in a subtelomeric position in a region likely to have undergone duplication	alpha-glucoside transporter		YJR160C	S000003921
MPM1		Mitochondrial membrane protein of unknown function, contains no hydrophobic stretches			YJL066C	S000003602
MPP10		Component of the SSU processome, which is required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p	U3 snoRNP protein		YJR002W	S000003762
MPR1		L-Azetidine-2-carboxylic acid acetyltransferase involved in L-proline analog resistance; member of N-acetyltransferase superfamily; not found in the S288C strain	N-acetyltransferase			S000029666
MPS1	RPK1	Dual-specificity kinase required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, and checkpoint protein Mad1p		Null mutant is inviable. Eliminating the expression of MPS1 causes accumulation of non-viable cells with less than a 1 N DNA content. Allele-specific suppression and synthetic lethal interactions occur between mps1 and cdc37. Overexpression of Mps1p induces modification of Mad1p and arrests wild-type yeast cells in mitosis with morphologically normal spindles. mps1 does not arrest in the absence of spindle pole body duplication and monopolar spindle formation, or nocodozole treatment. Required for sporulation.	YDL028C	S000002186
MPS2	MMC1	Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p		Null mutant is inviable, however some null spore clones can survive with abnormal ploidy; the mps2-1 mutant is incapable of proper duplication of the SPB, resulting in a defective pole that only nucleates cytoplasmic microtubules. Overexpression of MPS2 in a cim5-1 ts mutant is toxic to cells.	YGL075C	S000003043
MPS3	NEP98|YJL018W	Essential integral membrane protein required for spindle pole body duplication and for nuclear fusion, localizes to the spindle pole body half bridge, interacts with DnaJ-like chaperone Jem1p and with centrin homolog Cdc31p		Null: null mutant is inviable. Other phenotypes: ts mutants fail in SPB duplication; The temperature-sensitve nep98-7 mutant shows defects in the organization of the spindle pole body, nuclear division and nuclear fusion during mating	YJL019W	S000003556
MPT5	HTR1|PUF5|UTH4	Member of the Puf family of RNA-binding proteins; binds to mRNAs encoding chromatin modifiers and spindle pole body components; involved in longevity, maintenance of cell wall integrity, and sensitivity to and recovery from pheromone arrest		Null mutant is viable, temperature sensitive	YGL178W	S000003146
MRC1	YCL060C	S-phase checkpoint protein found at replication forks, required for DNA replication; also required for Rad53p activation during DNA replication stress, where it forms a replication-pausing complex with Tof1p and is phosphorylated by Mec1p; protein involved in replication checkpoint		Null: sensitive to hydroxyurea; replication checkpoint defective; slower DNA replication than wild type; partial loss of silencing at telomeres and HM loci; synthetic lethal with rad9 null, rad53-21, and mec1-21.	YCL061C	S000000566
MRD1		Essential conserved protein that associates with 35S precursor rRNA and is required for its initial processing at the A(0)-A(2) cleavage sites, shows partial nucleolar localization, contains five consensus RNA-binding domains		Null mutant is inviable (haploid divides 2-3 times)	YPR112C	S000006316
MRE11	NGS1|RAD58|XRS4	Subunit of a complex with Rad50p and Xrs2p (RMX complex) that functions in repair of DNA double-strand breaks and in telomere stability, exhibits nuclease activity that appears to be required for RMX function; widely conserved		Null mutant is viable, methyl methanesulfonate-sensitive and displays hyper-recombination in mitosis. mre11 is rescued by spo13 and epistatic to rad50s, suggesting it is an early recombination function.	YMR224C	S000004837
MRF1		Mitochondrial polypeptide chain release factor, involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability	mitochondrial translation release factor	Null mutant is viable but shows high instability of the mitochondrial genome, reduced synthesis of mitochondrial translation products, and respiratory deficiency	YGL143C	S000003111
MRH1		Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; has similarity to Hsp30p and Yro2p, which are induced during heat shock			YDR033W	S000002440
MRH4		Mitochondrial RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function	ATP-dependent RNA helicase	Null: viable, slow growth, respiratory deficient	YGL064C	S000003032
MRK1		Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation	serine/threonine protein kinase	Null mutant is viable and does not alter glycogen accumulation. mck1 mds1 mrk1 triple mutant is viable	YDL079C	S000002237
MRL1		Membrane protein with similarity to mammalian mannose-6-phosphate receptors, possibly functions as a sorting receptor in the delivery of vacuolar hydrolases			YPR079W	S000006283
MRM1	PET56	Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA			YOR201C	S000005727
MRM2		Mitochondrial 21S rRNA methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ	2'O-ribose methyltransferase	Null: thermosensitive respiration; loses mitochondrial DNA with high frequency	YGL136C	S000003104
MRN1		Putative RNA binding protein	RNA binding protein		YPL184C	S000006105
MRP1		Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein	mitochondrial ribosomal small subunit component	defective mitochondrial protein synthesis; absence of a and b type cytochromes; reduced levels of mitochondrial 15 S rRNA; defective processing of apocytochrome b intron; convert to rho- and rho0 at high frequency	YDR347W	S000002755
MRP10		Mitochondrial ribosomal protein of the small subunit	mitochondrial ribosomal small subunit component	Null mutant is viable, defective in mitochondrial translation and shows a tendency to accumulate deletions in mitochondrial DNA	YDL045W-A	S000006430
MRP13		Mitochondrial ribosomal protein of the small subunit	mitochondrial ribosomal small subunit component	Null mutant is viable, no impairment in ribosome synthesis or function	YGR084C	S000003316
MRP17		Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator	mitochondrial ribosomal small subunit component	petite	YKL003C	S000001486
MRP2		Mitochondrial ribosomal protein of the small subunit	mitochondrial ribosomal small subunit component	defective mitochondrial protein synthesis; absence of a and b type cytochromes; reduced levels of mitochondrial 15 S rRNA; defective processing of apocytochrome b intron; convert to rho- and rho0 at high frequency	YPR166C	S000006370
MRP20	MRPL41	Mitochondrial ribosomal protein of the large subunit	YmL41	Null mutant is viable, becomes [rho-] or [rho0]	YDR405W	S000002813
MRP21	MRP50	Mitochondrial ribosomal protein of the large subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences	mitochondrial ribosomal small subunit component	Null mutant is viable, exhibits completely blocked mitochondrial gene expression; missense mutations suppress 5'-UTL mutations in at least 2 mitochondrial mRNAs	YBL090W	S000000186
MRP4		Mitochondrial ribosomal protein of the small subunit	mitochondrial ribosomal small subunit component		YHL004W	S000000996
MRP49		Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation	mitochondrial ribosomal large subunit component	Null mutant is viable, cold-sensitive, respiration deficient, defective in assembly of stable 54S ribosomal subunits	YKL167C	S000001650
MRP51		Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences	mitochondrial ribosomal small subunit component	Null mutant is viable, exhibits completely blocked mitochondrial gene expression; missense mutations suppress 5'-UTL mutations in at least 2 mitochondrial mRNAs	YPL118W	S000006039
MRP7	MRPL2	Mitochondrial ribosomal protein of the large subunit	YmL23		YNL005C	S000004950
MRP8	YKL3	Putative mitochondrial ribosomal protein, has similarity to E. coli ribosomal protein S2			YKL142W	S000001625
MRPL1		Mitochondrial ribosomal protein of the large subunit			YDR116C	S000002523
MRPL10	MRPL18	Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels	YmL10|YmL18		YNL284C	S000005228
MRPL11		Mitochondrial ribosomal protein of the large subunit	YmL11	Null mutant is viable, respiratory deficient accompanied by a loss of mitochondrial DNA	YDL202W	S000002361
MRPL12		Possible mitochondrial ribosomal protein of the large subunit (see Locus History note)	YmL12			S000029307
MRPL13	YK105	Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation	YmL13		YKR006C	S000001714
MRPL15		Mitochondrial ribosomal protein of the large subunit	YmL15		YLR312W-A	S000004304
MRPL16		Mitochondrial ribosomal protein of the large subunit	mitochondrial ribosomal large subunit component		YBL038W	S000000134
MRPL17	MRPL30	Mitochondrial ribosomal protein of the large subunit	YmL30		YNL252C	S000005196
MRPL19		Mitochondrial ribosomal protein of the large subunit	YmL19		YNL185C	S000005129
MRPL20		Mitochondrial ribosomal protein of the large subunit	YmL20	Null mutant is viable; shows loss of mitochondrial function, instability of mitochondrial DNA	YKR085C	S000001793
MRPL22		Mitochondrial ribosomal protein of the large subunit			YNL177C	S000005121
MRPL23		Mitochondrial ribosomal protein of the large subunit	YmL23		YOR150W	S000005676
MRPL24	MRPL14	Mitochondrial ribosomal protein of the large subunit	YmL14|YmL24		YMR193W	S000004806
MRPL25	YMR26	Mitochondrial ribosomal protein of the large subunit	YmL25	Null mutant is viable, cells become Pet-	YGR076C	S000003308
MRPL27		Mitochondrial ribosomal protein of the large subunit	YmL27		YBR282W	S000000486
MRPL28		Mitochondrial ribosomal protein of the large subunit	YmL28		YDR462W	S000002870
MRPL3		Mitochondrial ribosomal protein of the large subunit	YmL30		YMR024W	S000004626
MRPL31		Mitochondrial ribosomal protein of the large subunit	YmL31		YKL138C	S000001621
MRPL32		Mitochondrial ribosomal protein of the large subunit	YmL32|mitochondrial ribosomal large subunit component		YCR003W	S000000596
MRPL33		Mitochondrial ribosomal protein of the large subunit	YmL33		YMR286W	S000004899
MRPL35		Mitochondrial ribosomal protein of the large subunit	YmL35		YDR322W	S000002730
MRPL36		Mitochondrial ribosomal protein of the large subunit; overproduction suppresses mutations in the COX2 leader peptide-encoding region	YmL36		YBR122C	S000000326
MRPL37		Mitochondrial ribosomal protein of the large subunit	YmL37		YBR268W	S000000472
MRPL38	MRPL34	Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels	YmL34|YmL38		YKL170W	S000001653
MRPL39		Mitochondrial ribosomal protein of the large subunit	YmL39		YML009C	S000004468
MRPL4		Mitochondrial ribosomal protein of the large subunit	YmL40	Null mutant is viable, fails to grow on nonfermentable carbon sources, has growth defects on fermentable carbon sources	YLR439W	S000004431
MRPL40		Mitochondrial ribosomal protein of the large subunit	YmL40		YPL173W	S000006094
MRPL44	YMR44	Mitochondrial ribosomal protein of the large subunit	YmL44		YMR225C	S000004838
MRPL49		Mitochondrial ribosomal protein of the large subunit	YmL49		YJL096W	S000003632
MRPL50		Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation			YNR022C	S000005305
MRPL51		Mitochondrial ribosomal protein of the large subunit			YPR100W	S000006304
MRPL6		Mitochondrial ribosomal protein of the large subunit	YmL16		YHR147C	S000001190
MRPL7		Mitochondrial ribosomal protein of the large subunit	YmL5/7		YDR237W	S000002645
MRPL8	HRD238	Mitochondrial ribosomal protein of the large subunit	YmL8	Null mutant is viable; shows loss of mitochondrial function, instability of mitochondrial DNA	YJL063C	S000003599
MRPL9		Mitochondrial ribosomal protein of the large subunit	YmL9		YGR220C	S000003452
MRPS16		Mitochondrial ribosomal protein of the small subunit			YPL013C	S000005934
MRPS17		Mitochondrial ribosomal protein of the small subunit			YMR188C	S000004800
MRPS18		Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins	YmS18		YNL306W	S000005250
MRPS28		Mitochondrial ribosomal protein of the small subunit	mitochondrial ribosomal small subunit component	Null mutant is viable, unable to respire, spontaneously loses portions of its mitochondrial genomes at a high frequencY	YDR337W	S000002745
MRPS35		Mitochondrial ribosomal protein of the small subunit			YGR165W	S000003397
MRPS5		Mitochondrial ribosomal protein of the small subunit			YBR251W	S000000455
MRPS8		Mitochondrial ribosomal protein of the small subunit			YMR158W	S000004767
MRPS9		Mitochondrial ribosomal protein of the small subunit		Null mutant is viable, respiration deficient, exhibits defects in mitochondrial protein synthesis as indicated by a loss of cytochrome c oxidase activity	YBR146W	S000000350
MRS1	PET157	Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA		Null mutant is viable, Pet-, exhibits accumulation of mitochondrial RNA precursors	YIR021W	S000001460
MRS11	TIM10	Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that mediates insertion of hydrophobic proteins at the inner membrane, has homology to Mrs5p, which is also involved in this process		Null mutant is inviable; depletion of Mrs11p results in accumulation of the precursor form of mitochondrial hsp60, inability to form spectrophotometrically detectable amounts of cytochromes and changes in the mitochondrial morphology; when overexpressed, restores respiration competence to yeast defective in the splicing of mitochondrial group II introns	YHR005C-A	S000003530
MRS2		Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns	magnesium ion transporter	Null mutant is viable; has a pet- phenotype, associated with a block in mitochondrial RNA splicing of all mitochondrial group II introns	YOR334W	S000005861
MRS3		Mitochondrial iron transporter of the mitochondrial carrier family (MCF), very similar to and functionally redundant with Mrs4p; functions under low-iron conditions; may transport other cations in addition to iron	iron transporter	Null mutant is viable; high copy MRS3 can suppress the mitochondrial RNA splicing defects of several mit- intron mutations	YJL133W	S000003669
MRS4		Mitochondrial iron transporter of the mitochondrial carrier family (MCF), very similar to and functionally redundant with Mrs3p; functions under low-iron conditions; may transport other cations in addition to iron	iron transporter	Null mutant is viable, has no defects in mitochondrial function. Mrs4p overexpression causes a temperature sensitive petite phenotype in a wild-type background and can suppress the mitochondrial RNA splicing defects ofmit- intron mutants	YKR052C	S000001760
MRS5	TIM12	Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins		Null mutant is inviable. Mrs5p depletion causes accumulation of unprocessed precursors of the mitochondrial hsp60 protein and defects in all cytochrome complexes	YBR091C	S000000295
MRS6	MSI4	Rab escort protein, forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)	rab geranylgeranyltransferase regulatory subunit	Null mutant is inviable; multicopy MRS6 causes a mild pet- phenotype; multicopy MRS6 suppresses the pet- phenotype of mrs2-1 mutants; suppresses ts ypt1	YOR370C	S000005897
MRT2		Involved in mRNA Turnover		altered mRNA stability		S000029311
MRT3		Involved in mRNA Turnover		Mutant shows slower rate of deadenylation-dependent decapping of mRNAs and transcript-specific effects on mRNA decay rates but does not show affects on the rapid turnover of an mRNA containing an early nonsense codon, which is degraded by deadenylation-independent decapping mechanism		S000029312
MRT4		Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus		Null mutant exhibits slow growth. ts mutation results in decreased decay rates of mRNAs	YKL009W	S000001492
MSB1		Protein involved in positive regulation of both 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway, potential Cdc28p substrate; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4		multicopy suppressor of cdc24 and cdc42 ts mutations	YOR188W	S000005714
MSB2		Mucin family member at the head of the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate		multicopy suppressor of cdc24 ts mutation	YGR014W	S000003246
MSB3	GYP3	GTPase-activating protein for Sec4p and several other Rab GTPases, regulates exocytosis via its action on Sec4p, also required for proper actin organization; similar to Msb4p; both Msb3p and Msb4p localize to sites of polarized growth	GTPase activating protein (GAP)  for Ypt6	Null mutant is viable. msb3/msb4 double mutant exhibits slow growth and disorganized actin cytoskeleton	YNL293W	S000005237
MSB4		GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization		Null mutant is viable. msb3/msb4 double mutant exhibits slow growth and disorganized actin cytoskeleton	YOL112W	S000005472
MSC1		Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YML128C	S000004597
MSC2		Member of the cation diffusion facilitator family, localizes to the endoplasmic reticulum and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids		Null mutant is inviable on glycerol-ethanol at 37oC and exhibits sensitivity to H2O2	YDR205W	S000002613
MSC3		Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate			YLR219W	S000004209
MSC6		Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YOR354C	S000005881
MSC7		Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids			YHR039C	S000001081
MSD1	LPG5	Mitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene	mitochondrial aspartyl-tRNA synthetase	Null mutant is viable but shows pleiotropic phenotypes consistent with a lesion in mitochondrial protein synthesis and is unable to acylate mitochondrial aspartyl-tRNA	YPL104W	S000006025
MSE1		Mitochondrial glutamyl-tRNA synthetase, encoded by a nuclear gene	mitochodrial glutamyl-tRNA synthetase	An uncharacterized allele is respiratory deficient.	YOL033W	S000005393
MSF1		Mitochondrial phenylalanyl-tRNA synthetase alpha subunit, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase	mitochondrial phenylalanyl-tRNA synthetase		YPR047W	S000006251
MSG5		Dual-specificity protein phosphatase required for maintenance of a low level of signaling through the cell integrity pathway; regulates and is regulated by Slt2p; also required for adaptive response to pheromone	protein tyrosine phosphatase	Null mutant is viable, shows diminished adaptive response to pheromone	YNL053W	S000004998
MSH1		DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis		Null mutant is viable, petite	YHR120W	S000001162
MSH2	PMS5	Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity; Msh2p-Msh6p binds to and hydrolyzes ATP		Haploid mutants display 85-fold increased rate of spontaneous mutation to canavanine resistance. Mutants are defective for gene conversion polarity gradients and high spore viability. Inactivation of MSH2 causes high rates of accumulation of both base-substitution and frameshift mutations.	YOL090W	S000005450
MSH3		Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability		Null mutant is viable. Inactivation of MSH3 results in low rates of frameshift mutations.	YCR092C	S000000688
MSH4		Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein		Null mutant is viable, has no apparent defect in mismatch repair, wild-type levels of gene conversion and postmeiotic segregation	YFL003C	S000001891
MSH5		Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans		Null mutant is viable. Diploids lacking the MSH5 gene display decreased levels of spore viability, increased levels of meiosis I chromosome nondisjuction, and decreased levels of reciprocal exchange between, but not within, homologs. Gene conversion is not reduced. Msh5 mutants are phenotypically similar to mutants in the meiosis-specific gene MSH4. msh5 is epistatic to msh4, suggesting they act in the same pathway.	YDL154W	S000002313
MSH6	PMS3	Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; potentially phosphorylated by Cdc28p		Mutations in MSH6 or MSH3 cause partial defects in MMR, with inactivation of MSH6 resulting in high rates of base-substitution mutations and low rates of frameshift mutations; msh3 msh6 double deletion mutants exhibit microsatellite instability and mutability similar to that in a msh2 mutant.	YDR097C	S000002504
MSI1	CAC3	Subunit of chromatin assembly factor I (CAF-1), regulates the RAS/cAMP pathway via sequestration of Npr1p kinase; localizes to the nucleus and cytoplasm; homologous to human retinoblastoma binding proteins RbAp48 and RbAp46	chromatin assembly factor-I (CAF-I) p50 subunit|negative regulator of ras-mediated cAMP induction		YBR195C	S000000399
MSK1		Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria	mitochondrial lysyl-tRNA synthetase	An uncharacterized allele is respiratory deficient.	YNL073W	S000005017
MSL1	YIB9|YIB9w	U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro; does not contain the conserved C-terminal RNA binding domain found in other family members	U2 snRNP component|YU2B''	msl1 mutants exhibit synthetic lethality in combination with mud2 deletion mutants	YIR009W	S000001448
MSL5		Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA	BBP		YLR116W	S000004106
MSM1		Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p	mitochondrial methionyl-tRNA synthetase		YGR171C	S000003403
MSN1	FUP1|HRB382|MSS10|PHD2	Transcriptional activator involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus	transcriptional activator	Null mutant is viable, exhibits a decrease in invertase expression; exhibits a reduction in wild-type iron uptake by 2-fold in cells grown in raffinsoe, but has no effect on glucose grown cells; exhibits media-specific extinction of glucoamylase synthesis; exhibits reduced pseudohyphal differentiation and invasive growth	YOL116W	S000005476
MSN2		Transcriptional activator related to Msn4p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression	transcription factor	Null mutant is viable; msn2 msn4 double deletion mutants exhibit higher sensitivity to different stresses, including carbon source starvation, heat shock, and severe osmotic and oxidative stresses	YMR037C	S000004640
MSN4		Transcriptional activator related to Msn2p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression	transcription factor	Null mutant is viable; msn2 msn4 double deletion mutants exhibit higher sensitivity to different stresses, including carbon source starvation, heat shock and severe osmotic and oxidative stresses	YKL062W	S000001545
MSN5	KAP142|STE21	Karyopherin involved in nuclear import and export; shown to be responsible for nuclear import of replication protein A and for export of several proteins including Swi6p, Far1p, and Pho4p; cargo dissociation involves binding to RanGTP		Disruptants are not completely sterile	YDR335W	S000002743
MSO1		Probable component of the secretory vesicle docking complex, acts at a late step in secretion; shows genetic and physical interactions with Sec1p and is enriched in microsomal membrane fractions; required for sporulation		Null mutant is viable, exhibits accumulation of secretory vesicles in the bud; mso1 null mutants exhibit double mutant inviability in combinaiton with sec1, sec2, and sec4 mutants	YNR049C	S000005332
MSP1	YTA4	Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase	40 kDa membrane-spanning ATPase	Null mutant is viable, exhibits no observable growth defects	YGR028W	S000003260
MSR1		Mitochondrial arginyl-tRNA synthetase	mitochondrial arginyl-tRNA synthetase	mutants are deficient in mitochondrial protein synthesis because they cannot acylate the mitochondrial arginyl-tRNA	YHR091C	S000001133
MSS1	PET53	Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3		respiratory deficient in presence of pr454 mutation in mitochondrial 15S rRNA; block in splicing of mitochondrial introns	YMR023C	S000004625
MSS11		Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of MUC1 and STA2 in response to nutritional signals		Null mutant is viable, exhibits diminished transcription of STA2; multiple copies suppress repressive effect of STA10, enhance expression of STA2 in non-STA10 strains	YMR164C	S000004774
MSS116		DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing	ATP-dependent RNA helicase	mss116 mutations affect the splicing of several introns of the cytochrome B and cytochrome C oxidase subunit I primary transcripts	YDR194C	S000002602
MSS18		Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions		blocked in splicing of cox1 pre-mRNA	YPR134W	S000006338
MSS2		Peripherally bound inner membrane protein of the mitochondrial matrix, binds to the Cox2p C-terminal tail to facilitate its translocation through the inner membrane		Suppression of a mitochondrial RNA splice defect; COX1 pre-mRNA processing factor	YDL107W	S000002265
MSS4		Phosphatidylinositol-4-phosphate 5-kinase, involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation	phosphatidylinositol 4-phosphate kinase		YDR208W	S000002616
MSS51		Nuclear encoded protein required for translation of COX1 mRNA; binds to Cox1 protein		necessary for cox1 pre-mRNA processing and translation	YLR203C	S000004193
MST1		Mitochondrial threonyl-tRNA synthetase			YKL194C	S000001677
MST27		Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles			YGL051W	S000003019
MST28		Putative integral membrane protein, involved in vesicle formation; forms complex with Mst27p; member of DUP240 gene family; binds COPI and COPII vesicles			YAR033W	S000000079
MSW1		Mitochondrial tryptophanyl-tRNA synthetase	mitochondrial tryptophanyl-tRNA synthetase	Null mutant is viable, respiratory deficient, defective in mitochondrial protein synthesis	YDR268W	S000002676
MSY1		Mitochondrial tyrosyl-tRNA synthetase	mitochondrial tyrosyl-tRNA synthetase		YPL097W	S000006018
MTD1		NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline	NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase	Null mutant is viable, associated with loss of NAD-dependent 5,10-methylene-THF dehydrogenase activity and a purine requirement in some genetic backgrounds	YKR080W	S000001788
MTF1		Mitochondrial RNA polymerase specificity factor with structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors, interacts with mitochondrial core polymerase Rpo41p	mitochondrial transcription factor	Null mutant is viable, defective in respiration, and lacks mtDNA.	YMR228W	S000004841
MTF2	NAM1	Mitochondrial matrix protein that interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription		petite	YDL044C	S000002202
MTG1		Peripheral GTPase of the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals	GTPase		YMR097C	S000004703
MTG2		Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly	GTPase		YHR168W	S000001211
MTH1	BPC1|DGT1|HTR1	Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation		Null mutant is viable; mth1(htr1) mutants are deficient in glucose update and transcription of glucose transporters; mth1 (htr1) mutation suppresses glucose sensitivity of tpi1 mutant; multicopy expression of HXT genes suppresses some defects of mth1 (htr1) mutants; msn3 mth1 double deletion mutants are impaired in derepression of invertase in response to glucose limitation	YDR277C	S000002685
MTH3						S000029313
MTL1		Protein with both structural and functional similarity to Mid2p, which is a plasma membrane sensor required for cell integrity signaling during pheromone-induced morphogenesis; suppresses rgd1 null mutations		Null mutant is viable. mtl1 mutants increase severity of mid2 phenotypes	YGR023W	S000003255
MTM1		Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor		Null: strong loss of SOD2 activity, mitochondrial iron accumulation	YGR257C	S000003489
MTO1	IPS1	Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants			YGL236C	S000003205
MTP1		involved in transport of melezitose, alpha-methylglucoside and maltose		defective melezitose fermentation		S000029314
MTQ1		S-adenosylmethionine-dependent Methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene			YNL063W	S000005007
MTQ2		S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; methylates release factor eRF1 (Sup45p) in vitro; is not an essential gene; similar to E.coli PrmC			YDR140W	S000002547
MTR10	KAP111	Nuclear import receptor, mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p			YOR160W	S000005686
MTR2		mRNA transport regulator, essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA	mRNA transport regulator	Null mutant is inviable; mtr2 mutants exhibit nuclear mRNA accumulation and nucleolar fragmentation	YKL186C	S000001669
MTR3		3'5' exoribonuclease, exosome subunit; nucleolar protein involved in export of mRNA and ribosomal subunits; homologous to the E. coli exonuclease RNase PH		null is inviable; mutant with mtr3-1 allele has defects in both mRNA transport and in rRNA synthesis/processing, with polyA+ mRNA accumulated in the nucleolus	YGR158C	S000003390
MTR4	DOB1	Dead-box family ATP dependent helicase required for mRNA export from the nucleus; co-factor of the exosome complex, required for 3' end formation of 5.8S rRNA			YJL050W	S000003586
MTW1	DSN3|NSL2	Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly		Null mutant is inviable. ts mtw1 mutant exhibits longer metaphase spindles and unequal sister chromatid segregation	YAL034W-A	S000000032
MUB1		Protein of unknown function, deletion causes multi-budding phenotype; has similarity to Aspergillus nidulans samB gene		Null mutant is viable but shows multi-budding	YMR100W	S000004706
MUC1	FLO11|STA4	GPI-anchored cell surface glycoprotein required for diploid pseudohyphal formation and haploid invasive growth, transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p)	cell surface flocculin with structure similar to serine/threonine-rich GPI-anchored cell wall proteins	Null mutant is viable, does not exhibit pseudohyphal differentiation as a diploid or invasive growth as a haploid	YIR019C	S000001458
MUD1		U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing	U1 snRNP A protein|U1-A|U1A		YBR119W	S000000323
MUD2		Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65			YKL074C	S000001557
MUK1		Protein of unknown function, localized to the cytoplasm; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation			YPL070W	S000005991
MUM2	SPOT8	Cytoplasmic protein essential for meiotic DNA replication and sporulation; interacts with Orc2p, which is a component of the origin recognition complex		Mutant is sporualtion defective and fails to perform premiotic DNA synthesis; overexpression suppresses a TOR2 allele	YBR057C	S000000261
MUM3		Protein of unknown function involved in the organization of the outer spore wall layers; has similarity to the tafazzins superfamily of acyltransferases			YOR298W	S000005824
MUM4						S000080476
MUP1		High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake	methionine permease	Null mutant is viable but cannot perform high-affinity methionine update.	YGR055W	S000003287
MUP2		Methionine uptake 2	methionine permease			S000029316
MUP3		Low affinity methionine permease, similar to Mup1p	methionine permease		YHL036W	S000001028
MUQ1	ECT1	Choline phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases	choline phosphate cytidylyltransferase (also called phosphoethanolamine cytidylyltransferase or phosphocholine cytidylyltransferase)		YGR007W	S000003239
MUS81	SLX3	Helix-hairpin-helix protein, involved in DNA repair and replication fork stability; functions as an endonuclease in complex with Mms4p; interacts with Rad54p		Null mutant is viable but is MMS and UV sensitive and meiosis defective, null is synthetically lethal with sgs1 null	YDR386W	S000002794
MUT1				An uncharacterized allele increases teh reversion rate of the ochre alleles lys1-1 and arg4-17.		S000029317
MVB12		ESCRT-I subunit necessary for the efficient transport of cargo proteins to the vacuolar lumen; deletion mutant sensitive to rapamycin and nystatin; green fluorescent protein (GFP)-fusion protein localizes to endosome			YGR206W	S000003438
MVD1	ERG19	Mevalonate pyrophosphate decarboxylase, essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer	mevalonate pyrophosphate decarboxylase	Null mutant is inviable; a single leucine to proline mutation causes temperature sensitivity.	YNR043W	S000005326
MVP1		Protein required for sorting proteins to the vacuole; overproduction of Mvp1p suppresses several dominant VPS1 mutations; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole		MVP1 was identified as a multicopy suppressor of dominant-negative vps1 mutations, as well as an extragenic suppressor of a temperature-sensitive pma1 mutation (sop gene)	YMR004W	S000004606
MXR1	MSRA	Peptide methionine sulfoxide reductase, reverses the oxidation of methionine residues; involved in oxidative damage repair, providing resistance to oxidative stress and regulation of lifespan	peptide methionine sulfoxide reductase		YER042W	S000000844
MYO1		Type II myosin heavy chain, required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively	class II myosin	Null mutant is viable, exhibts abnormal chitin distribution and cell wall organization at the mother-bud neck in a high proportion of dividing cells; exhibits abberant nuclear migration and cytokinesis; bem2 myo1 double mutants are inviable	YHR023W	S000001065
MYO2	CDC66	One of two type V myosin motors (along with MYO4) involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle	class V myosin	Null mutant is inviable. myo2-66 (E511K), a temperature-sensitive allele, accumulates secretory vesicles and exhibits defects in initiation of new buds and delocalized chitin.	YOR326W	S000005853
MYO3		One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization	myosin I	Null mutant is viable, myo3 myo5 double deletion mutants exhibit severe defects in growth and actin cytoskeletal organization	YKL129C	S000001612
MYO4	FUN22|SHE1	One of two type V myosin motors (along with MYO2) involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p	class V myosin	Null mutant is viable, has no detectable phenotype, either alone or in conjunction with mutations in other myosin genes. Overexpression of MYO4 results in several morphological abnormalities, including the formation of short strings of unseparated cells in diploid strains, or clusters of cells in haploid strains	YAL029C	S000000027
MYO5		One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization	myosin I	Null mutant is viable; myo3 myo5 double deletion mutants exhibit loss of actin polarity, growth arrest at 37 degrees or high osmotic strength, accumulation of intracellular membranes, and loss of polarized cell surface growth; myo3 myo5 double mutants have longer doubling times and thicker cell walls	YMR109W	S000004715
NAB2		Nuclear polyadenylated RNA-binding protein; autoregulates mRNA levels; related to human hnRNPs; has nuclear localization signal sequence that binds to Kap104p; required for poly(A) tail length control and nuclear mRNA export	polyadenylated RNA binding protein		YGL122C	S000003090
NAB3	HMD1	Single stranded RNA binding protein; acidic ribonucleoprotein; required for termination of non-poly(A) transcripts and efficient splicing; interacts with Nrd1p	polyadenylated RNA binding protein|polyadenylated single strand DNA-binding protein	null is inviable; overexpression reduces the expression of the G1 cyclin CLN3	YPL190C	S000006111
NAB6		Putative RNA-binding protein, based on computational analysis of large-scale protein-protein interaction data			YML117W	S000004585
NAF1		Protein required for the assembly of box H/ACA snoRNPs and for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; has similarity to Gar1p and other RNA-binding proteins		Null: inviable. Other phenotypes: Depletion leads to loss of independently transcribed box H/ACA snoRNAs	YNL124W	S000005068
NAM2	MSL1	Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance	LeuRS|mitochondrial leucyl-tRNA synthetase	Null mutant is viable, respiration deficient	YLR382C	S000004374
NAM7	IFS2|MOF4|UPF1	ATP-dependent RNA helicase of the SFI superfamily, required for nonsense mediated mRNA decay and for efficient translation termination at nonsense codons; involved in telomere maintenance		Null mutant is viable, exhibits impairment in respiratory growth that is exacerbated by low temperatures; exhibits stabilization of nonsense-containing mRNAs which leads to a nonsense suppression phenotype	YMR080C	S000004685
NAM8	MRE2|MUD15	RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of MER2 pre-mRNA	RNA-binding protein|U1 snRNP protein	Null mutant is viable; defective in meiotic recombination, formation of viable spores, and formation of meiosis-specific double-strand breaks and crossover and noncrossover recombinants; overexpression suppresses mitochondrial splicing defects; impaired association of yeast-specific U1 snRNP proteins but hyperstabilized association of Snu65p/Prp42p with the U1 snRNP; affects in vivo splicing of introns with non-canonical 5'-splice sites; mutant contains a U1 snRNP with aberrant migration behaviour on native gels	YHR086W	S000001128
NAM9	MNA6	Mitochondrial ribosomal component of the small subunit		Null mutant is viable but is respiration-deficient and loses mitochondrial DNA integrity	YNL137C	S000005081
NAN1	UTP17	U3 snoRNP protein, component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA	U3 snoRNP protein		YPL126W	S000006047
NAP1		Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus	nucleosome assembly protein I	Null mutant is viable but exhibits defects in Clb2 function.	YKR048C	S000001756
NAR1		Nuclear architecture related protein; component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins; homologous to human Narf			YNL240C	S000005184
NAS2		Protein with similarity to the p27 subunit of mammalian proteasome modulator; not essential; interacts with Rpn4p			YIL007C	S000001269
NAS6		Regulatory, non-ATPase subunit of the 26S proteasome; homolog of the human oncoprotein gankyrin, which interacts with the retinoblastoma tumor suppressor (Rb) and cyclin-dependent kinase 4/6			YGR232W	S000003464
NAT1	AAA1	Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing	N-terminal acetyltransferase	Null mutant is viable, has reduced acetyltransferase activity, derepressed silent mating type locus (HML) and fails to enter G0	YDL040C	S000002198
NAT2		N alpha-acetyl-transferase, transfers acetyl group from acetyl coenzyme A to the N-terminal methionine residues of proteins	N alpha-acetyltransferase		YGR147C	S000003379
NAT3		Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met	N-terminal acetyltransferase	Lack of N-terminal acetylation of proteins with Met-Glu-, Met-Asp- and certain other termini.	YPR131C	S000006335
NAT4		N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2A	N-alpha acetyltransferase	Null: viable; histones H4 and H2A are no longer acetylated on their N-terminal serine residues	YMR069W	S000004673
NAT5	ARD2|ROG2	Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing	N-acetyltransferase		YOR253W	S000005779
NBA1		Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, and bud neck; potential Cdc28p substrate			YOL070C	S000005431
NBP1		Spindle pole body (SPB) component, required for the insertion of the duplication plaque into the nuclear membrane during SPB duplication; essential for bipolar spindle formation; component of the Mps2p-Bbp1p complex			YLR457C	S000004449
NBP2		Protein involved in the HOG (high osmolarity glycerol) pathway, negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex, found in the nucleus and cytoplasm, contains an SH3 domain that binds Pbs2p			YDR162C	S000002569
NBP35		Essential P-loop NTPase that functions in nuclear and cytosolic iron-sulfur (FeS) protein assembly; has a highly conserved N-terminus			YGL091C	S000003059
NCA2		Protein involved in regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; functions with Nca3p			YPR155C	S000006359
NCA3		Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family			YJL116C	S000003652
NCB2	YDR1	Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta	transcriptional regulator		YDR397C	S000002805
NCE1		Negative regulator of CTS1 expression		Mutations in NCE genes were identified as suppressors of an ace2 mutant which allow restoration of CTS1 expression in the absence of ACE2, a CTS1 activator.		S000029318
NCE101	NCE1|YJL205C-A|YJL206C-A	Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences		An uncharacterized allele exhibits defects in the export of the mammalian protein galectin-1.	YJL205C	S000003742
NCE102	NCE2	Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs)		An uncharacterized allele exhibits defects in the export of the mammalian protein galectin-1.	YPR149W	S000006353
NCE103	NCE3	Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway			YNL036W	S000004981
NCE2		Negative regulator of CTS1 expression		Mutations in NCE genes were identified as suppressors of an ace2 mutant which allow restoration of CTS1 expression in the absence of ACE2, a CTS1 activator.		S000029319
NCE3		Negative regulator of CTS1 expression		Mutations in NCE genes were identified as suppressors of an ace2 mutant which allow restoration of CTS1 expression in the absence of ACE2, a CTS1 activator.		S000029320
NCL1	TRM4	S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; similar to Nop2p and human proliferation associated nucleolar protein p120	m5C tRNA methyltransferase	Null mutant is viable, sensitive to paromomycin, lacks m5C methylation in total yeast tRNA	YBL024W	S000000120
NCP1	CPR1	NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p	NADP-cytochrome P450 reductase		YHR042W	S000001084
NCR1		Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; glycoprotein and functional orthologue of human Niemann Pick C1 (NPC1) protein		dominant mutation in the putative sterol-sensing domain of Ncr1p confers temperature and polyene antibiotic sensitivity; mutant cells resistant to inhibitors of sphingolipid biosynthesis and super sensitive to sphingosine and C2-ceramide	YPL006W	S000005927
NCS2		Protein with a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts			YNL119W	S000005063
NCS6	YGL210W-A	Protein with a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts			YGL211W	S000003179
NDC1		Nuclear envelope protein with multiple putative transmembrane domains, required for nuclear pore complex assembly and spindle pole body duplication; required for meiosis II	nuclear pore complex subunit	Null mutant is inviable. Conditional lethal mutants are available that show asymmetric chromosomal segregation during mitosis and meiosis II due to a defect in spindle pole body duplication	YML031W	S000004493
NDD1		Transcriptional activator essential for nuclear division; localized to the nucleus; essential component of the mechanism that activates the expression of a set of late-S-phase-specific genes		Null mutant is inviable and arrests prior to nuclear division but after DNA replication; cells are large budded with short mitotic spindles.	YOR372C	S000005899
NDE1	NDH1	Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain	NADH:ubiquinone oxidoreductase|Type II NAD(P)H:quinone oxidoreductase		YMR145C	S000004753
NDE2	NDH2	Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain	Type II NAD(P)H:quinone oxidoreductase		YDL085W	S000002243
NDI1		NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; homolog of human AMID	NADH:ubiquinone oxidoreductase|Type II NAD(P)H:quinone oxidoreductase		YML120C	S000004589
NDJ1	TAM1	Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution (interference), sister chromatid cohesion at meiotic telomeres, and segregation of small chromosomes		Null allele exhibits errors in meiotic chromosome segregation about 10-fold higher than the wild-type error rate. Spore viability of homozygous diploids with the null allele is approximately 50% of wild-type. Mutant also shows delayed meiotic chromosome synapsis, disrupted crossover interference and increased frequency of nonexchange chromosomes leading to meiosis I nondisjunction and disruption of distributive disjunction	YOL104C	S000005464
NDL1		homolog of nuclear distribution factor NudE, NUDEL			YLR254C	S000004244
NDT80		Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE)	DNA binding transcription factor that activates middle sporulation genes	Null mutant is viable, arrests in pachytene stage of meiosis at the mononucleate stage with duplicated spindle pole bodies and no spindles, is not rescued by spo11 or rad50; no mitotic phenotype detected, dispensable for double-stranded breaks	YHR124W	S000001166
NEJ1	LIF2	Protein involved in regulation of nonhomologous end joining; repressed by MAT heterozygosity; associates with Lif1p and regulates its cellular distribution	Mating-type regulated component of NHEJ	Null mutant is viable, defective in NHEJ; Overexpression restores NHEJ in MATa/MATalpha cells	YLR265C	S000004255
NEM1		Catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme, which regulates nuclear growth by controlling recruitment of Pah1p onto promoters of phospholipid biosynthetic genes; required for normal nuclear envelope morphology and sporulation		Null mutant is viable but exhibits slow growth at 37 deg. and 16 deg and has an abnormal nuclear envelope. Homozygous diploid null mutants exhibit defects in sporulation.	YHR004C	S000001046
NEO1		Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus		Null mutant is inviable. When overexpressed, Neo1 confers neomycin resistance.	YIL048W	S000001310
NET1	CFI1|ESC5|SRM8	Core subunit of the RENT complex, which is a complex involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure		Null mutant is viable and grows slowly	YJL076W	S000003612
NEW1		ATP binding cassette family member; Asn/Gln-rich rich region supports [NU+] prion formation, susceptibility to [PSI+] prion induction and aggregation of a fragment of the human Machado-Joseph Disease protein			YPL226W	S000006147
NFI1	SIZ2	SUMO ligase, catalyzes the covalent attachment of SUMO (Smt3p) to proteins; involved in maintenance of proper telomere length	chromatin protein	Null mutant is viable. SIZ2 is a dosage bypass suppressor of an SMT4 deletion. A siz1 siz2 deletion has a synthetic phenotype (slow growth).	YOR156C	S000005682
NFS1	SPL1	Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis; required for the post-transcriptional thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria		Null mutant is inviable; spl1-1 mutant allele affects tRNA splicing	YCL017C	S000000522
NFT1		Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds.	Putative MRP-type ABC transporter		YKR103W	S000001811
NFU1	NUB1	Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria		Null mutant is viable on YPD 30 degrees C, and is synthetically lethal with SSQ1	YKL040C	S000001523
NGG1	ADA3|SWI7	Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex	Ada histone acetyltransferase complex component	Null mutant is viable, grows poorly on minimal media	YDR176W	S000002583
NGL1		Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YOL042W	S000005402
NGL2		Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p and Ngl3p	RNase		YMR285C	S000004898
NGL3		Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p and Ngl2p			YML118W	S000004587
NGM2				ngm2-1 mutants are defective with respect to induced mutagenesis by nitrosoguanidine; homozygous diploids sporulate normally		S000029321
NGR1	RBP1	RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; expressed in stationary phase	glucose-repressible RNA binding protein	Null mutant is viable and shows increased cell growth rate in early log phase	YBR212W	S000000416
NHA1		Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH		Null mutant is viable but shows increased sensitivity to sodium and lithium; overexpression of NHA1 confers higher and partially Phenotype-dependent tolerance to those ions	YLR138W	S000004128
NHP10	HMO2	Protein related to mammalian high mobility group proteins; likely component of the INO80 complex, which is an ATP-dependent chromatin-remodeling complex		null mutant is viable and has normal growth rate	YDL002C	S000002160
NHP2		Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing			YDL208W	S000002367
NHP6A		High-mobility group non-histone chromatin protein, functionally redundant with Nhp6Bp; homologous to mammalian high mobility group proteins 1 and 2; acts to recruit transcription factor Rcs1p to certain promoters	11 kDa nonhistone chromosomal protein		YPR052C	S000006256
NHP6B	YBR090C-A	High-mobility group non-histone chromatin protein, functionally redundant with Nhp6Ap; homologous to mammalian high mobility group proteins 1 and 2; acts to recruit transcription factor Rcs1p to certain promoters	11 kDa nonhistone chromosomal protein	Deleting both NHP6A and NHP6B gives temperature-sensitive yeast with morphological and cytoskeletal defects at the restrictive temperature; defects are suppressed by 1 M sorbitol in the medium; nhp6a nhp6b double mutant also lacks induction of a subset of genes	YBR089C-A	S000002157
NHS1		Inhibitor of hydrogen sulfide production				S000029322
NHX1	NHA2|VPL27|VPS44	Endosomal Na+/H+ exchanger, required for intracellular sequestration of Na+; required for osmotolerance to acute hypertonic shock	Na+/H+ exchanger		YDR456W	S000002864
NIC96		Component of the nuclear pore complex, required for nuclear pore formation; forms a subcomplex with Nsp1p, Nup57p, and Nup49p	nuclear pore complex subunit		YFR002W	S000001898
NIF3		Protein of unknown function, similar to Listeria monocytogenes major sigma factor (rpoD gene product); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YGL221C	S000003189
NIP1		Subunit of the eukaryotic translation initiation factor 3 (eIF3), involved in the assembly of preinitiation complex and start codon selection	translation initiation factor eIF3 subunit	Null mutant is inviable; nip1-1 is a temperature-sensitive mutant defective in nuclear transport	YMR309C	S000004926
NIP100	PAC13	Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued)		Null mutant is viable but exhibits slow growth and defects in partitioning into daughter cells.	YPL174C	S000006095
NIP7		Nucleolar protein required for 60S ribosome subunit biogenesis, constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p		Null mutant is inviable; in the temperature-sensitive mutant nip7-1, glycine 71 is replaced by aspartic acid	YPL211W	S000006132
NIS1	JIP1	Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network			YNL078W	S000005022
NIT1		Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene			YIL164C	S000001426
NIT2		Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member			YJL126W	S000003662
NIT3		Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member			YLR351C	S000004343
NKP1		Non-essential kinetochore protein, subunit of the Ctf19 central kinetochore complex (Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p-Nkp1p-Nkp2p-Ame1p-Mtw1p)			YDR383C	S000002791
NKP2		Non-essential kinetochore protein, subunit of the Ctf19 central kinetochore complex (Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p-Nkp1p-Nkp2p-Ame1p-Mtw1p)			YLR315W	S000004307
NLE2						S000029324
NMA1		Nicotinic acid mononucleotide adenylyltransferase, involved in NAD(+) salvage pathway	nicotinamide/nicotinic acid mononucleotide adenylyltransferase	Null: viable. Other phenotypes: 2 or more copies increase rDNA and telomeric silencing	YLR328W	S000004320
NMA111	YNM3	Protein of unknown function which may contribute to lipid homeostasis and/or apoptosis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases			YNL123W	S000005067
NMA2		Nicotinic acid mononucleotide adenylyltransferase, involved in NAD(+) salvage pathway	nicotinamide/nicotinic acid mononucleotide adenylyltransferase	Null: viable. Other phenotypes: 2 or more copies increase rDNA and telomeric silencing	YGR010W	S000003242
NMD2	IFS1|SUA1|UPF2	Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance		Null mutant is viable, exhibits stabilization of nonsense-containing mRNAs	YHR077C	S000001119
NMD3	SRC5	Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex		Null mutant is inviable, at nonpermissive temperature, nmd3 ts mutants exhibit decreased levels of 60S subunits resulting in formation of half-mer polysomes; nmd3 xrn1(kem1) double mutants are inviable	YHR170W	S000001213
NMD4		Protein interacting with Nam7p, may be involved in the nonsense-mediated mRNA decay pathway			YLR363C	S000004355
NMD5	KAP119	Karyopherin, a carrier protein involved in nuclear import of proteins; importin beta homolog		Null mutant is viable, exhibits mislocalization of TFIIS and Hog1p	YJR132W	S000003893
NME1	RRP2	RNA component of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; human ortholog is implicated in cartilage-hair hypoplasia (CHH)	RNase MRP subunit			S000007436
NMT1	CDC72	N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction	N-myristoyl transferase		YLR195C	S000004185
NNF1		Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation		Null mutant is inviable; cells depleted of Nnf1p or containing a temperature-sensitive nnf1 mutation have elongated microtubules and become bi- and multinucleate	YJR112W	S000003873
NNF2		Protein that exhibits physical and genetic interactions with Rpb8p, which is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation			YGR089W	S000003321
NNT1		Putative nicotinamide N-methyltransferase, has a role in rDNA silencing and in lifespan determination		Null: Decreased rDNA and telomeric silencing. Other phenotypes: Overexpression increases silencing and Sir2 activity	YLR285W	S000004275
NOB1	YOR29-07	Essential nuclear protein involved in proteasome maturation and synthesis of 40S ribosomal subunits; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA			YOR056C	S000005582
NOC2		Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors			YOR206W	S000005732
NOC3		Protein that forms a nuclear complex with Noc2p that binds to 66S ribosomal precursors to mediate their intranuclear transport; also binds to chromatin to promote the association of DNA replication factors and replication initiation			YLR002C	S000003992
NOC4	UTP19	Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits	U3 snoRNP protein	Null: lethal. Other phenotypes: required for 18S RNA production	YPR144C	S000006348
NOG1		Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins			YPL093W	S000006014
NOG2		Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation	part of a pre-60S complex		YNR053C	S000005336
NOP1	LOT3	Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin	U3 snoRNP protein	Null mutant is inviable. Temperature-sensitive alleles exhibit various defects in rRNA processing.|	YDL014W	S000002172
NOP10		Constituent of small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs, which are required for pseudouridylation and processing of pre-18S rRNA	H/ACA-box snoRNPs component		YHR072W-A	S000007455
NOP12		Nucleolar protein, required for pre-25S rRNA processing; contains an RNA recognition motif (RRM) and has similarity to Nop13p, Nsr1p, and putative orthologs in Drosophila and S. pombe		Null mutant is viable and shows slow growth and cold sensitivity	YOL041C	S000005401
NOP13		Protein of unknown function, localizes to the nucleolus and nucleoplasm; contains an RNA recognition motif (RRM) and has similarity to Nop12p, which is required for processing of pre-18S rRNA			YNL175C	S000005119
NOP14	UTP2	Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA	U3 snoRNP protein		YDL148C	S000002307
NOP15		Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm			YNL110C	S000005054
NOP16		Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis			YER002W	S000000804
NOP2	YNA1	Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles		Null mutant is inviable; overexpression leads to changes in nucleolar morphology	YNL061W	S000005005
NOP4	NOP77	Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)		Null mutant is inviable; conditional mutant shows diminished accumulation of 60S ribosomal subunits due to a lack of production of mature 25S rRNA from 27S precursor rRNA	YPL043W	S000005964
NOP53	RRP16	Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p; null mutant is viable but growth is severely impaired			YPL146C	S000006067
NOP58	NOP5	Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA	U3 snoRNP protein	Null mutant is inviable; in vivo depletion impairs synthesis of the 40S ribosomal subunit	YOR310C	S000005837
NOP6		Putative RNA-binding protein implicated in ribosome biogenesis; contains an RNA recognition motif (RRM) and has similarity to hydrophilins; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes			YDL213C	S000002372
NOP7	YPH1	Nucleolar protein involved in rRNA processing and 60S ribosomal subunit biogenesis; constituent of several different pre-ribosomal particles; required for exit from G<sub>0</sub> and the initiation of cell proliferation			YGR103W	S000003335
NOP8		Nucleolar protein required for 60S ribosomal subunit biogenesis			YOL144W	S000005504
NOP9		Essential nucleolar protein required for 18S rRNA synthesis			YJL010C	S000003547
NOT3		Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation	CCR4-NOT transcriptional complex subunit	Null mutant is viable, overexpression of NOT3 suppresses cdc39(not1) and cdc36(not2) mutations	YIL038C	S000001300
NOT5		Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation	CCR4-NOT transcriptional complex subunit	Null mutant is viable, mutations in not4(mot2) are synthetically lethal with mutations in not5, overexpression of NOT3 or NOT4(MOT2) suppresses not5 mutations	YPR072W	S000006276
NOV1				novobiocin resistance		S000029325
NP16		Nuclear protein important for nuclear protein localization				S000029326
NPA3	EPA1	Essential, conserved, cytoplasmic ATPase; phosphorylated by the Pcl1p-Pho85p kinase complex			YJR072C	S000003833
NPC2		Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes			YDL046W	S000002204
NPL3	MTR13|MTS1|NAB1|NOP3	RNA-binding protein that carries poly(A)+ mRNA from the nucleus into the cytoplasm; dissociation from mRNAs is promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm	nuclear shuttling protein	Null mutant is inviable, npl3 mutants are temperature-sensitive for growth, but do not exhibit a defect in localization of nuclear proteins	YDR432W	S000002840
NPL4	HRD4	Endoplasmic reticulum and nuclear membrane protein, forms a complex with Cdc48p and Ufd1p that recognizes ubiquitinated proteins in the endoplasmic reticulum and delivers them to the proteasome for degradation		Temperature-sensitive mutants accumulate nuclear-targeted proteins in the cytoplasm and poly(A)+RNA in the nucleus and show defects in nuclear membrane integrity at the nonpermissive temperature	YBR170C	S000000374
NPL6	RSC7	Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Ldb7p, and Htl1p to form a module important for a broad range of RSC functions; involved in nuclear protein import and maintenance of proper telomere length			YMR091C	S000004697
NPP1		Nucleotide pyrophosphatase/phosphodiesterase family member; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation	nucleotide phosphatase		YCR026C	S000000621
NPP2		Nucleotide pyrophosphatase/phosphodiesterase family member; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation	nucleotide phosphatase		YEL016C	S000000742
NPR1		Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation		inactive ammonia-sensitive amino acid permeases	YNL183C	S000005127
NPR2		Protein with a possible role in regulating expression of nitrogen permeases; transcription is induced in response to proline and urea; contains two PEST sequences; null mutant is resistant to cisplatin and doxorubicin			YEL062W	S000000788
NPT1		Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus	nicotinate phosphoribosyltransferase	Mutations weaken silencing and also cause a reduction in the intracellular NAD(+) level.	YOR209C	S000005735
NPY1		NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes	NADH pyrophosphatase 1	No readily detected phenotype	YGL067W	S000003035
NQM1		Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity			YGR043C	S000003275
NRD1		RNA-binding protein that interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), required for transcription termination and 3' end maturation of nonpolyadenylated RNAs			YNL251C	S000005195
NRG1		Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response	transcriptional repressor	Null mutant is viable, relieves glucose repression of SUC2 and STA1; suppresses snf mutations	YDR043C	S000002450
NRG2		Transcriptional repressor that mediates glucose repression and negatively regulates filamentous growth; has similarity to Nrg1p		Null mutant is viable with no detected phenotypes	YBR066C	S000000270
NRK1		Nicotinamide riboside kinase, catalyzes the synthesis of nicotinamide nucleotide (NMN) from nicotinamide riboside; involved in a salvage pathway for NAD+ biosynthesis	nicotinamide riboside kinase		YNL129W	S000005073
NRM1		Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase	transcriptional repressor		YNR009W	S000005292
NRP1		Protein of unknown function, rich in asparagine residues			YDL167C	S000002326
NSA1		Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis			YGL111W	S000003079
NSA2		Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA		Heterozygous diploid mutant exhibit haploinsufficiency K1 killer toxin resistance	YER126C	S000000928
NSE1		Essential subunit of the Mms21-Smc5-Smc6 complex; nuclear protein required for DNA repair and growth		nse1 mutants are highly sensitive to DNA-damaging treatments and exhibit abnormal cellular morphologies.	YLR007W	S000003997
NSE3		Essential subunit of the Mms21-Smc5-Smc6 complex; protein of unknown function; required for DNA repair and growth			YDR288W	S000002696
NSE4	QRI2	Nuclear protein that plays a role in the function of the Smc5p-Rhc18p complex			YDL105W	S000002263
NSE5		Essential subunit of the Mms21-Smc5-Smc6 complex; required for cell viability and DNA repair	non-SMC element of the Smc5-Smc6 complex		YML023C	S000004485
NSG1		Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins		Null: none	YHR133C	S000001175
NSG2		Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins		Null: none	YNL156C	S000005100
NSL1		Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation			YPL233W	S000006154
NSP1		Essential component of the nuclear pore complex, which mediates nuclear import and export	nuclear pore complex subunit		YJL041W	S000003577
NSR1	SHE5	Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis	nuclear localization sequence binding protein	Null mutant is viable, shows severe growth defect.	YGR159C	S000003391
NST1		Protein of unknown function, mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1			YNL091W	S000005035
NTA1	DEA1	Amidase, removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation	52 kDa amidase specific for N-terminal asparagine and glutamine	Null mutant is viable but cannot degrade N-end rule substrates that have N-terminal asparagine or glutamine	YJR062C	S000003823
NTC20		Member of a complex, including Prp19p, that binds to the spliceosome; required for pre-mRNA splicing	splicing factor	Null mutant is viable. ntc20 ntc30 double mutant is very sick and accumulates pre-mRNA. Null mutant is synthetically lethal with prp19.	YBR188C	S000000392
NTE1		Serine esterase that deacylates exogenous lysophospholipids, homolog of human neuropathy target esterase (NTE); mammalian NTE1 deacylates phosphatidylcholine to glycerophosphocholine	phosphatidylcholine and lysophosphatidylcholine phospholipase		YML059C	S000004524
NTF2		Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport	nuclear transport factor	Null mutant is inviable; temperature-sensitive mutants are defective in localization of nuclear proteins at nonpermissive temperature	YER009W	S000000811
NTG1	FUN33|SCR1	DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair, localizes to the nucleus and mitochondrion	DNA glycosylase	Null mutant is viable but is sensitive to H202 and menadione	YAL015C	S000000013
NTG2	SCR2	DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair, localizes to the nucleus	endonuclease III DNA base excision repair N-glycosylase		YOL043C	S000005403
NTH1		Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p	neutral trehalase		YDR001C	S000002408
NTH2		Putative neutral trehalase, required for thermotolerance and may mediate resistance to other cellular stresses	neutral trehalase	Null mutant is viable but lacks thermotolerance	YBR001C	S000000205
NTO1		Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3	HAT complex component	Null: viable. Other phenotypes: require for NuA3 complex integrity	YPR031W	S000006235
NTR2		Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly			YKR022C	S000001730
NTS1-1	NTS1	Nontranscribed region of the rDNA repeat located between the 3'ETS and RDN5, required for rDNA repeat expansion; contains RNA polymerase I termination site				S000029328
NTS1-2	NTS1	Non-transcribed region of the rDNA repeat located between the 3' ETS and RDN5, required for rDNA repeat expansion				S000029714
NTS2-1		Nontranscribed region of the rDNA repeat, located between RND5 and the 5'ETS; contains RNA polymerase I termination site				S000029329
NTS2-2	NTS2	Non-transcribed region of the rDNA repeat, located between RDN5 and the 5' ETS				S000029706
NUC1		Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy	nuclease		YJL208C	S000003744
NUD1		Component of the spindle pole body outer plaque, required for exit from mitosis			YOR373W	S000005900
NUF2		Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering		Null mutant is inviable; temperature-sensitive mutants arrest with single undivided or partially divided nucleus in the bud neck, shortened mitotic spindle, and fully replicated DNA	YOL069W	S000005430
NUG1		GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits from the nucleus	Nuclear GTPase involved in Ribosome biogenesis		YER006W	S000000808
NUM1	PAC12	Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex		Null mutant is viable; num1-disrupted strains contain many budded cells with two nuclei in mother cell, and haploid num1 strains tend to diploidize during mitosis	YDR150W	S000002557
NUP1		Nuclear pore complex (NPC) subunit, involved in protein import/export and in export of RNAs, possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; potential Cdc28p substrate	nuclear pore complex subunit	Davis and Fink (Cell 61:965-978) report that a NUP1 deletion is inviable, whereas Schlaich and Hurt (Eur J Cell Biol 127:319-332) report that NUP1 deletion is viable.	YOR098C	S000005624
NUP100	NSP100	Subunit of the nuclear pore complex (NPC) that is localized to both sides of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup116p	nuclear pore complex subunit	Null mutant is viable with no obvious phenotypes; synthetically lethal with nup116 and gle2 mutants	YKL068W	S000001551
NUP116	NSP116	Subunit of the nuclear pore complex (NPC) that is localized to both sides of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup100p	nuclear pore complex subunit	Null mutant grows slowly, accumulates unspliced pre-tRNAs, acumulates poly(A)+ RNA in the nucleus, and is temperature-sensitive; at nonpermissive temperature, null mutants show membrane seals covering cytoplasmic face of nuclear pore complexes; synthetically lethal with nsp1, nup100, and nup145	YMR047C	S000004650
NUP120	RAT2	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), required for even distribution of NPCs around the nuclear envelope, involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p	nuclear pore complex subunit	Null mutant is viable but grows slower, is temperature-sensitive, and shows nucleolar fragmentation and clustering of nuclear pore complexes; at nonpermissive temperature, null mutant accumulates poly(A)+ mRNA in nucleus and shows nucleolar fragmentation and spindle defects; temperature sensitivity can be suppressed by growth in high osmolarity media; synthetically lethal with nup133 and nup159	YKL057C	S000001540
NUP133	RAT3	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), localizes to both sides of the NPC, required to establish a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p	nuclear pore complex subunit	Null mutant is viable but grows slowly and is temperature-sensitive; at nonpermissive temperature, poly(A)+ RNA accumulates in nucleus (although nuclear import of karyophilic proteins is not blocked) and nuclear pores cluster; synthetically lethal with nup120	YKR082W	S000001790
NUP145	RAT10	Essential nucleoporin, catalyzes its own cleavage in vivo to generate a C-terminal fragment that assembles into the Nup84p subcomplex of the nuclear pore complex, and an N-terminal fragment of unknown function that is homologous to Nup100p	nuclear pore complex subunit	Null mutant is inviable, depletion of Nup145p in vivo leads rapidly to nuclear retention of polyadenylated RNAs and more slowly to cytoplasmic accumulation of a nuclear reporter protein	YGL092W	S000003060
NUP157		Abundant subunit of the nuclear pore complex (NPC), present on both sides of the NPC, has similarity to Nup170p	nuclear pore complex subunit	Null mutant is viable; synthetically lethal with nup170 and nup188	YER105C	S000000907
NUP159	NUP158|RAT7	Subunit of the nuclear pore complex that is found exclusively on the cytoplasmic side, forms a subcomplex with Nup82p and Nsp1p, required for mRNA export	nucleoporin	Null mutant is inviable; at nonpermissive temperature, a temperature-sensitive mutant shows cessation of mRNA export without cytoplasmic accumulation of NLS-containing reporter protein, while at permissive temperature, the nuclear pore complexes are clustered; temperature-sensitive allele is synthetically lethal with nup120 and is suppressed by high copy GLE1	YIL115C	S000001377
NUP170	NLE3	Abundant subunit of the nuclear pore complex (NPC), required for proper localization of specific nucleoporins within the NPC, involved in nuclear envelope permeability and in chromosome segregation, has similarity to Nup157p	nuclear pore complex subunit	Null mutant is viable; synthetically lethal with nup157, nup188, and pom152; changing NUP170 expression causes morphological abnormalities in nuclear envelope	YBL079W	S000000175
NUP188		Subunit of the nuclear pore complex (NPC), involved in the structural organization of the complex and of the nuclear envelope, also involved in nuclear envelope permeability, interacts with Pom152p and Nic96p	nuclear pore complex subunit	Null mutant is viable but exhibits abnormalities in nuclear envelope and nuclear pore morphology; dominant mutants of nup188 are temperature-sensitive and show nuclear envelope herniations; synthetically lethal with pom152, nup157, and nup170	YML103C	S000004571
NUP192		Essential structural subunit of the nuclear pore complex (NPC), localizes to the nuclear periphery of nuclear pores, homologous to human p205	nuclear pore complex subunit		YJL039C	S000003576
NUP2		Protein involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization	nucleoporin	Null mutant is viable; some combinations of alleles of nup1, nsp1 and nup2 are synthetically lethal	YLR335W	S000004327
NUP42	RIP1|UIP1	Subunit of the nuclear pore complex (NPC) that localizes exclusively to the cytoplasmic side; involved in RNA export, most likely at a terminal step; interacts with Gle1p	nuclear pore complex subunit	Null mutant is viable, NUP42 is essential for the export of heat shock mRNAs following stress	YDR192C	S000002600
NUP49	NSP49	Subunit of the Nsp1p-Nup57p-Nup49p-Nic96p subcomplex of the nuclear pore complex (NPC), required for nuclear export of ribosomes	nuclear pore complex subunit	Null mutant is inviable; some nsp1 nsp49 alleles exhibit synthetic lethality	YGL172W	S000003140
NUP53		Subunit of the nuclear pore complex (NPC), interacts with karyopherin Kap121p or with Nup170p via overlapping regions of Nup53p, involved in activation of the spindle checkpoint mediated by the Mad1p-Mad2p complex	karyopherin docking complex component of the nuclear pore complex|nuclear pore complex subunit	Null mutant is viable but disrupts Kap121 localization to the nuclear envelope.	YMR153W	S000004762
NUP57		Essential subunit of the nuclear pore complex (NPC), functions as the organizing center of an NPC subcomplex containing Nsp1p, Nup49p, Nup57p, and Nic96p	nucleoporin		YGR119C	S000003351
NUP60		Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a process controlled by the nucleoplasmic concentration of Gsp1p-GTP; potential Cdc28p substrate; involved in telomere maintenance	nuclear pore complex subunit		YAR002W	S000000063
NUP63						S000029330
NUP82	HRB187	Subunit of the nuclear pore complex (NPC), forms a subcomplex with Nup159p and Nsp1p, interacts with Nup116p and is required for proper localization of Nup116p in the NPC	nuclear pore complex subunit|nucleoporin	Null mutant is inviable; cells depleted of Nup82p, or cells with temperature-sensitive Nup82p at nonpermissive temperature, show defect in poly(A)+RNA export but no major alterations in nuclear envelope structure or nuclear pore density	YJL061W	S000003597
NUP84		Subunit of the nuclear pore complex (NPC), forms a subcomplex with Nup85p, Nup120p, Nup145p-C, Sec13p, and Seh1p that plays a role in nuclear mRNA export and NPC biogenesis	nuclear pore complex subunit	Null mutant is viable but has defects in nuclear membrane and nuclear pore complex organization and in poly(A)+ RNA transport	YDL116W	S000002274
NUP85	RAT9	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), required for assembly of the subcomplex and also for formation of the nucleocytoplasmic Gsp1p concentration gradient that plays a role in nuclear trafficking	nuclear pore complex subunit	Null mutant is viable but is temperature-sensitive; at nonpermissive temperature, null mutant accumulates poly(A)+ RNA and has fragmented nucleolus; at permissive temperature, nuclear envelope of null mutant detaches from nucleus	YJR042W	S000003803
NUS1		Prenyltransferase, required for cell viability; involved in protein trafficking			YDL193W	S000002352
NUT1	MED5	Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription	mediator complex subunit	Null mutant is viable, deletion of NUT1 causes a constitutive, Swi4p-independent phenotype in combination with the nut2-1 allele or an allele of CCR4	YGL151W	S000003119
NUT2	MED10	Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription	mediator complex subunit	Null mutant is inviable, nut2-1 perturbs repression of URS2	YPR168W	S000006372
NVJ1	VAB36	Nuclear envelope protein that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN)		Null mutant is viable; cells do not form nucleus-vacuole junctions	YHR195W	S000001238
NYV1	MAM2	v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane	v-SNARE		YLR093C	S000004083
OAC1		Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, and thiosulfate; member of the mitochondrial carrier family	oxaloacetate transporter		YKL120W	S000001603
OAF1	YAF1	Oleate-activated transcription factor, acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis	transcription factor		YAL051W	S000000048
OAF3		Zinc cluster protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YKR064W	S000001772
OAR1		Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase, may comprise a type II mitochondrial fatty acid synthase along with Mct1p	3-oxoacyl-[acyl-carrier-protein] reductase	Null mutant is viable, respiratory deficient	YKL055C	S000001538
OAZ1	YPL052W-A	Regulator of ornithine decarboxylase (Spe1p), antizyme that binds to Spe1p to regulate ubiquitin-independent degradation; ribosomal frameshifting during synthesis of Oaz1p and its ubiquitin-mediated degradation are both polyamine-regulated			YPL052W	S000005973
OCA1		Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA			YNL099C	S000005043
OCA2		Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene			YNL056W	S000005001
OCA4		Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts			YCR095C	S000000691
OCA5		Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts			YHL029C	S000001021
OCA6		Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts			YDR067C	S000002474
OCH1	LDB12|NGD29	Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins	alpha-1,6-mannosyltransferase	Null mutant is viable, temperature sensitive, lacks mannose outer chains	YGL038C	S000003006
OCT1		Mitochondrial intermediate peptidase, cleaves N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis	mitochondrial intermediate peptidase	Null mutant is viable, unable to grow on nonfermentable substrates	YKL134C	S000001617
ODC1		Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation	2-oxodicarboxylate transporter		YPL134C	S000006055
ODC2		Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism	2-oxodicarboxylate transporter		YOR222W	S000005748
OGG1		Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA	43 kDa 8-oxo-guanine DNA glycosylase	Inactivation of OGG1 creates a mutator phenotype specific for the generation of GC to TA transversions.	YML060W	S000004525
OKP1		Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly			YGR179C	S000003411
OLA1		P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; protein levels are induced by hydrogen peroxide			YBR025C	S000000229
OLE1	MDM2	Fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria	delta-9-fatty acid desaturase	The null mutant is inviable but can be rescued by addition of unsaturarted fatty acids to the growth medium. Some alleles are temperature-sensitive for growth and show defective intracellular mitochondrial movement atthe non- permissive temperature.	YGL055W	S000003023
OLI1	ATP9|OLI3	F0-ATP synthase subunit 9 (ATPase-associated proteolipid), encoded on the mitochondrial genome; mutation confers oligomycin resistance; expression is specifically dependent on the nuclear genes AEP1 and AEP2	F1F0 ATP synthase subunit 9	Loss-of-function mutants lack rutamycin-sensitive ATPase activity, are oligomycin resistant, and do not grow on nonfermentable substrates. Some alleles are resistant to venturicidin or ossamycin.	Q0130	S000007274
OM14		Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron			YBR230C	S000000434
OM45		Protein of unknown function, major constituent of the mitochondrial outer membrane; located on the outer (cytosolic) face of the outer membrane		Null mutant is viable and shows normal growth, viability, mitochondrial function and mitochondrial protein import	YIL136W	S000001398
OMA1		Metalloendopeptidase of the mitochondrial inner membrane, involved in turnover of membrane-embedded proteins; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes			YKR087C	S000001795
OMS1		Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations			YDR316W	S000002724
OPI1		Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance		The null mutant is viable but constitutively accumulates INO1 mRNA.	YHL020C	S000001012
OPI10		Protein with a possible role in phospholipid biosynthesis, based on inositol-excreting phenotype of the null mutant and its suppression by exogenous choline			YOL032W	S000005392
OPI11		Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RPL43A/YPR043W; deletion confers sensitivity to GSAO			YPR044C	S000006248
OPI3	PEM2	Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis	unsaturated phospholipid N-methyltransferase	Null mutant is viable, temperature sensitive in the presence of monomethylethanolamine, exhibits an inositol secretion phenotype	YJR073C	S000003834
OPI6		Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential			YDL096C	S000002254
OPI7		Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene VID21/YDR359C.			YDR360W	S000002768
OPI8		Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene DID2/YKR035W-A			YKR035C	S000001743
OPI9		Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF VRP1/YLR337C			YLR338W	S000004330
OPT1	GSH11|HGT1	Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family	oligopeptide transporter	Null mutant is viable, exhibits loss of plasma membrane glutathione transport	YJL212C	S000003748
OPT2		Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans	peptide transporter		YPR194C	S000006398
OPY1		Protein of unknown function, overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YBR129C	S000000333
OPY2		Integral membrane protein that functions in the signaling branch of the high-osmolarity glycerol (HOG) pathway; interacts with Ste50p; overproduction blocks cell cycle arrest in the presence of mating pheromone			YPR075C	S000006279
ORC1		Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; may be phosphorylated by Cdc28p	origin recognition complex (ORC) 120 kDa (largest) subunit		YML065W	S000004530
ORC2	RRR1|SIR5	Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; may be phosphorylated by Cdc28p	origin recognition complex subunit 2		YBR060C	S000000264
ORC3		Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing	origin recognition complex subunit		YLL004W	S000003927
ORC4		Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing	origin recognition complex (ORC) 56 kDa subunit		YPR162C	S000006366
ORC5		Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing	origin recognition complex fifth largest subunit	orc5-1 mutant is temperature-sensitive, has defects in transcriptional silencing, has elevated rate of plasmid loss and inefficient initiation of DNA replication at the permissive temperature, and arrests at the nonpermissive temperature; CDC6 is multicopy suppressor of orc5-1	YNL261W	S000005205
ORC6		Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; may be phosphorylated by Cdc28p	ORC 50 kDa subunit		YHR118C	S000001160
ORI1		Mitochondrial DNA replication origin, non-essential for mitochondrial function				S000029667
ORI2		Mitochondrial origin of replication				S000029668
ORI3		Mitochondrial origin of replication				S000029669
ORI4		Mitochondrial origin of replication				S000029670
ORI5		Mitochondrial origin of replication				S000029671
ORI6		Mitochondrial origin of replication				S000029672
ORI7		Mitochondrial origin of replication				S000029673
ORI8		Mitochondrial origin of replication				S000029331
ORM1		Evolutionarily conserved protein with similarity to Orm2p, required for resistance to agents that induce the unfolded protein response; human ortholog is located in the endoplasmic reticulum			YGR038W	S000003270
ORM2		Evolutionarily conserved protein with similarity to Orm1p, required for resistance to agents that induce the unfolded protein response; human ortholog is located in the endoplasmic reticulum		Null: Single knockout is viable. <br> Double ORM1 ORM2 knockout shows impaired growth and high sensitivity to several toxic agents, particularly to tunicamycin, DTT and HgCl2.	YLR350W	S000004342
ORT1	ARG11	Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome		Null mutant is viable, arginine bradytroph	YOR130C	S000005656
OSH2		Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability			YDL019C	S000002177
OSH3		Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability			YHR073W	S000001115
OSH6		Member of an oxysterol-binding protein family with overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery			YKR003W	S000001711
OSH7		Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability			YHR001W	S000001043
OSM1	FRDS2	Fumarate reductase, catalyzes the reduction of fumarate to succinate, required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity	osmotic growth protein	Null mutant is viable, sensitive to hypertonic medium. Simultaneous disruption of YEL047C and OSM1 results in a growth defect of the yeast under anaerobic conditions, while disruption of OSM1 causes slow growth.	YJR051W	S000003812
OSR10		Involved in osmotic stress response		poor growth in the presence of elevated concentrations of NaCl and glucose		S000029332
OSR2		Involved in osmotic stress response		poor growth in the presence of elevated concentrations of NaCl and glucose		S000029333
OSR3		Involved in osmotic stress response		poor growth in the presence of elevated concentrations of NaCl and glucose		S000029334
OSR4		Involved in osmotic stress response		poor growth in the presence of elevated concentrations of NaCl and glucose		S000029335
OSR6		Involved in osmotic stress response		poor growth in the presence of elevated concentrations of NaCl and glucose		S000029336
OSR7		Involved in osmotic stress response		poor growth in the presence of elevated concentrations of NaCl and glucose		S000029337
OSR8		Involved in osmotic stress response		poor growth in the presence of elevated concentrations of NaCl and glucose		S000029338
OSR9		Involved in osmotic stress response		poor growth in the presence of elevated concentrations of NaCl and glucose		S000029339
OSS1				resistant to ossamycin		S000029340
OST1	NLT1	Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins	64 kDa, alpha subunit of oligosaccharyltransferase complex; homologous to mammalian ribophorin I	Null mutant is inviable; temperature-sensitive mutants show pleiotropic underglycosylation of soluble and membrane-bound glycoproteins	YJL002C	S000003539
OST2		Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins	oligosaccharyltransferase complex 16 kDa epsilon subunit	Null mutant is inviable; overexpression of OST2 suppresses temperature-sensitivity of wbp1-2 mutant; conditional mutants show pleiotropic underglycosylation of soluble and membrane-bound glycoproteins	YOR103C	S000005629
OST3		Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins	oligosaccharyl transferase glycoprotein complex 34 kDa gamma subunit	Null mutant is viable but shows underglycosylation of soluble and membrane-bound glycoproteins and contains less oligosaccharyltransferase activity in vitro	YOR085W	S000005611
OST4		Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes protein asparagine-linked glycosylation; type I membrane protein required for incorporation of Ost3p or Ost6p into the OST complex		Null mutant is viable but is cold- and heat-sensitive; vanadate-resistant, hygromycin B-sensitive; defective in oligosaccharyltransferase activity in vivo and in vitro	YDL232W	S000002391
OST5		Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins	oligosaccharyltransferase complex 9.5 kDa zeta subunit		YGL226C-A	S000003194
OST6		Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p			YML019W	S000004481
OSW1		Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p			YOR255W	S000005781
OSW2		Protein of unknown function proposed to be involved in the assembly of the spore wall			YLR054C	S000004044
OTU1	YOD1	Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family	De-ubiquitylation enzyme (DUB) of the OTU (ovarian tumor) family		YFL044C	S000001850
OTU2		Protein of unknown function that may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization			YHL013C	S000001005
OXA1	PET1402	Mitochondrial inner membrane insertase, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; conserved from bacteria to animals			YER154W	S000000956
OXR1		Protein of unknown function required for normal levels of resistance to oxidative damage, null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes but not in prokaryotes			YPL196W	S000006117
OXT1				Resistance to oxythiamin		S000029341
OYE2		Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye3p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism	NAPDH dehydrogenase (old yellow enzyme), isoform 2|Old Yellow Enzyme		YHR179W	S000001222
OYE3	ZRG6	Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism	NADPH dehydrogenase|Old Yellow Enzyme		YPL171C	S000006092
PAA1		Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication	polyamine acetyltransferase	Null: Mutant is viable. It is somewhat HU sensitive. It shows genetic interactions with gcn5, spt8 and spt15	YDR071C	S000002478
PAB1		Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G	poly(A) binding protein		YER165W	S000000967
PAC1		Protein involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; synthetic lethal with bni1; homolog of human LIS1			YOR269W	S000005795
PAC10	GIM2|PFD3|RKS2	Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding	prefoldin complex subunit	Null mutant is viable, benomyl sensitive, cold sensitive, microtubules disassemble at 14 degrees celsius, pac10 mutants exhibit synthetic lethality with tub4-1, cin8, cin1, pac2 and rbl2 mutants	YGR078C	S000003310
PAC11		Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microtubule capture site with Num1p; null mutant is defective in nuclear migration, essential in the absence of CIN8			YDR488C	S000002896
PAC2		Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl	tubulin folding cofactor E		YER007W	S000000809
PAD1	POF1	Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives	phenylacrylic acid decarboxylase	Null mutant is viable but is cinnamic acid-sensitive	YDR538W	S000002946
PAF1		RNAP II-associated protein; defines large complex biochemically and functionally distinct from the Srb-Mediator form of Pol II holoenzyme; required for full expression of a subset of cell cycle-regulated genes; homolog of human PD2/hPAF1			YBR279W	S000000483
PAH1	SMP2	Mg<sup>2+</sup>-dependent phosphatidate (PA) phosphatase, catalyzes the dephosphorylation of PA to yield diacylglycerol and P<sub>i</sub>, responsible for de novo lipid synthesis; homologous to mammalian lipin 1	phosphatidate phosphohydrolase	Null mutant is viable, respiration deficient and show increased stability of heterologous plasmids	YMR165C	S000004775
PAI3		Cytoplasmic proteinase A inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact	IA3|inhibitor of proteinase Pep4p	Null mutant is viable but shows increased rate of protein degradation	YMR174C	S000004786
PAM1		Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype		Multicopy PAM1 suppresses loss of protein phosphatase 2A (PP2A, encoded by PPH21, PPH21, and PPH3); overexpression of PAM1 inhibits growth and causes a filamentous phenotype	YDR251W	S000002659
PAM16	MIA1|TIM16	Constituent of the mitochondrial import motor associated with the presequence translocase, along with Ssc1p, Tim44p, Mge1p, and Pam18p; forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains J-like domain		Null mutant is inviable; MIA1 is required for respiration	YJL104W	S000003640
PAM17	FMP18	Presequence translocase-associated motor subunit, required for stable complex formation between cochaperones Pam16p and Pam18p, promotes association of Pam16p-Pam18p with the presequence translocase			YKR065C	S000001773
PAM18	TIM14	J-protein constituent of the mitochondrial import motor associated with the presequence translocase, with Ssc1p, Tim44p, Mge1p, and Pam16p; stimulates ATPase activity of Ssc1p to drive mitochondrial import; activity is inhibited by Pam16p	co-chaperone		YLR008C	S000003998
PAN1	DIM2|MDP3|MIP3	Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p, associates with actin patches on the cell cortex; promotes protein-protein interactions essential for endocytosis; previously thought to be a subunit of poly(A) ribonuclease		Null mutant is inviable; conditional mutants show arrest of translation initiation, alterations in mRNA poly(A) tail lengths, and altered cellular location of Mod5p	YIR006C	S000001445
PAN2		Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes	poly(A) ribonuclease 135 kDa subunit	Null mutant is viable but shows an increase in average length of mRNA poly(A) tails and a loss of Pab1p-stimulated poly(A) ribonuclease activity in vitro	YGL094C	S000003062
PAN3	ECM35	Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes	Pab1p-dependent poly(A) ribonuclease (PAN) 76 kDa subunit	Null mutant is viable but lacks Pab1p-dependent poly(A) ribonuclease activity in vitro; Tn3 insertion into PAN3 causes hypersensitivity to calcofluor white	YKL025C	S000001508
PAN5		2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE	2-dehydropantoate 2-reductase		YHR063C	S000001105
PAN6		Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC	pantothenate synthase	Null mutant is viable and shows pantothenate auxotrophy	YIL145C	S000001407
PAP1		Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs	poly(A) polymerase	lethal	YKR002W	S000001710
PAP2	TRF4	Catalytic subunit of TRAMP (Trf4/Pap2p-Mtr4p-Air1p/2p), a nuclear poly (A) polymerase complex involved in RNA quality control; catalyzes polyadenylation of unmodified tRNAs, and snoRNA and rRNA precursors; disputed role as a DNA polymerase	DNA polymerase sigma|poly(A) polymerase		YOL115W	S000005475
PAT1	MRT1	Topoisomerase II-associated deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; functionally linked to Pab1p		Null mutant is viable; slow growth rate, reduced fidelity of chromosome segregation during both mitosis and meiosis; slower rate of deadenylation-dependent decapping of mRNAs and transcript-specific effects on mRNA decay rates.	YCR077C	S000000673
PAU1		Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme			YJL223C	S000003759
PAU10		Hypothetical protein			YDR542W	S000002950
PAU11		Putative protein of unknown function; mRNA expression appears to be regulated by SUT1 and UPC2			YGL261C	S000003230
PAU12		Hypothetical protein			YGR294W	S000003526
PAU13		Putative protein of unknown function; not an essential gene			YHL046C	S000001038
PAU14		Hypothetical protein			YIL176C	S000001438
PAU15		Hypothetical protein			YIR041W	S000001480
PAU16		Putative protein of unknown function			YKL224C	S000001707
PAU17		Putative protein of unknown function; YLL025W is not an essential gene			YLL025W	S000003948
PAU18		Hypothetical protein			YLL064C	S000003987
PAU19		Hypothetical protein			YMR325W	S000004944
PAU2		Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme			YEL049W	S000000775
PAU20		Hypothetical protein			YOL161C	S000005521
PAU21		Hypothetical protein			YOR394W	S000005921
PAU22		Hypothetical protein			YPL282C	S000006203
PAU3		Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme			YCR104W	S000000701
PAU4		Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme			YLR461W	S000004453
PAU5		Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme			YFL020C	S000001874
PAU6		Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme			YNR076W	S000005359
PAU7		Part of 23-member seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme			YAR020C	S000000073
PAU8		Hypothetical protein			YAL068C	S000002142
PAU9		Hypothetical protein identified by homology. See FEBS Letters [2000] 487:31-36.			YBL108C-A	S000007592
PBA1		Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly			YLR199C	S000004189
PBD1				decreased expression of PRB1		S000029342
PBD2				decreased expression of PRB1		S000029343
PBD3				decreased expression of PRB1		S000029344
PBI2	I2B|IB2|LMA1	Cytosolic inhibitor of vacuolar proteinase B, required for efficient vacuole inheritance; with thioredoxin forms protein complex LMA1, which assists in priming SNARE molecules and promotes vacuole fusion	proteinase inhibitor I2B (PBI2)	Null mutant is viable but shows 50% elevation of protein degradation rate when cells are subject to nutritional stress	YNL015W	S000004960
PBN1		Essential component of glycosylphosphatidylinositol-mannosyltransferase I, required for the autocatalytic post-translational processing of the protease B precursor Prb1p, localizes to ER in lumenal orientation; homolog of mammalian PIG-X	protease B nonderepressible form	Null mutant is inviable; overexpression of both PBN1 and LRE1 confers resistance to laminarinase, which degrades cell wall beta(1-3) glucan linkages; overexpression of either gene alone has no effect on cell wall glucans or glucan synthase activity	YCL052C	S000000557
PBP1	MRS16	Protein interacting with poly(A)-binding protein Pab1p; likely involved in controlling the extent of mRNA polyadenylation; forms a complex with Mkt1p that may regulate HO translation; interacts with Lsm12p in a copurification assay		Null mutant is viable; other mutant suppresses pab1 null mutant.	YGR178C	S000003410
PBP2	HEK1	RNA binding protein with similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length			YBR233W	S000000437
PBP4		Pbp1p binding protein, interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay			YDL053C	S000002211
PBS1				mutants are resitant to polymyxin B, and pbs1 mutations are synthetically lethal with mutations in calcineurin		S000029345
PBS2	HOG4|SFS4|SSK4	MAP kinase kinase that plays a pivotal role in the osmosensing signal-transduction pathway, activated under severe osmotic stress	MAP kinase kinase (MEK)	Null mutant is viable, sensitive to high osmolarity, sensitive to the antibiotic polymyxin B; shows marked decreased induction of transcription by osmotic stress that is mediated by stress response elements; a deletion in RGA1 and PBS2 activates the pheromone-dependent signal transduction pathway independently of the G protein	YJL128C	S000003664
PBY1		Putative tubulin tyrosine ligase associated with P-bodies			YBR094W	S000000298
PCA1	CAD2|PAY2	Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; S288C and most other lab strains contain a G970R mutation which eliminates normal cadmium transport function	cadmium-translocating ATPase	Null mutant is viable but ceases growth earlier when grown in minimal medium with high copper concentration; overexpression of PCA1 causes poor growth; multicopy PCA1 results in slower growth on synthetic medium with 0.3 mM CuSO4	YBR295W	S000000499
PCC1		Proposed transcription factor involved in the expression of genes regulated by alpha-factor and galactose; component of the EKC/KEOPS protein complex with Kae1p, Gon7p, Bud32p, and Cgi121p; related to human cancer-testis antigens		Null: viable, but very sick	YKR095W-A	S000028512
PCD1		Peroxisomal nudix pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids	coenzyme A diphosphatase		YLR151C	S000004141
PCF11		mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p)	cleavage and polyadenylation factor CF I component involved in pre-mRNA 3'-end processing	Null mutant is inviable; pcf11 (ts) mutations are synthetically lethal with rna14 (ts) and rna15 (ts) mutations	YDR228C	S000002636
PCH2		Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA		Null mutant is viable and bypasses meiotic arrest of zip1 mutant, resulting in chromosome segregation defects	YBR186W	S000000390
PCI8	CSN11|YIH1|YIL071W	Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain	COP9 signalosome (CSN) subunit		YIL071C	S000001333
PCK1	JPM2|PPC1	Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol	phosphoenolpyruvate carboxylkinase		YKR097W	S000001805
PCL1	HCS26	Pho85 cyclin of the Pcl1,2-like subfamily, involved in entry into the mitotic cell cycle and regulation of morphogenesis, localizes to sites of polarized cell growth	G1 cyclin	Required for passage through G(sub)1 in diploid cells lacking CLN1	YNL289W	S000005233
PCL10		Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate			YGL134W	S000003102
PCL2	CLN4	G1 cyclin, associates with Pho85p cyclin-dependent kinase (Cdk) to contribute to entry into the mitotic cell cycle, essential for cell morphogenesis; localizes to sites of polarized cell growth	G1 cyclin		YDL127W	S000002285
PCL5		Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity			YHR071W	S000001113
PCL6		Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; involved in the control of glycogen storage by Pho85p; stabilized by Elongin C binding		Null mutant is viable. A Ty insertion mutant exhibits slow growth.	YER059W	S000000861
PCL7		Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated	cyclin		YIL050W	S000001312
PCL8		Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation	cyclin		YPL219W	S000006140
PCL9		Cyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p			YDL179W	S000002338
PCM1	AGM1	Essential N-acetylglucosamine-phosphate mutase, a hexosephosphate mutase involved in the biosynthesis of chitin	phosphoacetylglucosamine mutase	Null mutant is inviable; a Ty insertion mutant exhibits slow growth.	YEL058W	S000000784
PCP1	MDM37|RBD1	Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases	rhomboid protease	Null: lack of Ccp1 maturation, slow growth on non-fermentable media	YGR101W	S000003333
PCS60	FAT2	Peroxisomal AMP-binding protein, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase			YBR222C	S000000426
PCT1	BSR2|CCT1	Cholinephosphate cytidylyltransferase, also known as CTP:phosphocholine cytidylyltransferase, rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding	cholinephosphate cytidylyltransferase|phosphorylcholine transferase		YGR202C	S000003434
PDA1		E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA, regulated by glucose	pyruvate dehydrogenase alpha subunit (E1 alpha)	Null mutant is viable, exhibits reduced growth on glucose and increased formation of petites	YER178W	S000000980
PDB1		E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria	pyruvate dehydrogenase beta subunit (E1 beta)		YBR221C	S000000425
PDC1		Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism	pyruvate decarboxylase	undetectable pyruvate decarboxylase activity in pdc1pdc5 double mutants	YLR044C	S000004034
PDC2		Transcription factor required for the synthesis of the glycolytic enzyme pyruvate decarboxylase, required for high level expression of both the THI and the PDC genes	transcriptional regulator	Null mutant is viable but shows strongly reduced pyruvate decarboxylase specific activity; slow, respiration-dependent growth on glucose; and accumulation of pyruvate	YDR081C	S000002488
PDC3		May be involved in pyruvate decarboxylase activity				S000029346
PDC5		Minor isoform of pyruvate decarboxylase, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, repressed by thiamine, involved in amino acid catabolism	pyruvate decarboxylase	undetectable pyruvate decarboxylase activity in pdc1pdc5 double mutants	YLR134W	S000004124
PDC6		Minor isoform of pyruvate decarboxylase, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, involved in amino acid catabolism	pyruvate decarboxylase isozyme	Null mutant is viable and shows reduced pyruvate decarboxylase activity only in cells grown in ethanol	YGR087C	S000003319
PDE1		Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation	3',5'-cyclic-nucleotide phosphodiesterase, low affinity		YGL248W	S000003217
PDE2	SRA5	High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon	high affinity cAMP phosphodiesterase	null suppresses the heat-shock and starvation phenotypes of ras2Val119 mutation and of the ras1 ras2 double mutant; null by itself shows slow growth in presence of external cAMP, and is thermo-sensitive when nitrogen-starved in presence of cAMP	YOR360C	S000005887
PDE5		Putative high affinity cAMP phosphodiesterase				S000029347
PDG1						S000029348
PDH1		Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate		Null: sensitive to exogenous propionate	YPR002W	S000006206
PDI1	MFP1|TRG1	Protein disulfide isomerase, multifunctional protein resident in the endoplasmic reticulum lumen, essential for the formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds	protein disulfide isomerase		YCL043C	S000000548
PDR1	AMY1|ANT1|BOR2|CYH3|NRA2|SMR2|TIL1|TPE1|TPE3	Zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes	transcription factor	pleiotropic drug resistance, resistant to borrelidin, oligomycin, antimycin, cycloheximide, antibiotic, thioisoleucine, sulfometuron methyl; accumulation of neutral red	YGL013C	S000002981
PDR10		ABC (ATP-binding cassette) membrane pump involved in the pleiotropic drug resistance network, regulated by Pdr1p and Pdr3p, similar to Pdr5p	multidrug transporter		YOR328W	S000005855
PDR11		Membrane protein of the ATP-binding cassette (ABC) transporter superfamily, involved in multiple drug resistance, mediates sterol uptake when sterol biosynthesis is compromised, regulated by Pdr1p, required for anaerobic growth	multidrug transporter		YIL013C	S000001275
PDR12		Plasma membrane weak-acid-inducible ATP-binding cassette (ABC) transporter, required for weak organic acid resistance, strongly induced by sorbate and benzoate, regulated by War1p, mutants exhibit sorbate hypersensitivity	multidrug transporter		YPL058C	S000005979
PDR15		ATP binding cassette (ABC) transporter of the plasma membrane; general stress response factor implicated in cellular detoxification; target of Pdr1p, Pdr3p and Pdr8p transcription regulators; promoter contains a PDR responsive element	multidrug transporter		YDR406W	S000002814
PDR16	SFH3	Phosphatidylinositol transfer protein (PITP) controlled by the multiple drug resistance regulator Pdr1p, localizes to lipid particles and microsomes, controls levels of various lipids, may regulate lipid synthesis, homologous to Pdr17p		Null mutant is viable, exhibits hypersensitivity to azole inhibitors of ergosterol biosynthesis, alterations in sterol composition of the plasma membrane; pdr16 pdr17 double deletion mutants exhibit additive exacerbated phenotypes	YNL231C	S000005175
PDR17	ISS1|SFH4	Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition		Null mutant is viable, exhibits no observable phenotypes; pdr16 pdr17 double deletion mutants exhibit altered lipid levels and drug hypersensitivity	YNL264C	S000005208
PDR3	AMY2|TPE2	Transcriptional activator of the pleiotropic drug resistance network, regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements)		pleiotropic drug resistance	YBL005W	S000000101
PDR5	LEM1|STS1|YDR1	Short-lived membrane ABC (ATP-binding cassette) transporter, actively exports various drugs, expression regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth	multidrug transporter	pleiotropic drug resistance	YOR153W	S000005679
PDR7		Required for normal PDR5 (multi-drug resistance pump) mRNA levels		pleiotropic drug resistance		S000029350
PDR8		Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon	transcription factor	Null: Slight resistance to hygromycin B. Other phenotypes: Artificial activation and overexpression gives resistance to ketoconazole and oligomycin and gives sensitivity to NaCL, LiCl and Hygromycin B|Null mutant is viable; cannot utilize glycerol and lactate as sole carbon source; hypersensitive to calcofluor white	YLR266C	S000004256
PDR9		Regulates expression of PDR5		pleiotropic drug resistance		S000029351
PDS1		Securin that inhibits anaphase by binding separin Esp1p, also blocks cyclin destruction and mitotic exit, essential for cell cycle arrest in mitosis in the presence of DNA damage or aberrant mitotic spindles; also present in meiotic nuclei	42 kDa nuclear securin	Null mutant is viable but is temperature-sensitive; shows higher rates of chromosome loss at permissive temperature; at restrictive temperature, fails to elongate spindles and shows uncoupling of cell cycle progression from completion of anaphase	YDR113C	S000002520
PDS5		Protein required for establishment and maintenance of sister chromatid condensation and cohesion, colocalizes with cohesin on chromosomes in an interdependent manner, may function as a protein-protein interaction scaffold			YMR076C	S000004681
PDX1		Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core	pyruvate dehydrogenase complex protein X component		YGR193C	S000003425
PDX2				pyridoxin requiring		S000029352
PDX3		Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism	pyridoxine (pyridoxiamine) phosphate oxidase		YBR035C	S000000239
PEA2	DFG9|PPF2	Coiled-coil polarisome protein required for polarized morphogenesis, cell fusion, and low affinity Ca2+ influx; forms polarisome complex with Bni1p, Bud6p, and Spa2p; localizes to sites of polarized growth		Null mutant is viable, exhibits defects in mating that subtly affect mating efficiency; pea2 mutants form bilobed, peanut-like shapes when treated with pheromone, such that they can mate with wild-type but not a mating-enfeebled partner	YER149C	S000000951
PEF1		Putative protein of unknown function; GFP-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS; null mutant is sensitive to perfluorononanoic acid			YGR058W	S000003290
PEP1	VPS10|VPT1	Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments		proteinase deficient	YBL017C	S000000113
PEP12	VPL6|VPS6|VPT13	Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin	c-terminal TMD	proteinase deficient	YOR036W	S000005562
PEP16				proteinase deficient		S000029353
PEP3	VAM8|VPS18|VPT18	Vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis, forms complex with Pep5p that mediates protein transport to the vacuole		Null mutant is viable, exhibits growth defects at 37 degrees celsius, exhibits vacuolar protein sorting and processing and defects, exhibits decreased levels of protease A, protease B, and carboxylpeptidase Y antigens; decreased repressible alkaline phosphatase activity; null mutants contain very few normal vacuolelike organelles; homozygous null mutants are sporulation defective	YLR148W	S000004138
PEP4	PHO9|PRA1|yscA	Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; synthesized as a zymogen, self-activates	vacuolar proteinase A	Null mutant is viable, proteinase deficient, phosphatase deficient; pep4 mutants exhibit a 60-70% reduction in total protein degradation during sporulation	YPL154C	S000006075
PEP5	END1|VAM1|VPL9|VPS11|VPT11	Peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis; forms complex with Pep3p that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, also interacts with Pep7p			YMR231W	S000004844
PEP7	VAC1|VPL21|VPS19|VPT19	Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance		Null mutant is viable but grows more slowly and is temperature-sensitive; defective in vacuole segregation; mislocalizes carboxypeptidase Y and other vacuolar proteins; shows loss of vacuolar acidity and defects in vacuolar morphology	YDR323C	S000002731
PEP8	GRD6|VPS26|VPT4	Vacuolar protein sorting protein that forms part of the multimeric membrane-associated retromer complex along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport		Null mutant is viable but is defective in processing of soluble vacuole proteases due to inability of soluble vacuolar hydrolase to reach the vacuole	YJL053W	S000003589
PER1	COS16	Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1			YCR044C	S000000640
PES4		Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation, similar to Mip6p	poly(A) binding protein		YFR023W	S000001919
PET1		Gene required for respiratory growth				S000029354
PET10		Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange			YKR046C	S000001754
PET100		Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme	chaperone		YDR079W	S000002486
PET11		Gene required for respiratory growth		petite; unable to grow on non-fermentable carbon sources		S000029355
PET111		Specific translational activator for the COX2 mRNA, located in the mitochondrial inner membrane	mitochondrial translational activator		YMR257C	S000004870
PET112		Protein required for mitochondrial translation; mutation is functionally complemented by a Bacillus subtilis ortholog		Null mutant is viable but shows destabilization of the mitochondrial genome, making cells rho- and unable to grow on non-fermentable carbon sources; pet112-1 mutant is blocked in accumulation of cytochrome c oxidase subunit II	YBL080C	S000000176
PET114						S000029356
PET117		Protein required for assembly of cytochrome c oxidase		petite; unable to grow on non-fermentable carbon sources	YER058W	S000000860
PET122		Specific translational activator for the COX3 mRNA that acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane	mitochondrial translational activator	petite; unable to grow on non-fermentable carbon sources	YER153C	S000000955
PET123		Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator	mitochondrial ribosomal small subunit component	Null mutant is viable but is rho- (with large deletions in mtDNA); pet123 mutations can suppress pet122 mutations; some pet123 alleles show synthetic phenotypes with mrp1 mutations	YOR158W	S000005684
PET127		Protein with a role in mitochondrial RNA stability and/or processing, located in the mitochondrial membrane		Null mutant is viable; pet127 mutations suppress pet122 mutations and have pleiotropic effects on stability and 5'-end processing of mitochondrial RNAs; overexpression of PET127 blocks respiration and causes cells to lose mtDNA	YOR017W	S000005543
PET130		Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YJL023C	S000003560
PET14		Gene required for respiratory growth		petite; unable to grow on non-fermentable carbon sources		S000029357
PET17		Gene required for respiratory growth		petite; unable to grow on non-fermentable carbon sources		S000029358
PET18	HIT2	Protein required for respiratory growth and stability of the mitochondrial genome		petite; unable to grow on non-fermentable carbon sources	YCR020C	S000000613
PET191		Protein required for assembly of cytochrome c oxidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies		petite; unable to grow on non-fermentable carbon sources	YJR034W	S000003795
PET2		Gene required for respiratory growth				S000029359
PET20		Mitochondrial protein, required for respiratory growth under some conditions and for stability of the mitochondrial genome		Null: exhibits growth defect on non-fermentable carbon source at 15 degree centigrade, making cells rho-.	YPL159C	S000006080
PET3		Gene required for respiratory growth				S000029360
PET309		Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; located in the mitochondrial inner membrane		petite; unable to grow on non-fermentable carbon sources	YLR067C	S000004057
PET4		Gene required for respiratory growth				S000029361
PET494		Specific translational activator for the COX3 mRNA that acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane	mitochondrial translational activator	petite; unable to grow on non-fermentable carbon sources	YNR045W	S000005328
PET5		Gene required for respiratory growth				S000029362
PET54		Protein required for splicing of the COX1 intron AI5 beta; also specifically required, together with Pet122p and Pet494p, for translation of the COX3 mRNA; located in the mitochondrial inner membrane	mitochondrial translational activator	petite; unable to grow on non-fermentable carbon sources	YGR222W	S000003454
PET6		Gene required for respiratory growth				S000029363
PET7		Gene required for respiratory growth				S000029364
PET8	SAM5	S-adenosylmethionine transporter of the mitochondrial inner membrane, member of the mitochondrial carrier family; required for biotin biosynthesis and respiratory growth			YNL003C	S000004948
PET9	AAC2|ANC2|OP1	Major ADP/ATP carrier of the mitochondrial inner membrane, exchanges cytosolic ADP for mitochondrially synthesized ATP; required for viability in many common lab strains carrying a mutation in the polymorphic SAL1 gene	ADP/ATP carrier	null is viable but petite (unable to grow on non-fermentable carbon sources); pet9,aac3 double null mutant is inviable under anaerobic conditions; pet9 mutations are lethal in combination with rho- mutations	YBL030C	S000000126
PETX		Gene required for respiratory growth		petite; unable to grow on non-fermentable carbon sources		S000029365
PEX1	PAS1	AAA-family ATPase peroxin required for peroxisome biogenesis, contains two 230 amino acid ATP-binding AAA cassettes, upregulated in anaerobiosis; Pex1p and Pex6p interact via their N-terminal AAA-cassettes	AAA ATPase|peroxin		YKL197C	S000001680
PEX10	PAS4	RING finger peroxisomal membrane peroxin required for peroxisomal matrix protein import, interacts with Pex12p, links ubiquitin-conjugating Pex4p to protein import machinery; mutations in human homolog cause a variety of peroxisomal disorders	C3HC4 zinc-binding integral peroxisomal membrane protein|peroxin	mutant lacks morphologically recognizable peroxisomes and shows cytosolic mislocalization of peroxisomal matrix proteins	YDR265W	S000002673
PEX11	PMP24|PMP27	Peroxisomal membrane protein required for peroxisome proliferation and medium-chain fatty acid oxidation, most abundant protein in the peroxisomal membrane, regulated by Adr1p and Pip2p-Oaf1p, promoter contains ORE and UAS1-like elements	peroxin		YOL147C	S000005507
PEX12	PAS11	RING-finger peroxisomal membrane peroxin that plays an essential role in peroxisome biogenesis and peroxisomal matrix protein import, forms translocation subcomplex with Pex2p and Pex10p	C3HC4 zinc-binding integral peroxisomal membrane protein	mutant lacks morphologically recognizable peroxisomes and shows cytosolic mislocalization of peroxisomal matrix proteins	YMR026C	S000004628
PEX13	PAS20	Integral peroxisomal membrane receptor for the PTS1 peroxisomal matrix protein signal recognition factor Pex5p, required for the translocation of peroxisomal matrix proteins, also interacts with Pex7p and Pex14p, contains a C-terminal SH3 domain		Defective in peroxisome assembly	YLR191W	S000004181
PEX14		Peroxisomal membrane protein that is a central component of the peroxisomal protein import machinery, interacts with PTS1 (Pex5p) and PTS2 (Pex7p) peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p	peroxin	Null mutant is viable but is unable to grow on oleate and lacks peroxisomes	YGL153W	S000003121
PEX15	PAS21	Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis, cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol, overexpression results in impaired peroxisome assembly			YOL044W	S000005404
PEX17	PAS9	Peroxisomal membrane protein component of the peroxisomal translocation machinery, required for peroxisome biogenesis, binds Pex14p	peroxin	mutant lacks morphologically recognizable peroxisomes and shows mislocalization of peroxisomal matrix proteins	YNL214W	S000005158
PEX18		Part of a two-member peroxin family (Pex18p and Pex21p) specifically required for peroxisomal targeting of the Pex7p peroxisomal signal recognition factor and PTS2 peroxisomal matrix proteins	peroxin	Null mutant is viable but has reduced growth on oleate, partial impairment of peroxisome biogenesis	YHR160C	S000001203
PEX19	PAS12	Chaperone and import receptor for newly-synthesized class I peroxisomal membrane proteins (PMPs), binds PMPs in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane		mutant lacks morphologically recognizable peroxisomes and shows mislocalization of peroxisomal matrix proteins	YDL065C	S000002223
PEX2	CRT1|PAS5	RING-finger peroxin, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms putative translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import	peroxin	Null mutant is viable but lacks morphologically recognizable peroxisomes and shows cytosolic mislocalization of peroxisomal matrix proteins	YJL210W	S000003746
PEX21		Part of a two-member peroxin family (Pex18p and Pex21p) specifically required for peroxisomal targeting of the Pex7p peroxisomal signal recognition factor and PTS2-type peroxisomal matrix proteins	peroxin		YGR239C	S000003471
PEX22	YAF5	Putative peroxisomal membrane protein required for import of peroxisomal proteins, functionally complements a Pichia pastoris pex22 mutation		Null mutant is viable and oleate minus	YAL055W	S000000051
PEX25		Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p	peroxin		YPL112C	S000006033
PEX27		Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p			YOR193W	S000005719
PEX28		Peroxisomal integral membrane protein, involved in regulation of peroxisome size and number; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p	peroxin	Peroxisomes of cells deleted for either or both of PEX28 and PEX29 are increased in number, exhibit extensive clustering, are smaller, and often exhibit membrane thickening between adjacent peroxisomes in a cluster.	YHR150W	S000001193
PEX29		Peroxisomal integral membrane protein, involved in regulation of peroxisome size and number; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p	peroxin	Peroxisomes of cells deleted for either or both of PEX28 and PEX29 are increased in number, exhibit extensive clustering, are smaller, and often exhibit membrane thickening between adjacent peroxisomes in a cluster.	YDR479C	S000002887
PEX3	PAS3	Peroxisomal membrane protein (PMP) required to recruit Pex19p chaperone to peroxisomes; plays selective, essential, direct role in PMP import as a docking factor for Pex19p		Mutant lacks peroxisomes and shows cytosolic mislocalization of peroxisomal matrix enzymes	YDR329C	S000002737
PEX30		Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p			YLR324W	S000004316
PEX31		Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p			YGR004W	S000003236
PEX32		Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p			YBR168W	S000000372
PEX4	PAS2|UBC10	Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis			YGR133W	S000003365
PEX5	PAS10	Peroxisomal membrane signal receptor for C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import, tetratricopeptide repeat protein, also involved in PTS1-independent import	peroxin	Null mutant is viable but accumulates peroxisomal, leaflet-like membrane structures and exhibits deficient import of some peroxisomal matrix enzymes, particularly proteins with an SKL-like import signal	YDR244W	S000002652
PEX6	PAS8	Peroxisomal membrane AAA-family ATPase peroxin required for peroxisome assembly, contains two 230 amino acid ATP-binding AAA cassettes, interacts with Pex1p	AAA ATPase	lack of peroxisome biogenesis	YNL329C	S000005273
PEX7	PAS7|PEB1	Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP)		Mutant is defective in assembling specific proteins into peroxisomes (assembles catalase and acyl-CoA oxidase but not thiolase) and cannot utilize oleic acid	YDR142C	S000002549
PEX8	PAS6	Intraperoxisomal organizer of the peroxisomal import machinery, tightly associated with the lumenal face of the peroxisomal membrane, essential for peroxisome biogenesis, binds PTS1-signal receptor Pex5p			YGR077C	S000003309
PFA3		Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions	palmitoyltransferase for Vac8p		YNL326C	S000005270
PFA4		Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases	palmitoyltransferase		YOL003C	S000005363
PFA5		Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain	palmitoyltransferase		YDR459C	S000002867
PFD1	GIM6	Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin			YJL179W	S000003715
PFK1		Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes	phosphofructokinase alpha subunit	Null mutant is viable, accumulates fructose-6-phosphate, glucose-6-phosphate, and sedoheptulose-7-phosphate, exhibits decreased levels of fructose-1,6-bisphosphate; pfk1 pfk2 double deletion mutants fail to grow on 2% glucose	YGR240C	S000003472
PFK2		Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes	phosphofructokinase beta subunit	Null mutant is viable but exhibits slow growth and decreased efficiency of glucose utilization.	YMR205C	S000004818
PFK26		6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, has negligible fructose-2,6-bisphosphatase activity, transcriptional regulation involves protein kinase A	6-phosphofructose-2-kinase|PFK-2	Null mutant is viable; on pyrvuate medium, no fructose 2,6-P2 is detectable in mutant	YIL107C	S000001369
PFK27		6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A	6-phosphofructo-2-kinase|PFK-2		YOL136C	S000005496
PFK4				lacking phosphofructokinase		S000029366
PFK5				lacking phosphofructokinase		S000029367
PFS1	ADY1	Sporulation protein required for prospore membrane formation at selected spindle poles, ensures functionality of all four spindle pole bodies of a cell during meiosis II; not required for meiotic recombination or meiotic chromosome segregation		Null mutant is viable; homozygous null diploid accumulates nonsister-spore dyads, normal meiotic spindles	YHR185C	S000001228
PFS2		Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex; plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex	polyadenylation factor I (PF I)	Null mutant is inviable; conditionally lethal mutations exhibit defects in 3'-end processing in vitro	YNL317W	S000005261
PFY1	PRF1	Profilin, actin- and phosphatidylinositol 4,5-bisphosphate-binding protein, plays a role in cytoskeleton organization, required for normal timing of actin polymerization in response to thermal stress; localizes to plasma membrane and cytosol	profilin		YOR122C	S000005648
PGA1		Essential protein required for maturation of Gas1p and Pho8p; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; has synthetic genetic interations with secretory pathway genes			YNL158W	S000005102
PGA2		Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect			YNL149C	S000005093
PGA3		Essential protein required for maturation of Gas1p and Pho8p, protein trafficking; GFP-fusion protein localizes to the endoplasmic reticulum; null mutants have a cell separation defect			YML125C	S000004594
PGD1	HRS1|MED3	Subunit of the Mediator global transcriptional cofactor complex, which is part of the RNA polymerase II holoenzyme and plays an essential role in basal and activated transcription; direct target of the Cyc8p-Tup1p transcriptional corepressor	mediator complex subunit	Suppresses hyper-deletion phenotype of hpr1 null mutant; reduces frequency of deletions in rad52-1 mutant	YGL025C	S000002993
PGI1	CDC30	Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation	phosphoglucose isomerase	phosphoglucose isomerase deficient; exhibits defects in gluconeogenesis and sporulation	YBR196C	S000000400
PGK1		3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis	3-phosphoglycerate kinase	The null mutant is viable but unable to use glucose as a carbon source.	YCR012W	S000000605
PGM1		Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism	phosphoglucomutase minor isoform		YKL127W	S000001610
PGM2	GAL5	Phosphoglucomutase, catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase	phosphoglucomutase	Null mutant is viable, pgm1 pgm2 deletion mutants fail to grow on galactose	YMR105C	S000004711
PGS1	PEL1|YCL003W	Phosphatidylglycerolphosphate synthase, catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis	17 kDa phosphatidylglycerolphosphate synthase	Null mutant is viable but is synthetically lethal with cho1 and mitochondrial petite mutations; nonviable at higher temperatures; cannot utilize glycerol and ethanol on synthetic media; cannot survive ethidium bromide mutagenesis; contains low levels of cardiolipin, phosphatidyglycerol and phosphatidylcholine but increased levels of phosphatidylinositol	YCL004W	S000000510
PGU1	PGL1|PSM1	Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins	endo-polygalacturonase	Null mutant is viable; exhibits clear halo around colonies on polygalacturonate medium	YJR153W	S000003914
PHA2		Prephenate dehydratase, catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway	prephenate dehydratase		YNL316C	S000005260
PHB1		Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation	mitochondrial protein		YGR132C	S000003364
PHB2		Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation			YGR231C	S000003463
PHD1		Transcriptional activator that enhances pseudohyphal growth; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate		Null mutant is viable, diploid homozygous null mutants undergo pseudohyphal growth when starved for nitrogen. Overexpression of PHD1 in diploids and in bud4 haploids causes precocious and unusually vigorous pseudohyphal growth	YKL043W	S000001526
PHD3				overexpression in diploids causes precocious and unusually vigorous pseudohyphal growth		S000029368
PHD4				overexpression in diploids causes precocious and unusually vigorous pseudohyphal growth		S000029369
PHD6				overexpression in diploids causes precocious and unusually vigorous pseudohyphal growth		S000029370
PHD7				overexpression in diploids causes precocious and unusually vigorous pseudohyphal growth		S000029371
PHM6		Protein of unknown function, expression is regulated by phosphate levels			YDR281C	S000002689
PHM7		Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole		transcription is regulated by PHO system	YOL084W	S000005444
PHM8		Protein of unknown function, expression is induced by low phosphate levels and by inactivation of Pho85p			YER037W	S000000839
PHO11		One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2	acid phosphatase	phosphatase deficient	YAR071W	S000000094
PHO12	PHO10	One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; nearly identical to Pho11p; upregulated by phosphate starvation	acid phosphatase		YHR215W	S000001258
PHO13		Alkaline phosphatase specific for p-nitrophenyl phosphate, involved in dephosphorylation of histone II-A and casein	p-nitrophenyl phosphatase		YDL236W	S000002395
PHO2	BAS2|GRF10	Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of Pho2p facilitates interaction with Pho4p	homeobox transcription factor|positive regulator of PHO5 and other genes	The null mutant is viable but unable to sporulate. Many genes regulated by GRF10 are expressed at non-wild type levels in GRF10 null mutants.	YDL106C	S000002264
PHO23		Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; C-terminus has similarity to human candidate tumor suppressor p33(ING1)		Null mutant is viable but shows constitutive PHO5 expression	YNL097C	S000005041
PHO3		Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin	acid phosphatase	phosphatase deficient	YBR092C	S000000296
PHO4		Basic helix-loop-helix (bHLH) transcription factor; binds cooperatively with Pho2p to the PHO5 promoter; function is regulated by phosphorylation at multiple sites and by phosphate availability	myc-family transcription factor		YFR034C	S000001930
PHO5		Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2	acid phosphatase	phosphatase deficient	YBR093C	S000000297
PHO8		Repressible alkaline phosphatase, a glycoprotein localized to the vacuole; regulated by levels of inorganic phosphate and by a system consisting of Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides	alkaline phosphatase	phosphatase deficient	YDR481C	S000002889
PHO80	AGS3|TUP7|VAC5	Cyclin, negatively regulates phosphate metabolism; Pho80p-Pho85p (cyclin-CDK complex) phosphorylates Pho4p and Swi5p; deletion of PHO80 leads to aminoglycoside supersensitivity; truncated form of PHO80 affects vacuole inheritance	Pho80p cyclin	The null mutant is viable but constitutively derepresses PHO5 (acid phosphatase) transcription and is postive for deoxythymidine monophosphate uptake. The null mutant is supersensitive to aminoglycoside.	YOL001W	S000005361
PHO81		Cyclin-dependent kinase (CDK) inhibitor, regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p		phosphatase deficient	YGR233C	S000003465
PHO82				pho82 mutations may confer constitutive synthesis of repressible acid phosphatase		S000029372
PHO83				Constitutive production of repressible acid phosphatase		S000029373
PHO84		High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p	inorganic phosphate transporter		YML123C	S000004592
PHO85	LDB15	Cyclin-dependent kinase, with ten cyclin partners; involved in environmental stress response; in phosphate-rich conditions, Pho85p-Pho80p complex phosphorylates Pho4p which in turn represses PHO5	cyclin-dependent protein kinase		YPL031C	S000005952
PHO86		Endoplasmic reticulum (ER) resident protein required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles		Null mutant is viable and expresses repressible acid phosphatase in high phosphate medium; pho86 pho87 double mutant and pho86 pho88 double mutant constituvely synthesize repressible acid phosphatase and are arsenate-resistant; pho84 pho86 pho87 triple mutant grows more slowly than pho84 mutant	YJL117W	S000003653
PHO87		Low-affinity inorganic phosphate (Pi) transporter, involved in activation of PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments	phosphate permease	Null mutant is viable; pho86 pho87 double mutant constitutively synthesizes repressible acid phosphatase and is aresenate-resistant	YCR037C	S000000633
PHO88		Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations		Null mutant is viable; pho88 pho86 double mutant shows enhanced synthesis of repressible acid phosphatase in high phosphate media and arsenate resistance; disruption or high dosage of PHO88 results in reduced phosphate intake	YBR106W	S000000310
PHO89	ITN1	Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p			YBR296C	S000000500
PHO90		Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth			YJL198W	S000003734
PHO91		Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth	phosphate transporter		YNR013C	S000005296
PHR1		DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p	photolyase	photoreactivation repair deficient	YOR386W	S000005913
PHR2						S000029374
PHS1		Protein of unknown function; homolog of mammalian PTPLA; involved in sphingolipid biosynthesis, protein trafficking; required for cell viability			YJL097W	S000003633
PIB1		RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain			YDR313C	S000002721
PIB2		Protein binding phosphatidylinositol 3-phosphate, involved in telomere-proximal repression of gene expression; similar to Fab1 and Vps27			YGL023C	S000002991
PIC2		Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature			YER053C	S000000855
PIE1		Proliferations Induced in the ER				S000029376
PIF1	TST1	DNA helicase involved in telomere formation and elongation; acts as a catalytic inhibitor of telomerase; also plays a role in repair and recombination of mitochondrial DNA	5'-3' DNA helicase	Mitochondrial DNA is heat-labile; abnormal telomere formation	YML061C	S000004526
PIG1		Putative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthase			YLR273C	S000004263
PIG2		Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase			YIL045W	S000001307
PIH1	NOP17	Protein of unresolved function; may function in protein folding and/or rRNA processing, interacts with a chaperone (Hsp82p), two chromatin remodeling factors (Rvb1p, Rvb2p) and two rRNA processing factors (Rrp43p, Nop58p)		null has both reduced growth and reduced protein synthesis rates	YHR034C	S000001076
PIK1	PIK120|PIK41	Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokineses through the actin cytoskeleton	phosphatidylinositol 4-kinase	Null mutant is inviable; overexpression of PIK1 enhances response to mating pheromone; temperature-sensitive mutants can be suppressed by high osmolarity or an elevated concentration of Ca2+; conditional mutants have a cytokinesis defect	YNL267W	S000005211
PIL1		Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Lsp1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways			YGR086C	S000003318
PIM1	LON1	Mitochondrial ATP-dependent protease involved in intramitochondrial proteolysis; involved in degradation of misfolded proteins in mitochondria; required for bigenesis and maintenance of mitochondria	ATP-dependent protease|Lon	no growth on non-fermentable carbon sources; unable to maintain mDNA	YBL022C	S000000118
PIN2		Protein that induces appearance of [PIN+] prion when overproduced		Other phenotypes: overexpression of PIN2 allows for the induction of the [PSI+] prion by Sup35p overproduction in strains cured of [PIN+].	YOR104W	S000005630
PIN3	LSB2	Protein that induces appearance of [PIN+] prion when overproduced		Other phenotypes: overexpression of PIN3 allows for the induction of the [PSI+] prion in strains cured of [PIN+].	YPR154W	S000006358
PIN4	MDT1	Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage		Other phenotypes: overexpression of PIN4 allows for the induction of the [PSI+] prion by Sup35p overproduction in the strains cured of [PIN+].	YBL051C	S000000147
PIP2	OAF2	Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes	transcription factor		YOR363C	S000005890
PIR1	CCW6	O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle		Null mutant is viable; pir1 hsp150 (pir2) double mutant and pir1 hsp150 (pir2) pir3 triple mutant are slow-growing on agar slab and sensitive to heat shock	YKL164C	S000001647
PIR3	CCW8	O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway		Null mutant is viable; pir1 hsp150 (pir2) pir3 triple mutant is slow-growing on agar slab and sensitive to heat shock	YKL163W	S000001646
PIS1		Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins	phosphatidylinositol synthase		YPR113W	S000006317
PKC1	CLY15|HPO2|STT1	Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)	protein kinase C	The null mutant is inviable and lyses rapidly in hypotonic media. Cells lacking PKC1 arrest growth with small buds at a point after DNA replication but prior to mitosis.	YBL105C	S000000201
PKH1		Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p		Null mutant is viable; pkh1, pkh2 double mutant is lethal	YDR490C	S000002898
PKH2		Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p		Null mutant is viable; pkh1, pkh2 double mutant is lethal	YOL100W	S000005460
PKH3		Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant			YDR466W	S000002874
PKP1		Mitochondrial kinase, phosphorylates pyruvate dehydrogenase alpha subunit Pda1p			YIL042C	S000001304
PKR1		V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V<sub>0</sub>); overproduction confers resistance to Pichia farinosa killer toxin	V-ATPase Assembly Factor	Confers resistance to Pichia farinosa killer toxin (SMK toxin) when overexpressed	YMR123W	S000004730
PLB1		Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol	phospholipase B	Null mutant is viable but releases greatly reduced levels of phosphatidylcholine and phosphatidylethanolamine metabolites	YMR008C	S000004610
PLB2		Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine	phospholipase B	overexpression confers resistance to lysophosphatidylcholine	YMR006C	S000004608
PLB3		Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro	phospholipase B		YOL011W	S000005371
PLC1		Phosphoinositide-specific phospholipase C, hydrolyzes phosphatidylinositol 4,5-biphosphate (PIP2) to generate inositol 1,4,5-triphosphate (IP3) and 1,2-diacylglycerol (DAG); involved in kinetochore function and pseudohyphal differentiation	phosphoinositide-specific phospholipase C		YPL268W	S000006189
PLM2		Protein required for partitioning of the 2-micron plasmid		Null mutant is viable and shows 2mu-m plasmid instability	YDR501W	S000002909
PLP1		Protein with a possible role in folding of beta-tubulin; has weak similarity to phosducins, which are G-protein regulators			YDR183W	S000002591
PLP2		Essential protein with similarity to phosducins, which are G-protein regulators; lethality of null mutation is functionally complemented by expression of mouse phosducin-like protein MgcPhLP			YOR281C	S000005807
PMA1		Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; part of the P2 subgroup of cation-transporting ATPases	H(+)-ATPase	inviable; pma1 mutants are resistant to Dio-9, ethidium bromide and guanidine derivatives	YGL008C	S000002976
PMA2		Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential	plasma membrane ATPase		YPL036W	S000005957
PMC1		Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a		Null mutant is viable but fails to grow in high Ca2+ medium; this death in high calcium is suppressed by mutations in calcineurin (CNA1, CNA2, CNB1) and calmodulin (CMD1); pmc1 vcx1 double mutant is even more sensitive to Ca2+	YGL006W	S000002974
PMD1		Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Mds3p, for growth under alkaline conditions			YER132C	S000000934
PMI40	PMI	Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation	mannose-6-phosphate isomerase	Null mutant requires D-mannose for growth; temperature-sensitive mutant, in the absence of exogenous D-mannose, is unable to synthesize GDP-mannose and dolichol-phosphate-mannose and is unable to secrete some cell wall-associated proteins at the restrictive temperature	YER003C	S000000805
PML1		Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p			YLR016C	S000004006
PML39		Protein required for nuclear retention of unspliced pre-mRNAs along with Mlp1p and Pml1p; anchored to nuclear pore complex via Mlp1p and Mlp2p; found with the subset of nuclear pores farthest from the nucleolus; may interact with ribosomes			YML107C	S000004575
PMP1		Small single-membrane span proteolipid that functions as a regulatory subunit of the plasma membrane H(+)-ATPase Pma1p, forms unique helix and positively charged cytoplasmic domain that is able to specifically segregate phosphatidylserines		Null mutant is viable; pmp1 pmp2 double mutant displays a lower Vmax for the plasma membrane H(+)-ATPase (Pma1p)	YCR024C-A	S000000619
PMP2		Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; nearly identical to PMP1			YEL017C-A	S000002103
PMP3	SNA1	Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential		Null mutant is viable and sensitive to cations such as sodium	YDR276C	S000002684
PMR1	BSD1|LDB1|SSC1	High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease	Ca2+-translocating ATPase	pmr1 null mutants suppress ypt1-1	YGL167C	S000003135
PMS1		ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL		Null mutant is viable; postmeiotic segregation increased	YNL082W	S000005026
PMS6		Involved in DNA mismatch repair		An uncharacterized mutant allele exhibits elevated mitotic/meiotic prototrophs due to mismatch repair failures at heteroallelic loci.		S000029377
PMT1		Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt2p, can instead interact with Pmt3p in some conditions; target for new antifungals	dolichyl phosphate-D-mannose:protein O-D-mannosyltransferase	Null mutant is viable but shows decrease by 40-50% of in vivo protein O-mannosylation; pmt1 pmt2 double mutant shows severe growth defect but residual O-mannosylation activity; the pmt1 pmt2 pmt3 pmt4 quadruple mutant is inviable	YDL095W	S000002253
PMT2	FUN25	Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt1p, can instead interact with Pmt5p in some conditions; target for new antifungals	dolichyl phosphate-D-mannose:protein O-D-mannosyltransferase	Null mutants are viable but show diminished in vitro and in vivo O-mannosylation activity; pmt1 pmt2 double mutant shows severe growth defect but has residual O-mannosylation activity; pmt2 pmt3 pmt4 triple mutant is inviable	YAL023C	S000000021
PMT3		Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; target for new antifungals	dolichyl phosphate-D-mannose:protein O-D-mannosyltransferase	Null mutant is viable; pmt2 pmt3 pmt4 triple mutant is inviable	YOR321W	S000005848
PMT4		Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; appears to form homodimers in vivo and does not complex with other Pmt proteins; target for new antifungals	dolichyl phosphate-D-mannose:protein O-D-mannosyltransferase	Null mutant is viable but shows under glycosylation of chitinase; pmt2 pmt3 pmt4 triple mutant is inviable	YJR143C	S000003904
PMT5		Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals	dolichyl phosphate-D-mannose:protein O-D-mannosyltransferase		YDL093W	S000002251
PMT6		Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases	dolichyl phosphate-D-mannose:protein O-D-mannosyltransferase		YGR199W	S000003431
PMT7		Transfers mannose residues from dolichyl phosphate-D-mannose to specific serine/threonine residues of proteins in the secretory pathway	dolichyl phosphate-D-mannose:protein O-D-mannosyltransferase			S000029378
PMU1		Putative phosphomutase, contains a region homologous to the active site of phsophomutases; overexpression of the gene suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant		Null mutant is viable; overproduction suppresses the ts growth of a tps2 mutant and prevents accumulation of trehalose-6-phosphate in the tps2 mutant	YKL128C	S000001611
PNC1		Nicotinamidase that converts nicotinamide to nicotinic acid as part of the NAD(+) salvage pathway, required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span	nicotinamidase|pyrazinamidase	Null mutant is viable. Deletion causes silencing defect; does not significantly reduce intracellular NAD(+) concentration. Silencing in absence of PNC1 is dependent upon import of nicotinic acid from growth medium.	YGL037C	S000003005
PND1				pnd1 mutants exhibit incomplete derepression of PRB1		S000029379
PND2				pnd2 mutants exhibit incomplete derepression of PRB1		S000029380
PNG1		Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation, localizes to the cytoplasm and nucleus, interacts with the DNA repair protein Rad23p	PNGase|peptide:N-glycanase	Null mutant is viable and shows no growth or viability defect under experimental conditions	YPL096W	S000006017
PNO1	DIM2|RRP20	Essential nucleolar protein required for pre-18S rRNA processing, interacts with Dim1p, an 18S rRNA dimethyltransferase, and also with Nob1p, which is involved in proteasome biogenesis; contains a KH domain		Essential for growth. Other phenotypes: temperature sensitive phenotype of pno1-1.	YOR145C	S000005671
PNP1		Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides	purine nucleoside phosphorylase	null mutants excrete inosine and guanosine into the growth medium	YLR209C	S000004199
PNS1		Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport			YOR161C	S000005687
PNT1		Mitochondrial inner membrane protein involved in export of proteins from the mitochondrial matrix; overexpression of PNT1 confers resistance to the anti-Pneumocystis carinii drug pentamidine, and deletion confers increased sensitivity		Null mutant is viable and shows slightly increased susceptibility to pentamidine (an anti-Pneumocystis carinii drug) and related compounds; confers resistance to pentamidine when present in high copy number	YOR266W	S000005792
POA1		Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing	dUTP pyrophosphatase		YBR022W	S000000226
POB3		Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which facilitates RNA Polymerase II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure	DNA polymerase delta binding protein		YML069W	S000004534
POG1		Putative transcriptional activator that promotes recovery from pheromone induced arrest; inhibits both alpha-factor induced G1 arrest and repression of CLN1 and CLN2 via SCB/MCB promoter elements; potential Cdc28p substrate; SBF regulated			YIL122W	S000001384
POL1	CDC17|CRT5|HPR3	Catalytic subunit of the DNA polymerase alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis	DNA polymerase I alpha subunit p180	Null mutant is inviable. pol1(ts) mutants show blocked cell division at 36 degrees C	YNL102W	S000005046
POL12		B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation	DNA polymerase alpha-primase complex B subunit		YBL035C	S000000131
POL2	DUN2	Catalytic subunit of DNA polymerase epsilon, one of the major chromosomal DNA replication polymerases characterized by processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair	DNA polymerase II		YNL262W	S000005206
POL30		Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair	PCNA|Proliferating Cell Nuclear Antigen (PCNA)		YBR088C	S000000292
POL32		Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p	DNA polymerase delta subunit	Null mutant is viable but is cold-sensitive, hydroxyurea-sensitive, defective for induced mutagenesis, synthetic lethal with pol3, pol30 and pol31	YJR043C	S000003804
POL4	POLX	DNA polymerase IV, undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta	DNA polymerase IV	Null mutant is viable but shows hyper-recombination, higher frequency of illegitimate mating, and weak sensitivity to MMS	YCR014C	S000000607
POL5		Protein with sequence similarity to the human MybBP1A and weak sequence similar to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA	DNA polymerase phi		YEL055C	S000000781
POM152		Nuclear pore membrane glycoprotein; may be involved in duplication of nuclear pores and nuclear pore complexes during S-phase;	nuclear pore complex subunit	Null mutant is viable; overproduction inhibits cell growth; synthetically lethal with NUP170 and NUP188	YMR129W	S000004736
POM34		Integral membrane protein of the nuclear pore; has an important role in maintaining the architecture of the pore complex	nuclear pore complex subunit		YLR018C	S000004008
POP1		Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; binds to the RPR1 RNA subunit in RNase P	RNase MRP subunit|nuclear RNase P subunit	Null mutant is inviable; temperature-sensitive mutant shows defect in processing pre-tRNAs and pre-rRNA at nonpermissive temperature	YNL221C	S000005165
POP2	CAF1	RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation	CCR4-NOT transcriptional complex subunit	Mutant is resistant to glucose derepression, temperature-sensitive, and unable to sporulate and contains reduced amounts of reserve carbohydrates	YNR052C	S000005335
POP3		Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends	RNase MRP subunit|nuclear RNase P subunit		YNL282W	S000005226
POP4		Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; binds to the RPR1 RNA subunit in Rnase P	RNase MRP subunit|nuclear RNase P subunit		YBR257W	S000000461
POP5	FUN53	Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends	RNase MRP subunit|nuclear RNase P subunit	Null mutant is inviable; transient depletion of Pop5p causes loss of RNase P and RNase MRP function	YAL033W	S000000031
POP6		Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends	RNase MRP subunit|nuclear RNase P subunit	Null mutant is inviable; transient depletions cause loss of RNase P and RNase MRP function	YGR030C	S000003262
POP7	RPP2	Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends	RNase MRP subunit|nuclear RNase P subunit	Null mutant is inviable; transient depletions cause loss of RNase P and RNase MRP function	YBR167C	S000000371
POP8		Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends	RNase MRP subunit|nuclear RNase P subunit	Null mutant is inviable; transient depletions cause loss of RNase P and RNase MRP function	YBL018C	S000000114
POR1	OMP2|YVDAC1	Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability	porin|voltage-dependent anion channel	Null mutant is viable, shows strain-dependent delayed growth on glycerol	YNL055C	S000005000
POR2	YVDAC2	Putative mitochondrial porin (voltage-dependent anion channel), related to Por1p but not required for mitochondrial membrane permeability or mitochondrial osmotic stability	voltage dependent anion channel (YVDAC2)	Null mutant is viable; omp2 por2 double null mutant shows poor growth; POR2 is a multicopy suppressor of omp2 null temperature-sensitive petite phenotype	YIL114C	S000001376
POS1		involved in oxidative stress		peroxide sensitive		S000029381
POS11		involved in oxidative stress		peroxide sensitive		S000029382
POS12		involved in oxidative stress		peroxide sensitive		S000029383
POS13		involved in oxidative stress		peroxide sensitive		S000029384
POS14		involved in oxidative stress		peroxide sensitive		S000029385
POS15		involved in oxidative stress		peroxide sensitive		S000029386
POS16		involved in oxidative stress		peroxide sensitive		S000029387
POS2		involved in oxidative stress		peroxide sensitive		S000029388
POS3		involved in oxidative stress		peroxide sensitive		S000029389
POS4		involved in oxidative stress		peroxide sensitive		S000029390
POS5		Mitochondrial NADH kinase, phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress		pos5 mutants are peroxide sensitive	YPL188W	S000006109
POS6		involved in oxidative stress		peroxide sensitive		S000029391
POS7		involved in oxidative stress		peroxide sensitive		S000029392
POS8		involved in oxidative stress		peroxide sensitive		S000029393
POT1	FOX3|POX3	3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids	3-oxoacyl CoA thiolase	Null mutant is viable, unable to use oleic acid as a carbon source	YIL160C	S000001422
POX1	FOX1	Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix	fatty-acyl coenzyme A oxidase	Null mutant is viable, exhibits diminished ability to use oleic acid as a carbon source	YGL205W	S000003173
PPA1	VMA16	Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain	V-ATPase V0 sector subunit c''	Null mutant is inviable in some genetic backgrounds, in others, exhibits no V-ATPase activity and failure to assemble V-ATPase subunits onto the vacuolar membrane	YHR026W	S000001068
PPA2	IPP2	Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate	inorganic pyrophosphatase	Null mutant is viable but is unable to grow on respiratory carbon sources and lacks mitochondrial DNA	YMR267W	S000004880
PPE1	MRPS2	Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein	YmS2	Other phenotypes: Shortens the G1 phase of the cell cycle when present in high-copy|Mutant exhibits no growth defects at any temperature and exhibits normal sensitivity to rapamycin, benomyl, nocodazole.	YHR075C	S000001117
PPG1		Putative serine/threonine protein phosphatase, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases		Null mutant is viable but accumulates less glycogen	YNR032W	S000005315
PPH21	PPH1	Catalytic subunit of protein phosphatase 2A, functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis	protein phosphatase type 2A	Null mutant is viable, pph21 pph22 mutants produce very small spores in some strain backgrounds and are inviable in others, pph21 pph22 pph3 mutants are inviable	YDL134C	S000002292
PPH22	PPH2	Catalytic subunit of protein phosphatase 2A, functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis	protein phosphatase type 2A	Null mutant is viable, pph21 pph22 mutants produce very small spores in some strain backgrounds and are inviable in others, pph21 pph22 pph3 mutants are inviable	YDL188C	S000002347
PPH3		Catalytic subunit of an evolutionarily conserved protein phosphatase complex containing Psy2p and the regulatory subunit Psy4p; required for cisplatin resistance; involved in activation of Gln3p	protein phosphatase type 2A	Null mutant is viable, pph3 pph21 pph22 mutants are inviable	YDR075W	S000002482
PPM1		Carboxyl methyl transferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits	farnesyl cysteine-carboxyl methyltransferase	Mutant is rapamycin resistant, benomyl supersensitive, and nocodazole sensitive.	YDR435C	S000002843
PPM2	TYW4	Putative carboxymethyltransferase, similar to Ppm1p but biochemical activity not yet demonstrated; required for the synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA		Mutant exhibits no growth defects at any temperature and exhibits normal sensitivity to rapamycin, benomyl, nocodazole.	YOL141W	S000005501
PPN1	PHM5	Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer	endopolyphosphatase	Null mutant is viable and shows accumulation of long chain polyphosphate; a double mutant of <i>PPN1</i> and <i>PPX1</i> (the gene encoding a potent exopolyphosphatase) loses viability rapidly in stationary phase.	YDR452W	S000002860
PPQ1	SAL6	Putative protein serine/threonine phosphatase; null mutation enhances efficiency of translational suppressors		Null mutants are viable, show an altered morophology, have a slight growth defect on several carbon sources, have lower cell density in stationary phase in the absence of an essential amino acid, show a reduced rate of protein synthesis in exponential phase, are hypersensitive to protein synthesis inhibitors, and have an allosuppressor phenotype in suppressor strain backgrounds (i.e. enhanced efficiency of translational suppressors),	YPL179W	S000006100
PPR1		Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of genes involved in uracil biosynthesis; activity may be modulated by interaction with Tup1p	transcription factor	Null mutant is viable, deficient in pyrimidine biosynthetic pathway	YLR014C	S000004004
PPS1		Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle	protein phosphatase	Null mutant is viable; overexpression causes cell cycle arrest	YBR276C	S000000480
PPT1		Protein serine/threonine phosphatase with similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth			YGR123C	S000003355
PPT2		Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation	PPTase|phosphopantetheine:protein transferase|phosphopantetheinyl transferase	The null mutant is viable but cannot respire, synthesize lipoic acid, or pantetheinylate mitochondrial low molecular weight acyl carrier protein.	YPL148C	S000006069
PPX1		Exopolyphosphatase, hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cytosol, plasma membrane, and mitochondrial matrix	exopolyphosphatase	Null mutant is viable, but lysates from mutant show considerably lower exopolyphosphatase activity. Inactivation of PPX1 results in a change of exopolyphosphatase spectra.	YHR201C	S000001244
PPZ1		Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance	protein phosphatase Z	Null mutant is viable, exhibits increased tolerance to Na+ and Li+ cations, increased cell size and lysis; ppz1 ppz2 double deletion mutants exhibit a temperature sensitive cell lysis defect and fail to grow in the presence of 5 mM caffeine	YML016C	S000004478
PPZ2		Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance	protein phosphatase Z	Null mutant is viable but shows increase in cell size and cell lysis (remediated by 1 M sorbitol); ppz1 ppz2 double mutant shows increased expression of ENA1, resistance to sodium and lithium, and sensitivity to 5 mM caffeine (which is suppressed by 1 M sorbitol)	YDR436W	S000002844
PRB1	CVT1	Vacuolar proteinase B (yscB), a serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation	proteinase B	Null mutant is viable, protease B deficient, has smaller spores than wild-type embedded in a thick matrix	YEL060C	S000000786
PRC1	LBC1	Vacuolar carboxypeptidase Y (proteinase C), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family	carboxypeptidase yscY|proteinase C	Null mutant is viable,proteinase C deficient	YMR297W	S000004912
PRD1		Zinc metalloendopeptidase, found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins		Null mutant is viable but exhibits a decrease in the intracellular degradation of peptides	YCL057W	S000000562
PRE1		20S proteasome beta-type subunit; localizes to the nucleus throughout the cell cycle	22.6 kDa proteasome subunit	Null mutant is inviable, pre1 mutants accumulate ubiquitin-protein conjugates	YER012W	S000000814
PRE10		20S proteasome alpha-type subunit	proteasome component YC1 (protease yscE subunit 1)		YOR362C	S000005889
PRE2	DOA3|PRG1|SRR2	20S proteasome beta-type subunit, responsible for the chymotryptic activity of the proteasome	proteasome subunit	Null mutant is inviable, pre2 mutants exhibit defects in chymotrypsin-like proteolysis, stress response and ubiquitin signaled protein degradation	YPR103W	S000006307
PRE3	CRL21	20S proteasome beta-type subunit, responsible for cleavage after acidic residues in peptides	20S proteasome subunit		YJL001W	S000003538
PRE4		20S proteasome beta-type subunit	proteasome subunit		YFR050C	S000001946
PRE5		20S proteasome alpha-type subunit	20S proteasome alpha-type subunit		YMR314W	S000004931
PRE6		20S proteasome alpha-type subunit; green fluorescent protein (GFP)-fusion protein relocates from the cytosol to the mitochondrial outer surface upon oxidative stress	20S proteasome alpha-type subunit		YOL038W	S000005398
PRE7	PRS3	20S proteasome beta-type subunit	proteasome subunit		YBL041W	S000000137
PRE8		20S proteasome beta-type subunit	proteasome component Y7		YML092C	S000004557
PRE9		20S proteasome beta-type subunit; the only nonessential 20S subunit	proteasome component Y13		YGR135W	S000003367
PRI1		Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair	DNA primase p48 polypeptide	Null mutant is inviable; pri1 pri2 mutants are inviable	YIR008C	S000001447
PRI2		Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair	DNA primase p58 polypeptide	lethal	YKL045W	S000001528
PRK1	PAK1	Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton through the phosphorylation of the Pan1p-Sla1p-End3p protein complex	serine/threonine protein kinase	Null mutant is viable. Strains that overexpress Prk1 are inviable.	YIL095W	S000001357
PRM1		Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p		Null mutant is viable but exhibits a mating defect.	YNL279W	S000005223
PRM10		Pheromone-regulated protein, predicted to have 5 transmembrane segments			YJL108C	S000003644
PRM2		Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p			YIL037C	S000001299
PRM3		Pheromone-regulated protein required for karyogamy; localizes to the inner membrane of the nuclear envelope			YPL192C	S000006113
PRM4		Pheromone-regulated protein, predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift			YPL156C	S000006077
PRM5		Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling			YIL117C	S000001379
PRM6		Pheromone-regulated protein, predicted to have 2 transmembrane segments; regulated by Ste12p during mating			YML047C	S000004510
PRM7		Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements			YDL039C	S000002197
PRM8		Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family			YGL053W	S000003021
PRM9		Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family			YAR031W	S000000078
PRO1		Gamma-glutamyl kinase, catalyzes the first step in proline biosynthesis	gamma-glutamyl kinase	Proline requiring and unable to grow on YPD (yeast extract-peptone-glucose)	YDR300C	S000002708
PRO2		Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis	gamma-glutamyl phosphate reductase	Proline requiring and unable to grow on YPD (yeast extract-peptone-glucose); synthetic lethality with ctk1	YOR323C	S000005850
PRO3	ORE2	Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis	delta 1-pyrroline-5-carboxylate reductase	proline requiring	YER023W	S000000825
PRP11	RNA11	Subunit of the SF3a splicing factor complex, required for spliceosome assembly	snRNA-associated protein	RNA processing defective	YDL043C	S000002201
PRP16		RNA helicase in the DEAH-box family involved in the second catalytic step of splicing, exhibits ATP-dependent RNA unwinding activity			YKR086W	S000001794
PRP18		Splicing factor involved in the positioning of the 3' splice site during the second catalytic step of splicing, recruited to the spliceosome by Slu7p	RNA splicing factor|U5 snRNP protein	Null mutant is viable, temperature sensitive	YGR006W	S000003238
PRP19	PSO4	Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases	RNA splicing factor	Null mutant is inviable; pso4-1 mutants are sensitive to 8-methoxypsoralen, UV, MMS, and X-rays. prp19 ntc20 double mutants are inviable; prp19 isy1 double mutants are inviable.	YLL036C	S000003959
PRP2	RNA2	RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing	RNA splicing factor RNA-dependent NTPase with DEAD-box motif	The null mutant is inviable. Temperature-sensitive alleles arrest with an accumulation of unprocessed pre-mRNA from intron-containing genes. An in vivo and in vitro temperature-sensitive allele of prp2 is often used to facilitate the isolation of pre-catalytic spliceosomes.	YNR011C	S000005294
PRP21	SPP91	Subunit of the SF3a splicing factor complex, required for spliceosome assembly	RNA splicing factor	Null mutant is inviable, certain prp21 mutations are allele-specific suppressors of prp9 mutations	YJL203W	S000003739
PRP22		DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes			YER013W	S000000815
PRP24		Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling		defective in splicing	YMR268C	S000004881
PRP28		RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site	RNA helicase	Null mutant is inviable; conditional alleles of prp28 and prp24 are synthetically lethal	YDR243C	S000002651
PRP3	RNA3	Splicing factor, component of the U4/U6-U5 snRNP complex	snRNP from U4/U6 and U5 snRNPs	RNA synthesis defective	YDR473C	S000002881
PRP31		Splicing factor, component of the U4/U6-U5 snRNP complex	pre-mRNA splicing protein	Null mutant is inviable; temperature-sensitive mutant accumulates unspliced pre-mRNA at the restrictive temperature and is suppressed by multicopy PRP2	YGR091W	S000003323
PRP38		Unique component of the U4/U6.U5 tri-snRNP particle, dispensable for spliceosome assembly, but required for conformational changes which lead to catalytic activation of the spliceosome	RNA splicing factor		YGR075C	S000003307
PRP39		U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats	RNA splicing factor|U1 snRNP protein	Temperature-sensitive mutant arrests at the nonpermissive temperature and shows block in pre-mRNA splicing	YML046W	S000004509
PRP4	RNA4	Splicing factor, component of the U4/U6-U5 snRNP complex		Null mutant is inviable; other alleles are defective in RNA synthesis and unable to grow at 36 degrees C.	YPR178W	S000006382
PRP40		U1 snRNP protein involved in splicing, interacts with the branchpoint-binding protein during the formation of the second commitment complex	U1 snRNP protein	Null mutant is inviable; temperature-sensitive mutants show a splicing defect	YKL012W	S000001495
PRP42	MUD16|SNU65	U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats	U1 snRNP protein	Null mutant is inviable; prp39-1 is a point mutant that is temperature-sensitive for pre-mRNA splicing	YDR235W	S000002643
PRP43	JA1	RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome	RNA helicase		YGL120C	S000003088
PRP45	FUN20	Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene	pre-mRNA splicing factor		YAL032C	S000000030
PRP46	NTC50	Splicing factor that is found in the Cef1p subcomplex of the spliceosome	pre-mRNA splicing factor		YPL151C	S000006072
PRP5	RNA5	RNA helicase in the DEAD-box family, necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA	RNA helicase	RNA synthesis defective	YBR237W	S000000441
PRP6	RNA6|TSM7269	Splicing factor, component of the U4/U6-U5 snRNP complex	RNA splicing factor		YBR055C	S000000259
PRP8	DBF3|DNA39|RNA8|SLT21|USA2	Component of the U4/U6-U5 snRNP complex, involved in the second catalytic step of splicing	U5 snRNP and spliceosome component	Null mutant is inviable; synthetic lethal with U2 snRNA (LSR1); blocks pre-mRNA splicing in vivo and in vitro	YHR165C	S000001208
PRP9		Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex	RNA splicing factor		YDL030W	S000002188
PRR1		Protein kinase with a possible role in MAP kinase signaling in the pheromone response pathway	serine/threonine protein kinase		YKL116C	S000001599
PRR2		Protein kinase with a possible role in MAP kinase signaling in the pheromone response pathway	serine/threonine protein kinase		YDL214C	S000002373
PRS1	PRP1	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involved in nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes	ribose-phosphate pyrophosphokinase		YKL181W	S000001664
PRS2		5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involved in nucleotide, histidine, and tryptophan biosynthesis; one of a five related enzymes, which are active as heteromultimeric complexes	ribose-phosphate pyrophosphokinase		YER099C	S000000901
PRS3		5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involved in nucleotide, histidine, and tryptophan biosynthesis; one of a five related enzymes, which are active as heteromultimeric complexes	ribose-phosphate pyrophosphokinase		YHL011C	S000001003
PRS4		5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involved in nucleotide, histidine, and tryptophan biosynthesis; one of a five related enzymes, which are active as heteromultimeric complexes	ribose-phosphate pyrophosphokinase		YBL068W	S000000164
PRS5		5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involved in nucleotide, histidine, and tryptophan biosynthesis; one of a five related enzymes, which are active as heteromultimeric complexes	phosphoribosylpyrophosphate synthetase|ribose-phosphate pyrophosphokinase	Null mutant is viable but reduces the cellular 5-phosphoribosyl-1(alpha)-pyrophosphate synthetase activity by 84%. prs5 mutations are synthetically lethal with mutations in prs1 or prs3.	YOL061W	S000005422
PRT1	CDC63|DNA26	Subunit of the core complex of translation initiation factor 3(eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes	translation initiation factor eIF3 subunit		YOR361C	S000005888
PRT2				Protein synthesis defective at 36 degrees C		S000029394
PRT3				A temperature-sensitive prt3 mutant shows increased sensitivity to UV light and diepoxybutane after exposure to the restrictive temperature		S000029395
PRX1		Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress	peroxiredoxin		YBL064C	S000000160
PRY1		Protein of unknown function, has similarity to Pry2p and Pry3p and to the plant PR-1 class of pathogen related proteins			YJL079C	S000003615
PRY2	YFW12	Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathogen related proteins			YKR013W	S000001721
PRY3		Protein of unknown function, has similarity to Pry1p and Pry2p and to the plant PR-1 class of pathogen related proteins			YJL078C	S000003614
PSA1	MPG1|SRB1|VIG9	GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure	GDP-mannose pyrophosphorylase|mannose-1-phosphate guanyltransferase		YDL055C	S000002213
PSD1		Phosphatidylserine decarboxylase of the mitochondrial inner membrane, converts phosphatidylserine to phosphatidylethanolamine	phosphatidylserine decarboxylase	Null mutant is viable, shows little change in growth properties or phospholipid composition, but shows loss of detectable decarboxylase activity; psd1 psd2 double mutant is auxotrophic for ethanolamine and shows severe defect in conversion of phosphatidylserine to phosphatidylethanolamine	YNL169C	S000005113
PSD2		Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine	phosphatidylserine decarboxylase	Null mutant is viable and shows small decrease in phosphatidylserine decarboxylase activity; psd1 psd2 double mutant is an ethanolamine auxotroph and expresses no detectable phosphatidylserine decarboxylase activity	YGR170W	S000003402
PSE1	KAP121	Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p	karyopherin	Null mutant is viable but grows very slowly; overexpression of PSE1 results in enhanced protein secretion	YMR308C	S000004925
PSF1	CDC101	Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery	subunit of the GINS complex		YDR013W	S000002420
PSF2	CDC102	Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery	subunit of the GINS complex		YJL072C	S000003608
PSF3		Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery	subunit of the GINS complex		YOL146W	S000005506
PSH1		Nuclear protein, putative RNA polymerase II elongation factor; isolated as Pob3p/Spt16p-binding protein			YOL054W	S000005415
PSK1	FUN31	One of two (see also PSK2) PAS domain containing S/T protein kinases; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status			YAL017W	S000000015
PSK2		One of two (see also PSK1) PAS domain containing S/T protein kinases; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation)	serine/threonine protein kinase		YOL045W	S000005405
PSO2	SNM1	Required for a post-incision step in the repair of DNA single and double-strand breaks that result from interstrand crosslinks produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation	interstrand crosslink repair protein	sensitive to photoaddition of psoralens, nitrogen mustard	YMR137C	S000004745
PSP1	GIN5	Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition		Null mutant is viable, exhibits no apparent phenotype; psp1 psp2 double deletion mutants are viable; overexpression of PSP1 causes lethality	YDR505C	S000002913
PSP2	MRS15	Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing		Null mutant is viable, exhibits no apparent defects; psp1 psp2 double deletion mutants are viable	YML017W	S000004479
PSR1		Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p	protein phosphatase	Mutant is sensitive to sodium ions.	YLL010C	S000003933
PSR2		Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p	protein phosphatase	Mutant is sensitive to sodium ions.	YLR019W	S000004009
PST1	HPF2	Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1			YDR055W	S000002462
PST2		Protein with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YDR032C	S000002439
PSY1		Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C			YKL076C	S000001559
PSY2		Putative subunit of an evolutionarily conserved protein phosphatase complex containing the catalytic subunit Pph3p and the regulatory subunit Psy4p; required for cisplatin and oxaliplatin resistance; localizes to nucleus			YNL201C	S000005145
PSY3		Protein of unknown function; deletion results in a mutator phenotype suggesting a role for this protein as a mutational suppressor; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C			YLR376C	S000004368
PSY4		Putative regulatory subunit of an evolutionarily conserved protein phosphatase complex containing the catalytic subunit Pph3p and a third subunit Psy2p; required for cisplatin resistance; GFP-fusion protein localizes to the nucleus	protein phosphatase regulatory subunit		YBL046W	S000000142
PTA1	FUN39	Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII	cleavage factor II (CF II) component|polyadenylation factor I (PF I)	Null mutant is inviable; temperature-sensitive mutant shows defects in pre-tRNA processing	YAL043C	S000000041
PTC1	CWH47|KCS2|TPD1	Type 2C protein phosphatase (PP2C); inactivates the osmosensing MAPK cascade by dephosphorylating Hog1p; mutation delays mitochondrial inheritance; deletion reveals defects in precursor tRNA splicing, sporulation and cell separation	protein phosphatase type 2C	Null mutant is viable; exhibits synthetic phenotypes in combination with ptp2, kcs1, and mpk1 (slt2) mutants; ptc1 mutations suppress the hyper-recombination of pkc1 mutants	YDL006W	S000002164
PTC2		Type 2C protein phosphatase; dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; role in DNA checkpoint inactivation	protein phosphatase type 2C		YER089C	S000000891
PTC3		Type 2C protein phosphatase; dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA checkpoint inactivation	protein phosphatase type 2C		YBL056W	S000000152
PTC4	GCT1	Cytoplasmic type 2C protein phosphatase; identified as a high-copy number suppressor of the synthetic lethality of a cnb1 mpk1 double deletion; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity	protein phosphatase type 2C		YBR125C	S000000329
PTC5	PPP1	Mitochondrially localized type 2C protein phosphatase involved in regulation of pyruvate dehydrogenase activity; contains Mg2+/Mn2+-dependent casein phosphatase activity in vitro	protein phosphatase type 2C		YOR090C	S000005616
PTC6	AUP1	Phosphoprotein phosphatase type 2C similar to mammalian PP1Ks; involved in mitophagy; localized to mitochondrial inner membrane space; null mutant is sensitive to rapamycin	protein phosphatase type 2C		YCR079W	S000002133
PTC7		Mitochondrially localized type 2C protein phosphatase; expression induced by growth on ethanol and by sustained osmotic stress; possible role in carbon source utilization in low oxygen environments	protein phosphatase type 2C		YHR076W	S000001118
PTH1	PTH	One of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for cell growth and for mitochondrial respiration	peptidyl-tRNA hydrolase		YHR189W	S000001232
PTH2		One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth	peptidyl-tRNA hydrolase		YBL057C	S000000153
PTI1		Pta1p Interacting protein			YGR156W	S000003388
PTK1	KKT8|POT1|STK1|YKL199C|YKT9	Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein		Mutant shows decrease in total polyamine accumulation and resistance to polyamine analogs; ptk1 ptk2 double mutant shows virtually abolished high-affinity spermidine transport	YKL198C	S000001681
PTK2	STK2	Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake		Mutant shows reduced spermine and putrescine uptake and is resistant to toxic polyamine analogs and Li+ and Na+ ions; ptk1 ptk2 double mutant shows virtaully abolished high-affinity spermidine transport	YJR059W	S000003820
PTM1		Protein of unknown function, copurifies with late Golgi vesicles containing the v-SNARE Tlg2p		Null mutant is viable, no observable phenotype	YKL039W	S000001522
PTP1		Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria	protein tyrosine phosphatase		YDL230W	S000002389
PTP2		Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus	protein tyrosine phosphatase	Null mutant is viable, grows slowly, is hypersensitive to heat; ptp2 ptc1 mutants exhibit synthetic lethality	YOR208W	S000005734
PTP3		Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm	tyrosine phosphatase	Null mutant is viable; disruption of PTP3 in combination with its homolog PTP2 results in constitutive tyrosine phosphorylation,enhanced kinase activity of Fus3p MAP kinase on stimulation, and delayed recovery from cell cycle arrest	YER075C	S000000877
PTR2		Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p	peptide transporter		YKR093W	S000001801
PTR3	SSY3	Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes		Null mutant is viable, resistant to toxic dipeptides and the toxic amino acid analogs ethionine and f-phenylalanine in presence of ammonium. Depressed rate of uptake of di-/tripeptides. Other mutant alleles characterized exhibit the same phenotype as the null mutant. Sensitive to sulfonylurea herbicides on complex media (YPD)	YFR029W	S000001925
PUB1	RNP1	Poly(A)+ RNA-binding protein, abundant mRNP-component protein that binds mRNA and is required for stability of a number of mRNAs; not reported to associate with polyribosomes	poly(A) binding protein		YNL016W	S000004961
PUF2		Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins	mRNA binding protein		YPR042C	S000006246
PUF3		Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins			YLL013C	S000003936
PUF4	YGL023	Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors			YGL014W	S000002982
PUF6		Pumilio-homology domain protein that binds ASH1 mRNA at PUF consensus sequences in the 3' UTR and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA		Deletion reduces the asymmetric localization of both Ash1p and ASH1 mRNA and affects the HO promoter activity.	YDR496C	S000002904
PUP1		Endopeptidase with trypsin-like activity that cleaves after basic residues; beta-type subunit of 20S proteasome synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z			YOR157C	S000005683
PUP2	DOA5	Alpha subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta	proteasome subunit		YGR253C	S000003485
PUP3	SCS32	Beta subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10	20S proteasome subunit beta3_sc		YER094C	S000000896
PUS1		tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA	tRNA-pseudouridine synthase	pus1 los1 double mutant exhibits loss of suppressor tRNA activity; pus1, los1 and nsp1 mutations cause synthetic lethality	YPL212C	S000006133
PUS2		Putative pseudouridine synthase			YGL063W	S000003031
PUS4		Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype)	pseudouridine synthase	Null mutant is viable; mutant is available that is defective in exit from late anaphase/early telophase (Raymond, Wendy E.)	YNL292W	S000005236
PUS5		Pseudouridine synthase, catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability			YLR165C	S000004155
PUS6		Pseudouridine synthase responsible for modification of cytoplasmic and mitochondrial tRNAs at position 31; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability			YGR169C	S000003401
PUS7		Pseudouridine synthase, catalyzes pseudouridylation at position 35 in U2 snRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); Asp(256) mutation abolishes activity; conserved in archaea, some bacteria, and vertebrates	pseudouridine synthase		YOR243C	S000005769
PUS9		Mitochondrial tRNA pseudouridine synthase involved in pseudouridylation of mitochondrial tRNAs at position 32	tRNA-pseudouridine synthase		YDL036C	S000002194
PUT1		Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source	proline oxidase	inability to use proline as a nitrogen source	YLR142W	S000004132
PUT2		Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism	delta-1-pyrroline-5-carboxylate dehydrogenase	inability to use proline as a nitrogen source	YHR037W	S000001079
PUT3		Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences and undergoes a conformational change to form the active state; has a Zn(2)-Cys(6) binuclear cluster domain	transcription factor	null is unable to use proline as sole nitrogen source due to deficient expression of PUT genes; mutants lacking C-terminal 76 codons show constitutive expression of PUT genes; other mutants show non-inducible expression of PUT genes	YKL015W	S000001498
PUT4		Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells	proline permease	inability to use proline as a nitrogen source	YOR348C	S000005875
PUT5				dominant PUT5 mutation results in low-level constitutive expression of PUT2-lacZ; mutation is epistatic to the recessive, noninducible put3-75 allele		S000029397
PWP1		Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily		Null mutants are viable but show severely retarded growth	YLR196W	S000004186
PWP2	UTP1|YCR055C|YCR058C	Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis	U3 snoRNP protein		YCR057C	S000000653
PXA1	LPI1|PAL1|PAT2|SSH2	Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins	long-chain fatty acid transporter subunit	Null mutant is viable but cannot grow on media with oleic acid as sole carbon source	YPL147W	S000006068
PXA2	PAT1	Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins	long-chain fatty acid transporter subunit	Null mutant is viable; reduces stability of Pxa1p	YKL188C	S000001671
PXL1		LIM domain-containing protein that localizes to sites of polarized growth, required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; has similarity to metazoan paxillin			YKR090W	S000001798
PXR1	GNO1	Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain	PinX1		YGR280C	S000003512
PYC1		Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc2p but differentially regulated; mutations in the human homolog are associated with lactic acidosis	pyruvate carboxylase	Null mutant is viable but shows greatly reduced pyruvate carboxylase activity and cannot grow on ethanol in the absence of aspartate	YGL062W	S000003030
PYC2		Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc1p but differentially regulated; mutations in the human homolog are associated with lactic acidosis	pyruvate carboxylase	Null mutant is viable; pyc1 pyc2 double mutant is unable to grow on glucose as sole carbon source unless aspartate is added to the medium	YBR218C	S000000422
PYK2		Pyruvate kinase that appears to be modulated by phosphorylation; PYK2 transcription is repressed by glucose, and Pyk2p may be active under low glycolytic flux		Null mutant is viable and shows no obvious phenotypes; however, a pyk1 pyk2 double-deletion mutant shows growth defects more pronounced than in the pyk1 mutant strain	YOR347C	S000005874
PZF1	TFC2	Transcription factor IIIA (TFIIIA), essential protein with nine C2H2 Zn-fingers, binds the 5S rRNA gene through the zinc finger domain and directs assembly of a multiprotein initiation complex for RNA polymerase III; also binds DNA			YPR186C	S000006390
QCR10		Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain	ubiquinol-cytochrome c oxidoreductase complex subunit	Null mutant is viable, even on nonfermentable carbon sources, but shows reduced ubiquinol-cytochrome c oxidoreductase activity and loss of Rieske iron-sulfur protein from the complex; qcr10 mutation exacerbates the temperature-sensitivty of qcr6 mutation	YHR001W-A	S000003529
QCR2	COR2|UCR2	Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme	ubiquinol-cytochrome c oxidoreductase complex subunit	Null mutant is viable and grows slowly on glycerol	YPR191W	S000006395
QCR6	COR3|UCR6	Subunit 6 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1	ubiquinol-cytochrome c oxidoreductase complex subunit	Disruptants are viable but are temperature-sensitive petite, lacking ubiquinol-cytochrome c oxidoreductase activity and showing loss of assembly of cytochrome bc1 complex; qcr6 is suppressed by multicopy QCR9; shows synthetic interactions with qcr10; synthetically lethal with grc5 and qsr2	YFR033C	S000001929
QCR7	COR4|CRO1|UCR7	Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly	ubiquinol-cytochrome c oxidoreductase complex subunit		YDR529C	S000002937
QCR8	COR5	Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p	ubiquinol-cytochrome c oxidoreductase complex subunit		YJL166W	S000003702
QCR9	UCR9	Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex	ubiquinol-cytochrome c oxidoreductase complex subunit	Null mutant is viable, is unable to grow on non-fermentable carbon sources	YGR183C	S000003415
QDR1		Multidrug transporter required for resistance to quinidine, ketoconazole, fluconazole, and barban; member of the major facilitator superfamily of transporters conferring multiple drug resistance (MFS-MDR)	multidrug transporter		YIL120W	S000001382
QDR2		Multidrug transporter required for resistance to quinidine, barban, cisplatin, and bleomycin; may have a role in potassium uptake; member of the major facilitator superfamily of transporters conferring multiple drug resistance (MFS-MDR)	multidrug transporter		YIL121W	S000001383
QDR3	AQR2	Multidrug transporter required for resistance to quinidine, barban, cisplatin, and bleomycin; member of the major facilitator superfamily of transporters conferring multiple drug resistance (MFS-MDR)			YBR043C	S000000247
QNQ1		Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity			YLR312C	S000004303
QNS1		Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide	glutamine-dependent NAD synthetase		YHR074W	S000001116
QRI1	UAP1	UDP-N-acetylglucosamine pyrophosphorylase, catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis	UDP-N-acetylglucosamine pyrophosphorylase		YDL103C	S000002261
QRI5	COX24	Mitochondrial protein of unknown function			YLR204W	S000004194
QRI7		Putative metalloprotease, similar to O-sialoglycoprotein metallopeptidase from P. haemolytica; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YDL104C	S000002262
QRI8	UBC7	Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly	ubiquitin-conjugating enzyme	Overexpression confers resistance to methylmercury.	YMR022W	S000004624
QSR2				synthetically lethal with QCR6		S000029398
RAA1				resistance to amino acid analogs		S000029399
RAA2				resistance to certain amino acid analogs		S000029400
RAA3						S000029401
RAA4				Resistance to certain amino acid analogs; unable to use proline as a nitrogen source; unable to take in leucine from liquid culture		S000029402
RAD1	LPB9	Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein	UV endonuclease	radiation sensitive|Deletion of this nucleotide excision repair (NER) gene results in lower levels of cross-link-induced recombination but higher mutation frequencies than wild-type cells.	YPL022W	S000005943
RAD10		Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein	ssDNA endonuclease	radiation sensitive|Deletion of this nucleotide excision repair (NER) gene results in lower levels of cross-link-induced recombination but higher mutation frequencies than wild-type cells.	YML095C	S000004560
RAD14		Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein		Null mutant is viable and radiation sensitive	YMR201C	S000004814
RAD16	PSO5	Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex		radiation sensitive	YBR114W	S000000318
RAD17		Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins			YOR368W	S000005895
RAD18		Protein involved in postreplication repair; binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; forms heterodimer with Rad6p; contains RING-finger motif		Radiation-sensitive. mgs1 exhibits a synergistic growth defect with rad18. Growth defects of mgs1 rad18 double mutants are suppressed by a mutation in SRS2 or by overexpression of Rad52.|Deletion mutants of this post-replication repair (PRR) gene do not have any cross-link-induced mutations but show increased levels of recombination.	YCR066W	S000000662
RAD2		Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein		Null mutant is viable, radiation sensitive	YGR258C	S000003490
RAD23		Protein with ubiquitin-like N terminus, recognizes and binds damaged DNA (with Rad4p) during nucleotide excision repair; regulates Rad4p levels, subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human HR23A and HR23B proteins		radiation sensitive	YEL037C	S000000763
RAD24	RS1	Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein		radiation sensitive	YER173W	S000000975
RAD26		Protein involved in transcription-coupled repair nucleotide excision repair of UV-induced DNA lesions; homolog of human CSB protein	DNA dependent ATPase	Null mutant is viable, defective in transcription-coupled repair, and hypermutable following exposure to UV light and shows delayed recovered of growth after UV exposure; rad7 rad26 and rad16 rad26 double mutants show enhanced sensitivity to UV light	YJR035W	S000003796
RAD27	ERC11|FEN1|RTH1	5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family	42 kDa 5' to 3' exonuclease required for Okazaki fragment processing	Null mutant demonstrates temperature-sensitive growth and sensitivity to UV light and methylmethane sulfonate. rad27 mutant cells are defective in Okazaki fragment maturation.	YKL113C	S000001596
RAD28		Protein involved in transcription-coupled repair nucleotide excision repair of UV-induced DNA lesions; homolog of human CSA protein		Null mutant is viable but is hypermutable following exposure to UV light and is slightly more sensitive to UV light in the presence of mutations in rad7 or rad16	YDR030C	S000002437
RAD29						S000029403
RAD3	REM1	5' to 3' DNA helicase, involved in nucleotide excision repair and transcription; subunit of RNA polymerase II transcription initiation factor TFIIH; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein	transcription initiation factor TFIIH subunit	Null mutant is inviable; rad3 mutants are radiation sensitive|Deletion of this nucleotide excision repair (NER) gene results in lower levels of cross-link-induced recombination but higher mutation frequencies than wild-type cells.	YER171W	S000000973
RAD30	DBH1	DNA polymerase eta, involved in the predominantly error-free bypass replication of DNA lesions, catalyzes the efficient and accurate synthesis of DNA opposite cyclobutane pyrimidine dimers; homolog of human POLH and bacterial DinB proteins	DNA polymerase eta	Null mutant shows increased sensitivity to UV (254 nm). Deletion of RAD30 did not affect spontaneous mutagenesis. Overproduction of Rad30p slightly mutagenic in wild-type yeast strain, moderately mutagenic in strains with inactive 3'->5'-exonuclease of DNA polymerase epsilon or DNA mismatch repair.	YDR419W	S000002827
RAD31						S000029404
RAD33		Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus			YML011C	S000004472
RAD34		Protein involved in nucleotide excision repair (NER); homologous to RAD4			YDR314C	S000002722
RAD4		Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human XPC protein		Null mutant is viable and radiation sensitive|Deletion of this nucleotide excision repair (NER) gene results in lower levels of cross-link-induced recombination but higher mutation frequencies than wild-type cells.	YER162C	S000000964
RAD5	REV2|SNM2	Single-stranded DNA-dependent ATPase, involved in postreplication repair; contains RING finger domain		Radiation-sensitive. mgs1 exhibits a synergistic growth defect with rad5. mgs1 rad5 double mutant has increased sensitivity to hydroxyurea and a greatly increased spontaneous mutation rate.|Deletion mutants of this post-replication repair (PRR) gene do not have any cross-link-induced mutations but show increased levels of recombination.	YLR032W	S000004022
RAD50		Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining	Mre11-Rad50-Xrs2 protein complex member involved in joining double-stranded breaks and DNA recombination	Null mutant is viable but defective for X-ray damage repair, sporulation, chromosome pairing, formation and processing of DS breaks, gene conversion and reciprocal recombination in non-rDNA, tripartite synaptonemal complexes and heteroduplex DNA. Exhibits blocked meiotic recombination and formation of synaptonemal complex at early stages. rad50-1 or null is rescued by spo13 and rescues rad52 spo13.	YNL250W	S000005194
RAD51	MUT5	Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein		Null mutant is viable; accumulates meiosis-specific double strand breaks at a recombination hotspot and reduces the formation of physical recombinants and processed double strand breaks with long heterogeneous tails; rad51 mutants are also defective for X-ray damage repair and gene conversions; rad51 rad27 mutants are inviable.|Deletion of this homologous recombination (HR) gene decreases psoralen-induced recombination and increases mutation frequencies.	YER095W	S000000897
RAD52		Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis		Null mutant is viable, radiation sensitive; rad52 rad27 double mutants are inviable, double strand break ends are excessively recessed in mutant, rad52 is rescued by rad50 spo13, but not spo13, and is classified as late recombination gene. Growth defects of mgs1 rad18 double mutants are suppressed by overexpression of Rad52.|Deletion of this homologous recombination (HR) gene decreases psoralen-induced recombination and increases mutation frequencies.	YML032C	S000004494
RAD53	LSD1|MEC2|SPK1	Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication	serine/threonine protein kinase	Null mutant is inviable, radiation sensitive	YPL153C	S000006074
RAD54	XRS1	DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family		Null mutant is viable, radiation sensitive|Deletion of this homologous recombination (HR) gene decreases psoralen-induced recombination and increases mutation frequencies.	YGL163C	S000003131
RAD55		Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p		Null mutant is viable, radiation sensitive, x-ray sensitive|Deletion of this homologous recombination (HR) gene decreases psoralen-induced recombination and increases mutation frequencies.	YDR076W	S000002483
RAD56				radiation sensitive		S000029405
RAD57		Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p		Null mutant is viable, radiation sensitive|Deletion of this homologous recombination (HR) gene decreases psoralen-induced recombination and increases mutation frequencies.	YDR004W	S000002411
RAD59		Protein involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; homologous to Rad52p		gamma-ray sensitivity, mitotic recombination defects. rad59 is epistatic to rad52 for its repair and recombination defects.	YDL059C	S000002217
RAD6	UBC2	Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (with Rad18p), sporulation, telomere silencing, and ubiquitin-mediated N-end rule protein degradation (with Ubr1p)	ubiquitin-conjugating enzyme	Radiation sensitive. Defective for postreplication repair, repression of retrotransposition, meiotic gene conversion and sporulation. Mutations in srs2 suppress rad6 radiation-sensitivity but not the sporulation defect. rad6 forms recombination intermediates. mgs1 is synthetic lethal with rad6.|Deletion mutants of this post-replication repair (PRR) gene do not have any cross-link-induced mutations but show increased levels of recombination.	YGL058W	S000003026
RAD61		Protein of unknown function; mutation confers radiation sensitivity		Null mutant is sensitive to ionizing radiation. Other phenotypes: Affects radiation sensitivity.	YDR014W	S000002421
RAD7		Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex	nucleotide excision NEF4 component	radiation sensitive	YJR052W	S000003813
RAD9		DNA damage-dependent checkpoint protein, required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; potential Cdc28p substrate		radiation sensitive	YDR217C	S000002625
RAF1		Anti-repressor that increases 2 micron plasmid copy number by relieving repression of the FLP1 site-specific recombinase caused by the Rep1-Rep2p trascription regulator; also itself repressed by the Rep1p-Rep2p complex	2-micron circle protein D		R0030W	S000029674
RAH1		identified in a screen for suppressors of the osmosensitivity (but not temperature sensitivity) phenotype of act1-1				S000029406
RAH2		identified in a screen for suppressors of the osmosensitivity (but not temperature sensitivity) phenotype of act1-1				S000029407
RAH3		identified in a screen for suppressors of the osmosensitivity (but not temperature sensitivity) phenotype of act1-1				S000029408
RAI1		Nuclear protein that binds to and stabilizes the exoribonuclease Rat1p, required for pre-rRNA processing			YGL246C	S000003215
RAM1	DPR1|FUS8|SCG2|SGP2|STE16	Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit	farnesyltransferase subunit	Null mutant is viable, temperature-sensitive, a-specific sterile, exhibits defect in prenylation of ras proteins and other substrates	YDL090C	S000002248
RAM2		Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor	CAAX geranylgeranyltransferase alpha subunit|farnesyltransferase subunit	lethal	YKL019W	S000001502
RAP1	GRF1|TBA1|TUF1	DNA-binding protein involved in either activation or repression of transcription, depending on binding site context; also binds telomere sequences and plays a role in telomeric position effect (silencing) and telomere structure	repressor activator protein	null is inviable; some mutations abolish silencing (at telomeres and at the silent mating-type loci), other mutations or overproduction alter telomere length	YNL216W	S000005160
RAS1		GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes			YOR101W	S000005627
RAS2	CTN5|CYR3|GLC5|TSL7	GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes	small GTP-binding protein	Loss of function mutants grow poorly on nonfermentable carbon sources, sporulate in rich media and are unable to differentiate into a pseudohyphal form	YNL098C	S000005042
RAT1	HKE1|TAP1|XRN2	Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as mRNA transcription termination	5'-3' exoribonuclease		YOR048C	S000005574
RAT6						S000029409
RAV1	SOI3	Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate			YJR033C	S000003794
RAV2		Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme			YDR202C	S000002610
RAX1		Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily			YOR301W	S000005827
RAX2		N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p		Null mutant is defective in bipolar pattern	YLR084C	S000004074
RBA50		Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1			YDR527W	S000002935
RBD2		Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p			YPL246C	S000006167
RBG1	FUN11	Member of the DRG family of GTP-binding proteins; interacts with translating ribosomes and with Tma46p			YAL036C	S000000034
RBG2	GIR1	Protein with similarity to mammalian developmentally regulated GTP-binding protein			YGR173W	S000003405
RBK1		Putative ribokinase			YCR036W	S000000632
RBL2		Protein involved in microtubule morphogenesis, required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin	tubulin folding cofactor A	Overexpression rescues lethality caused by excess beta-tubulin	YOR265W	S000005791
RBS1		Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain	R3H-domain protein		YDL189W	S000002348
RCE1		Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone	metalloprotease	Null mutant is viable, has defects in Ras localization and signaling, and suppresses the activated phenotype of the RAS2val19 allele	YMR274C	S000004887
RCK1		Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations			YGL158W	S000003126
RCK2	CLK1|CMK3	Protein kinase involved in the response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations			YLR248W	S000004238
RCL1		RNA terminal phosphate cyclase-like protein involved in rRNA processing at sites A0, A1, and A2; does not possess detectable RNA cyclase activity			YOL010W	S000005370
RCN1		Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region	calcineurin inhibitor		YKL159C	S000001642
RCO1		Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p			YMR075W	S000004680
RCR1		Protein of the ER membrane involved in cell wall chitin deposition; may function in the endosomal-vacuolar trafficking pathway, helping determine whether plasma membrane proteins are degraded or routed to the plasma membrane			YBR005W	S000000209
RCR2		Vacuolar protein that presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; similar to Rcr1p			YDR003W	S000002410
RCY1		F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth		Deletion leads to an early block in the endocytic pathway before the intersection with the vacuolar protein sorting pathway	YJL204C	S000003740
RDH54	TID1	DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during mitosis and meiosis; proposed to be involved in crossover interference		Required for meiosis. Early meiotic induction of gene conversion is wild-type in a tid1 deletion but mature crossover products form slowly and cells block with single nuclei even though the spindle pole bodies duplicate and separate twice, as if progressing to entry into the second meiotic division.	YBR073W	S000000277
RDI1		Rho GDP dissociation inhibitor involved in the localization and regulation of Cdc42p			YDL135C	S000002294
RDN1		An approximately 1-2 Mb region on the right arm of chr. XII consisting of 100-200 tandem copies of a 9.1 kb repeat which contains the genes for 5S, 5.8S, 25S and 18S rRNAs (represented by the RDN37, RDN25, RDN18, RDN58, and RDN5 loci)				S000029411
RDN18-1	RDN18	18S ribosomal RNA, component of the small (40S) ribosomal subunit; involved in codon recognition by tRNAs or the release factor eRF1 (Sup45p); encoded in the rDNA repeat (RDN1) as part of the 35S primary transcript	18S ribosomal RNA			S000006482
RDN18-2	RDN18	18S ribosomal RNA, component of the small (40S) ribosomal subunit; involved in codon recognition by tRNAs or the release factor eRF1 (Sup45p); encoded in the rDNA repeat (RDN1) as part of the 35S primary transcript	18S ribosomal RNA			S000006483
RDN25-1	RDN25	25S ribosomal RNA, component of the large (60S) ribosomal subunit; encoded in the rDNA repeat (RDN1) as part of the 35S primary transcript	25S ribosomal RNA			S000006484
RDN25-2	RDN25	25S ribosomal RNA, component of the large (60S) ribosomal subunit; encoded in the rDNA repeat (RDN1) as part of the 35S primary transcript	25S ribosomal RNA			S000006485
RDN37-1	RDN37	35S ribosomal RNA transcript, encoded by the RDN1 locus, that is processed into the 25S, 18S and 5.8S rRNAs (represented by the RDN25, RDN18, and RDN58 loci)				S000006486
RDN37-2	RDN37	35S ribosomal RNA transcript, encoded by the RDN1 locus, that is processed into the 25S, 18S and 5.8S rRNAs (represented by the RDN25, RDN18, and RDN58 loci)				S000006487
RDN5-1	RDN5	5S ribosomal RNA, component of the large (60S) ribosomal subunit; localized to the nucleolus via interaction with Rpl5p; may play a role in maintenance of translational frame; transcription is mediated by PolIII and activated by TFIIIA	5S ribosomal RNA			S000006479
RDN5-2	RDN5	5S ribosomal RNA, component of the large (60S) ribosomal subunit; localized to the nucleolus via interaction with Rpl5p; may play a role in maintenance of translational frame; transcription is mediated by PolIII and activated by TFIIIA	5S ribosomal RNA			S000006480
RDN5-3	RDN5	5S ribosomal RNA, component of the large (60S) ribosomal subunit; localized to the nucleolus via interaction with Rpl5p; may play a role in maintenance of translational frame; transcription is mediated by PolIII and activated by TFIIIA	5S ribosomal RNA			S000006481
RDN5-4	RDN5	5S ribosomal RNA, component of the large (60S) ribosomal subunit; localized to the nucleolus via interaction with Rpl5p; may play a role in maintenance of translational frame; transcription is mediated by PolIII and activated by TFIIIA	5S ribosomal RNA			S000029708
RDN5-5	RDN5	5S ribosomal RNA, component of the large (60S) ribosomal subunit; localized to the nucleolus via interaction with Rpl5p; may play a role in maintenance of translational frame; transcription is mediated by PolIII and activated by TFIIIA	5S ribosomal RNA			S000029710
RDN5-6	RDN5	5S ribosomal RNA, component of the large (60S) ribosomal subunit; localized to the nucleolus via interaction with Rpl5p; may play a role in maintenance of translational frame; transcription is mediated by PolIII and activated by TFIIIA	5S ribosomal RNA			S000029711
RDN58-1	RDN58	5.8S ribosomal RNA, component of the 60S ribosomal subunit; encoded in the rDNA repeat (RDN1) as part of the 35S primary transcript; 3' end formation involves processing by the exosome complex while 5' end is generated by Kem1p and Rat1p	5.8S ribosomal RNA			S000006488
RDN58-2	RDN58	5.8S ribosomal RNA, component of the 60S ribosomal subunit; encoded in the rDNA repeat (RDN1)	5.8S ribosomal RNA			S000006489
RDR1		Transcriptional repressor involved in the control of multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins		Null: resistant to cycloheximide, inability to grow on non-fermentable carbon sources, hypersensitivity to calcofluor white.|Null mutant is viable; cannot utilize glycerol and lactate as sole carbon source; hypersensitive to calcofluor white	YOR380W	S000005907
RDS1		Zinc cluster protein involved in conferring resistance to cycloheximide	transcriptional regulator		YCR106W	S000000703
RDS2		Zinc cluster protein involved in conferring resistance to ketoconazole	transcriptional regulator	Null: sensitive to ketoconazole. Other phenotypes: inability to grow on non-fermentable carbon sources, sensitivity to calcofluor white|Null mutant is viable; cannot utilize glycerol and lactate as sole carbon source; hypersensitive to calcofluor white	YPL133C	S000006054
RDS3		Zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance			YPR094W	S000006298
REB1	GRF2	RNA polymerase I enhancer binding protein; DNA binding protein which binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription	RNA polymerase I enhancer binding protein		YBR049C	S000000253
REC1		Required for mitotic intragenic and intergenic recombination and for sporulation		recombination deficient		S000029412
REC102		Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination	meiosis specific recombination protein	Reduced meiotic recombination; inviable spores; mutant is rescued by spo13 and is epistatic to rad52	YLR329W	S000004321
REC104		Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination		Null mutant is viable, rec104 mutants exhibit reduced meiotic DNA recombination, executes meiosis I early; rec104 is rescued by spo13 and is epistatic to rad52 spo13	YHR157W	S000001200
REC107	MER2	Protein involved in early stages of meiotic recombination; involved in altering chromatin structure at DNA double-stranded break sites and in coordination between the initiation of recombination and the first division of meiosis	ds break formation complex subunit	reduced meiotic recombination	YJR021C	S000003782
REC114		Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division		reduced meiotic recombination, rec114 mutants execute meiosis I early, are rescued by spo13 and are epistatic to rad52 spo13	YMR133W	S000004740
REC4		Required for mitotic intragenic and intergenic recombination and for sporulation		Uncharacterized allele rec4-1 exhibits conditional hyporecombination.		S000029413
REC8	SPO69	Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p		Null mutant is viable, does not undergo meiotic division and is unable to sporulate. The null mutant also exhibits a loss of sister chromatid cohesion, an absence of the synaptonemal complex, and chaotic chromosome segregation.	YPR007C	S000006211
RED1		Protein component of the axial elements of the synaptonemal complex, involved in chromosome segregation during the first meiotic division; interacts with Hop1p; required for wild-type levels of Mek1p kinase activity	meiosis-specific component of synaptonemal complex axial element protein core		YLR263W	S000004253
REF2		RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes	RNA-binding protein		YDR195W	S000002603
REG1	HEX2|PZF240|SPP43|SRN1	Regulatory subunit of type 1 protein phosphatase Glc7p, involved in negative regulation of glucose-repressible genes	Glc7p regulatory subunit		YDR028C	S000002435
REG2		Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease	Glc7p regulatory subunit		YBR050C	S000000254
REH1		Protein of unknown function, similar to Rei1p but not involved in bud growth; contains dispersed C2H2 zinc finger domains			YLR387C	S000004379
REI1		Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network			YBR267W	S000000471
REL1						S000029414
REP1		Master regulator that acts in concert with Rep2p to regulate transcript levels of the FLP1 gene that promotes plasmid copy amplification; autoregulates levels of its own transcript	2-micron circle protein B	Mutant exhibits defects in maintenance of 2 micron plasmids.	R0020C	S000029675
REP2		Master regulator that acts in concert with Rep1p to regulate transcript levels of the FLP1 gene that promotes plasmid copy amplification; also autoregulates levels of its own transcript	2-micron circle protein C	Mutant exhibits defects in maintenance of 2 micron plasmids.	R0040C	S000029676
RER1		Protein involved in retention of membrane proteins, including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER		Null mutant is viable and shows mislocalization of transmembrane proteins that are normally retained in the early secretory compartments	YCL001W	S000000507
RER2		Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting	cis-prenyltransferase	Null mutant is viable but both heat and cold sensitive and mislocalizes several ER proteins. rer2-1 (G164D) and rer2-2 (S209N) mutant alleles exhibit similar phenotypes as the null mutant, though have less dramatic growth defects.	YBR002C	S000000206
RES1				RES1-1 is a dominant allele allowing IME1 induction and sporulation of a/a or a/a in the presence of high copy RME1		S000029415
RET1	PDS2|RPC128|RPC2	Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs	C128		YOR207C	S000005733
RET2		Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER		ret2-1 mutant is thermosensitive and shows defects in retrieval of dilysine-tagged proteins from the Golgi back to the ER and, at the non-permissive temperature, in forward ER-to-Golgi transport	YFR051C	S000001947
RET3		Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER	vesicle coat component	ret3-1 mutant is thermosensitive and shows defects in retrieval of dilysine-tagged proteins from the Golgi back to the ER	YPL010W	S000005931
REV1		Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA	deoxycytidyl transferase	Null mutant is viable, exhibts decreased revertibility	YOR346W	S000005873
REV3	PSO1	Catalytic subunit of DNA polymerase zeta, which is involved in DNA repair and translesion synthesis; required for mutagenesis induced by DNA damage	DNA polymerase zeta subunit	The null mutant is viable and resists ultraviolet (UV) mutagenesis in both haploid and homozygous mutant diploid cells. Other antimutator phenotypes are also observed.	YPL167C	S000006088
REV5				Mutant shows impairment of induced mutagenesis		S000029416
REV7		Processivity subunit of DNA polymerase zeta, which is involved in DNA repair and translesion synthesis; required for mutagenesis induced by DNA damage	DNA polymerase zeta (pol-zeta) subunit		YIL139C	S000001401
REX2	YNT20	RNA exonuclease, required for U4 snRNA maturation; functions redundantly with Rnh70p in 5.8S rRNA maturation, and with Rnh70p and Rex3p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases	RNA exonuclease	Null mutant is viable and shows cold-sensitive respiratory defect	YLR059C	S000004049
REX3		RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases		Mutants exhibit RNase MRP RNA processing defect; functions redundantly with REX1 and REX2 in U5 snRNA and RNase P RNA processing	YLR107W	S000004097
REX4		Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly			YOL080C	S000005440
RF2						S000029417
RFA1	BUF2|FUN3|RPA1	Subunit of heterotrimeric Replication Factor A (RF-A), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination	RF-A|heterotrimeric RPA (RF-A) single-stranded DNA binding protein 69 kDa subunit	Null mutant is inviable; cells lacking RFA1 accumulate as multiply budded cells with a single nucleus suggesting a defect in DNA replication; rfa1 repair defects are suppressed by high copy RAD52	YAR007C	S000000065
RFA2	BUF1|RPA2	Subunit of heterotrimeric Replication Factor A (RF-A), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination	replication factor RF-A subunit 2	Null mutant is inviable; arrests as budded and multiply budded cells; rfa2 (ts) cells have a mutator and a hyper-recombination phenotype and are more sensitive to hydroxyurea and methyl-methane-sulfonate than wild-type cells	YNL312W	S000005256
RFA3		Subunit of heterotrimeric Replication Factor A (RF-A), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination	replication factor-A subunit 3	Null mutant is inviable and arrests as budded and multiply budded cells	YJL173C	S000003709
RFC1	CDC44	Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon	replication factor C subunit 1	Null mutant is inviable, rfc1 conditional mutants arrest before mitosis	YOR217W	S000005743
RFC2		Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon	replication factor C subunit 2		YJR068W	S000003829
RFC3		Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon	replication factor C subunit 3		YNL290W	S000005234
RFC4		Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon	replication factor C subunit 4		YOL094C	S000005454
RFC5		Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon	replication factor C subunit 5		YBR087W	S000000291
RFM1		DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance		Null mutant is viable, derepression of middle meiosis-specific genes; required for SUM1-1 mediated suppression of sir2 mutants	YOR279C	S000005805
RFS1		Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern			YBR052C	S000000256
RFT1		Flippase, essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane; mutation is suppressed by expression human p53 protein		Null mutant is inviable and is defective in cell cycle progression	YBL020W	S000000116
RFX1	CRT1	Protein involved in DNA damage and replication checkpoint pathway; recruits repressors Tup1p and Cyc8p to promoters of DNA damage-inducible genes; similar to a family of mammalian DNA binding RFX1-4 proteins			YLR176C	S000004166
RGA1	DBM1|THE1	GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth	rho GTPase activating protein (GAP)	Null mutant is viable but shows increased signaling in the pheromone pathway; haploid null mutants bud predominantly in a bipolar, rather than the normal axial, manner	YOR127W	S000005653
RGA2		GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth	Rho-GTPase Activating Protein	Null mutants are viable but increase the restrictive temperature of a cdc24-4 strain and increase the constitutive activation of the pheromone response pathway in conjungtion with mutations in RGA1 and BEM3; overexpression of RGA2 causes a decrease in the restrictive temperature of a cdc42-1 strain	YDR379W	S000002787
RGD1		GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization		Null mutant is viable and exhibits slightly decreased viability during late exponential and stationary phase in minimal medium	YBR260C	S000000464
RGD2		GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p			YFL047W	S000001847
RGM1		Putative transcriptional repressor with proline-rich zinc fingers; overproduction impairs cell growth		Null mutant is viable; overexpression of RGM1 greatly impairs cell growth.	YMR182C	S000004794
RGP1		Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p		reduced growth	YDR137W	S000002544
RGR1	MED14	Component of RNA polymerase II holoenzyme/mediator complex; affects chromatin structure and transcriptional regulation of diverse genes; required for glucose repression, HO repression, RME1 repression and sporulation	mediator complex subunit	Null mutant is inviable, rgr1 mutants exhibit resistance to glucose represion, temperature sensitivity, sporulation; rgr1-ts allows sporulation of a/a diploids overexpressing RME1	YLR071C	S000004061
RGS1				rgs1 mutants accumulate secretory vesicles in the cytoplasm and stop the secretion of proteins at a restrictive temperature; rgs1 mutation is suppressed by SEC4; rgs1 is synthetically lethal with sec4		S000029418
RGS2		Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p	GTPase activating protein (GAP)	Null mutant is viable but exhibits high PKA phenotypes (low trehalose and glycogen levels, heat sensitivity, low expression of HSP12). Overexpression results in low PKA phenotypes and suppresses the glucose induced cAMP signal.	YOR107W	S000005633
RGT1		Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor	transcriptional activator|transcriptional repressor	Null mutant is viable, shows consitutive expression of glucose-induced HXT geness	YKL038W	S000001521
RGT2		Plasma membrane glucose receptor, highly similar to Snf3p; both Rgt2p and Snf3p serve as transmembrane glucose sensors generating an intracellular signal that induces expression of glucose transporter (HXT) genes	glucose receptor	Dominant mutant suppresses growth defect of snf3 mutants on low concentrations of glucose or fructose	YDL138W	S000002297
RHB1	RSG1	Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins	GTP-binding protein	Mutant exhibits shortened lag phase, failure to arrest in stationary phase; overexpression causes delayed growth.	YCR027C	S000000622
RHO1		GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)	GTP-binding protein	null is inviable; synthetic lethal with bem2	YPR165W	S000006369
RHO2		Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly	GTP-binding protein		YNL090W	S000005034
RHO3		Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p	GTP-binding protein	severe growth delay and decrease in cell viability	YIL118W	S000001380
RHO4		Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity	GTP-binding protein	Null mutant is viable; rho3 rho4 cells are inviable at 30 degrees C	YKR055W	S000001763
RHO5		Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity	rho GTPase		YNL180C	S000005124
RHR2	GPP1	Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress	DL-glycerol-3-phosphatase	Mutants lacking RHR2 show poor anaerobic growth. Mutants lacking RHR2 and HOR2 lack glycerol 3-phosphatase activity, produce only a small amount of glycerol. Overproduction of both genes does not significantly enhance glycerol production.	YIL053W	S000001315
RIA1	EFL1	Cytoplasmic GTPase involved in biogenesis of the 60S ribosome; has similarity to translation elongation factor 2 (Eft1p and Eft2p)	GTPase	Null: quasi essential; null mutant exhibits very slow growth. Other phenotypes: Depletion of Ria1p leads to modification of the polysome profile, with the apperance of halfmers and a reduced level of 60S subunits; defect in rRNA processing and 60S export	YNL163C	S000005107
RIB1		GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway	GTP cyclohydrolase II		YBL033C	S000000129
RIB2	PUS8	DRAP deaminase, catalyzes the third step of the riboflavin biosynthesis pathway; cytoplasmic tRNA pseudouridine synthase involved in pseudouridylation of cytoplasmic tRNAs at position 32	DRAP deaminase|pseudouridine synthase		YOL066C	S000005427
RIB3		3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration	3,4-dihydroxy-2-butanone 4-phosphate synthase		YDR487C	S000002895
RIB4		Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, also known as DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin	6,7-dimethyl-8-ribityllumazine synthase (DMRL synthase)	Null mutant is viable but is a riboflavin auxotroph	YOL143C	S000005503
RIB5		Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway	riboflavin synthase	Null mutant is viable, exhibits riboflavin auxotrophy	YBR256C	S000000460
RIB7		Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway	diaminohydroxyphoshoribosylaminopyrimidine deaminase		YBR153W	S000000357
RIC1		Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes		defective in the transcription of both ribosomal protein genes and ribosomal RNA	YLR039C	S000004029
RIF1		Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation		defective in telomeric silencing and telomere length regulation	YBR275C	S000000479
RIF2		Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation			YLR453C	S000004445
RIM1		Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication	DNA binding protein		YCR028C-A	S000007222
RIM101	RIM1	Transcriptional repressor involved in response to pH and in cell wall construction; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by proteolytic processing; similar to A. nidulans PacC		Poor growth at low temperature, altered colony morphology, inefficient sporulation due to reduced expression of the meiotic activator IME1, and defective invasive growth	YHL027W	S000001019
RIM11	GSK3|MDS1	Protein kinase required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta		Null mutant is viable; some alleles are Spo+ and sporulate slowly; rim11 is epistatic to the lethality of IME1 overexpression in haploids and permits Ime1p accumulation; RIM11 is a high copy suppressor of mck1 (cs) mutants	YMR139W	S000004747
RIM13	CPL1	Calpain-like protease involved in proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans palB	cysteine protease	Mutant shows reduced expression of IME1, defect in Rim1p C-terminal proteolytic processing, reduced sporulation, slow growth at 17 degrees, smooth colony morphology and slow growth in alkaline medium (pH8.0).	YMR154C	S000004763
RIM15	TAK1	Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase	serine/threonine protein kinase	Null mutant is viable, demonstrates delayed sporulation, decreased sporulation efficiency, and diminished expression of early meiotic genes; rim4, rim11 and rim15 mutants can't be suppressed by overexpression of IME1	YFL033C	S000001861
RIM2	PYT1	Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family		Null mutant is viable but lacks mitochondrial DNA and grows slowly on glucose	YBR192W	S000000396
RIM20		Protein involved in proteolytic activation of Rim101p in response to alkaline pH; member of the PalA/AIP1/Alix family; interacts with the ESCRT-III subunits Snf7p, suggesting a relationship between the response to pH and multivesicular body formation		Null: Affected in sporulation and invasive growth. Other phenotypes: Alkaline sensitivity	YOR275C	S000005801
RIM21	PAL2	Component of the RIM101 pathway, has a role in cell wall construction and alkaline pH response; has similarity to A. nidulans PalH		Null: Affected in sporulation and invasive growth. Other phenotypes: Alkaline sensitivity	YNL294C	S000005238
RIM4		Putative RNA-binding protein required for the expression of early and middle sporulation genes		Null mutant is viable. Homozygous null diploid fails to sporulate, does not form meiosis I or II spindles, and exhibits reduced expression of early and middle sporulation-specific genes. Null mutant is suppressed by hyperactive Ime2p derivative, but not by overexpression IME1	YHL024W	S000001016
RIM8	PAL3|YGL046W	Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalF		Mutant shows reduced expression of IME1, defect in Rim1p C-terminal proteolytic processing, reduced sporulation, slow growth at 17 degrees, and a smooth colony morphology; RIM1, RIM8, RIM9, and RIM13 acti in a single pathway, functioning in parallel to MCK1 by epistasis analysis	YGL045W	S000003013
RIM9		Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalI; putative membrane protein		Null mutant is viable but displays reduced sporulation (due to defect in proteolytic processing of Rim101p) and smooth colony morphology; haploid grows slowly at low temperature and is defective in invasive growth; RIM101, 8,9 and 13 act in a single pathway (RIM101 pathway) functioning in parallel to MCK1 by epistasis analysis	YMR063W	S000004667
RIO1	RRP10	Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA	homoserine kinase		YOR119C	S000005645
RIO2		Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p			YNL207W	S000005151
RIP1		Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration	ubiquinol-cytochrome c oxidoreductase complex subunit		YEL024W	S000000750
RIS1	DIS1	Member of the SWI/SNF family of DNA-dependent ATPases, plays a role in antagonizing silencing during mating-type switching, contains an N-terminal domain that interacts with Sir4p and a C-terminal SNF2 domain		Null mutant is viable but shows slower mating type switching; interferes with silencing when overexpressed	YOR191W	S000005717
RIT1		2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA	initiator methionine tRNA 2'-O-ribosyl phosphate transferase	Abolishes requirement for elongator methionine tRNA	YMR283C	S000004896
RIX1	IPI2	Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles			YHR197W	S000001240
RIX7		Putative ATPase of the AAA family, required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions			YLL034C	S000003957
RKI1		Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis	ribose-5-phosphate ketol-isomerase		YOR095C	S000005621
RKM1		SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit protein L23a (RPL23A and RPL23B)	methyltransferase		YPL208W	S000006129
RKM2		Ribosomal protein lysine methyltransferase, responsible for epsilon-trimethylation of the lysine residue at position 10 of Rpl12Ap and Rpl12Bp	lysine methyltransferase		YDR198C	S000002606
RKR1		Nuclear RING domain protein with functional connections to chromatin modification; may interact with ribosomes, based on co-purification experiments; YMR247C is not an essential gene			YMR247C	S000004861
RLF2	CAC1	Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) with Cac2p and Msi1p that assembles newly synthesized histones onto recently replicated DNA; involved in the maintenance of transcriptionally silent chromatin	chromatin assembly factor-I (CAF-I) p90 subunit		YPR018W	S000006222
RLI1		Essential iron-sulfur protein required for ribosome biogenesis and translation initiation; facilitates binding of a multifactor complex (MFC) of translation initiation factors to the small ribosomal subunit; predicted ABC family ATPase		Null mutant is inviable; overexpression of RLI1 from a galactose-inducible promoter has a moderate inhibitory effect on growth.	YDR091C	S000002498
RLM1		MADS-box transcription factor, component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p		Null mutant is viable but shows caffeine sensitivity	YPL089C	S000006010
RLP24		Ribosomal Like Protein 24	part of a pre-60S complex		YLR009W	S000003999
RLP7	RPL7	Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs		Null mutant is inviable<br> required for an early step in large ribosomal subunit biogenesis	YNL002C	S000004947
RLR1	LDB5|THO2|ZRG13	Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids		Null mutant is viable but shows poor growth and a temperature-sensitive phenotype.Increased frequencies of recombination between direct repeats (>1000-fold above wild-type levels) that is linked to transcriptional elongation defects. General defects in RNA polII transcription. Incapacity to transcribe lacZ. Overexpression of RLR1 suppresses the ts phenotype and the incapacity to transcribe lacZ sequences of hpr1-delta mutants	YNL139C	S000005083
RMA1		Putative dihydrofolate synthetase; has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YKL132C	S000001615
RMD1		Cytoplasmic protein required for sporulation			YDL001W	S000002159
RMD11		Protein required for sporulation			YHL023C	S000001015
RMD5	GID2	Cytosolic protein required for sporulation; also required for the ubiquitination of the gluconeogenetic enzyme fructose-1,6-bisphosphatase, which is degraded rapidly after the switch from gluconeogenesis to glycolysis			YDR255C	S000002663
RMD6		Protein required for sporulation			YEL072W	S000000798
RMD8		Cytosolic protein required for sporulation			YFR048W	S000001944
RMD9		Mitochondrial protein required for sporulation			YGL107C	S000003075
RME1	CSP1	Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-a2 regulator; mediates cell type control of sporulation		Null mutant is viable, rme1 allows alpha/alpha and a/a diploids to sporulate, and a and alpha haploids to form viable spores in the presence of spo13|Overexpression activates invasive growth in the absence of elements of the invasive growth-regulating MAP kinase cascade.	YGR044C	S000003276
RMI1	NCE4	Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)		Null mutant is viable and suppresses the failure of an ace2 null to activate CTS1; also grows slowly at 37 C	YPL024W	S000005945
RML2		Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor	mitochondrial ribosomal large subunit component	Null mutant is viable but is respiration-deficient and converts to rho- cytoplasmic petites	YEL050C	S000000776
RMP1		Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P	RNase MRP subunit		YLR145W	S000004135
RMR1		Putative protein of unknown function; deletion mutant results in reduced PIS1 expression and has growth defects on non-fermentable carbon sources and on minimal media; GFP-fusion protein localizes to both the cytoplasm and the nucleus			YGL250W	S000003219
RMT2		Arginine methyltransferase; ribosomal protein L12 is a substrate	arginine methyltransferase		YDR465C	S000002873
RNA1		GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport	GTPase activating protein (GAP) for Gsp1p	inviable, RNA synthesis defective	YMR235C	S000004848
RNA14		Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex	cleavage and polyadenylation factor CF I component involved in pre-mRNA 3'-end processing		YMR061W	S000004665
RNA15		Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p	cleavage and polyadenylation factor CF I component involved in pre-mRNA 3'-end processing		YGL044C	S000003012
RNH1		Ribonuclease H1, removes RNA primers during Okazaki fragment synthesis; degrades RNA attached to the 5'-end of a DNA strand	ribonuclease H		YMR234W	S000004847
RNH201	RNH35	Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis; cooperates with Rad27p nuclease	Rnh2A	Null mutant is viable but shows 75% reduction of RNase H activity in cell extracts	YNL072W	S000005016
RNH202		Ribonuclease H2 subunit, required for RNase H2 activity	Rnh2B		YDR279W	S000002687
RNH203		Ribonuclease H2 subunit, required for RNase H2 activity	Rnh2C	Null: viable. Other phenotypes: required for RNase H2 activity	YLR154C	S000004144
RNH70	REX1	3' exoribonuclease, required for 5S and tRNA-Arg3 maturation	ribonuclease H		YGR276C	S000003508
RNP1		Ribonucleoprotein that contains two RNA recognition motifs (RRM)			YLL046C	S000003969
RNQ1	[PIN(+)]	[PIN(+)] prion, an infectious protein conformation that is generally an ordered protein aggregate	transferable epigenetic modifier, forms a prion responsible for the [PIN(+)] phenotype		YCL028W	S000000533
RNR1	CRT7|RIR1|SDS12	Ribonucleotide-diphosphate reductase (RNR), large subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits	ribonucleotide reductase, large (R1) subunit		YER070W	S000000872
RNR2	CRT6	Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits	ribonucleotide reductase subunit		YJL026W	S000003563
RNR3	DIN1|RIR3	Ribonucleotide-diphosphate reductase (RNR), large subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits	ribonucleotide reductase, large (R1) subunit		YIL066C	S000001328
RNR4	CRT3|PSO3	Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits		Null mutant is inviable in the W303 strain background, but viable and sick in another (Wang et al.[1997] Mol. Cell Biol.17:6114-6121). An rnr4 mutant is resistant to 40 ug/ml benomyl, supersensitive to hydroxyurea (HU)[dead at 0.005M HU], and cold sensitive [cells arrest at 14 deg. C. with a large bud and short mitotic spindle].	YGR180C	S000003412
RNT1		RNAase III; cleaves a stem-loop structure at the 3' end of U2 snRNA to ensure formation of the correct U2 3' end	ribonuclease III		YMR239C	S000004852
RNY1		RNAse; member of the T(2) family of endoribonucleases	ribonuclease, T2 family		YPL123C	S000006044
ROC2				roc2 mutants exhibit decreased expression of Ty1		S000029419
ROD1		Membrane protein; overexpression confers resistance to the GST substrate o-dinitrobenzene as well as to zinc and calcium; contains 2 PY motifs, which are required for Rod1p interaction with Rsp5p, a hect-type ubiquitin ligase		Null mutant is viable but is hypersensitive to o-dinitrobenzene, calcium, and zinc	YOR018W	S000005544
ROG1		Protein with putative serine active lipase domain			YGL144C	S000003112
ROG3		Protein that binds to Rsp5p, which is a hect-type ubiquitin ligase, via its 2 PY motifs; has similarity to Rod1p; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant			YFR022W	S000001918
ROK1		ATP-dependent RNA helicase of the DEAD box family; required for 18S rRNA synthesis		Null mutant is inviable. Depletion of Rok1p inhibits pre-rRNA processing at sites A0, A1, and A2, thereby blocking 18S rRNA synthesis.	YGL171W	S000003139
ROM1	SKC1	GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP		Synthetically lethal with ROM2 (growth arrest with small bud and cell lysis)	YGR070W	S000003302
ROM2		GDP/GTP exchange protein (GEP) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEP		Null mutant is viable but shows temperature- and cold-sensitive growth defects at 37 and 11 degrees, increased sensitivity to benomyl, and elongated buds and abnormal mating projections at the permissive temperature; synthetically lethal with rom1	YLR371W	S000004363
ROS2				ros2 bar1 double mutant suppresses sterility of ste4 mutants		S000029420
ROS3				ros3 bar1 double mutant suppresses ste4 sterility		S000029421
ROT1		Essential ER membrane protein; may be involved in protein folding; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations		Null mutant is inviable; rot1 mutations can suppress tor2 mutations; synthetically lethal with rot2	YMR200W	S000004813
ROT2	GLS2	Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations	glucosidase II catalytic subunit	Null mutant is inviable; rot2 mutations can suppress tor2 mutations; synthetically lethal with rot1	YBR229C	S000000433
ROX1	REO1	Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity	HMG-domain site-specific DNA binding protein.	The null mutant is viable but misexpresses several heme-regulated genes.	YPR065W	S000006269
ROX3	MED19|NUT3|SSN7	RNA polymerase II holoenzyme component	mediator complex subunit		YBL093C	S000000189
RPA12	RRN4	RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex	A12.2|RNA polymerase I A12.2 subunit	Null mutant is viable but is temperature sensitive; synthetically lethal with RPA14	YJR063W	S000003824
RPA135	RPA2|RRN2|SRP3	RNA polymerase I subunit A135	A135|RNA polymerase I subunit	suppression of rpb1, cold sensitive	YPR010C	S000006214
RPA14		RNA polymerase I subunit A14	A14|RNA polymerase I subunit	Null mutant is viable but is temperature sensitive	YDR156W	S000002563
RPA190	RRN1	RNA polymerase I subunit; largest subunit of RNA polymerase I	A190|RNA polymerase I subunit		YOR341W	S000005868
RPA34		RNA polymerase I subunit A34.5	A34.5	Null mutant is viable but its RNA polymerase I lacks subunit A49 (rpa49p); synthetically lethal with RPA14; shows synthetic interactions with DNA topoisomerase I (TPO1)	YJL148W	S000003684
RPA43		RNA polymerase I subunit A43	A43|DNA dependent RNA polymerase I subunit A43		YOR340C	S000005867
RPA49		RNA polymerase I subunit A49	A49|RNA polymerase A 49 kDa alpha subunit	Null mutant is viable but grows slowly and is temperature or cold sensitive; synthetically lethal with RPA14	YNL248C	S000005192
RPB10		RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III	ABC10-beta|RNA polymerase II core subunit		YOR210W	S000005736
RPB11		RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit	B12.5|RNA polymerase II core subunit		YOL005C	S000005365
RPB2	RPB150|RPO22|SIT2|SOH2	RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit	B150		YOR151C	S000005677
RPB3		RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit	B44|RNA polymerase II 45 kDa subunit	Null mutant is inviable; rpb3(ts) mutants at restrictive temperature exhibit no assembly of RNA polymerase II	YIL021W	S000001283
RPB4	CTF15	RNA polymerase II subunit B32; forms two subunit dissociable complex with Rpb7p; dispensable under some environmental conditions; involved in export of mRNA to cytoplasm under stress conditions; involved in telomere maintenance	B32|RNA polymerase II fourth largest subunit	Null mutant is viable, rbp4 mutants are heat and cold sensitive, exhibit slow growth at intermediate temperatures	YJL140W	S000003676
RPB5		RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation	25 kDa RNA polymerase subunit (common to polymerases I, II and III)|ABC27		YBR154C	S000000358
RPB7		RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p	B16|RNA polymerase II dissociable subunit		YDR404C	S000002812
RPB8		RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III	16 kDa RNA polymerase subunit (common to polymerases I, II and III)|ABC14.5		YOR224C	S000005750
RPB9	SHI1|SSU73	RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site; involved in telomere maintenance	B12.6|RNA polymerase II core subunit	Null mutant is viable, heat and cold sensitive, exhibits altered transcription start sites at various genes	YGL070C	S000003038
RPC10	RPB12	RNA polymerase subunit, found in RNA polymerase complexes I, II, and III	ABC10-alpha|RNA polymerase II subunit		YHR143W-A	S000001185
RPC11		RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription	C11|TFIIS-like small Pol III subunit C11		YDR045C	S000002452
RPC17		RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex	C17		YJL011C	S000003548
RPC19		RNA polymerase subunit, common to RNA polymerases I and III	AC19|RNA polymerases I (A) and III (C) subunit		YNL113W	S000005057
RPC25	YKL1	RNA polymerase III subunit C25	C25|RNA polymerase III subunit		YKL144C	S000001627
RPC31	ACP2|RPC8	RNA polymerase III subunit C31; contains HMG-like C-terminal domain	C31|RNA polymerase III (C) 31 kDa subunit		YNL151C	S000005095
RPC34		RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex	C34|RNA polymerase III (C) 34 kDa subunit		YNR003C	S000005286
RPC37		RNA polymerase III subunit C37	C37|RNA polymerase III subunit		YKR025W	S000001733
RPC40	RPC5	RNA polymerase subunit, common to RNA polymerase I and III	AC40|RNA polymerase III subunit		YPR110C	S000006314
RPC53	RPC4	RNA polymerase III subunit C53	C53|RNA polymerase III subunit	Null mutant is inviable; temperature sensitive mutants show rapid inhibition of tRNA synthesis after shift to restricitive temperature and arrest in G1	YDL150W	S000002309
RPC80		Genetic locus thought to encode an RNA poymerase III subunit				S000029422
RPC82	RPC3	RNA polymerase III subunit C82	82 kDa subunit of RNA polymerase III (C)|C82		YPR190C	S000006394
RPD3	MOF6|REC3|SDI2|SDS6	Histone deacetylase; regulates transcription and silencing	histone deacetylase	Null mutant is viable and shows reduced potassium dependency, mating defects, hypersensitivity to cycloheximide, and constitutive derepression of acid phosphatase; mutant epistasis analysis indicates that RPD3 acts in the same pathway as UME4/SIN3; homozygous mutant diploid is defective in sporulation and recombination	YNL330C	S000005274
RPE1	EPI1|POS18	D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress	D-ribulose-5-phosphate 3-epimerase		YJL121C	S000003657
RPF1		Nucleolar protein involved in the assembly of the large ribosomal subunit; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA			YHR088W	S000001130
RPF2		Essential protein involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles			YKR081C	S000001789
RPG1	TIF32	Subunit of the core complex of translation initiation factor 3(eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes	translation initiation factor eIF3 subunit	Null mutant is inviable; temperature sensitive mutant arrests in G1 phase	YBR079C	S000000283
RPH1		JmjC domain-containing histone demethylase which can specifically demethylate H3K36 tri- and dimethyl modification states; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway	transcriptional repressor	Null mutation is viable, exhibits minor de-repression of PHR1 expression	YER169W	S000000971
RPI1		Putative transcriptional regulator; overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation	ras inhibitor	Null mutant is viable but shows heat-shock sensitivity	YIL119C	S000001381
RPL10	GRC5|QSR1	Protein component of the large (60S) ribosomal subunit, responsible for joining the 40S and 60S subunits; regulates translation initiation; has similarity to rat L10 ribosomal protein and to members of the QM gene family	ribosomal protein L10	Null mutant is inviable; temperature-sensitive mutant, at restrictive temperature (on rich medium), arrests after 1-3 cell divisions as large budded cells with aberrent septum and cytoskeleton	YLR075W	S000004065
RPL11A		Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Bp; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11	ribosomal protein L11A		YPR102C	S000006306
RPL11B		Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11	ribosomal protein L11B	Null mutant is viable, rp111b rp111a mutants are inviable. rpl11 mutants are deficient in 60S ribosomal subunits relative to 40S subunits. 43S preinitiation complexes accumulate in half-mer polyribosomes in the absence of sufficient 60S subunits.	YGR085C	S000003317
RPL12A		Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Bp; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins	ribosomal protein L12A		YEL054C	S000000780
RPL12B		Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Ap; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins	ribosomal protein L12B		YDR418W	S000002826
RPL13A		Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Bp; not essential for viability; has similarity to rat L13 ribosomal protein	ribosomal protein L13A		YDL082W	S000002240
RPL13B		Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Ap; not essential for viability; has similarity to rat L13 ribosomal protein	ribosomal protein L13B		YMR142C	S000004750
RPL14A		N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl14Bp and has similarity to rat L14 ribosomal protein; rpl14a csh5 double null mutant exhibits synthetic slow growth	ribosomal protein L14A		YKL006W	S000001489
RPL14B		Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl14Ap and has similarity to rat L14 ribosomal protein	ribosomal protein L14B		YHL001W	S000000993
RPL15A	RPL10A	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Bp and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA	ribosomal protein L15A		YLR029C	S000004019
RPL15B		Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Ap and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA	ribosomal protein L15B		YMR121C	S000004728
RPL16A	RPL13	N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p	ribosomal protein L16A		YIL133C	S000001395
RPL16B	RP23	N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Ap, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p	ribosomal protein L16B		YNL069C	S000005013
RPL17A	RPL17	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Bp and has similarity to E. coli L22 and rat L17 ribosomal proteins; copurifies with the Dam1 complex (aka DASH complex)	ribosomal protein L17A		YKL180W	S000001663
RPL17B		Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Ap and has similarity to E. coli L22 and rat L17 ribosomal proteins	ribosomal protein L17B		YJL177W	S000003713
RPL18A	RP28A	Protein component of the large (60S) ribosomal subunit, identical to Rpl18Bp and has similarity to rat L18 ribosomal protein; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation	ribosomal protein L18A		YOL120C	S000005480
RPL18B	RP28B	Protein component of the large (60S) ribosomal subunit, identical to Rpl18Ap and has similarity to rat L18 ribosomal protein	ribosomal protein L18B		YNL301C	S000005245
RPL19A		Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Bp and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal	ribosomal protein L19A	Null mutant is viable but grows slowly.	YBR084C-A	S000002156
RPL19B		Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Ap and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal	ribosomal protein L19B	Null mutant is viable but grows slowly.	YBL027W	S000000123
RPL1A	SSM1	N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Bp and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal	ribosomal protein L1A	Null mutant is viable; shows double mutant lethality with rpl1b (ssm2b) null mutants	YPL220W	S000006141
RPL1B	SSM2	N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Ap and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal	ribosomal protein L1B		YGL135W	S000003103
RPL20A	RPL18A2	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Bp and has similarity to rat L18a ribosomal protein	ribosomal protein L20A		YMR242C	S000004855
RPL20B	RPL18A1	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Ap and has similarity to rat L18a ribosomal protein	ribosomal protein L20B		YOR312C	S000005839
RPL21A	URP1	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Bp and has similarity to rat L21 ribosomal protein	ribosomal protein L21A		YBR191W	S000000395
RPL21B		Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Ap and has similarity to rat L21 ribosomal protein	ribosomal protein L21B		YPL079W	S000006000
RPL22A		Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Bp and to rat L22 ribosomal protein	ribosomal protein L22A		YLR061W	S000004051
RPL22B	YFL035C-B	Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Ap and to rat L22 ribosomal protein	ribosomal protein L22B		YFL034C-A	S000006436
RPL23A		Protein component of the large (60S) ribosomal subunit, identical to Rpl23Bp and has similarity to E. coli L14 and rat L23 ribosomal proteins	ribosomal protein L23A		YBL087C	S000000183
RPL23B		Protein component of the large (60S) ribosomal subunit, identical to Rpl23Ap and has similarity to E. coli L14 and rat L23 ribosomal proteins	ribosomal protein L23B		YER117W	S000000919
RPL24A	RPL30A	Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate	ribosomal protein L24A		YGL031C	S000002999
RPL24B	RPL30B	Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Ap and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate	ribosomal protein L24B		YGR148C	S000003380
RPL25		Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit, has similarity to E. coli L23 and rat L23a ribosomal proteins; binds to 26S rRNA via a conserved C-terminal motif	ribosomal protein L25		YOL127W	S000005487
RPL26A		Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Bp and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA	ribosomal protein L26A		YLR344W	S000004336
RPL26B		Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Ap and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA	ribosomal protein L26B		YGR034W	S000003266
RPL27A	RPL27	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Bp and has similarity to rat L27 ribosomal protein	ribosomal protein L27A		YHR010W	S000001052
RPL27B		Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Ap and has similarity to rat L27 ribosomal protein	ribosomal protein L27B		YDR471W	S000002879
RPL28	CYH2	Ribosomal protein L29 of the large (60S) ribosomal subunit, has similarity to E. coli L15 and rat L27a ribosomal proteins; may have peptidyl transferase activity; can mutate to cycloheximide resistance	ribosomal protein L28		YGL103W	S000003071
RPL29		Protein component of the large (60S) ribosomal subunit, has similarity to rat L29 ribosomal protein; not essential for translation, but required for proper joining of the large and small ribosomal subunits and for normal translation rate	ribosomal protein L29		YFR032C-A	S000006437
RPL2A	RPL5B	Protein component of the large (60S) ribosomal subunit, identical to Rpl2Bp and has similarity to E. coli L2 and rat L8 ribosomal proteins	ribosomal protein L2A		YFR031C-A	S000002104
RPL2B	LOT2|RPL5A	Protein component of the large (60S) ribosomal subunit, identical to Rpl2Ap and has similarity to E. coli L2 and rat L8 ribosomal proteins; expression is upregulated at low temperatures	ribosomal protein L2B		YIL018W	S000001280
RPL3	MAK8|TCM1|YOR29-14	Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus	ribosomal protein L3	Tricodermin resistance	YOR063W	S000005589
RPL30		Protein component of the large (60S) ribosomal subunit, has similarity to rat L30 ribosomal protein; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript	ribosomal protein L30		YGL030W	S000002998
RPL31A	RPL34	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Bp and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p	ribosomal protein L31A		YDL075W	S000002233
RPL31B		Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Ap and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p	ribosomal protein L31B		YLR406C	S000004398
RPL32		Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencing	ribosomal protein L32	overexpression disrupts telomeric silencing	YBL092W	S000000188
RPL33A	RPL37A	N-terminally acetylated ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Bp and has similarity to rat L35a; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable	ribosomal protein L33A	Null mutant is viable, severely impaired in growth. rpl33a rpl33b double deletion mutants are inviable	YPL143W	S000006064
RPL33B	RPL37B	Ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Ap and has similarity to rat L35a; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable	ribosomal protein L33B		YOR234C	S000005760
RPL34A		Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Bp and has similarity to rat L34 ribosomal protein	ribosomal protein L34A		YER056C-A	S000002135
RPL34B		Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Ap and has similarity to rat L34 ribosomal protein	ribosomal protein L34B		YIL052C	S000001314
RPL35A	SOS1	Protein component of the large (60S) ribosomal subunit, identical to Rpl35Bp and has similarity to rat L35 ribosomal protein	ribosomal protein L35A		YDL191W	S000002350
RPL35B	SOS2	Protein component of the large (60S) ribosomal subunit, identical to Rpl35Ap and has similarity to rat L35 ribosomal protein	ribosomal protein L35B		YDL136W	S000002295
RPL36A	RPL39B	N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Bp and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA	ribosomal protein L36A		YMR194W	S000004807
RPL36B		Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Ap and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA	ribosomal protein L36B		YPL249C-A	S000006438
RPL37A		Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Bp and to rat L37 ribosomal protein	ribosomal protein L37A		YLR185W	S000004175
RPL37B		Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Ap and to rat L37 ribosomal protein	ribosomal protein L37B		YDR500C	S000002908
RPL38		Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein	ribosomal protein L38		YLR325C	S000004317
RPL39	PUB2|RPL46|SPB2	Protein component of the large (60S) ribosomal subunit, has similarity to rat L39 ribosomal protein; required for ribosome biogenesis; exhibits genetic interactions with SIS1 and PAB1	ribosomal protein L39	Null mutant is viable, cold-sensitive in some genetic backgrounds, exhibits reduced levels of 60S subunits; rpl39 mutations suppress mutations in poly-A binding protein (PAB1)	YJL189W	S000003725
RPL40A	CEP52A|UB11|UBI1	Fusion protein, identical to Rpl40Bp, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes	ribosomal protein L40A		YIL148W	S000001410
RPL40B	CEP52B|UB12|UBI2	Fusion protein, identical to Rpl40Ap, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes	ribosomal protein L40B		YKR094C	S000001802
RPL41A	RPL47A	Ribosomal protein L47 of the large (60S) ribosomal subunit, identical to Rpl41Bp and has similarity to rat L41 ribosomal protein; comprised of only 25 amino acids; rpl41a rpl41b double null mutant is viable	ribosomal protein L41A		YDL184C	S000002343
RPL41B	RPL47B|YDL134C-A	Ribosomal protein L47 of the large (60S) ribosomal subunit, identical to Rpl41Ap and has similarity to rat L41 ribosomal protein; comprised of only 25 amino acids; rpl41a rpl41b double null mutant is viable	ribosomal protein L41B		YDL133C-A	S000002293
RPL42A		Protein component of the large (60S) ribosomal subunit, identical to Rpl42Bp and has similarity to rat L44 ribosomal protein	ribosomal protein L42A		YNL162W	S000005106
RPL42B	MAK18	Protein component of the large (60S) ribosomal subunit, identical to Rpl42Ap and has similarity to rat L44; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus	ribosomal protein L42B	Deficient in maintenance of killer. The mak18-1 mutant allele is deficient in 60S ribosomal subunits.	YHR141C	S000001183
RPL43A		Protein component of the large (60S) ribosomal subunit, identical to Rpl43Bp and has similarity to rat L37a ribosomal protein; null mutation confers a dominant lethal phenotype	ribosomal protein L43A		YPR043W	S000006247
RPL43B		Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein	ribosomal protein L43B		YJR094W-A	S000003855
RPL4A		N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Bp and has similarity to E. coli L4 and rat L4 ribosomal proteins	ribosomal protein L4A		YBR031W	S000000235
RPL4B		Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Ap and has similarity to E. coli L4 and rat L4 ribosomal proteins	ribosomal protein L4B		YDR012W	S000002419
RPL5	LPI14|RPL1	Protein component of the large (60S) ribosomal subunit with similarity to E. coli L18 and rat L5 ribosomal proteins; binds 5S rRNA and is required for 60S subunit assembly	ribosomal protein L5		YPL131W	S000006052
RPL6A	YL16A	N-terminally acetylated protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Bp and to rat L6 ribosomal protein; binds to 5.8S rRNA	ribosomal protein L6A		YML073C	S000004538
RPL6B		Protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Ap and to rat L6 ribosomal protein; binds to 5.8S rRNA	ribosomal protein L6B	Null mutant is viable, grows slower than wild-type. rpl6a rpl6b double mutants are inviable; rpl6 mutants are deficient in 60S ribosomal subunits relative to 40S subunits; 43S preinitiation complexes accumulate in half-mer polyribosomes in the absence of sufficient 60S subunits.	YLR448W	S000004440
RPL7A		Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Bp and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)	ribosomal protein L7A	Null mutant is viable; grows more slowly than wild-type	YGL076C	S000003044
RPL7B		Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Ap and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)	ribosomal protein L7B	Null mutant is viable; disruption of both RPL7A and RPL7B is lethal	YPL198W	S000006119
RPL8A	MAK7	Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Bp and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits	ribosomal protein L8A	Null mutant is viable, rpl4A rpl4B double mutant is inviable; deficient in maintenance of killer	YHL033C	S000001025
RPL8B	KRB1|SCL41	Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits	ribosomal protein L8B	Null mutant is viable. rpl8a rpl8b mutants are inviable. The rpl8b allele, krb1, can suppress some mak mutations and represents a chromosomal rearrangement involving chromosome XII	YLL045C	S000003968
RPL9A		Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins	ribosomal protein L9A		YGL147C	S000003115
RPL9B		Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Ap and has similarity to E. coli L6 and rat L9 ribosomal proteins	ribosomal protein L9B		YNL067W	S000005011
RPM1		RNA component of mitochondrial RNase P, which also contains the protein subunit Rpm2p; Rnase P removes 5' extensions from mitochondrial tRNA precursors; RPM1 is conserved in bacteria, fungi, and protozoa	mitochondrial RNase P subunit			S000029023
RPM2		Multifunctional protein that is distributed to mitochondria, cytoplasmic processing bodies, and the nucleus; has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation	mitochondrial RNase P subunit	Null mutant is viable, respiratory deficient, accumulate mitochondrial tRNA precursors with 5' extensions, arrest after 25 generations on fermentable media. Spontaneous mutations that suppress arrest occur at approx 9E-6. Resultant mutants do not grow on nonfermentable carbon sources.	YML091C	S000004556
RPN1	HRD2|NAS1	Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for protein?protein interactions	26S proteasome PA700 subunit	Null mutant is inviable; hrd2-1 mutation slows degradation of Hmg2p. hrd2-1 strains are sensitive to canavanine and show a global accumulation of ubiquitin-conjugated proteins, but are not temperature-sensitive	YHR027C	S000001069
RPN10	MCB1|SUN1	Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein	26S proteasome component	Null mutant is viable, exhibits a modest sensitivity to amino acid analogs and has increased steady-state levels of ubiquitin-protein conjugates	YHR200W	S000001243
RPN11	MPR1	Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates			YFR004W	S000001900
RPN12	NIN1	Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p		Null mutant is inviable; nin1-1 mutant is temperature-sensitive mutant that shows i) higher rates of recombination and chromosome and plasmid loss; ii) greater sensitivity to UV irradiation; iii) at restrictive temperature, arrest in G2, failure to activate histone H1 kinase, and accumulation of polyubiquinated proteins	YFR052W	S000001948
RPN13		Subunit of the 19S regulatory particle of the 26S proteasome lid		Null mutant is viable but defective in degradation of ubiquitinated substrates.	YLR421C	S000004413
RPN14		Putative non-ATPase subunit of the 19S regulatory particle of the 26S proteasome; localized to the cytoplasm			YGL004C	S000002972
RPN2	SEN3	Subunit of the 26S proteasome, substrate of the N-acetyltransferase Nat1p		Null mutant is inviable/null mutant is viable, but shows temperature sensitivity (conflicting reports)	YIL075C	S000001337
RPN3	SUN2	Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control	26S proteasome regulatory module component	Null mutant is inviable. RPN3 is a high copy suppressor of the nin1-1 temperature sensitive phenotype	YER021W	S000000823
RPN4	SON1|UFD5	Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses		Null mutant is viable, exhibits synthetic interactions with sen3, sun1, and cdc28-1N	YDL020C	S000002178
RPN5	NAS5	Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p	proteasome regulatory particle subunit		YDL147W	S000002306
RPN6	NAS4	Essential, non-ATPase regulatory subunit of the 26S proteasome lid required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion	proteasome regulatory particle subunit		YDL097C	S000002255
RPN7		Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits	proteasome regulatory particle subunit		YPR108W	S000006312
RPN8		Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p	proteasome regulatory particle subunit		YOR261C	S000005787
RPN9		Non-ATPase regulatory subunit of the 26S proteasome, has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects	proteasome regulatory particle subunit	Null mutant is viable, temperature sensitive; rpn9 rpn10 double deletion mutants are viable	YDR427W	S000002835
RPO21	RPB1|RPB220|SUA8	RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime	B220|RNA polymerase II core subunit		YDL140C	S000002299
RPO26	RPB6	RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit	ABC23|RNA polymerases I, II, and III subunit		YPR187W	S000006391
RPO31	RPC1|RPC160	RNA polymerase III subunit C160, part of core enzyme; similar to bacterial beta-prime subunit	C160|RNA polymerase III subunit		YOR116C	S000005642
RPO41		Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition	mitochondrial RNA polymerase		YFL036W	S000001858
RPP0	RPL10E	Conserved ribosomal protein P0 similar to rat P0, human P0, and E. coli L10e; shown to be phosphorylated on serine 302	ribosomal protein P0		YLR340W	S000004332
RPP1		Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends	RNase MRP subunit|nuclear RNase P subunit		YHR062C	S000001104
RPP1A	RPLA1	Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component	ribosomal protein P1A		YDL081C	S000002239
RPP1B	RPL44'|RPLA3	Ribosomal protein P1 beta, component of the ribosomal stalk, which is involved in interaction of translational elongation factors with ribosome; accumulation is regulated by phosphorylation and interaction with the P2 stalk component	ribosomal protein P1B		YDL130W	S000002288
RPP2A	RPL44|RPLA2	Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm	ribosomal protein P2A		YOL039W	S000005399
RPP2B	RPL45|YPA1	Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm	ribosomal protein P2B	Null mutant is viable. Overexpression affects cell growth by interfering with the joining of the 60S subunit to the initiation complex generating the accumulation of polysome half-mers.	YDR382W	S000002790
RPR1		RNA component of nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; may be responsible for recognition of substrate tRNAs	nuclear RNase P subunit			S000006490
RPR2		Subunit of nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits	nuclear RNase P subunit	Null mutant is inviable; transient depletions cause loss of RNase P	YIR015W	S000001454
RPS0A	NAB1|NAB1A|YST1	Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal	ribosomal protein S0A	Null mutant is viable; yst1 (rps0a) yst2 (rps0b) double deletion mutant is inviable; yst1 (rps0a) mutants are defective for filamentous growth	YGR214W	S000003446
RPS0B	NAB1B|YST2	Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Ap; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal	ribosomal protein S0B	Null mutant is viable with significant reduction in growth rate and change in distribution and make up of ribosomes; yst1 (rps0a) yst2 (rps0b) double mutant is inviable	YLR048W	S000004038
RPS10A		Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Bp and has similarity to rat ribosomal protein S10	ribosomal protein S10A		YOR293W	S000005819
RPS10B		Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Ap and has similarity to rat ribosomal protein S10	ribosomal protein S10B		YMR230W	S000004843
RPS11A		Protein component of the small (40S) ribosomal subunit; identical to Rps11Bp and has similarity to E. coli S17 and rat S11 ribosomal proteins	ribosomal protein S11A		YDR025W	S000002432
RPS11B		Protein component of the small (40S) ribosomal subunit; identical to Rps11Ap and has similarity to E. coli S17 and rat S11 ribosomal proteins	ribosomal protein S11B		YBR048W	S000000252
RPS12		Protein component of the small (40S) ribosomal subunit; has similarity to rat ribosomal protein S12	ribosomal protein S12		YOR369C	S000005896
RPS13	RPS13B|RPS13C	Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S15 and rat S13 ribosomal proteins	ribosomal protein S13		YDR064W	S000002471
RPS14A	CRY1|RPL59	Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Bp and similar to E. coli S11 and rat S14 ribosomal proteins	ribosomal protein S14A	Cryptopleurine resistance	YCR031C	S000000627
RPS14B	CRY2	Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Ap and similar to E. coli S11 and rat S14 ribosomal proteins	ribosomal protein S14B		YJL191W	S000003727
RPS15	RPS21	Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S19 and rat S15 ribosomal proteins	ribosomal protein S15		YOL040C	S000005400
RPS16A		Protein component of the small (40S) ribosomal subunit; identical to Rps16Bp and has similarity to E. coli S9 and rat S16 ribosomal proteins	ribosomal protein S16A		YMR143W	S000004751
RPS16B		Protein component of the small (40S) ribosomal subunit; identical to Rps16Ap and has similarity to E. coli S9 and rat S16 ribosomal proteins	ribosomal protein S16B		YDL083C	S000002241
RPS17A	RP51A|RPL51A	Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Bp and has similarity to rat S17 ribosomal protein	ribosomal protein S17A	Null mutant is viable and grows slowly; rps17A rps17B double null mutant is inviable	YML024W	S000004486
RPS17B	RP51B|RPL51B	Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Ap and has similarity to rat S17 ribosomal protein	ribosomal protein S17B	Null mutant is viable, rp51a (rps17a) rp51b (rps17b) deletion mutants are inviable	YDR447C	S000002855
RPS18A		Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Bp and has similarity to E. coli S13 and rat S18 ribosomal proteins	ribosomal protein S18A		YDR450W	S000002858
RPS18B		Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Ap and has similarity to E. coli S13 and rat S18 ribosomal proteins	ribosomal protein S18B		YML026C	S000004488
RPS19A		Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles; mutations in human RPS19 are associated with Diamond Blackfan anemia; nearly identical to Rps19Bp	ribosomal protein S19A		YOL121C	S000005481
RPS19B	RP55B	Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles; mutations in human RPS19 are associated with Diamond Blackfan anemia; nearly identical to Rps19Ap	ribosomal protein S19B		YNL302C	S000005246
RPS1A	RP10A	Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Bp and has similarity to rat S3a ribosomal protein	ribosomal protein S1A		YLR441C	S000004433
RPS1B	PLC2|RP10B	Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Ap and has similarity to rat S3a ribosomal protein	ribosomal protein S1B		YML063W	S000004528
RPS2	RPS4|SUP138|SUP38|SUP44	Protein component of the small (40S) subunit, essential for control of translational accuracy; has similarity to E. coli S5 and rat S2 ribosomal proteins	ribosomal protein S2	Omnipotent suppressor of nonsense mutations	YGL123W	S000003091
RPS20	URP2	Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; has similarity to E. coli S10 and rat S20 ribosomal proteins	ribosomal protein S20		YHL015W	S000001007
RPS21A	RPS25	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Bp and has similarity to rat S21 ribosomal protein	ribosomal protein S21A		YKR057W	S000001765
RPS21B		Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Ap and has similarity to rat S21 ribosomal protein	ribosomal protein S21B		YJL136C	S000003672
RPS22A	RPS24	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Bp and has similarity to E. coli S8 and rat S15a ribosomal proteins	ribosomal protein S22A		YJL190C	S000003726
RPS22B		Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Ap and has similarity to E. coli S8 and rat S15a ribosomal proteins	ribosomal protein S22B		YLR367W	S000004359
RPS23A		Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; nearly identical to Rps23Bp and similar to E. coli S12 and rat S23 ribosomal proteins; deletion of both RPS23A and RPS23B is lethal	ribosomal protein S23A	Null mutant is viable; rps23a rps23b double deletion mutants are inviable. Mutations in different parts of RPS23 have opposite affects on translational accuracy or antibiotic sensitivity.	YGR118W	S000003350
RPS23B		Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; nearly identical to Rps23Ap and similar to E. coli S12 and rat S23 ribosomal proteins; deletion of both RPS23A and RPS23B is lethal	ribosomal protein S23B	Null mutant is viable, rps23a rps23b double deletion mutants are inviable. Mutations in different parts of RPS23 have opposite affects on translational accuracy or antibiotic sensitivity.	YPR132W	S000006336
RPS24A	RPS24EA	Protein component of the small (40S) ribosomal subunit; identical to Rps24Bp and has similarity to rat S24 ribosomal protein	ribosomal protein S24A		YER074W	S000000876
RPS24B	RPS24EB	Protein component of the small (40S) ribosomal subunit; identical to Rps24Ap and has similarity to rat S24 ribosomal protein	ribosomal protein S24B		YIL069C	S000001331
RPS25A	RPS31A	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Bp and has similarity to rat S25 ribosomal protein	ribosomal protein S25A		YGR027C	S000003259
RPS25B		Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Ap and has similarity to rat S25 ribosomal protein	ribosomal protein S25B		YLR333C	S000004325
RPS26A	RPS26	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Bp and has similarity to rat S26 ribosomal protein	ribosomal protein S26A	Null mutant is viable and grows slowly	YGL189C	S000003157
RPS26B		Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein	ribosomal protein S26B		YER131W	S000000933
RPS27A		Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Bp and has similarity to rat S27 ribosomal protein	ribosomal protein S27A		YKL156W	S000001639
RPS27B		Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Ap and has similarity to rat S27 ribosomal protein	ribosomal protein S27B		YHR021C	S000001063
RPS28A	RPS33A	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps28Bp and has similarity to rat S28 ribosomal protein	ribosomal protein S28A		YOR167C	S000005693
RPS28B	RPS33B	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps28Ap and has similarity to rat S28 ribosomal protein	ribosomal protein S28B		YLR264W	S000004254
RPS29A	YS29A	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Bp and has similarity to rat S29 and E. coli S14 ribosomal proteins	ribosomal protein S29A		YLR388W	S000004380
RPS29B	YS29B	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Ap and has similarity to rat S29 and E. coli S14 ribosomal proteins	ribosomal protein S29B		YDL061C	S000002219
RPS3	SUF14	Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins	ribosomal protein S3		YNL178W	S000005122
RPS30A		Protein component of the small (40S) ribosomal subunit; nearly identical to Rps30Bp and has similarity to rat S30 ribosomal protein	ribosomal protein S30A	Null mutant is viable, exhibits a slow growth phenotype; ribosomes are normal	YLR287C-A	S000004278
RPS30B		Protein component of the small (40S) ribosomal subunit; nearly identical to Rps30Ap and has similarity to rat S30 ribosomal protein	ribosomal protein S30B	Null mutant is viable, but it shows slow growth; Deletion of both RPS30A and RPS30B genes is lethal	YOR182C	S000005708
RPS31	RPS37|UBI3	Fusion protein that is cleaved to yield a ribosomal protein of the small (40S) subunit and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B	ribosomal protein S31		YLR167W	S000004157
RPS4A		Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; identical to Rps4Bp and has similarity to rat S4 ribosomal protein	ribosomal protein S4A	Null mutant is viable; rps4a rps4b double deletion is inviable	YJR145C	S000003906
RPS4B		Protein component of the small (40S) ribosomal subunit; identical to Rps4Ap and has similarity to rat S4 ribosomal protein	ribosomal protein S4B		YHR203C	S000001246
RPS5		Protein component of the small (40S) ribosomal subunit, the least basic of the non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal proteins	ribosomal protein S5	null is inviable; transcription of RPS5 is sensitive to heat-shock and carbon source shift.	YJR123W	S000003884
RPS6A		Protein component of the small (40S) ribosomal subunit; identical to Rps6Bp and has similarity to rat S6 ribosomal protein	ribosomal protein S6A		YPL090C	S000006011
RPS6B	LPG18|RPS101|RPS102	Protein component of the small (40S) ribosomal subunit; identical to Rps6Ap and has similarity to rat S6 ribosomal protein	ribosomal protein S6B		YBR181C	S000000385
RPS7A	RPS30	Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins	ribosomal protein S7A		YOR096W	S000005622
RPS7B		Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Ap; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins	ribosomal protein S7B		YNL096C	S000005040
RPS8A		Protein component of the small (40S) ribosomal subunit; identical to Rps8Bp and has similarity to rat S8 ribosomal protein	ribosomal protein S8A		YBL072C	S000000168
RPS8B		Protein component of the small (40S) ribosomal subunit; identical to Rps8Ap and has similarity to rat S8 ribosomal protein	ribosomal protein S8B		YER102W	S000000904
RPS9A		Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Bp and has similarity to E. coli S4 and rat S9 ribosomal proteins	ribosomal protein S9A		YPL081W	S000006002
RPS9B	RPS13A|SUP46	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Ap and has similarity to E. coli S4 and rat S9 ribosomal proteins	ribosomal protein S9B		YBR189W	S000000393
RPT1	CIM5|YTA3	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and the E3 ubiquitin-protein ligase Ubr1p	ATPase		YKL145W	S000001628
RPT2	YHS4|YTA5	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle	one of the ATPase subunits of the proteasome		YDL007W	S000002165
RPT3	YNT1|YTA2	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B		Null mutant is inviable; yta2 is an extragenic suppressor of yme1 mutations	YDR394W	S000002802
RPT4	CRL13|PCS1|SUG2	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for spindle pole body duplication; localized mainly to the nucleus throughout the cell cycle	26S proteasome cap subunit component|ATPase	Null mutant is inviable; ts mutant strain arrests as large-budded cells after 1, 2, 3 divisions with a G2 content of DNA and a monopolar spindle; unduplicated spindle pole body is enlarged as in other monopolar mutants; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole	YOR259C	S000005785
RPT5	YTA1	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription			YOR117W	S000005643
RPT6	CIM3|CRL3|SCB68|SUG1	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle	ATPase		YGL048C	S000003016
RRB1		Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p			YMR131C	S000004738
RRD1	YPA1	Activator of the phosphotyrosyl phosphatase activity of PP2A; regulates G1 phase progression, the G2/M phase transition, microtubule dynamics, the osmoresponse, bud morphogenesis and DNA repair; subunit of the Tap42p-Sit4p-Rrd1p complex		Null mutant shows pleiotropic phenotypes (eg. caffeine and rapamycin resistance, vanadate and calcium sensitivity, etc.); synthetic lethal with RRD2; lethality of rrd1rrd2 suppressed by increased osmolarity and also under oxygen-limited conditions.	YIL153W	S000001415
RRD2	YPA2	Activator of the phosphotyrosyl phosphatase activity of PP2A; regulates G1 phase progression, the osmoresponse and microtubule dynamics; implicated in the spindle assembly check; subunit of the Tap42p-Pph21p-Rrd2p complex		Null mutant shows rapamycin resistance; synthetic lethal with RRD1; lethality of rrd1rrd2 suppressed by increased osmolarity and also under oxygen-limited conditions.	YPL152W	S000006073
RRF1	FIL1|KIM4	Mitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria	mitochondrial ribosome recycling factor	Null mutant is viable but grows slowly; growth is further impaired by addition of diepoxybutane or mitomycin C to medium. Null mutant also exhibits decreased abundance of mitochondrial proteins.	YHR038W	S000001080
RRI1	CSN5|JAB1	Catalytic subunit of the COP9 signalosome (CSN) complex that acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling	COP9 signalosome (CSN) subunit	Null mutant is viable; accumulates cdc53 in rub1 conjugated form	YDL216C	S000002375
RRI2	CSN10	Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response	COP9 signalosome (CSN) subunit	Null: viable. Other phenotypes: Cdc53 accumulates exclusively in the 'rubinylated' form in an rri2-null	YOL117W	S000005477
RRM14		Rdna recombination mutation				S000029423
RRM3	RTT104	DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p	DNA helicase	Null mutant is viable and causes increased Ty1 transposition, rDNA breakage, and accumulation of rDNA circles	YHR031C	S000001073
RRN10		Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I	upstream activation factor subunit	Mutant shows reduction in the transcription of rDNA	YBL025W	S000000121
RRN11		Protein required for rDNA transcription by RNA polymerase I, component of the core factor (CF) of rDNA transcription factor, which also contains Rrn6p and Rrn7p	rDNA transcription factor component		YML043C	S000004507
RRN3		Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA	DNA independent RNA polymerase I transcription factor		YKL125W	S000001608
RRN5		Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p	UAF member (upstream activation factor) along with Rrn9p and Rrn10p|transcription factor		YLR141W	S000004131
RRN6		Protein involved in the transcription of 35S rRNA genes by RNA polymerase I; component of the core factor (CF) complex also composed of Rrn11p, Rrn7p and TATA-binding protein	yeast Pol I core factor (CF) also composed of Rrn11p, Rrn7p and TATA-binding protein		YBL014C	S000000110
RRN7		Protein involved in the transcription of 35S rRNA genes by RNA polymerase I; component of the core factor (CF) complex also composed of Rrn11p, Rrn6p and TATA-binding protein	yeast Pol I core factor (CF) also composed of Rrn11p, Rrn6p and TATA-binding protein		YJL025W	S000003562
RRN9		Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I	upstream activation factor subunit		YMR270C	S000004883
RRP1		Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles		Null mutant is inviable, cannot be suppressed by srd1 mutations. rrp1-1 mutations are associated with temperature-sensitive growth, a conditional defect in processing of 27S pre-rRNA to mature 25S rRNA, and a nonconditional increase in sensitivity to several aminoglycoside antibiotics. srd1 is an allele-specific suppressor of rrp1-1.	YDR087C	S000002494
RRP12		Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; contains HEAT-repeats			YPL012W	S000005933
RRP14		Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family			YKL082C	S000001565
RRP15		Nucleolar protein, constituent of pre-60S ribosomal particles; required for processing of the 27S pre-rRNA at the A2 site to yield 5.8S and 25S rRNA			YPR143W	S000006347
RRP17		Protein required for cell viability			YDR412W	S000002820
RRP3		Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity		In strains where Rrp3 is depleted, 35S precursor RNA is improperly processed. Cleavage normally occurs at sites A0O, Al and A2, but in the Rrp3 depletion stain cleavage occurs between A2 and B1.	YHR065C	S000001107
RRP4		Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex with Rrp41p, Rrp42p, Rrp43p and Dis3p	3'-5' exoribonuclease|3'-5' exoribonuclease complex component with Rrp4p, Rrp41p, Rrp42p and Dis3p (Rrp44p)	Null is inviable; Defective in 3' processing of 5.8S rRNA	YHR069C	S000001111
RRP40		Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex	3' -> 5' exoribonuclease	The null mutant is inviable and defective in 3' processing of 5.8S rRNA	YOL142W	S000005502
RRP42		Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex with Rrp4p, Rrp41p, Rrp43p and Dis3p	exosome 3->5 exoribonuclease complex component with Rrp4p, Rrp41p, Rrp43p and Dis3p (Rrp44p)	Null mutant is inviable, rrp42 mutants are defective in 3' processing of 5.8S RNA	YDL111C	S000002269
RRP43		Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex with Rrp41p, Rrp42p, Rrp4p and Dis3p; required for efficient maturation of 5.8S, 18S and 25S rRNA	exosome 3->5 exoribonuclease complex component with Rrp4p, Rrp41p, Rrp42p and Dis3p (Rrp44p)	Null mutant is inviable in some strain backgrounds; rrp43 mutants are defective in 3' processing of 5.8S RNA	YCR035C	S000000631
RRP45		Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex	3'->5' exoribonuclease	Null mutant is inviable; mutant is defective in 3' processing of 5.8S rRNA	YDR280W	S000002688
RRP46		Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex	3'->5' exoribonuclease	Null mutant is inviable; mutant is defective in 3' processing of 5.8S rRNA	YGR095C	S000003327
RRP5		Protein required for the synthesis of both 18S and 5.8S rRNA; C-terminal region is crucial for the formation of 18S rRNA and N-terminal region is required for the 5.8S rRNA; component of small ribosomal subunit (SSU) processosome	U3 snoRNP protein	Overexpression of RRP5 facilitates mitochondrial import of hydrophobic proteins; overexpression of an RRP5 mutant complements the rRNA processing defect of the null alllele, but does not facilitate mitochondrial import; required for processing of pre-rRNA	YMR229C	S000004842
RRP6		Exonuclease component of the nuclear exosome; contributes to the quality-control system that retains and degrades aberrant mRNAs in the nucleus		Null mutant is viable, heat sensitive; other mutants show a 5.8S rRNA 3' end formation defect	YOR001W	S000005527
RRP7		Essential protein involved in rRNA processing and ribosome biogenesis			YCL031C	S000000536
RRP8		Nucleolar protein involved in rRNA processing, pre-rRNA cleavage at site A2; also involved in telomere maintenance; mutation is synthetically lethal with a gar1 mutation			YDR083W	S000002490
RRP9		Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein	U3 snoRNP protein	null mutant is inviable; genetic depletion inhibits pre-rRNA processing at sites A0, A1 and A2, and thereby inhibits synthesis of 18S rRNA	YPR137W	S000006341
RRS1		Essential protein that binds ribosomal protein L11 and is required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; mouse homolog shows altered expression in Huntington's disease model mice		Null mutant is inviable. Rsr1p depletion causes defects in pre-rRNA processing and ribosome assembly. The rrs1-1 mutant exhibits reduced transcriptional repression of both rRNA and ribosomal protein genes.	YOR294W	S000005820
RSA1		Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly		Null mutant is viable but shows weak, slow-growth at 30C and is temperature-sensitive at 37C; synthetically lethal with dbp6 mutation	YPL193W	S000006114
RSA3		Protein with a likely role in ribosomal maturation, required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus			YLR221C	S000004211
RSA4		WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus			YCR072C	S000000668
RSB1		Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane		Cells overproducing Rsb1p show a decrease in accumulation of exogenously added sphingosine and dihydrosphingosine due to their increased release.	YOR049C	S000005575
RSC1		Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook	RSC complex member	Null mutant is viable, grows slowly	YGR056W	S000003288
RSC2		Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance	RSC complex member		YLR357W	S000004349
RSC3		Component of the RSC chromatin remodeling complex; essential gene required for regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc30p		inviable; ts mutants display a G2/M arrest	YDR303C	S000002711
RSC30		Component of the RSC chromatin remodeling complex; non-essential gene required for regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc3p; null mutants are osmosensitive			YHR056C	S000001098
RSC4		Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling	RSC complex member		YKR008W	S000001716
RSC58		Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance58KDa subunit	58KDa Subunit of RSC Chromatin Remodeling Complex		YLR033W	S000004023
RSC6		Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p			YCR052W	S000000648
RSC8	SWH3	Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters			YFR037C	S000001933
RSC9		Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway			YML127W	S000004596
RSE1		Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport		An uncharacterized mutant allele grows slowly and exhibits defects in ER-to-Golgi transport and mRNA splicing.	YML049C	S000004513
RSF1		Protein required for respiratory growth; localized to both the nucleus and mitochondrion; mutant displays decreased transcription of specific nuclear and mitochondrial genes whose products are involved in respiratory growth			YMR030W	S000004632
RSF2	ZMS1	Zinc-finger protein involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions			YJR127C	S000003888
RSM10		Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins	mitochondrial ribosomal small subunit component		YDR041W	S000002448
RSM18		Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein	mitochondrial ribosomal small subunit component	null is unable to grow on glycerol	YER050C	S000000852
RSM19		Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein	mitochondrial ribosomal small subunit component		YNR037C	S000005320
RSM22		Mitochondrial ribosomal protein of the small subunit	mitochondrial ribosomal small subunit component	Null mutant is viable, unable to respire	YKL155C	S000001638
RSM23		Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p	mitochondrial ribosomal small subunit component		YGL129C	S000003097
RSM24		Mitochondrial ribosomal protein of the small subunit	mitochondrial ribosomal small subunit component		YDR175C	S000002582
RSM25		Mitochondrial ribosomal protein of the small subunit	mitochondrial ribosomal small subunit component	Null mutant is viable, but unable to respire.	YIL093C	S000001355
RSM26		Mitochondrial ribosomal protein of the small subunit	mitochondrial ribosomal small subunit component		YJR101W	S000003862
RSM27		Mitochondrial ribosomal protein of the small subunit	mitochondrial ribosomal small subunit component		YGR215W	S000003447
RSM28		Mitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiation	mitochondrial ribosomal small subunit component	Null: Viable, Pet+, mild H2O2 sensitivity. Other phenotypes: Dominant suppressor allele, due to internal deletion, selected by asking for increased expression of COX2 alleles with short deletions in the leader peptide coding region.	YDR494W	S000002902
RSM7		Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein	mitochondrial ribosomal small subunit component		YJR113C	S000003874
RSN1		Membrane protein of unknown function; overexpression suppresses NaCl sensitivity of sro7 mutant		Null: viable in both high and low salinity	YMR266W	S000004879
RSP1				reverses spt- phenotype		S000029424
RSP5	MDP1|MUT2|NPI1|SMM1|UBY1	Ubiquitin-protein ligase involved in ubiquitin-mediated protein degradation; functions in multivesicular body sorting, heat shock response and ubiquitylation of arrested RNAPII; contains a hect (homologous to E6-AP carboxyl terminus) domain		Null mutant is inviable; an rsp5 mutation was isolated as a suppressor of mutations in SPT3; certain rsp5 mutants also exhibit hypersensitivity to stresses such as cadmium and canavanine, and sporulation defects	YER125W	S000000927
RSR1	BUD1	GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases		random budding pattern	YGR152C	S000003384
RTA1		Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions		Null mutant is viable; overexpression confers resistance to 7-aminocholesterol	YGR213C	S000003445
RTF1	CSL3	Subunit of the RNA polymerase II-associated Paf1 complex; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in telomere maintenance		Null mutant is viable and can suppress TATA box-binding protein mutants (SPT15) in an allele-specific fashion	YGL244W	S000003213
RTG1		Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus	transcription factor	Null mutant is viable but cannot grow on acetate as the sole carbon source, is a glutamate and aspartate auxotroph, and shows decreased citrate synthase, acetyl-CoA synthetase, NAD isocitrate dehydrogenase, and pyruvate carboxylase activities	YOL067C	S000005428
RTG2		Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p		Null mutant is viable, fails to grow on acetate as a sole carbon source, auxotrophic for glutamate and aspartate; respiratory competent. <li>In rtg2 mutants, expansions of CTG/CAG repeats show modest increase in rate, depending on starting tract length; contractions are suppressed.	YGL252C	S000003221
RTG3		Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways	phosphoprotein		YBL103C	S000000199
RTM1		Hydrophobic 34-kD protein with seven potential transmembrane domains, present in multiple copies always associated with SUC telomeric loci, amplified in yeasts used for industrial biomass or ethanol production with molasses as substrate		Null mutant is viable. Overexpression confers resistance to molasses.		S000029677
RTN1		ER membrane protein that interacts with exocyst subunit Sec6p and with Yip3p; null mutant has an altered (mostly cisternal) ER morphology; has similarity to mammalian reticulon proteins and member of the RTNLA (reticulon-like A) subfamily			YDR233C	S000002641
RTN2		Protein of unknown function; has similarity to mammalian reticulon proteins; member of the RTNLA (reticulon-like A) subfamily			YDL204W	S000002363
RTS1	SCS1	B-type regulatory subunit of protein phosphatase 2A (PP2A); homolog of the mammalian B' subunit of PP2A	protein phosphatase 2A regulatory subunit B	Null mutant is viable but is temperature-sensitive, hypersensitive to ethanol, and unable to grow with glycerol as the sole carbon source	YOR014W	S000005540
RTS2	YOR29-28	Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication			YOR077W	S000005603
RTS3		Putative component of the protein phosphatase type 2A complex			YGR161C	S000003393
RTT101	CUL8|CULC	Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex; deletion phenotype suggests a role in anaphase progression; interacts with Mms22p and implicated in Mms22-dependent DNA repair; modified by the ubiquitin-like protein, Rub1p	CULLIN 8	Null mutant is viable and causes an increase in Ty1 transposition	YJL047C	S000003583
RTT102		Component of both the SWI/SNF and RSC chromatin remodeling complexes, suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition			YGR275W	S000003507
RTT103		Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition		Gene disruption causes Ty1 hypertransposition phenotype	YDR289C	S000002697
RTT105		Protein with a role in regulation of Ty1 transposition		Null mutant is viable; disruption causes increase in Ty1 retrotransposition.	YER104W	S000000906
RTT106		Protein with a role in regulation of Ty1 transposition		Null mutant is viable, but Ty1 retrotransposition is increased.	YNL206C	S000005150
RTT107	ESC4	Protein implicated in Mms22-dependent DNA repair during S phase, DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition		Null: increases transposition of Ty1	YHR154W	S000001197
RTT109	KIM2|REM50	Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase, acetylates H3-K56; plays a role in regulation of Ty1 transposition		Mutant exhibits abnormal mitochondrial morphology and slight growth defect in dextrose; insertion/truncation at amino acid 332 yields sensitivity to diepoxybutane and to mitomycin C; increase in Ty1 transposition	YLL002W	S000003925
RUB1		Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)		Null mutant is viable, with no obvious phenotypes, but is synethic lethal with cdc34(ubc3) ts mutant	YDR139C	S000002546
RUD3	GRP1	Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1		Null mutant shows severe growth defect or inviability in combination with many ER-to-Golgi transport mutants, such as uso1-1, sec34, sec35-1, sec22-3, and bos1-1. Overproduction suppresses mutations in many of the same genes.	YOR216C	S000005742
RUF4		Deleted noncoding RNA, does not encode a discrete transcript; identified by comparative sequence analysis but removed at the request of the authors				S000028469
RUF5-1	RUF5	RNA of Unknown Function				S000028470
RUF5-2	RUF5	RNA of Unknown Function				S000028474
RUF6		Deleted noncoding RNA, does not encode a discrete transcript; identified by comparative sequence analysis but removed at the request of the authors				S000028471
RUF7		Deleted noncoding RNA, does not encode a discrete transcript; identified by comparative sequence analysis but removed at the request of the authors	non-coding RNA			S000028472
RUF8		Deleted noncoding RNA, does not encode a discrete transcript; identified by comparative sequence analysis but removed at the request of the authors	non-coding RNA			S000028473
RUP1		Protein involved in regulation of Rsp5p, which is an essential HECT ubiquitin ligase; required for binding of Rsp5p to Ubp2p; contains an UBA domain			YOR138C	S000005664
RVB1	TIH1|TIP48|TIP49A	Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; member of the RUVB-like protein family			YDR190C	S000002598
RVB2	TIH2|TIP49|TIP49B	Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; member of the RUVB-like protein family	transcriptional regulator		YPL235W	S000006156
RVS161	END6|FUS7|SPE161	Amphiphysin-like lipid raft protein; subunit of a complex (Rvs161p-Rvs167p) that regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress		Null mutant is viable, rvs161 mutations result in a delocalization of the actin cytoskeleton, high salt sensitivity, random budding pattern in diploid cells, defects in endocytosis, and reduced viability upon starvation; rvs161 mutants exhibit synthetic lethality with sst2 mutants	YCR009C	S000000602
RVS167		Actin-associated protein, subunit of a complex (Rvs161p-Rvs167p) involved in regulation of actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; homolog of mammalian amphiphysin		Null mutant is viable but exhibits reduced viability upon starvation	YDR388W	S000002796
RXT2	RAF60	Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth			YBR095C	S000000299
RXT3		Protein of unknown function, may be involved in chromatin silencing			YDL076C	S000002234
RYE4		Regulation of YGP1 Expression				S000029425
RYE6		Regulation of YGP1 Expression				S000029426
RYE7		Regulation of YGP1 Expression				S000029427
RYE8		Regulation of YGP1 Expression				S000029428
SAC1	RSD1	Lipid phosphoinositide phosphatase of the ER and Golgi, involved in protein trafficking and secretion	phosphoinositide phosphatase	suppressor of actin mutations, suppressor of sec14 alleles, inositol auxotrophy	YKL212W	S000001695
SAC3	LEP1	Nuclear pore-associated protein, forms a complex with Thp1p that is involved in transcription and in mRNA export from the nucleus		Null mutant is viable, grows more slowly and is larger than wild-type cells; exhibits increased benomyl resistance; in contrast to sac3-1, sac3 null mutants do not suppress the temperature and osmosensitivity of act1-1 mutants	YDR159W	S000002566
SAC6	ABP67	Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton	actin filament bundling protein	suppressor of actin mutations, abnormal actin structures, defective morphogenesis	YDR129C	S000002536
SAC7		GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate	GTPase activating protein (GAP) for RHO1	null mutant is viable, has growth and actin assembly defects at low temperatures, displays allele-specific suppression and double mutant lethality with actin mutations, suprresses tor mutations	YDR389W	S000002797
SAD1		Conserved zinc-finger domain protein involved in pre-mRNA splicing, required for assembly of U4 snRNA into the U4/U6 particle		SnRNP assembly defective	YFR005C	S000001901
SAE2	COM1	Protein with a role in accurate meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents		Null mutant is viable, weakly sensitive to methyl methane sulfonate, shows blocked turnover of meiosis-specific double-strand breaks, similar to rad50S mutant	YGL175C	S000003143
SAE3	YHR079BC|YHR079C-B	Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p			YHR079C-A	S000001957
SAF1		F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1			YBR280C	S000000484
SAG1	AG(ALPHA)1	Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor	alpha-agglutinin	Null mutant is viable and shows loss of cellular agglutination in alpha cells	YJR004C	S000003764
SAH1		S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor			YER043C	S000000845
SAK1	PAK1	Upstream kinase for the SNF1 complex; partially redundant function with Elm1p and Tos3p; members of this family of kinases have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome	serine/threonine protein kinase		YER129W	S000000931
SAL1		Probable transporter, member of the Ca2+-binding subfamily of the mitochondrial carrier family, with two EF-hand motifs; Pet9p and Sal1p have an overlapping function critical for viability; polymorphic in different S. cerevisiae strains			YNL083W	S000005027
SAM1	ETH10	S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)	S-adenosylmethionine synthetase		YLR180W	S000004170
SAM2	ETH2	S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)			YDR502C	S000002910
SAM3		High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p	S-adenosylmethionine permease	Null mutant is viable but has inability to use S-adenosylmethionine as a sulfur source	YPL274W	S000006195
SAM35	FMP20|TOB38|TOM38	Essential component of the sorting and assembly machinery (SAM complex or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane	SAM complex subunit		YHR083W	S000001125
SAM37	MAS37|PET3027|TOM37	Component of the mitochondrial outer membrane sorting and assembly machinery (SAM) complex; required for the sorting of some proteins to the outer membrane after import by the TOM complex	SAM complex subunit	Null mutant is viable, temperature-sensitive for respiration driven growth, fails to import precursors into isolated mitochondria, exhibits double mutant inviability with strains deleted for TOM70 or TOM20.	YMR060C	S000004664
SAM4		S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio	AdoMet-homocysteine methyltransferase|S-adenosylmethionine-homocysteine methyltransferase	Slow growth on S-adenosylmethionine used as a sulfur source	YPL273W	S000006194
SAM50	OMP85|TOB55	Essential component of the Sorting and Assembly Machinery (SAM or Tob complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85	SAM complex subunit		YNL026W	S000004971
SAN1		Ubiquitin-protein ligase, involved in the proteasome-dependent degradation of aberrant nuclear proteins; san1 mutations suppress sir4, spt16, and cdc68 mutations, suggesting a role in chromatin silencing		Null mutant is viable, and null mutations are allele-nonspecific suppressors of mutations in SIR4. san1 null mutations also suppress mutations in cdc68.	YDR143C	S000002550
SAP1		Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system	AAA ATPase		YER047C	S000000849
SAP155		Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p		deletion shows slight slow growth	YFR040W	S000001936
SAP185		Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p		Null mutant is viable; sap185 sap190 double mutants grow slowly; sap155 sap185 sap190 triple mutants are inviable in ssd1-d backgrounds	YJL098W	S000003634
SAP190		Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p	type 2A-related serine/threonine phosphatase		YKR028W	S000001736
SAP30		Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance			YMR263W	S000004876
SAP4		Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p			YGL229C	S000003198
SAR1		GTPase, GTP-binding protein of the ARF family, component of COPII coat of vesicles; required for transport vesicle formation during ER to Golgi protein transport	ARF family|GTP-binding protein	Null mutant is inviable. When overexpressed, wild-type SAR1 suppresses a sec12 mutation.	YPL218W	S000006139
SAS10	UTP3	Component of the small (ribosomal) subunit (SSU) processosome required for pre-18S rRNa processing; essential nucleolar protein that, when overproduced, disrupts silencing	U3 snoRNP protein	Null mutant is inviable; derepresses HMR, HML and telomeres when overexpressed	YDL153C	S000002312
SAS2		Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family		Null mutant is viable, suppresses temperature sensitive defects of orc2-1 and orc5-1; has opposite effects on HML and HMR	YMR127C	S000004734
SAS3		Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; sas3 gcn5 double mutation confers lethality			YBL052C	S000000148
SAS4		Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which  acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p			YDR181C	S000002589
SAS5		Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which  acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity			YOR213C	S000005739
SAT4	HAL4	Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p			YCR008W	S000000601
SAY1		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum			YGR263C	S000003495
SBA1		Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins and like p23 can regulate telomerase activity	co-chaperone	Null mutant is viable, exhibits slow growth at 18 degrees and 37 degrees; synthetic growth defects in SBA1-1/sti1-1 double mutant	YKL117W	S000001600
SBE2		Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth			YDR351W	S000002759
SBE22		Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth		synthetic lethal with sbe2 mutation	YHR103W	S000001145
SBH1	SEB1|YER087C-A	Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex; homologous to Sbh2p		Null mutant is viable. sbh1 sbh2 double deletion mutants exhibit synthetic temperature sensitivity and accumulation of secretory protein precursors	YER087C-B	S000002128
SBH2	SEB2	Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p		Null mutant is viable. sbh1 sbh2 double deletion mutants exhibit synthetic temperature sensitivity and accumulation of secretory protein precursors	YER019C-A	S000002127
SBP1	SSB1|SSBR1	Nucleolar single-strand nucleic acid binding protein; associates with small nuclear RNAs			YHL034C	S000001026
SCC2		Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX			YDR180W	S000002588
SCC4		Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX			YER147C	S000000949
SCD1				some alleles (scd1-i alleles) cause lethality in combination with chc1 null mutants		S000029432
SCD5	FTB1	Protein required for normal cortical actin organization and endocytosis; multicopy suppressor of clathrin deficiency; acts as a targeting subunit for protein phosphatase type 1			YOR329C	S000005856
SCD6	LSM13	Protein containing an Lsm domain, may bind RNA and have a role in RNA processing; overproduction suppresses a null mutation in CHC1, which encodes the heavy chain of clathrin		viable with no obvious growth defect	YPR129W	S000006333
SCD7						S000029433
SCEI	OMEGA	I-SceI DNA endonuclease, encoded by the mitochondrial group I intron of the 21S_rRNA gene; mediates gene conversion that propagates the intron into intron-less copies of the 21S_rRNA gene	I-SceIV		Q0160	S000007279
SCH1		Locus that can mutate to suppress the lethality of the chs2 null mutation				S000029678
SCH9	KOM1	Protein kinase that regulates signal transduction activity and G1 progression, controls cAPK activity, required for nitrogen activation of the FGM pathway, involved in life span regulation, homologous to mammalian Akt/PKB	serine/threonine protein kinase	null mutant is viable, grows slowly, and has a prolonged G1 phase	YHR205W	S000001248
SCJ1		One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins		Null mutant is viable but exhibits defects in protein sorting and sensitivity to tunicamycin.	YMR214W	S000004827
SCL1	PRC2	Alpha subunit of the 20S core complex of the 26S proteasome involved in the degradation of ubiquitinated substrates; essential for growth; detected in the mitochondria	proteasome subunit YC7alpha/Y8 (protease yscE subunit 7)	Null mutant is inviable, SCL1 is a dominant suppressor of the ts lethality of crl3	YGL011C	S000002979
SCM3		Protein of unknown function; isolated as a high-copy suppressor of mutations in the histone fold domain (HFD) of CSE4			YDL139C	S000002298
SCM4		Potential regulatory effector of CDC4 function, suppresses a temperature-sensitive allele of CDC4, tripartite protein structure in which a charged region separates two uncharged domains, not essential for mitosis or meiosis		viable, suppressor of cdc4ts allele	YGR049W	S000003281
SCN1				Dominant SCN1-1 allele partially suppresses temperature-sensitivity of cns1-1 mutation.		S000029702
SCO1	PET161	Copper-binding protein of the mitochondrial inner membrane, required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; has similarity to thioredoxins		required for accumulation of mitochondrial cytochrome c oxidase subunits I and II	YBR037C	S000000241
SCO2		Protein anchored to the mitochondrial inner membrane, similar to Sco1p and may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p			YBR024W	S000000228
SCP1		Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin		Null mutant is viable and shows no apparent phenotype	YOR367W	S000005894
SCP160		Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins			YJL080C	S000003616
SCR1		small cytoplasmic RNA 1	small cytoplasmic RNA	Null mutant is viable but shows slow growth, aberrant cell division, high rate of segregation of petites, and impaired protein translocation across the ER membrane		S000006491
SCS2		Integral ER membrane protein that regulates phospholipid metabolism via an interaction with the FFAT motif of Opi1p, also involved in telomeric silencing, disruption causes inositol auxotrophy above 34 degrees C, VAP homolog			YER120W	S000000922
SCS22		Protein involved in regulation of phospholipid metabolism; homolog of Scs2p; similar to D. melanogaster inturned protein		Null: viable, deletion causes slight inositol auxotrophy at 37C and enhances the inositol auxotrophy of deletion of scs2	YBL091C-A	S000007228
SCS3		Protein required for inositol prototrophy, appears to be involved in the synthesis of inositol phospholipids from inositol but not in the control of inositol synthesis		null is viable but is auxotrophic for myo-inositol	YGL126W	S000003094
SCS7	FAH1	Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth	desaturase|hydroxylase|sphingolipid alpha-hydroxylase	Null mutant is viable, suppresses the Ca2+-sensitive phenotype of csg2 delta mutants	YMR272C	S000004885
SCT1	GAT2	Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed	dihydroxyacetone phosphate sn-1 acyltransferase|glycerol 3-phosphate sn-1 acyltransferase		YBL011W	S000000107
SCW1						S000029434
SCW10		Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p			YMR305C	S000004921
SCW11		Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p	exo-1,3-beta-glucanase	Null mutant is viable but exhibits defects in separation after division and displays flocculant growth.	YGL028C	S000002996
SCW2						S000029435
SCW4		Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating			YGR279C	S000003511
SCW5						S000029436
SCW6						S000029437
SCW7						S000029438
SCW8						S000029439
SCW9						S000029440
SCY1		Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase			YGL083W	S000003051
SDA1		Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis			YGR245C	S000003477
SDB21				suppressor of dbf		S000029441
SDC1	CPS25|SAF19	Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; has similarity to C. elegans Dpy-30	COMPASS (complex proteins associated with Set1p) component	Null: defective in silencing of expression of genes located near telomeres; hydroxyurea sensitive.	YDR469W	S000002877
SDC25		Non-essential Ras guanine nucleotide exchange factor (GEF) localized to the membrane; expressed in poor nutrients and on non-fermentable carbon sources; homologous to CDC25; contains a stop codon in S288C; full-length gene includes YLL017W				S000003939
SDH1		Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone	succinate dehydrogenase flavoprotein subunit		YKL148C	S000001631
SDH2	ACN17	Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone	succinate dehydrogenase (ubiquinone) iron-sulfur protein subunit		YLL041C	S000003964
SDH3	CYB3|YKL4	Cytochrome b subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone	succinate dehydrogenase cytochrome b	Null mutant is viable, has impaired mitochondrial function, fails to grow on non-fermentable carbon sources	YKL141W	S000001624
SDH4	ACN18	Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone	succinate dehydrogenase membrane anchor subunit	Null mutant is viable, retains ability to grow on rich glycerol media	YDR178W	S000002585
SDL1		Open reading frame, unlikely to produce a functional protein in S288C; in closely related species and other <i>S. cerevisiae</i> strain backgrounds YIL167W and adjacent ORF, YIL168W, constitute a single ORF encoding L-serine dehydratase	L-serine dehydratase			S000001429
SDO1		Essential protein involved in 60S ribosome maturation; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archae and eukaryotes			YLR022C	S000004012
SDP1		Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock			YIL113W	S000001375
SDS22	EGP1	Conserved nuclear regulatory subunit of Glc7p type 1 protein serine-threonine phosphatase (PP1), functions positively with Glc7p to promote dephosphorylation of nuclear substrates required for chromosome transmission during mitosis	Glc7p regulatory subunit		YKL193C	S000001676
SDS23		One of two S. cerevisiae homologs (Sds23p and Sds24p) of the Schizosaccharomyces pombe Sds23 protein, which genetic studies have implicated in APC/cyclosome regulation			YGL056C	S000003024
SDS24		One of two S. cerevisiae homologs (Sds23p and Sds24p) of the Schizosaccharomyces pombe Sds23 protein, which genetic studies have implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis			YBR214W	S000000418
SDS3		Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes		extragenic suppressor of a silencing defective rap 1s hmr delta A strain, sporulation defects	YIL084C	S000001346
SDT1	SSM1	Pyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives		null mutant is viable, but is sensitive to 6-azauracil	YGL224C	S000003192
SEC1		Sm-like protein involved in docking and fusion of exocytic vesicles through binding to assembled SNARE complexes at the membrane; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function		accumulates secretory vesicles	YDR164C	S000002571
SEC10		Essential 100kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis	exocyst complex component	accumulates secretory vesicles	YLR166C	S000004156
SEC11		18kDa catalytic subunit of the Signal Peptidase Complex (SPC; Spc1p, Spc2p, Spc3p, and Sec11p) which cleaves the signal sequence of proteins targeted to the endoplasmic reticulum			YIR022W	S000001461
SEC12	SED2	Guanine nucleotide exchange factor (GEF); glycosylated integral membrane protein of the endoplasmic reticulum, important for the initiation of transport vesicle budding from the endoplasmic reticulum through activation of the GTPase Sar1p	guanine nucleotide exchange factor for Sar1p	Null mutant is inviable. Defective in endoplasmic reticulum to Golgi transport.	YNR026C	S000005309
SEC13	ANU3	Component of both the Nup84 nuclear pore sub-complex and of the COPII complex (Sar1p, Sec13p, Sec16p, Sec23p, Sec24p, Sec31p, Sfb2p, and Sfb3p) which is important for the formation of ER to Golgi transport vesicles	nuclear pore complex subunit	Null mutant is inviable; ts mutants exhibit defects in secretion.	YLR208W	S000004198
SEC14	PIT1	Phosphatidylinositol/phosphatidylcholine transfer protein involved in coordinate regulation of PtdIns and PtdCho metabolism, products of which are regulators in Golgi to plasma membrane transport; functionally homologous to mammalian PITPs	phosphatidylcholine transporter	Null mutant is inviable; other mutations are temperature sensitive	YMR079W	S000004684
SEC15		Essential 113kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which mediates polarized targeting of vesicles to active sites of exocytosis; Sec15p associates with Sec4p and vesicles	exocyst complex component	accumulates secretory vesicles|The sec15-1 allele exhibits temperature-sensitive growth and defects in the secretory pathway.	YGL233W	S000003202
SEC16	LPF1	COPII vesicle coat protein required for ER transport vesicle budding and autophagosome formation; Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p	vesicle coat component	Null mutant is inviable; temperature-sensitive mutants accumulate Kar2 (BiP) and PDI at the nonpermissive temperature.	YPL085W	S000006006
SEC17		Peripheral membrane protein required for vesicular transport between ER and Golgi and for the 'priming' step in homotypic vacuole fusion, part of the cis-SNARE complex; has similarity to alpha-SNAP		secretion deficient	YBL050W	S000000146
SEC18	ANU4	ATPase required for the release of Sec17p during the 'priming' step in homotypic vacuole fusion and for ER to Golgi transport; homolog of the mammalian NSF	ATPase		YBR080C	S000000284
SEC2		Guanyl-nucleotide exchange factor for the small G-protein Sec4p, located on cytoplasmic vesicles; essential for post-Golgi vesicle transport	GDP/GTP exchange factor	accumulates secretory vesicles	YNL272C	S000005216
SEC20		Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; forms a complex with the cytosolic Tip20p	v-SNARE	secretion deficient	YDR498C	S000002906
SEC21		Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in  ER to Golgi transport of selective cargo	non-clathrin coat protein		YNL287W	S000005231
SEC22	SLY2|TSL26	R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog		null mutant is cold and heat sensitive. Defective in ER to Golgi transport.	YLR268W	S000004258
SEC23		GTPase-activating protein; component of the Sec23p-Sec24p heterodimeric complex of the COPII vesicle coat, involved in ER to Golgi transport and autophagy; stimulates the GDP-bound form of Sar1p	GTPase activating protein (GAP)	Defective for ER to Golgi transport	YPR181C	S000006385
SEC24	ANU1	Component of the Sec23p-Sec24p heterodimeric complex of the COPII vesicle coat; involved in ER to Golgi transport, cargo selection and autophagy; required for the binding of the Sec13 complex to ER membranes; homologous to Lst1p and Lss1p	vesicle coat component		YIL109C	S000001371
SEC26		Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)	yeast coatomer subunit		YDR238C	S000002646
SEC27		Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP	yeast coatomer beta'-subunit		YGL137W	S000003105
SEC28	ANU2	Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth	epsilon-COP coatomer subunit		YIL076W	S000001338
SEC3	PSL1	Non-essential subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, Exo84p) which mediates targeting of post-Golgi vesicles to sites of active exocytosis; Sec3p specifically is a spatial landmark for secretion	exocyst complex component	accumulates secretory vesicles	YER008C	S000000810
SEC31	WEB1	Essential phosphoprotein component (p150) of the COPII coat of secretory pathway vesicles, in complex with Sec13p; required for ER-derived transport vesicle formation	COPII coat of secretory pathway vesicles component (p150)		YDL195W	S000002354
SEC39		Protein of unknown function proposed to be involved in protein secretion			YLR440C	S000004432
SEC4	SRO6	Secretory vesicle-associated Rab GTPase essential for exocytosis; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane	small GTP binding protein	null is inviable; conditional mutants show defects in secretion and accumulation of post-Golgi vesicles under non-permissive conditions|accumulates secretory vesicles	YFL005W	S000001889
SEC5		Essential 107kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis	exocyst complex component	secretion deficient; Null is inviable|accumulates secretory vesicles	YDR166C	S000002573
SEC53	ALG4	Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen	phosphomannomutase		YFL045C	S000001849
SEC55				secretion deficient		S000029442
SEC59		Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation		secretion deficient. mutant may exhibit some extension and fragmentation of the ER membrane.	YMR013C	S000004615
SEC6		Essential 88kDa subunit of the exocyst complex, which mediates polarized targeting of secretory vesicles to active sites of exocytosis; dimeric form of Sec6p interacts with Sec9p in vitro and inhibits t-SNARE assembly	exocyst complex component	lethal|accumulates secretory vesicles	YIL068C	S000001330
SEC61		Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER			YLR378C	S000004370
SEC62	LPG14	Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER	ER protein translocation apparatus membrane component	secretion deficient	YPL094C	S000006015
SEC63	PTL1	Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER		lethal	YOR254C	S000005780
SEC65		Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19			YML105C	S000004573
SEC66	HSS1|SEC71	Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER	glycoprotein complexed with Sec62p and Sec63p in the Sec63 complex, an integral endoplasmic reticulum membrane protein complex required for translocation of presecretory proteins		YBR171W	S000000375
SEC7		Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles	guanine nucleotide exchange protein for ARF		YDR170C	S000002577
SEC72	SEC67|SIM2	Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER			YLR292C	S000004283
SEC8		Essential 121kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis	exocyst complex component	secretion deficient|accumulates secretory vesicles	YPR055W	S000006259
SEC9	HSS7	t-SNARE protein important for fusion of secretory vesicles with the plasma membrane; similar to but not functionally redundant with Spo20p; SNAP-25 homolog		accumulates secretory vesicles|An uncharacterized allele accumulates 100nm secretory vesicles and berkeley bodies and is defective in proteint transport to the cell surface. The sec9-4 allele has diploid-specific bud site selection defects.	YGR009C	S000003241
SED1		Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites		Null mutant is viable; during stationary phase, null mutants exhibit increased sensitivity to Zymolyase.	YDR077W	S000002484
SED4		Integral endoplasmic reticulum membrane protein, functions as a positive regulator of Sar1p probably through inhibition of GTPase activation by Sec23p; binds Sec16p, participates in vesicle formation, similar to Sec12p		Null mutant is viable, shows decreased rate of ER to Golgi transport	YCR067C	S000000663
SED5		cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins		Null mutant is inviable; cells depleted of Sed5p are unable to transport carboxypeptidase Y to the Golgi complex, and stop growing after a dramatic accumulation of ER	YLR026C	S000004016
SEF1		Putative transcription factor, has homolog in Kluyveromyces lactis		defective sporulation; high copy number suppressor of rpm2	YBL066C	S000000162
SEH1		Nuclear pore protein that is part of the evolutionarily conserved Nup84p complex (Nup84p, Nup85p, Nup120p, Nup145p, and Seh1p); homologous to Sec13p	nuclear pore complex subunit		YGL100W	S000003068
SEL1	UBX2	Protein involved in ER-associated protein degradation; proposed to coordinate the assembly of proteins involved in ERAD; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain		Null: enhanced secretion	YML013W	S000004475
SEM1	DSS1|HOD1	Component of the lid subcomplex of the regulatory subunit of the 26S proteasome; ortholog of human DSS1		Null mutant is viable but is temperature-sensitive in a sigma1278b background (but not in a S288C background). The null mutation suppresses the temperature sensitivity of sec3-2, sec8-9, sec10-2 and sec15-1.	YDR363W-A	S000007235
SEN1	CIK3|NRD2	Putative helicase required for RNA polymerase II transcription termination and processing of RNAs; homolog of Senataxin which causes Ataxia-Oculomotor Apraxia 2 and a dominant form of amyotrophic lateral sclerosis			YLR430W	S000004422
SEN15		Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p	tRNA splicing endonuclease subunit		YMR059W	S000004663
SEN2		Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease	tRNA splicing endonuclease subunit		YLR105C	S000004095
SEN34	FUN4	Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease	tRNA splicing endonuclease subunit	Null mutant is inviable and shows H242A impaired 3'splice site cleavage	YAR008W	S000000066
SEN54		Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p	tRNA splicing endonuclease subunit		YPL083C	S000006004
SEO1		Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide			YAL067C	S000000062
SER1	ADE9	3-phosphoserine aminotransferase, catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p	phosphoserine transaminase	Null mutant is viable, serine-requiring	YOR184W	S000005710
SER2		Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source	phosphoserine phosphatase	serine-requiring	YGR208W	S000003440
SER3		3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser33p	3-phosphoglycerate dehydrogenase	Null: enzyme activity of 3P-glycerate dehydrogenase is decreased in null mutant compared to wildtype and abolished in ser3 ser33 double deletion mutant	YER081W	S000000883
SER33		3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser3p	3-phosphoglycerate dehydrogenase	Null: enzyme activity of 3P-glycerate dehydrogenase is decreased in null mutant compared to wildtype and abolished in ser3 ser33 double deletion mutant, Ser33p is the major isoenyme	YIL074C	S000001336
SES1		Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p	SerRS|seryl-tRNA synthetase		YDR023W	S000002430
SET1	YTX1	Histone methyltransferase, subunit of the COMPASS (Set1C) complex which methylates histone H3 on lysine 4; required in transcriptional silencing near telomeres and at the silent mating type loci; contains a SET domain		Null mutant is viable, exhibits derepression of silenced genes at telomeres and the HML silent mating-type locus	YHR119W	S000001161
SET2	EZL1	Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of histone H3; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p		null is viable; a point mutant suppresses deletion of the UAS in the GAL4 promoter	YJL168C	S000003704
SET3		Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains			YKR029C	S000001737
SET4		Protein of unknown function, contains a SET domain			YJL105W	S000003641
SET5		Zinc-finger protein of unknown function, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus			YHR207C	S000001250
SET6		Protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability			YPL165C	S000006086
SET7	RMS1	Nuclear protein that contains a SET-domain, which have been shown to mediate methyltransferase activity in other proteins		null mutant is viable with no apparent defects	YDR257C	S000002665
SEY1		Protein of unknown function, contains two predicted GTP-binding motifs GXXXXGKS and DXXG near the N-terminus, homolog of the Arabidopsis gene RHD3 (Root Hair Defective)			YOR165W	S000005691
SFA1	ADH5	Bifunctional enzyme containing both alcohol dehydrogenase and glutathione-dependent formaldehyde dehydrogenase activities, functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p	glutathione-dependent formaldehyde dehydrogenase		YDL168W	S000002327
SFB2		Probable component of COPII coated vesicles that binds to Sec23p; similar to and functionally redundant with Sec24p, but expressed at low levels; involved in ER to Golgi transport and in autophagy			YNL049C	S000004994
SFB3	LST1	Member of the Sec24p family; forms a complex, with Sec23p, that is involved in sorting of Pma1p into COPII vesicles; peripheral ER membrane protein; potential Cdc28p substrate			YHR098C	S000001140
SFC1	ACR1	Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization	succinate-fumarate transporter		YJR095W	S000003856
SFG1		Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate			YOR315W	S000005842
SFH1		Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog	chromatin remodeling complex member, RSC	sfh1 mutants exhibit altered centromeric and centromere-proximal chromatin structure and increased missegregation of authentic chromosomes; null mutant is inviable; sfh1 temp-sensitive mutants arrest in G1.	YLR321C	S000004313
SFH5		Putative phosphatidylinositol transfer protein (PITP), exhibits phosphatidylinositol- but not phosphatidylcholine-transfer activity, mainly localized to cytosol and microsomes, similar to Sec14p; may be PITP regulator rather than actual PITP	phosphatidylinositol transfer protein		YJL145W	S000003681
SFI1		Centrin (Cdc31p)-binding protein required for spindle pole body (SPB) duplication, localizes to the half-bridge of the SPB, required for progression through G(2)-M transition, has similarity to Xenopus laevis XCAP-C			YLL003W	S000003926
SFK1		Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane			YKL051W	S000001534
SFL1		Transcription repressor involved in regulation of flocculation-related genes, inhibits transcription by recruiting general corepressor Cyc8p-Tup1p to different promoters; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p	transcription factor		YOR140W	S000005666
SFP1		Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation		Null mutant is viable, grows slowly, cells have multiple nucleated buds	YLR403W	S000004395
SFS1		serendipitously found suppressor				S000029443
SFT1		Intra-Golgi v-SNARE, required for transport of proteins between an early and a later Golgi compartment	v-SNARE		YKL006C-A	S000002101
SFT2		Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5		Null mutant is viable; got1 sft2 double mutant exhibits defects in transport to the Golgi complex.	YBL102W	S000000198
SGA1		Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation	glucoamylase	suppression of growth arrest of cdc25	YIL099W	S000001361
SGD1		Essential nuclear protein with a possible role in the osmoregulatory glycerol response; interacts with phospholipase C (Plc1p); putative homolog of human NOM1 which is implicated in acute myeloid leukemia		Null mutant is inviable; multi-copy suppressor of hog1 and pbs2 osmosensitive phenotypes	YLR336C	S000004328
SGE1	NOR1	Membrane-associated multidrug transporter, acts as an extrusion permease, member of the drug-resistance protein family within the major facilitator superfamily (MFS), partial multicopy suppressor of gal11 mutations		Null mutant is viable; shows decreased expression of galactose-inducible genes; shows increased sensitivity to crystal violet	YPR198W	S000006402
SGF11		Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation			YPL047W	S000005968
SGF29		SaGa associated Factor 29kDa; Probable 29kKDa Subunit of SAGA histone acetyltransferase complex			YCL010C	S000000516
SGF73	SCA7	73 kDa subunit of SAGA histone acetyltransferase complex; involved in formation of the preinitiation complex assembly at promoters			YGL066W	S000003034
SGM1		Protein of unknown function, required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus		sgm1 mutants show slow growth on maltose and galactose	YJR134C	S000003895
SGN1	RBP1|RBP29	Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation			YIR001C	S000001440
SGO1	YOR29-24	Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability			YOR073W	S000005599
SGS1		Nucleolar DNA helicase of the RecQ family involved in maintenance of genome integrity, regulates chromosome synapsis and meiotic crossing over; has similarity to human BLM and WRN helicases implicated in Bloom and Werner syndromes		Null mutant is viable; strains lacking SGS1 exhibit elevated levels of chromosome misseggregation during both mitotic and meiotic division. sgs1 null strains suppress the slow growth of a top3 delta strain lacking topoisomerase III and show an increase in subtelomeric Y' instability due to hyperrecombination.	YMR190C	S000004802
SGT1	YOR29-08	Probable cochaperone, regulates activity of Cyr1p (adenylyl cyclase); involved in assembly of the kinetochore complex, associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex			YOR057W	S000005583
SGT2		Glutamine-rich cytoplasmic protein of unknown function; contains tetratricopeptide (TPR) repeats, which often mediate protein-protein interactions; has similarity to human SGT, which is a cochaperone that negatively regulates Hsp70			YOR007C	S000005533
SGV1	BUR1	Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation; phosphorylates the carboxy-terminal domain of Rpo21p, which is the largest subunit of RNA polymerase II; regulated by Cak1p	serine/threonine protein kinase		YPR161C	S000006365
SHC1		Sporulation-specific activator of Chs3p (chitin synthase III), required for the synthesis of the chitosan layer of ascospores; has similarity to Skt5p, which activates Chs3p during vegetative growth; transcriptionally induced at alkaline pH			YER096W	S000000898
SHE1		Cytoskeletal protein of unknown function; overexpression causes growth arrest			YBL031W	S000000127
SHE10		Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function; overexpression causes growth arrest			YGL228W	S000003197
SHE2		RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud			YKL130C	S000001613
SHE3		Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance			YBR130C	S000000334
SHE4	DIM1	Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization			YOR035C	S000005561
SHE6		Mrna (identified by a library screen) that causes growth arrest when overexpressed				S000029444
SHE7		Mrna (identified by a library screen) that causes growth arrest when overexpressed				S000029445
SHE9	MDM33	Mitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane; forms a homo-oligomeric complex			YDR393W	S000002801
SHG1	CPS15	Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres	COMPASS (complex proteins associated with Set1p) component		YBR258C	S000000462
SHM1	SHMT1|TMP3	Mitochondrial serine hydroxymethyltransferase, involved in one-carbon metabolism			YBR263W	S000000467
SHM2	SHMT2	Cytosolic serine hydroxymethyltransferase, involved in one-carbon metabolism			YLR058C	S000004048
SHO1	SSU81	Transmembrane osmosensor, participates in activation of both the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway	transmembrane osmosensor	Null mutant is viable; mutants are high-osmolarity sensitive when combined with both ssk2 and ssk22	YER118C	S000000920
SHP1	UBX1	UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate		Null mutant is viable; sporulation defective, slow growth; is deficient in glycogen accumulation; low Glc7p specific activity	YBL058W	S000000154
SHQ1		Essential nuclear protein, required for accumulation of box H/ACA snoRNAs and for rRNA processing; interacts with Naf1p			YIL104C	S000001366
SHR3	APF1	Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface		Null mutants are viable, specifically accumulate amino acid permeases in the endoplasmic reticulum	YDL212W	S000002371
SHR5	ERF4	Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization		Null mutant is viable; exhibits normal palmityltransferase activity in vitro and attenuates Ras function in cells with mutant Ras2 proteins that are not farnesylated or palmitoylated; shr5 mutation originally isolated as suppressor of Ras function	YOL110W	S000005470
SHS1	SEP7	One of five related septins (Cdc3p, Cdc10p, Cdc11p, Cdc12p, Shs1p) that form a cortical filamentous collar at the mother-bud neck which is necessary for normal morphogenesis and cytokinesis	septin	deficient for cytokinesis	YDL225W	S000002384
SHU1		Protein of unassigned function involved in mutation suppression, important for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation; associates with Shu2p, Psy3p, and Csm2p		Null: Null mutant is viable and MMS sensitive, suppresses HU sensitivity of certain other mutations	YHL006C	S000000998
SHU2		Protein of unassigned function involved in mutation suppression, important for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation; associates with Shu1p, Psy3p, and Csm2p		Null: MMS sensitive	YDR078C	S000002485
SHY1		Mitochondrial inner membrane protein required for normal respiration, possible chaperone involved in assembly of cytochrome c oxidase; similar to SURF1 from mammals, chickens, and D. melanogaster		Deletion of part of SHY1 produces a phenotype similar to that of G91 mutants. Disruption of SHY1 at a BamHI site, located approximately 2/3 of the way into the gene, has no obvious phenotypic consequence.	YGR112W	S000003344
SIA1		Protein of unassigned function involved in activation of the Pma1p plasma membrane H+-ATPase by glucose			YOR137C	S000005663
SIC1	SDB25	Inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1		Null mutant is viable, shows increased frequency of broken and lost chromosomes; sic1 deletion mutant rescues lethality of cln1 cln2 cln3 triple mutant.	YLR079W	S000004069
SIF2	EMB1	WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus		Null mutant is viable, exhibits increased telomeric silencing	YBR103W	S000000307
SIK1	NOP56	Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects	U3 snoRNP protein	wild-type gene suppresses toxicity of GAL4-I-Kappa-B alpha in yeast|Other phenotypes: Shortens the G1 phase of the cell cycle when present in high-copy	YLR197W	S000004187
SIL1	SLS1	Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein	Nucleotide exchange factor		YOL031C	S000005391
SIM1		Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated		Null mutant is viable; mutant allows an extra round of DNA replication without mitosis	YIL123W	S000001385
SIN3	CPE1|GAM2|RPD1|SDI1|SDS16|UME4	Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity		inviable, reduced potassium dependency	YOL004W	S000005364
SIN4	BEL2|GAL22|MED16|RYE1|SDI3|SSF5|SSN4|TSF3	Subunit of the Mediator complex; interacts with the RNA polymerase II holoenzyme to postively or negatively regulate transcription; dispensible for basal transcription	mediator complex subunit	Null mutant is viable, temperature sensitive, displays defects in both positive and negative regulation of transcription, suppresses Ty insertion mutations (Spt-), exhibits decreased superhelical density of circular DNA molecules, exhibits expression from promoters lacking UAS elements; associated with a defect in RME1-dependent repression and a methionine or cysteine requirement, exhibits flocculant/lacy colony morphology, suppressor of snf/swi mutations	YNL236W	S000005180
SIN5		may be a negative regulator of ACE2		Suppression of swi5		S000029446
SIP1		Alternate beta-subunit of the Snf1p kinase complex, may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions	protein kinase complex component	Null mutant is viable, exhibits a slight increase in GAL gene expression	YDR422C	S000002830
SIP18		Protein of unknown function whose expression is induced by osmotic stress			YMR175W	S000004787
SIP2	SPM2	One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane			YGL208W	S000003176
SIP3		Protein that activates transcription through interaction with DNA-bound Snf1p, C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate		Null mutant is viable; does not confer snf1 phenotypes	YNL257C	S000005201
SIP4		C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus			YJL089W	S000003625
SIP5		Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase		interaction between Reg1 and Snf1 is reduced threefold in a sip5Delta mutant.	YMR140W	S000004748
SIR1		Protein involved in repression of transcription at the silent mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin	silent mating loci repressor		YKR101W	S000001809
SIR2	MAR1	Conserved NAD+ dependent histone deacetylase of the Sirtuin family involved in regulation of lifespan;  plays roles in silencing at HML, HMR, telomeres, and the rDNA locus; negatively regulates initiation of DNA replication	nuclear NAD-dependent deacetylase	Null mutant is viable; sir2 mutations suppress mitotic and meiotic intra- and interchromosomal rDNA recombination (10-15 fold). RAD52 and RAD50 are dispensable for basal level rDNA exchange in SIR2 but are required for increased exchange in sir2	YDL042C	S000002200
SIR3	CMT1|MAR2|STE8	Silencing protein that interacts with Sir2p and Sir4p, and histone H3 and H4 tails, to establish a transcriptionally silent chromatin state; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1p	silencing regulator at HML, HMR, and telomeres	sterile	YLR442C	S000004434
SIR4	ASD1|STE9|UTH2	Silent information regulator that, together with SIR2 and SIR3, is involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; potentially phosphorylated by Cdc28p; some alleles of SIR4 prolong lifespan	silencing regulator at HML, HMR, and telomeres		YDR227W	S000002635
SIS1		Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; not functionally redundant with Ydj1p due to due to substrate specificity; shares similarity with bacterial DnaJ proteins		Null mutant is inviable; strains limited for SIS1 accumulate cells that appear blocked for migration from the nucleus from the mother cell into the daughter cell, may of the cells become very large and contain a large vacuole	YNL007C	S000004952
SIS2	HAL3	Negative regulatory subunit of the protein phosphatase 1 Ppz1p; involved in ion homeostasis and cell cycle progression			YKR072C	S000001780
SIT1	ARN3	Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p	ferrioxamine B transporter	Viable. Cells deleted from the gene are unable to take up ferrioxamine B	YEL065W	S000000791
SIT3				suppression of initiation of transcription		S000029447
SIT4	LGN4	Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization		sit1-sit4 or sit2-sit4 double mutants are lethal	YDL047W	S000002205
SIW14	OCA3	Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm		Null mutant fails to show cell cycle arrest upon nutrient starvation, is sensitive to 5mM caffeine and 1M NaCL, and shows delocalized actin upon nutrient starvation; synthetically lethal with whi2, on minimal medium only	YNL032W	S000004977
SIZ1	ULL1	SUMO ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring	chromatin protein; SUMO1/Smt3 ligase	Null mutant is viable. SIZ1 is a dosage bypass suppressor of an SMT4 deletion. A siz1 siz2 deletion has a synthetic phenotype (slow growth). Null mutant exhibits defective Smt3-modification of septins.	YDR409W	S000002817
SKG1	YKR099C-A	Transmembrane protein with a role in cell wall polymer composition; localizes on the inner surface of the plasma membrane at the bud and in the daughter cell			YKR100C	S000001808
SKG3		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Caf120p and Skg4p			YLR187W	S000004177
SKG6		Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p			YHR149C	S000001192
SKI2		Putative RNA helicase, involved in exosome mediated 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs; forms complex with Ski3p and Ski8p; required for repressing propagation of dsRNA viruses		Null mutant is viable; SKI2 is essential in cells carrying M dsRNA	YLR398C	S000004390
SKI3	SKI5	Protein involved in exosome mediated 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs; forms complex with Ski2p and Ski8p; required for repressing propagation of dsRNA viruses			YPR189W	S000006393
SKI6	ECM20|RRP41	3'-to-5' phosphorolytic exoribonuclease that is a subunit of the exosome; required for 3' processing of the 5.8S rRNA; involved in 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs		Null mutant is inviable; mutants show superkiller phenotype, improved translation of non-poly(A) mRNA, abnormal 60S ribosomal subunits and defective 3' processing of 5.8S rRNA; a Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white	YGR195W	S000003427
SKI7	YOR29-27	Antiviral adaptor protein that mediates interactions via its N-terminus between the exosome and Ski complex (Ski2p, Ski3p, Ski8p) which operate in the 3'-to-5' mRNA-decay pathway; cytoplasmic protein required for degrading nonstop mRNAs			YOR076C	S000005602
SKI8	REC103	Protein involved in exosome mediated 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs as well as double-strand break formation during meiotic recombination; required for repressing propagation of dsRNA viruses		Null mutant is viable; rec103 is rescued by spo13 and is episatic to rad52 spo13, suggesting it is an early recombination gene	YGL213C	S000003181
SKM1		Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; proposed to be a downstream effector of Cdc42p during polarized growth			YOL113W	S000005473
SKN1		Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p		Null mutant is viable; exhibits no alterations in killer sensitivity, growth, or (1->6)-beta-glucan levels; skn1 kre6 double deletion mutants show a dramatic reduction in both (1-->6)-beta-glucan levels and growth rate compared with either single disruptant	YGR143W	S000003375
SKN7	BRY1|POS9	Nuclear response regulator and transcription factor, part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation			YHR206W	S000001249
SKO1	ACR1	Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, forms a complex with Tup1p and Ssn6p to both activate and repress transcription; cytosolic and nuclear protein involved in osmotic and oxidative stress responses		Null mutant is viable, associated with partial derepression of the SUC2 gene; associated with increased transcription through ATF/CREB sites. SKO1 is a multicopy suppressor of the lethality caused by overexpressing cAMP-dependent protein kinase and of the toxicity caused by overexpressing Rap1p	YNL167C	S000005111
SKP1	CBF3D|MGO1	Evolutionarily conserved kinetochore protein that is part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase		Null mutant is inviable, temperature-sensitive mutations in SKP1 arrest in G1 or G2	YDR328C	S000002736
SKP2		Protein of unknown function that may interact with ribosomes, based on co-purification experiments; putative F-box protein; analysis of integrated high-throughput datasets predicts involvement in ubiquitin-dependent protein catabolism	F-box protein		YNL311C	S000005255
SKS1	SHA3	Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway		Null mutant is viable; Sks1 lacking the consensus ATP binding site cannot suppress snf3 mutants when overexpressed	YPL026C	S000005947
SKT5	CAL2|CHS4|CSD4	Activator of Chs3p (chitin synthase III), recruits Chs3p to the bud neck via interaction with Bni4p; has similarity to Shc1p, which activates Chs3p during sporulation		Null mutant is viable, resistant to Calcofluor white, exhibits a reduction in cell wall chitin and chitin synthase III activity	YBL061C	S000000157
SKY1		SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1		Slow growth; Decreased in vivo phosphorylation of npl3p	YMR216C	S000004829
SLA1		Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; contains 3 SH3 domains; interacts with proteins regulating actin dynamics and with proteins required for endocytosis	cytoskeletal protein binding protein	Null mutant is viable, temperature sensitive. sla1 mutants are synthetically lethal in combination with anc1 and abp1 mutants	YBL007C	S000000103
SLA2	END4|MOP2	Transmembrane actin-binding protein involved in membrane cytoskeleton assembly and cell polarization; adaptor protein that links actin to clathrin and endocytosis; present in the actin cortical patch of the emerging bud tip; dimer in vivo		Null mutant is viable and temperature sensitive	YNL243W	S000005187
SLC1		1-acyl-sn-gylcerol-3-phosphate acyltransferase, catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; located in lipid particles and endoplasmic reticulum		slc1-1 mutant suppresses sphingolipid long chain biosynthetic defect; the mutant also makes novel phosphatidylinositol derivatives and lacks sphingolipids	YDL052C	S000002210
SLC44						S000029448
SLD2	DRC1	Protein required for DNA replication, phosphorylated in S phase by S-phase cyclin-dependent kinases (Cdks), phosphorylation is essential for DNA replication and for complex formation with Dpb11p; potential Cdc28p substrate		Null mutant is inviable; conditional mutant is defective in DNA replication and DNA replication checkpoint	YKL108W	S000001591
SLD3		Protein involved in the initiation of DNA replication, required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p		Null mutant is inviable; temperature-sensitive mutants show defects in DNA replication.	YGL113W	S000003081
SLD5	CDC105	Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery	subunit of the GINS complex		YDR489W	S000002897
SLF1	SRO99	RNA binding protein that associates with polysomes; proposed to be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts			YDR515W	S000002923
SLG1	HCS77|WSC1	Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway involved in maintenance of cell wall integrity; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response		Null mutant is viable but exhibits caffeine sensitivity, a lysis defect at 37C on YPD that is suppressed by sorbitol, and mating pheromone-induced death; in combination with deletion of wsc2 and/or wsc3, the slg1 mutant shows a lysis defect on YPD at room temperature	YOR008C	S000005534
SLH1		Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses			YGR271W	S000003503
SLI1		N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin			YGR212W	S000003444
SLI15		Subunit of the Ipl1p-Sli15p-Bir1p complex that regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly; regulates the activity and localization of the Ipl1p aurora kinase		Null mutant is inviable; sli15 conditional mutations are sythentically lethal with ipl1-2 alleles.	YBR156C	S000000360
SLK19		Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate		Null mutant exibits long astral microtubules, short spindles, bypass meiosis I, partial mitotic arrest; synthetic lethal with kar3*, loss of both produces mitotic arrest	YOR195W	S000005721
SLM1	LIT2	Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; subunit of and phosphorylated by the TORC2 complex			YIL105C	S000001367
SLM2	LIT1	Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; subunit of and phosphorylated by the TORC2 complex			YNL047C	S000004992
SLM3	MTO2|MTU1	tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF)			YDL033C	S000002191
SLM4	EGO3|GSE1|NIR1	Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4			YBR077C	S000000281
SLM5		Mitochondrial asparaginyl-tRNA synthetase			YCR024C	S000000618
SLM6		Protein with a potential role in actin cytoskeleton organization; gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase			YBR266C	S000000470
SLN1	YPD2	Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators	histidine kinase osmosensor that regulates an osmosensing MAP kinase cascade|similar to bacterial two-component regulators	Null mutant is inviable owing to the constitutive activation of the HOG1 MAPK cascade; mutations in any of the four downstream genes (SSK1, SSK2, PBS2, and HOG1) suppress sln1 lethality	YIL147C	S000001409
SLO1		Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO			YER180C-A	S000028437
SLP1		Hypothetical protein	integral membrane protein		YOR154W	S000005680
SLR1				sulfite resistance		S000029452
SLS1		Mitochondrial membrane protein required for assembly of respiratory-chain enzyme complexes III and IV; coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery		Null mutant is viable on glucose and inviable on non-fermentable carbon sources; sls1-1 has a pet phenotype and is synthetically lethal with an ssm4 null mutation	YLR139C	S000004129
SLT2	BYC2|MPK1|SLK2	Serine/threonine MAP kinase involved in regulating the maintenance of cell wall integrity and progression through the cell cycle; regulated by the PKC1-mediated signaling pathway		Null mutant is viable but temperature sensitive. At elevated temperatures or in the presence of caffeine, mull mutants exhibit cell wall defects that result in cell lysis. Lysis is prevented by addition of 1M sorbitol.	YHR030C	S000001072
SLT3				suppression at low temperature		S000029453
SLU1		Essential for the first step of splicing		Synergistically lethal with U5 snRNA		S000029454
SLU2		Essential for the first step of splicing		Synergistically lethal with U5 snRNA		S000029455
SLU7	SLT17	RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain		Null mutant is inviable; synthetically lethal with prp16, prp18 and U2 snRNA (LSR1); blocks pre-mRNA splicing in vivo and in vitro	YDR088C	S000002495
SLX1		Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p			YBR228W	S000000432
SLX4		Subunit of a complex, with Slx1p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p			YLR135W	S000004125
SLX8		Protein containing a RING finger domain that interacts with Hex3p; mutant phenotypes and genetic interactions suggest a role in sumoylation and in genome stability			YER116C	S000000918
SLX9		Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant			YGR081C	S000003313
SLY1		Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex	t-SNARE-interacting protein that functions in ER-to-Golgi traffic	Null mutant is inviable; SLY1-20, which differs from wild-type SLY1 by a single amino acid, is a single copy suppressor of loss of YPT1	YDR189W	S000002597
SLY41		Protein involved in ER-to-Golgi transport			YOR307C	S000005834
SLZ1		Sporulation-specific protein with a leucine zipper motif			YNL196C	S000005140
SMA1		Protein of unknown function involved in the assembly of the prospore membrane during sporulation		undergoes meiotic nuclear divisions but does not form spores	YPL027W	S000005948
SMA2		Protein of unknown function involved in the assembly of the prospore membrane during sporulation		undergoes meiotic nuclear divisions but does not form spores|Undergoes both meiotic nuclear divisions without chromosome missegregation but fails to form spores	YML066C	S000004531
SMB1		Core Sm protein Sm B; part of heteroheptameric complex (with Smd1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm B and Sm B'	Sm B|SmB		YER029C	S000000831
SMC1	CHL10	Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure		null is inviable; other mutants show chromosome loss and defects in nuclear division	YFL008W	S000001886
SMC2		Component of the condensin complex, essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA, possibly in the cleft formed by the coiled-coil of the folded dimer		Null mutant is inviable; ts mutant (smc2-6) confers a defect in chromosome segregation and causes partial chromosome decondensation in cells arrested in mitosis	YFR031C	S000001927
SMC3		Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member			YJL074C	S000003610
SMC4		Subunit of the condensin complex, which reorganizes chromosomes during cell division, forms a stable complex with Smc2p that has ATP-hydrolyzing and DNA-binding activity and promotes knotting of circular DNA; potential Cdc28p substrate			YLR086W	S000004076
SMC5		Structural maintenance of chromosomes (SMC) protein; essential subunit of the Mms21-Smc5-Smc6 complex; required for growth and DNA repair; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair			YOL034W	S000005394
SMC6	RHC18	Protein involved in structural maintenance of chromosomes; essential subunit of Mms21-Smc5-Smc6 complex; required for growth, DNA repair, interchromosomal and sister chromatid recombination; homologous to S. pombe rad18			YLR383W	S000004375
SMD1	SPP92	Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D1	Sm D1		YGR074W	S000003306
SMD2		Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2	Sm D2		YLR275W	S000004265
SMD3	SLT16	Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3	Sm D3|core snRNP protein	Null mutant is inviable; depletion of Smd3p affects levels of U snRNAs and their cap modification; synthetic lethal with U2 snRNA (LSR1); blocks pre-mRNA splicing in vivo and in vitro	YLR147C	S000004137
SMD4		extragenic suppressor of nmt1 myristoylation defect				S000029456
SMD5		extragenic suppressor of nmt1 myristoylation defect				S000029457
SME1		Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E	Sm E|SmE		YOR159C	S000005685
SME2		Start of meiosis		Null: viable; no effect on sporulation		S000029458
SME3		start of meiosis		Null: viable; no effect on sporulation		S000029459
SMF1	SBS1	Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins			YOL122C	S000005482
SMF2		Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins		Null mutant is viable, shows double mutant sickness with smf1 null	YHR050W	S000001092
SMF3		Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins			YLR034C	S000004024
SMI1	KNR4	Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity		Null mutant is viable, shows osmotic sensitivity, sensitivity to cercosporamide, resistance to zymolase; temperature sensitive mutant arrests at S phase with small buds	YGR229C	S000003461
SMK1		Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p	MAP kinase kinase (MEK)	smk1 asci are defective in organizing spore wall assembly and display enhanced sensitivity to enzymatic digestion, heat shock, and ether	YPR054W	S000006258
SML1		Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase		Null mutant is viable and suppresses mec1 and rad53 lethality; suppresses mip1-1 at 37 C, suppresses dun1 DNA damage sensitivity; increased resistance to DNA damage; increased dNTP pools	YML058W	S000004523
SMM1	DUS2	Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs	tRNA dihydrouridine synthase	Overexpression weakly suppresses a mutation affecting the maturation of mitochondrial tRNA-Asp.	YNR015W	S000005298
SMP1		Putative transcription factor involved in regulating the response to osmotic stress; member of the MADS-box family of transcription factors		Null mutant is viable; overexpression of DNA-binding domain of SMP1 causes an 'osmoremedial' phenotype	YBR182C	S000000386
SMP3	LAS2|SAP2	Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure	alpha-1,2-mannosyltransferase	Null mutant is inviable; ts smp3-1 and smp3-2 mutants accumulate two major Man3-GlcN (acyl)-phosphatidylinositol intermediates: one isoform has a single phosphoethanolamine side-brranch on Man-1, the other isoform has its phosphoethanolamine on Man-2; smp3-2 mutant shows partial defect in Gas1p maturation; smp3 is epistatic to gpi13, gpi11, and gaa1; smp3-1/gaa1 double mutant fails to grow at 37 deg on YPD medium containing 0.25M KCl, whereas either single mutant does grow	YOR149C	S000005675
SMR3				sulfometuron methyl resistance		S000029460
SMT2		Suppressor of Mif Two				S000029461
SMT3		Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics	SUMO	isolated as suppressor of mif2 (centromeric protein) mutation	YDR510W	S000002918
SMX2	SNP2|YFL018W-A	Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G	Sm G|SmG|snRNP G protein (human Sm-G homolog)		YFL017W-A	S000002965
SMX3		Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F	Sm F|SmF|snRNP protein		YPR182W	S000006386
SMY1		Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins		high copy suppressor of myosin	YKL079W	S000001562
SMY2		Protein of unknown function that interacts with Myo2p; has similarity to S. pombe Mpd2			YBR172C	S000000376
SNA2		Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern			YDR525W-A	S000007236
SNA3		Integral membrane protein localized to vacuolar intralumenal vesicles, computational analysis of large-scale protein-protein interaction data suggests a possible role in either cell wall synthesis or protein-vacuolar targeting		Null mutant is viable, excretes inositol	YJL151C	S000003687
SNA4		Protein of unknown function, localized to the vacuolar outer membrane			YDL123W	S000002281
SNC1		Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins		Null mutant is viable; snc1 snc2 mutants are deficient in normal bulk secretion, accumulate large numbers of post-Golgi vesicles, and display a variety of conditional lethal phenotypes; snc1 mutations suppress loss of cap in strains possessing an activated ras2 allele	YAL030W	S000000028
SNC2		Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins		Null mutant is viable, snc1 snc2 double mutants are deficient in normal bulk secretion, accumulate large numbers of post-Golgi vesicles, and display a variety of conditional lethal phenotypes	YOR327C	S000005854
SNF1	CAT1|CCR1|GLC2|HAF3|PAS14	AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis	serine/threonine protein kinase	Null mutant is viable, sensitive to heat stress and starvation and fails to accumulate glycogen during growth in rich medium; sucrose nonfermenting, high copy MSI1 and PDE2 partially suppress snf1 sporulation defects	YDR477W	S000002885
SNF10				sucrose nonfermenting		S000029462
SNF11		Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p	SWI/SNF global transcription activator complex component		YDR073W	S000002480
SNF12	SWP73	73 kDa subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; homolog of Rsc6p subunit of the RSC chromatin remodeling complex; deletion mutants are temperature-sensitive	SWI/SNF transcription activation complex 73 kDa subunit	Null mutant is viable but is temperature-sensitive, fails to transcribe SWI/SNF-dependent genes such as SUC2 and INO1, sucrose non-fermenting, defective in transcriptional activation by the glucocorticoid receptor; snf12 mutants are insensitive to expression of Adenovirus E1A protein	YNR023W	S000005306
SNF2	GAM1|HAF1|SWI2|TYE3	Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p	transcriptional regulator		YOR290C	S000005816
SNF3		Plasma membrane glucose sensor that regulates glucose transport; has 12 predicted transmembrane segments; long cytoplasmic C-terminal tail is required for low glucose induction of hexose transporter genes HXT2 and HXT4	glucose sensor	Null mutant is viable, defective in high affinity glucose transport, unable to grow on low glucose media, unable to grow on raffinose; snf3 delta hxt1 delta hxt2 delta hxt3 delta hxt4 delta cells are unable to grow on media containing high concentrations of glucose (5%) but can grow on low-glucose (0.5%) media; expression of SNF3 abolishes growth of hxt1 delta hxt2 delta hxt3 delta hxt4 delta cells on low-glucose medium	YDL194W	S000002353
SNF4	CAT3|SCI1	Activating gamma subunit of the AMP-activated Snf1p kinase complex (contains Snf1p and a Sip1p/Sip2p/Gal83p family member); activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis		Null mutant is viable, sucrose nonfermenting; high copy MSI1 and PDE2 partially suppress sporulation defect	YGL115W	S000003083
SNF5	HAF4|SWI10|TYE4	Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p	chromatin remodeling Snf/Swi complex subunit	Null mutant is viable, sucrose and raffinose nonfermenter	YBR289W	S000000493
SNF6		Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p	chromatin remodeling Snf/Swi complex subunit	Null mutant is viable, sucrose and raffinose nonfermenter	YHL025W	S000001017
SNF7	DID1|VPS32	One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes			YLR025W	S000004015
SNF8	VPS22	Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression			YPL002C	S000005923
SNG1		Protein involved in nitrosoguanidine (MNNG) resistance; expression is regulated by transcription factors involved in multidrug resistance		Null mutant is viable, sensitive to various chemical mutagens	YGR197C	S000003429
SNL1		Protein of unknown function proposed to be involved in nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein		Null mutant is viable; SNL1 is a high copy suppressor of nup116, gle2 and nic96 alleles	YIL016W	S000001278
SNM1		Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP	RNase MRP subunit		YDR478W	S000002886
SNO1		Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase		Null mutant is viable, sensitive to 6-azauracil and methylene blue.	YMR095C	S000004701
SNO2		Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin			YNL334C	S000005278
SNO3		Protein of unknown function, nearly identical to Sno2p; expression is induced before the diauxic shift and also in the absence of thiamin			YFL060C	S000001834
SNO4	HSP34	Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Hsp33p; member of the DJ-1/ThiJ/PfpI superfamily; may have a role in pyridoxine metabolism			YMR322C	S000004941
SNP1		Component of U1 snRNP required for mRNA splicing via spliceosome; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein	U1 70K|U1-70K|U1snRNP 70K protein homolog	Null mutant is inviable in some strain backgrounds and in other strain backgrounds, null mutant is viable, exhibits greatly increased doubling rates, severe temperature sensitivities, and defects in nuclear pre-mRNA splicing	YIL061C	S000001323
SNQ2		ABC transporter protein involved in multidrug resistance and resistance to singlet oxygen species	multidrug transporter	null mutant is viable; overexpression confers multi-drug resistance	YDR011W	S000002418
SNR10		H/ACA box small nucleolar RNA (snoRNA); essential gene required for for preRNA processing, specifically for cleavage at sites A1 and A2; also guides pseudouridylation of large subunit (LSU) rRNA at position U2923	H/ACA box snoRNA	Strains lacking an intact copy of SNR10 are viable but considerably imparied in growth, particularly at elevated osmotic strengths or low temperatures, and are specifically defective in the processing of 35S RNA.		S000007499
SNR11		H/ACA box small nucleolar RNA (snoRNA); guides pseudouridylation of large subunit (LSU) rRNA at position U2416	H/ACA box snoRNA			S000007293
SNR128		C/D box small nucleolar RNA (snoRNA); commonly referred to as U14; essential gene required for cleavage of 35S primary rRNA transcript to release the precursor to the 18S rRNA; guides 2'-O-methylation of small subunit (SSU) rRNA at position C414	C/D box snoRNA|U14			S000006508
SNR13		C/D box small nucleolar RNA (snoRNA), guides 2'-O-methylation of large subunit (LSU) rRNA at positions A2280 and A2281	C/D box snoRNA			S000006498
SNR14		U4 spliceosomal RNA; interacts with U6; snRNA U4	U4 snRNA			S000006499
SNR161		H/ACA small nucleolar RNA (snoRNA); guides pseudouridylation of small subunit (SSU) rRNA at positions U632 and U766	H/ACA box snoRNA			S000087162
SNR17A		small nucleolar RNA (snoRNA) U3, part of Small ribosomal SubUnit (SSU) processosome; SNR17B also encodes snoRNA U3	U3 snoRNA	Null mutant is viable. snr17a snr17b double mutant strains are inviable		S000007294
SNR17B		small nucleolar RNA (snoRNA) U3; part of small (ribosomal) subunit (SSU) processosome; SNR17A also encodes snoRNA U3	U3 snoRNA	Null mutant is viable. snr17b snr17a double mutant strains are inviable		S000007441
SNR18		C/D box small nucleolar RNA (snoRNA); commonly referred to as U18; guides 2'-O-methylation of large subunit (LSU) rRNA at positions A649 and C650	C/D box snoRNA			S000007500
SNR189		H/ACA box small nucleolar RNA (snoRNA); guides pseudouridylation of large subunit (LSU) rRNA at position U2735 and small subunit (SSU) rRNA at position U466	H/ACA box snoRNA			S000007314
SNR19		U1 spliceosomal RNA; snRNA U1 homolog	U1|U1 snRNA			S000007295
SNR190		C/D box small nucleolar RNA (snoRNA) predicted to guide 2'-O-methylation of large subunit (LSU) rRNA at position G2395 but not shown to be active	C/D box snoRNA			S000006509
SNR191		H/ACA box small nucleolar RNA (snoRNA); guides pseudouridylation of large subunit (LSU) rRNA at positions U2258 and U2260; encoded within the intron of NOG2/YNR053C	H/ACA box snoRNA			S000029463
SNR24		C/D box small nucleolar RNA (snoRNA); commonly referred to as U24; guides 2'-O-methylation of large subunit (LSU) rRNA at positions C1437, C1449, and C1450	C/D box snoRNA|U24			S000007501
SNR3		H/ACA box small nucleolar RNA (snoRNA); guides pseudouridylation of large subunit (LSU) rRNA at positions U2129, U2133, and U2264	H/ACA box snoRNA			S000006492
SNR30		H/ACA box small nucleolar RNA (snoRNA); essential gene required for cleavage of 35S primary rRNA transcript to release the precursor to the 18S rRNA	H/ACA box snoRNA	Null mutant is inviable; snR30 depletion leads to increase in cell doubling time and disruption of rRNA processing		S000007497
SNR31		H/ACA box small nucleolar RNA (snoRNA); guides pseudouridylation of small subunit (SSU) rRNA at position U999	H/ACA box snoRNA	Null mutant is viable, shows mild impairment in the initial steps of pre-rRNA processing		S000007296
SNR32		H/ACA box small nucleolar RNA (snoRNA); guides pseudouridylation of large subunit (LSU) rRNA at position U2191	H/ACA box snoRNA			S000007297
SNR33		H/ACA box small nucleolar RNA (snoRNA); guides pseudouridylation of large subunit (LSU) rRNA at position U1042	H/ACA box snoRNA			S000007298
SNR34		H/ACA box small nucleolar RNA (snoRNA); guides pseudouridylation of large subunit (LSU) rRNA at positions U2826 and U2880	H/ACA box snoRNA			S000006500
SNR35		H/ACA box small nucleolar RNA (snoRNA); predicted to guide pseudouridylation of small subunit (SSU) rRNA at position 1191	H/ACA box snoRNA			S000007299
SNR36		H/ACA box small nucleolar RNA (snoRNA); guides pseudouridylation of small subunit (SSU) rRNA at position U1187	H/ACA box snoRNA			S000007300
SNR37		H/ACA box small nucleolar RNA (snoRNA); guides pseudouridylation of large subunit (LSU) rRNA at position U2944	H/ACA box snoRNA			S000006501
SNR38		C/D box small nucleolar RNA (snoRNA), guides 2'-O-methylation of large subunit (LSU) rRNA at position G2815	C/D box snoRNA			S000007301
SNR39		C/D box small nucleolar RNA (snoRNA), guides 2'-O-methylation of large subunit (LSU) rRNA at position A807	C/D box snoRNA			S000007302
SNR39B		C/D box small nucleolar RNA (snoRNA), guides 2'-O-methylation of large subunit (LSU) rRNA at position G805	C/D box snoRNA			S000007303
SNR4		C/D box small nucleolar RNA (snoRNA) but not shown to be active and no target site is predicted within the ribosomal RNAs	C/D box snoRNA			S000006493
SNR40		C/D box small nucleolar RNA (snoRNA), guides 2'-O-methylation of large subunit (LSU) rRNA at position U898 and small subunit (SSU) rRNA at position G1271	C/D box snoRNA			S000007304
SNR41		C/D box small nucleolar RNA (snoRNA), guides 2'-O-methylation of small subunit (SSU) rRNA at positions A541 and G1126	C/D box snoRNA			S000007305
SNR42		H/ACA box small nucleolar RNA (snoRNA); guides pseudouridylation of large subunit (LSU) rRNA at position U2975	H/ACA box snoRNA			S000006502
SNR43		H/ACA box small nucleolar RNA (snoRNA); predicted to guide pseudouridylation of large subunit (LSU) rRNA at position U966	H/ACA box snoRNA			S000006503
SNR44		H/ACA box small nucleolar RNA (snoRNA); guides pseudouridylation of large subunit (LSU) rRNA at position U1056 and small subunit (SSU) rRNA at position U106	H/ACA box snoRNA			S000006504
SNR45		C/D box small nucleolar RNA (snoRNA) but not shown to be active and no target site is predicted within the ribosomal RNAs	C/D box snoRNA			S000006505
SNR46		H/ACA box small nucleolar RNA (snoRNA); guides pseudouridylation of large subunit (LSU) rRNA at position U2865	H/ACA box snoRNA			S000006506
SNR47		C/D box small nucleolar RNA (snoRNA), guides 2'-O-methylation of large subunit (LSU) rRNA at position A2220 and small subunit (SSU) rRNA at position A619	C/D box snoRNA			S000006507
SNR48		C/D box small nucleolar RNA (snoRNA), guides 2'-O-methylation of large subunit (LSU) rRNA at positions G2791 and G2793	C/D box snoRNA			S000006440
SNR49		H/ACA box small nucleolar RNA (snoRNA); guides pseudouridylation of large subunit (LSU) rRNA at position U990 and small subunit (SSU) rRNA at positions U120, U211, and U302	H/ACA box snoRNA			S000007460
SNR5		H/ACA box small nucleolar RNA (snoRNA); guides pseudouridylation of large subunit (LSU) rRNA at positions U1004 and U1124	H/ACA box snoRNA			S000007291
SNR50		C/D box small nucleolar RNA (snoRNA), guides 2'-O-methylation of large subunit (LSU) rRNA at position G867	C/D box snoRNA			S000006441
SNR51		C/D box small nucleolar RNA (snoRNA), guides 2'-O-methylation of large subunit (LSU) rRNA at position U2729 and small subunit (SSU) rRNA at position A100	C/D box snoRNA			S000006442
SNR52		C/D box small nucleolar RNA (snoRNA), guides 2'-O-methylation of large subunit (LSU) rRNA at position U2921 and small subunit (SSU) rRNA at position A420	C/D box snoRNA			S000006443
SNR53		C/D box small nucleolar RNA (snoRNA), guides 2'-O-methylation of small subunit (SSU) rRNA at position A796	C/D box snoRNA			S000006444
SNR54		C/D box small nucleolar RNA (snoRNA), guides 2'-O-methylation of small subunit (SSU) rRNA at position A974	C/D box snoRNA			S000006445
SNR55		C/D box small nucleolar RNA (snoRNA), predicted to guide 2'-O-methylation of small subunit (SSU) rRNA at position U1269	C/D box snoRNA			S000006446
SNR56		C/D box small nucleolar RNA (snoRNA), guides 2'-O-methylation of small subunit (SSU) rRNA at position G1428	C/D box snoRNA			S000006447
SNR57		C/D box small nucleolar RNA (snoRNA), guides 2'-O-methylation of small subunit (SSU) rRNA at position G1572	C/D box snoRNA			S000006448
SNR58		C/D box small nucleolar RNA (snoRNA), guides 2'-O-methylation of large subunit (LSU) rRNA at position C663	C/D box snoRNA			S000006449
SNR59		C/D box small nucleolar RNA (snoRNA), guides 2'-O-methylation of large subunit (LSU) rRNA at position A807	C/D box snoRNA			S000006450
SNR6		U6 spliceosomal RNA, interacts with U4; homology to snRNA U6, interacts with snr14	U6 snRNA			S000006494
SNR60		C/D box small nucleolar RNA (snoRNA), guides 2'-O-methylation of large subunit (LSU) rRNA at positions A817 and G908	C/D box snoRNA			S000006451
SNR61		C/D box small nucleolar RNA (snoRNA), guides 2'-O-methylation of large subunit (LSU) rRNA at position A1133	C/D box snoRNA			S000006452
SNR62		C/D box small nucleolar RNA (snoRNA), guides 2'-O-methylation of large subunit (LSU) rRNA at position U1888	C/D box snoRNA			S000006453
SNR63		C/D box small nucleolar RNA (snoRNA), guides 2'-O-methylation of large subunit (LSU) rRNA at position A2256	C/D box snoRNA			S000006454
SNR64		C/D box small nucleolar RNA (snoRNA), guides 2'-O-methylation of large subunit (LSU) rRNA at position C2337	C/D box snoRNA			S000006455
SNR65		C/D box small nucleolar RNA (snoRNA), guides 2'-O-methylation of large subunit (LSU) rRNA at position U2347	C/D box snoRNA			S000006456
SNR66		C/D box small nucleolar RNA (snoRNA), guides 2'-O-methylation of large subunit (LSU) rRNA at position U2417	C/D box snoRNA			S000006457
SNR67		C/D box small nucleolar RNA (snoRNA), guides 2'-O-methylation of large subunit (LSU) rRNA at positions G2619 and U2724	C/D box snoRNA			S000006458
SNR68		C/D box small nucleolar RNA (snoRNA), guides 2'-O-methylation of large subunit (LSU) rRNA at position A2640	C/D box snoRNA			S000006459
SNR69		C/D box small nucleolar RNA (snoRNA), guides 2'-O-methylation of large subunit (LSU) rRNA at position C2948	C/D box snoRNA			S000006460
SNR7-L	SNR7	U5 spliceosomal RNA; homology to snRNA U5, associated with spliceosome	U5 snRNA	Null mutant is inviable; SNR7 depleted strains exhibit marked accumulation of unspliced mRNA precursors.		S000006495
SNR7-S	SNR7	U5 spliceosomal RNA; homology to snRNA U5, associated with spliceosome	U5 snRNA	Null mutant is inviable; SNR7 depleted strains exhibit marked accumulation ounspliced mRNA precursors.f		S000006496
SNR70		C/D box small nucleolar RNA (snoRNA), predicted to guide 2'-O-methylation of small subunit (SSU) rRNA at position C1639	C/D box snoRNA			S000006461
SNR71		C/D box small nucleolar RNA (snoRNA), guides 2'-O-methylation of large subunit (LSU) rRNA at position A2946	C/D box snoRNA			S000006462
SNR72		C/D box small nucleolar RNA (snoRNA), guides 2'-O-methylation of large subunit (LSU) rRNA at position A876	C/D box snoRNA			S000007306
SNR73		C/D box small nucleolar RNA (snoRNA), guides 2'-O-methylation of large subunit (LSU) rRNA at position C2959	C/D box snoRNA			S000007307
SNR74		C/D box small nucleolar RNA (snoRNA), guides 2'-O-methylation of small subunit (SSU) rRNA at position A28	C/D box snoRNA			S000007308
SNR75		C/D box small nucleolar RNA (snoRNA), guides 2'-O-methylation of large subunit (LSU) rRNA at position G2288	C/D box snoRNA			S000007309
SNR76		C/D box small nucleolar RNA (snoRNA), guides 2'-O-methylation of large subunit (LSU) rRNA at position C2197	C/D box snoRNA			S000007310
SNR77		C/D box small nucleolar RNA (snoRNA), guides 2'-O-methylation of small subunit (SSU) rRNA at position U578	C/D box snoRNA			S000007311
SNR78		C/D box small nucleolar RNA (snoRNA), guides 2'-O-methylation of large subunit (LSU) rRNA at position U2421	C/D box snoRNA			S000007312
SNR79		C/D box small nucleolar RNA (snoRNA), guides 2'-O-methylation of small subunit (SSU) rRNA at position C1007	C/D box snoRNA			S000007313
SNR8		H/ACA box small nucleolar RNA (snoRNA); guides pseudouridylation of large subunit (LSU) rRNA at positions U960 and U986	H/ACA box snoRNA			S000006497
SNR80		H/ACA box small nucleolar RNA (snoRNA); guides pseudouridylation of large subunit (LSU) rRNA at position U776 and small subunit (SSU) rRNA at position U759	H/ACA box snoRNA			S000081374
SNR81		H/ACA box small nucleolar RNA (snoRNA); guides pseudouridylation of large subunit (LSU) rRNA at position U1052	H/ACA box snoRNA			S000081375
SNR82	RUF2	H/ACA box small nucleolar RNA (snoRNA); guides pseudouridylation of large subunit (LSU) rRNA at positions U1110, U2349, and U2351	H/ACA box snoRNA			S000028467
SNR83	RUF3	H/ACA box small nucleolar RNA (snoRNA); guides pseudouridylation of small subunit (SSU) rRNA at positions U1290 and U1415	H/ACA box snoRNA			S000028468
SNR84	RUF1	H/ACA box small nucleolar RNA (snoRNA); guides pseudouridylation of large subunit (LSU) rRNA at position U2266	H/ACA box snoRNA			S000028466
SNR85		H/ACA box small nucleolar RNA (snoRNA); predicted to guide pseudouridylation of small subunit (SSU) rRNA at position U1181	H/ACA box snoRNA			S000081376
SNR86		H/ACA box small nucleolar RNA (snoRNA); guides pseudouridylation of large subunit (LSU) rRNA at position U2314	H/ACA box snoRNA			S000119075
SNR87		C/D box small nucleolar RNA (snoRNA); guides 2'-O-methylation of small subunit (SSU) rRNA at position A436	C/D box snoRNA			S000114301
SNR9		H/ACA box small nucleolar RNA (snoRNA); guides pseudouridylation of large subunit (LSU) rRNA at position U2340	H/ACA box snoRNA			S000007292
SNS1				sns1 mutant is insensitive to STA10-dependent repression of STA1 gene		S000029464
SNT1		Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein			YCR033W	S000000629
SNT2		DNA binding protein with similarity to the S. pombe Snt2 protein			YGL131C	S000003099
SNT309	NTC25	Component of NineTeen complex (NTC) containing Prp19p involved in mRNA splicing, interacts physically and genetically with Prp19p		Null mutant is viable, temperature sensitive, exhibits defects in splicing at elevated temperature; snt309 prp19 mutants are synthetically lethal	YPR101W	S000006305
SNU114	GIN10	GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2	U5 snRNP-specific protein related to EF-2	Null mutant is inviable; growth inhibitory when over-expressed; required for pre-mRNA splicing in vivo	YKL173W	S000001656
SNU13		RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein	U3 snoRNP protein|U4/U6.U5 snRNP component		YEL026W	S000000752
SNU23		Component of U4/U6.U5 snRNP involved in mRNA splicing via spliceosome			YDL098C	S000002256
SNU56	MUD10	Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex	U1 snRNP protein	Null mutant is inviable; mutation affects the in vitro formation of commitment complexes and spliceosomes and the in vivo splicing efficiency of certain introns.	YDR240C	S000002648
SNU66		Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; has homology to human SART-1 and to an S. pombe protein; snu66 null mutation confers cold-sensitivity but is not lethal at normal growth temperatures			YOR308C	S000005835
SNU71		Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart	U1 snRNP protein		YGR013W	S000003245
SNX3	GRD19	Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p	sorting nexin		YOR357C	S000005884
SNX4	ATG24|CVT13	Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX domain; forms complex with Snx41p and Atg20p		Defective in maturation of the vacuolar protein, aminopeptidase I	YJL036W	S000003573
SNX41		Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network; forms a complex with Snx4p and Atg20p			YDR425W	S000002833
SNZ1		Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins		Null mutant is viable, sensitive to 6-azauracil and methylene blue.	YMR096W	S000004702
SNZ2		Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p		hypersporulation	YNL333W	S000005277
SNZ3		Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO3		hypersporulation	YFL059W	S000001835
SOD1	CRS4	Cytosolic superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans	Cu, Zn superoxide dismutase	Null mutant is viable; dioxygen and paraquat sensitive; fails to grow on lactate as a carbon source; exhibits increased copper sensitivity; exhibits slower proliferation time due to increased length of G1; methionine auxotroph and oxygen sensitive; SOD1 is required for sporulation	YJR104C	S000003865
SOD2		Mitochondrial superoxide dismutase; protects cells against oxygen toxicity	Mn-containing superoxide dismutase	Null mutant is viable; growth is impaired by oxygen; SOD2 is required for sporulation	YHR008C	S000001050
SOE1		tRNA-Glu	tRNA-Glu	point mutation results in a missense suppressor of cdc8		S000006553
SOF1		Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p		Null mutant is inviable. sof1-56, a dominant suppressor of nop1 mutants can restore growth and pre-RNA processing at 35 degrees C. In vivo depletion of SOF1 leads to impaired pre-rRNA processing and inhibition of 18S rRNA production.	YLL011W	S000003934
SOG2		Key component of the RAM signaling network, required for proper cell morphogenesis and cell separation after mitosis			YOR353C	S000005880
SOH1	MED31	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits		Null mutant is viable, shows 10-fold increase in recombination. soh1 mutants were originally identified as suppressors of hyperrecombination hpr1 mutants. Soh1p may functionally interact with components of the RNA polymerase II complex as suggested from the synthetic lethality observed in soh1 rpb delta 104, soh1 rpb2, and soh1 sua7 double mutants.	YGL127C	S000003095
SOH3				suppressor of the temperature sensitive phenotype of hpr1 null mutations and the synthetic growth phenotypes of hpr1 top1 and hpr1 hht1-hhf1 double mutants		S000029466
SOH5				suppressor of the temperature sensitive phenotype of hpr1 null mutations and the synthetic growth phenotypes of hpr1 top1 and hpr1 hht1-hhf1 double mutants		S000029467
SOH6				suppressor of the temperature sensitive phenotype of hpr1 null mutations and the synthetic growth phenotypes of hpr1 top1 and hpr1 hht1-hhf1 double mutants		S000029468
SOH7				suppressor of the temperature sensitive phenotype of hpr1 null mutations and the synthetic growth phenotypes of hpr1 top1 and hpr1 hht1-hhf1 double mutants		S000029469
SOH8				suppressor of the temperature sensitive phenotype of hpr1 null mutations and the synthetic growth phenotypes of hpr1 top1 and hpr1 hht1-hhf1 double mutants		S000029470
SOI2		Suppressor of the rapid Onset of Impotence				S000029471
SOK1		Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13			YDR006C	S000002413
SOK2		Nuclear protein that plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; negatively regulates pseudohyphal differentiation; homologous to several transcription factors			YMR016C	S000004618
SOL1		Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol2p, Sol3p, and Sol4p			YNR034W	S000005317
SOL2	YCRX13W	Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol1p, Sol3p, and Sol4p			YCR073W-A	S000000718
SOL3		6-phosphogluconolactonase, catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p	6-phosphogluconolactonase		YHR163W	S000001206
SOL4		6-phosphogluconolactonase with similarity to Sol3p	6-phosphogluconolactonase		YGR248W	S000003480
SOM1		Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates		Null mutant is viable; proteolytic processing is prevented or reduced	YEL059C-A	S000002954
SON2		extragenic suppressor of mutations in the cytoplasmic C terminus of SEC63				S000029473
SON3		extragenic suppressor of mutations in the cytoplasmic C terminus of SEC63				S000029474
SON4		extragenic suppressor of mutations in the cytoplasmic C terminus of SEC63				S000029475
SON5		extragenic suppressor of mutations in the cytoplasmic C terminus of SEC63				S000029476
SOP4		ER-membrane protein; suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER			YJL192C	S000003728
SOR1	SDH1	Sorbitol dehydrogenase; expression is induced in the presence of sorbitol	sorbitol dehydrogenase		YJR159W	S000003920
SOR2		Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in fructose or mannose metabolism			YDL246C	S000002405
SOT1				Suppression of deoxythymidine monophosphate uptake		S000029477
SOV1		Mitochondrial protein of unknown function			YMR066W	S000004670
SOY1		Protein proposed to be associated with the nuclear pore complex			YBR194W	S000000398
SPA1		Involved in chromosome segregation and other mitotic functions		Null mutant is viable, grows poorly at 30 degrees C, misegregates chromosomes at increased frequency and often contains deformed spindles and two or more nuclei		S000029478
SPA2	FUS6|PEA1	Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate		impaired ability to form schmoos, do not mate well with other spa2 mutants	YLL021W	S000003944
SPB1		AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants	AdoMet-dependent rRNA methyltransferase		YCL054W	S000000559
SPB4		Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients	ATP-dependent RNA helicase	suppression of pab1 null mutant	YFL002C	S000001894
SPC1		Subunit of the signal peptidase complex (SPC), which cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER), homolog of the SPC12 subunit of mammalian signal peptidase complex		Null mutant is viable; synthetically lethal with a conditional mutation in sec11; high copy Spc1 suppresses the conditional sec11 mutation	YJR010C-A	S000003770
SPC105		Protein required for accurate chromosome segregation, localizes to the nuclear side of the spindle pole body; forms a complex with Ydr532cp	spindle pole component		YGL093W	S000003061
SPC110	NUF1|XCM1	Inner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner	spindle pole body component		YDR356W	S000002764
SPC19		Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body	spindle pole component		YDR201W	S000002609
SPC2	SPY1	Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25	signal peptidase complex subunit	Null mutant is viable. spc1 spc2 double deletion mutants grow relatively well as compared to wild-type. spc2 sec11 double deletion mutant is inviable. Spc2p is important for cell viability and signal peptidase activity at high temperatures (42 degrees celsius).	YML055W	S000004519
SPC24		Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering	spindle pole component		YMR117C	S000004723
SPC25		Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering	spindle pole component		YER018C	S000000820
SPC29	LPH3|NIP29	Inner plaque spindle pole body (SPB) component, links the central plaque component Spc42p to the inner plaque component Spc110p; required for SPB duplication			YPL124W	S000006045
SPC3		Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23			YLR066W	S000004056
SPC34		Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body	spindle pole component		YKR037C	S000001745
SPC42		Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane	spindle pole body component	Null mutant is inviable; temperature sensitive mutations show SBP duplication	YKL042W	S000001525
SPC72	LDB4	Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization		Null mutant is inviable. Cells lacking Spc72 can only generate very short (<1 micron) and unstable astral microtubules. Consequently, nuclear migration to the bud neck and orientation of the anaphase spindle along the mother-bud axis are absent in these cells.	YAL047C	S000000045
SPC97		Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque	gamma-tubulin complex component	Null mutant is inviable; required for microtubule organization and spindle pole body duplication	YHR172W	S000001215
SPC98		Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque	gamma-tubulin complex component	Null mutant is inviable; overexpression is toxic resulting in accumulation of cells with large buds, 2N DNA content, defect in microtubule structure. ts-phenotype: arrest in G2 of cell cycle with large bud, duplicated spindle pole bodies, short spindle and elongated cytoplasmic microtubules	YNL126W	S000005070
SPD1		mediates nitrogen repression of sporulation in rich media		sporulation not repressed in rich medium, spd1 sporulates in stationary phase		S000029479
SPD3		Derepressed for meiosis and spore formation		haploids are arrested on a range of non-fermentable media in the G1 phase of the cell division cycle as large unbudded cells; homozygous diploids confer poor growth and extensive sporulation on a range of non-fermentable media		S000029480
SPD4		Derepressed for meiosis and spore formation		haploids are arrested on a range of non-fermentable media in the G1 phase of the cell division cycle as large unbudded cells; homozygous diploids confer poor growth and extensive sporulation on a range of non-fermentable media		S000029481
SPE1	ORD1|SPE10	Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines	ornithine decarboxylase	spermidine or putrescine requirement	YKL184W	S000001667
SPE2		S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically		Null mutant is viable under anaerobic conditions, under aerobic conditions, spe2 null mutants demonstrate an absolute requirement for polyamines for growth and exhibit increase in cell size, a marked decrease in budding, accumulation of vesicle-like bodies, absence of specific localization of chitin-like material, and abnormal distribution of actin-like material; in addition, spe2 null mutants are associated with a marked elevation in +1 but no change in -1 ribosomal frameshifting	YOL052C	S000005412
SPE3		Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells	putrescine aminopropyltransferase|spermidine synthase	Null mutant is viable, has no spermidine synthase activity, requires spermine or spermidine for growth	YPR069C	S000006273
SPE4		Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid	spermine synthase		YLR146C	S000004136
SPF1	COD1|PER9|PIO1	P-type ATPase, ion transporter of the ER membrane involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1	ion-translocating ATPase	The null mutant is viable and resistant to the SMK toxin, but grows slowly and has glycosylation defects.	YEL031W	S000000757
SPG1		Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YGR236C	S000003468
SPG3		Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources			YDR504C	S000002912
SPG4		Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources			YMR107W	S000004713
SPG5		Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources			YMR191W	S000004803
SPH1	YLR312C-B	Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p			YLR313C	S000004305
SPI1		GPI-anchored, serine/threonine rich cell wall protein of unknown function; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p			YER150W	S000000952
SPL2		Protein with similarity to cyclin-dependent kinase inhibitors, overproduction suppresses a plc1 null mutation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern		Null mutant is viable and shows no obvious phenotype; spl2-delta plc1-delta double mutant fails to grow on SCD complete media, but grows on YPD at 25 degrees C	YHR136C	S000001178
SPN1	IWS1	Protein that interacts with Spt6p and copurifies with Spt5p and RNA polymerase II, probable transcriptional elongation factor; metazoan homologs contain an acidic N terminus; mutations in the gene confer an Spt- phenotype			YPR133C	S000006337
SPO1		Meiosis-specific protein with similarity to phospholipase B, required for meiotic spindle pole body duplication and separation; required for spore formation		Null mutant is viable, arrests as mononucleate cells with unduplicated/unseparated spindle pole bodies	YNL012W	S000004957
SPO10		Dispensable for mitosis and premeiotic DNA synthesis. Required for spindle pole body duplication, meiosis I, meiosis II, and spores.		spo10 arrests at the mononucleate stage with unduplicated spindle pole bodies and accumulates aggregates of synaptonemal complexes		S000029482
SPO11		Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation	endodeoxyribonuclease		YHL022C	S000001014
SPO12		Nucleolar protein of unknown function, positive regulator of exit from mitosis; involved in regulating the release of Cdc14p from the nucleolus in early anaphase; proposed to play similar role in meiosis		sporulation defective; loss of function in mitosis results in delay in G2; loss of function in meiosis results in a prolonged pachytene stage and presence of synaptonemal complexes, a single meiosis II-like equational division at the time of meiosis II, and dyad asci containing two diploid spores. Gain of function in mitosis suppresses M-phase anaphase arrest caused by overexpression of CLB2 deg- and mutants (e.g. dbf2-ts). mRNA is cell cycle regulated (with DBF2 ) in mitosis and increases 5-10x in meiosis.	YHR152W	S000001195
SPO13		Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II		Null mutant is viable, defective for sporulation; loss of function results in a single division during meiosis (with some chromosomes segregating reductionally or aberrantly depending on strain background), occurring slightly earlier or at the time of wild type meiosis I, and dyad asci containing two diploid spores. spo13 rescues the meiotic lethality of early Rec- mutants and Rec+ haploids. Gain of function causes a CDC28-dependent arrest at M-phase in mitosis and a delay in MI nucleardivision.	YHR014W	S000001056
SPO14	PLD1	Phospholipase D, catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis	phospholipase D	Null mutant is viable, deficient for growth on non-fermentable carbon sources; unable to catalyze hydrolysis of phosphatidylcholine; diploids are unable to sporulate; most spo14 mutant cells arrest at the binucleate stage; a small fraction proceed to the tetranucleate stage; unlike the wild type, spo14 cells can return to growth after either meiosis I or meiosis II	YKR031C	S000001739
SPO16		Protein of unknown function, required for spore formation		sporulation defective	YHR153C	S000001196
SPO17		dispensable for mitosis, required for premeiotic DNA synthesis and subsequent meiotic landmarks, and sporulation-specific amyloglucosidase activity		Null mutant is viable; sporulation defective		S000029483
SPO19		Meiosis-specific protein of unknown function, involved in completion of nuclear divisions; identified as a weak high-copy suppressor of the spo1-1 ts mutation; putative GPI-dependent cell-wall protein	meiosis-specific GPI-protein	Null mutant is viable; unable to form spores	YPL130W	S000006051
SPO2		dispensable for mitosis, premeiotic DNA synthesis, recombination, meiosis I, meiosis II. Required for nuclear membrane integrity at meiosis I and meiosis II, and localized prospore wall growth at the nuclear envelope.		In a spo2 mutant, the nucleus divides into two separate bodies at meiosis I and again at meiosis II; prospore walls initiate at spindle pole bodies normally but instead of elongating adjacent to the nuclear membrane they grow independently and curl backwards, forming small anucleate spores and free unenclosed nuclei.		S000029484
SPO20	DBI9	Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog		Null mutant is viable, other mutant fails to form spores	YMR017W	S000004619
SPO21	MPC70	Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation		meiosis proficient, fails to form spores	YOL091W	S000005451
SPO22	ZIP4	Meiosis-specific protein essential for chromosome synapsis, similar to phospholipase A2, involved in completion of nuclear divisions during meiosis; induced early in meiosis		Null mutant is viable; the first meiotic division is delayed by 2-4 hours; spore production is reduced by 50% compared to wild type.	YIL073C	S000001335
SPO23		Protein of unknown function; associates with meiosis-specific protein Spo1p			YBR250W	S000000454
SPO4		Dispensable for mitosis, premeiotic DNA synthesis, recomb., meiosis I, meiosis II & prospore wall initiation. Required for spore wall elongation, coordination of spore wall closure with meiosis II segregation, & spore wall maturation		spo4-1 at a semi-permissive temperature produces asci with one or two randomly packaged haploid spores; at a restrictive temperature, prospore walls grow and close prior to the completion of meiosis II, resulting in immature aneuploid and/or anucleate spores. Multinucleate cells completing meiosis II, but blocked in spore development, bud and resume division in return to growth assay.		S000029485
SPO5		Dispensable for mitosis, premeiotic DNA synthesis, recomb., meiosis I, meiosis II & prospore wall initiation. Required for spore wall elongation, coordination of spore wall closure with meiosis II segregation, & spore wall maturation		spo5-1 at a semi-permissive temperature produces asci with one or two randomly packaged haploid spores; at a restrictive temperature, prospore walls grow and close prior to the completion of meiosis II, resulting in immature aneuploid and/or anucleate spores. Multinucleate cells completing meiosis II, but blocked in spore development, bud and resume division in return to growth assay.		S000029486
SPO50		dispensable for mitosis, required for premeiotic DNA synthesis and recombination, and spores		Null mutant is viable; spo50 prevents precocious sporulation of spd1 mutant in rich medium		S000029487
SPO51		Required for sporulation				S000029488
SPO53		Required for sporulation				S000029489
SPO7		Regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, which regulates nuclear growth by controlling recruitment of Pah1p onto promoters of phospholipid biosynthetic genes; required for normal nuclear envelope morphology and sporulation		Null mutant is viable, sporulation defective	YAL009W	S000000007
SPO71		Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis		Null mutant is viable; upon sporulation, null mutants undergo both meiotic divisions but do not form a spore wall.	YDR104C	S000002511
SPO73		Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis		Null: Undergoes meiotic nuclear divisions but does not form spores	YER046W	S000000848
SPO74		Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation			YGL170C	S000003138
SPO75		Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis		Null: undergoes meiotic nuclear divisions but does not form spores	YLL005C	S000003928
SPO77		Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis		Null: Undergoes meiotic nuclear divisions but does not form spores	YLR341W	S000004333
SPO9		dispensable for mitosis; required for premeiotic DNA synthesis, spindle pole body duplication, meiosis I, meiosis II, and spores				S000029490
SPOT1				sporulation defective; premeiotic DNA synthesis does not occur		S000029491
SPOT11				sporulation defective, premeiotic DNA synthesis does not occur		S000029492
SPOT15				sporulation defective, meiosis I does not occur		S000029493
SPOT16				sporulation defective, meiosis II does not occur		S000029494
SPOT2				sporulation defective		S000029495
SPOT20				sporulation defective, mature spores do not form		S000029496
SPOT23				sporulation defective, mature spores do not form		S000029497
SPOT4				sporulation defective; premeiotic DNA synthesis does not occur		S000029498
SPOT7				sporulation defective; premeiotic DNA synthesis does not occur		S000029499
SPP1	CPS40|SAF41	Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein	COMPASS (complex proteins associated with Set1p) component	Null: defective in silencing of expression of genes located near telomeres; hydroxyurea sensitive.	YPL138C	S000006059
SPP2		Essential protein that promotes the first step of splicing and is required for the final stages of spliceosome maturation; interacts with Prp2p, which may release Spp2p from the spliceosome following the first cleavage reaction		Null mutant is inviable. Depletion of Spp2p from yeast cells results in accumulation of unspliced pre-mRNAs. A temperature-sensitive spp2-1 mutant accumulates pre-mRNAs in vivo and is unable to undergo the first splicing reaction in vitro.	YOR148C	S000005674
SPP381		mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p		Null mutant is viable, shows severe growth defect and inhibited cellular pre-mRNA splicing	YBR152W	S000000356
SPP382	CCF8|NTR1	Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation			YLR424W	S000004416
SPP41		Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3	negative transcriptional regulator of prp spliceosome genes	Null mutant is inviable; suppressor of prp mutations	YDR464W	S000002872
SPR1	SSG1	Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance	exo-1,3-beta-glucanase	Fail to hydrolyze p-nitrophenyl-beta-D-glucanase or laminarin; mutant spores exhibit reduced thermoresistance	YOR190W	S000005716
SPR2		Sporulation regulated genes				S000029500
SPR28		Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation	septin		YDR218C	S000002626
SPR3		Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI	septin		YGR059W	S000003291
SPR6		Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation		Null mutant is viable, shows no sporulation defects	YER115C	S000000917
SPS1		Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis			YDR523C	S000002931
SPS100		Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall	sporulation-specific cell wall maturation protein		YHR139C	S000001181
SPS18	SPX18	Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation		suppression of X-ray sensitivity of rad55	YNL204C	S000005148
SPS19	SPX19	Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate	2,4-dienoyl-CoA reductase	Null mutant is viable. SPS19 is dispensable for growth and sporulation on solid acetate and oleate media, but is essential for these processes to occur on petroselineate.	YNL202W	S000005146
SPS2		Protein expressed during sporulation, redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component			YDR522C	S000002930
SPS22		Protein of unknown function, redundant with Sps2p for the organization of the beta-glucan layer of the spore wall			YCL048W	S000000553
SPS4		Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage		normal sporulation	YOR313C	S000005840
SPT10	CRE1|SUD1	Putative histone acetylase, sequence-specific activator of histone genes, binds specifically and highly cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box	transcriptional regulator	Suppression of transcriptional defect of UAS-less sta1 gene; suppression of salt-sensitive phenotype caused by elevated TATA-binding protein; ts growth, reduced sporulation efficiency, sensitivity to heat shock & N starvation. Disruption of SPT10 lethal at high [Cu], correlated with slower induction and reduced max levels of CUP1 mRNA.	YJL127C	S000003663
SPT14	CWH6|GPI3	UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins	glycosyltransferase	suppression of Ty transcription	YPL175W	S000006096
SPT15	BTF1|TBP1	TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability	TBP|TFIID subunit		YER148W	S000000950
SPT16	CDC68|SSF1	Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), facilitates RNA Polymerase II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure		suppression of Ty insertion mutations	YGL207W	S000003175
SPT17						S000029501
SPT2	EXA1|SIN1	Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins	non-specific DNA binding protein	Suppression of Ty transcription; loss of function allele is extragenic supressor of hsp70 subfamily A. Mutations lead to accumulation of a previously uncharacterized form of hsp70.	YER161C	S000000963
SPT20	ADA5	Subunit of the SAGA transcriptional regulatory complex, involved in maintaining the integrity of the complex	histone acetyltransferase SAGA complex member|transcription factor	Null mutant is viable, exhibits growth defects on glucose and galactose, fails to grow on media lacking inositol	YOL148C	S000005508
SPT21		Protein required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p; involved in telomere maintenance	non-specific DNA binding protein	Null mutant is viable, spt21 mutations suppress Ty insertion mutations	YMR179W	S000004791
SPT23		ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting		Null mutant does not have an Spt- phenotype. Disruption does not significantly affect cell growth or fatty acid metabolism.	YKL020C	S000001503
SPT3		Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters	histone acetyltransferase SAGA complex member|transcription factor	Null mutant is viable, exhibits defects in mating and sporulation, Ty transcription, and suppression of certain Ty insertion mutations	YDR392W	S000002800
SPT4		Protein that forms a complex with Spt5p and mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing; in addition, Spt4p is involved in kinetochore function and gene silencing	RNA polymerase II elongation factor		YGR063C	S000003295
SPT5		Protein that forms a complex with Spt4p and mediates both activation and inhibition of transcription elongation; Spt4p-Spt5p complex also plays a role in pre-mRNA processing	RNA polymerase II elongation factor		YML010W	S000004470
SPT6	CRE2|SSN20	Essential protein that interacts with histones and is involved in nucleosome disassembly and reassembly during transcription elongation	RNA polymerase II elongation factor		YGR116W	S000003348
SPT7	GIT2	Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex	histone acetyltransferase SAGA complex member|transcription factor	Null mutant is viable, exhibits growth defects on glucose and galactose, fails to grow on media lacking inositol	YBR081C	S000000285
SPT8		Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters	transcription factor	Null mutant is viable, no growth defects, exhibits suppression of Ty insertion mutations, defects in Ty transcription	YLR055C	S000004045
SPY2		Signal Peptidase Yeast		null is lethal		S000029502
SQS1		Protein of unknown function; overexpression antagonizes the suppression of splicing defects by spp382 mutants; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	unknown		YNL224C	S000005168
SQT1		Essential protein involved in a late step of 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay		Null mutant is inviable. Loss of SQT1 function by down regulation from an inducible promoter results in formation of half-mer polyribosomes and descreased levels of Qsr1p on free 60S subunits	YIR012W	S000001451
SRA6				suppression of ras mutation		S000029503
SRA7				suppression of ras mutation		S000029504
SRB2	HRS2|MED20	General transcription factor, subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance	mediator complex subunit	Null mutant is viable, the semi-dominant SRB2-1 mutation suppresses truncation of the C-terminal domain of RNA polymerase II	YHR041C	S000001083
SRB4	MED17	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation	mediator complex subunit	Null mutant is inviable, srb4 (ts) mutants display global defects in mRNA synthesis; srb4 mutants are suppressed by mutations in NCB1	YER022W	S000000824
SRB5	MED18	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in telomere maintenance	mediator complex subunit		YGR104C	S000003336
SRB6	MED22	Essentital subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation	mediator complex subunit	Null mutant is inviable; temperature sensitive mutants are associated with decreased total polyA+ RNA levels	YBR253W	S000000457
SRB7	MED21	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p	mediator complex subunit		YDR308C	S000002716
SRB8	GIG1|MED12|NUT6|SSN5|YCR080W	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression	mediator complex subunit		YCR081W	S000000677
SRC1	YML033W	Protein with a putative role in sister chromatid segregation, potentially phosphorylated by Cdc28p; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery		Null mutant is viable and shows normal growth in standard media; expression is induced at G2/M transition.	YML034W	S000004497
SRD1		Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation		suppressor of rrp1	YCR018C	S000000611
SRG1		Non-protein-coding RNA that regulates the transcription of SER3; expression of SRG1 RNA represses expression of its neighboring gene SER3 via a transcription-interference mechanism				S000029010
SRL1		Mannoprotein that exhibits a tight association with the cell wall, required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants			YOR247W	S000005773
SRL2		Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation			YLR082C	S000004072
SRL3		Cytoplasmic protein that, when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate			YKR091W	S000001799
SRM1	MTR1|PRP20	Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; potentially phosphorylated by Cdc28p	pheromone response pathway suppressor	recessive mutation activates signal transduction pathway required for mating; leads to arrest in G1. mutant phenotype reveals defect in plasmid and chromosome stability, suggesting defect in DNA replication, mitosis, or their coordination.	YGL097W	S000003065
SRN11		extragenic suppressor of the temperature-sensitive phenotype of rna1-1				S000029505
SRN2	SRN10|VPS37	Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus			YLR119W	S000004109
SRO7	SNI1|SOP1	Putative effector of Rab GTPase Sec4p, forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Sro77p and Drosophila lgl tumor suppressor		Null mutant is viable but is cs- in combination with sni2(YBL106c) null; sni1 sni2 double mutant has exocytic defect, accumulating post-Golgi vesicles. Acts as a multicopy suppressor of rho3.	YPR032W	S000006236
SRO77	SNI2|SOP2	Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Sro7p and Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p		Null mutant is viable and shows no phenotypes, but is cs- in combination with sro7/sni1 (YPR032W) null; sro7/sni1 sro77/sni2 double mutants have an exocytic defect, accumulate post-Golgi vesicles, have partially delocalized actin, and suppress the growth and cell separation defects of myo1 cells.	YBL106C	S000000202
SRO9		Cytoplasmic RNA-binding protein that associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif		Null mutant is viable; multicopy SRO9 suppresses disappearance of cables of actin filaments in both rho3 and tpm1 mutants, growth defect in tpm1 tpm2 double mutant, and temperature sensitivity of act1-1 mutant; sro9 is synthetically lethal with tpm1 (but multicopy TPM2 suppresses that synthetic lethality	YCL037C	S000000542
SRP1	KAP60|SCM1	Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation	karyopherin alpha	supressor of rpb1, cold-sensitive	YNL189W	S000005133
SRP101		Signal recognition particle (SRP) receptor - alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with SRP102p		Null mutant is viable, cells show sixfold reduction in growth rate. Depletion of SRP101 causes impaired translocation of soluble and membrane proteins across the ER membrane	YDR292C	S000002700
SRP102		Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors Srp101p to the ER membrane		Null mutant is viable but exhibits slow growth and cannot grow on nonfermentable carbon sources. Temperature-sensitive alleles exhibit defects in translocation of some ER proteins at the nonpermissive temperature.	YKL154W	S000001637
SRP14		Signal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14			YDL092W	S000002250
SRP21		Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm	signal recognition particle component	Null mutant is viable, associated with slow cell growth and inefficient protein translocation across the ER membrane	YKL122C	S000001605
SRP40		Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140			YKR092C	S000001800
SRP5				suppression of rpb1, cold sensitive		S000029506
SRP54	SRH1	Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain			YPR088C	S000006292
SRP68		Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane	signal recognition particle component	Null mutant is viable, associated with slow cell growth and inefficient protein translocation across the ER membrane	YPL243W	S000006164
SRP72		Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane	signal recognition particle component	Null mutant is viable, associated with slow cell growth and inefficient protein translocation across the ER membrane	YPL210C	S000006131
SRS1				Dominant mutations suppress the trimethoprim and UV sensitivity of rad6 and rad18 strains		S000029507
SRT1		Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase	cis-prenyltransferase	Null mutant is viable, grows at all temperatures tested and is not hygromycin B sensitive; srt1 rer2 double disruption mutants are inviable; overexpression of SRT1 suppresses the temperature sensitive and slow growth phenotypes of rer2 mutants	YMR101C	S000004707
SRV2	CAP	CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis			YNL138W	S000005082
SRX1		Sulfiredoxin, contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxins Tsa1p and Ahp1p that are formed upon exposure to oxidants; conserved in higher eukaryotes	ATP-dependent cysteine sulfinic acid reductase	Null: sensitivity to hydroperoxide, overoxidation of Tsa1 catalytic cysteine to the sulfinic acid form	YKL086W	S000001569
SRY1		3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate			YKL218C	S000001701
SSA1	YG100	ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall		Null mutant is viable, temperature sensitive; ssa1 ssa2 ssa4 strains are inviable; an intact copy of SSA3 regulated by the constitutive SSA2 promoter is capable of rescuing the inviability of an ssa1 ssa2 ssa4 strain	YAL005C	S000000004
SSA2	YG102	ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall		Null mutant is viable, temperature sensitive; ssa1 ssa2 ssa4 strains are inviable; an intact copy of SSA3 regulated by the constitutive SSA2 promoter is capable of rescuing the inviability of an ssa1 ssa2 ssa4 strain	YLL024C	S000003947
SSA3	YG106	ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm		Null mutant is viable; an intact copy of SSA3 regulated by the constitutive SSA2 promoter is capable of rescuing the inviability of an ssa1 ssa2 ssa4 strain; an intact copy of SSA3 regulated by the constitutive SSA2 promoter is capable of rescuing the inviability of an ssa1 ssa2 ssa4 strain	YBL075C	S000000171
SSA4	YG107	Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation		Null mutant is viable; ssa1 ssa2 ssa4 strains are inviable; an intact copy of SSA3 regulated by the constitutive SSA2 promoter is capable of rescuing the inviability of an ssa1 ssa2 ssa4 strain	YER103W	S000000905
SSB1	YG101	Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p			YDL229W	S000002388
SSB2	YG103	Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; homolog of SSB1		Null mutant is viable, ssb1 ssb2 double disruption mutants exhibit poor growth at all temperatures, but particularly at low temperatures; as well as hypersensitivity to certain protein synthesis inhibitors, including aminoglycosides such as hygromycin B	YNL209W	S000005153
SSB20						S000029508
SSB38						S000029509
SSC1	ENS1|mtHSP70	Mitochondrial matrix ATPase that is a subunit of the presequence translocase-associated protein import motor (PAM); involved in protein translocation into the matrix and protein folding; member of the heat shock protein 70 (HSP70) family	Endo.SceI endonuclease subunit	Null mutant is inviable; some alleles demonstrate effects in sporulation and germination	YJR045C	S000003806
SSD1	CLA1|MCS1|RLT1|SRK1	Protein with a role in maintenance of cellular integrity, interacts with components of the TOR pathway; ssd1 mutant of a clinical S. cerevisiae strain displays elevated virulence		Suppressor of regulatory subunit of protein kinase	YDR293C	S000002701
SSE1	LPG3|MSI3	ATPase that is a component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm		Null mutant is viable, slow growing, shows no additive effects with sse2 null mutation; temperature sensitive in some strain backgrounds	YPL106C	S000006027
SSE2		Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; highly homologous to the heat shock protein Sse1p			YBR169C	S000000373
SSF1		Constituent of 66S pre-ribosomal particles, required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family		Null mutant is viable, ssf1 ssf2 double deletion mutants are inviable. SSF1 is a high copy suppressor of the mating defect caused by a temperature sensitive G beta subunit mutation. Depletion of SSF gene products from growing cultures caused both an arrest of cell division and a significant decrease in the ability of cells to mate. Mating efficiency was increased by extra copies of the SSF genes and decreased by elimination of the gene products	YHR066W	S000001108
SSF2		Protein required for ribosomal large subunit maturation, functionally redundant with Ssf1p; member of the Brix family		Null mutant is viable; displays double mutant lethality with ssf1 null mutations. Ssfp depletion is associated with arrest of cell division and decreased mating	YDR312W	S000002720
SSF9				suppresses requirement for swi4 in HO transcription; temperature sensitive lethal		S000029510
SSH1		Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential		Null mutant is viable, but grows slowly	YBR283C	S000000487
SSH4	MLF4	Vacuolar protein that presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane			YKL124W	S000001607
SSH5		Suppressor of SHR3				S000029511
SSK1		Cytoplasmic response regulator, part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate	two-component signal transducer that with Sln1p regulates osmosensing MAP kinase cascade(suppressor of sensor kinase)	Null mutant is viable; suppresses the lethality of sln1 or ypd1 disruption mutants	YLR006C	S000003996
SSK2		MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress	MAP kinase kinase kinase (MEKK)	Suppresses sln1 lethality. Synthetically high-osmolarity sensitive when it is combined with both ssk22 and sho1 mutations	YNR031C	S000005314
SSK22		MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; functionally redundant with, and homologous to, Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p			YCR073C	S000000669
SSL1		Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p	transcription initiation factor TFIIH subunit	Null mutant is inviable; temperature-sensitive mutants are UV-sensitive and deficient in nucleotide excision repair.	YLR005W	S000003995
SSL2	LOM3|RAD25	Component of the holoenzyme form of RNA polymerase transcription factor TFIIH, has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; involved in DNA repair; homolog of human ERCC3	DNA helicase		YIL143C	S000001405
SSM4	DOA10|KIS3	Ubiquitin-protein ligase of the ER/nuclear envelope, required for degradation of Alpha2p and other proteins containing a Deg1 degradation signal; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation		Null mutant is viable, suppresses temperature sensitive rna14 mutations; ssm4 sls1 mutants are inviable	YIL030C	S000001292
SSN2	MED13|NUT8|RYE3|SCA1|SRB9|UME2	Protein required for stable association of Srb10p-Srb11p kinase with RNA polymerase holoenzyme; subunit of the RNA polymerase II mediator complex; essential for transcriptional regulation	mediator complex subunit	Null mutant is viable; ssn2 mutations can suppress CTD truncations or phosphorylation mutants and snf1 mutations	YDR443C	S000002851
SSN3	CDK8|GIG2|NUT7|RYE5|SRB10|UME5	Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression	cyclin-dependent protein kinase|mediator complex subunit	null is viable, exhibits set of phenotypes common to strains defective in SSN6/TUP1-mediated transcriptional repression. Other mutations show unscheduled meiotic gene expression (derepression of early meiotic genes), suppression of SNF1.	YPL042C	S000005963
SSN8	CycC|GIG3|NUT9|RYE2|SRB11|UME3	Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance	mediator complex subunit	null is viable, exhibits set of phenotypes common to strains defective in SSN6/TUP1-mediated transcriptional repression. Other mutations show unscheduled meiotic gene expression (derepression of early meiotic genes), suppression of SNF1.	YNL025C	S000004970
SSO1		Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p	t-SNARE	SSO1, SSO2 double null mutant is inviable; high copy number of either SSO1 or SSO2 suppresses mutations in late-acting sec genes (sec1,3,5,9,15)	YPL232W	S000006153
SSO2		Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p	t-SNARE	SSO1, SSO2 double null mutant is inviable; high copy number of either SSO1 or SSO2 suppresses mutations in late-acting sec genes (sec1,3,5,9,15)	YMR183C	S000004795
SSP1	SPO3	Protein involved in the control of meiotic nuclear division and coordination of meiosis with spore formation; transcription is induced midway through meiosis		Null mutant is viable; spo3-1 at a semi-permissive temperature produces asci with one or two randomly packaged haploid spores; at a restrictive temperature, prospore walls grow and close prior to the completion of meiosis II, resulting in immature aneuploid and/or anucleate spores. Multinucleate cells completing meiosis II, but blocked in spore development, bud and resume division in return to growth assay.	YHR184W	S000001227
SSP120		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern			YLR250W	S000004240
SSP2		Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; SSP2 expression is induced midway in meiosis		Null mutant is viable, fails to sporulate	YOR242C	S000005768
SSQ1	SSC2	Mitochondrial hsp70-type molecular chaperone, required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia		Null mutant is viable, cold-sensitive, osmotically sensitive; ssq1 mutations can suppress the endogenous oxygen toxicity (methionine and lysine auxotrophies) of sod1 null mutants and exhibit diminished rates of respiratory oxygen consumption and reduced mitochondrial aconitase and succinate dehydrogenase activities	YLR369W	S000004361
SSS1		Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p	Sec61 trimeric complex component|Ssh1 trimeric complex component	Null mutant is inviable. Depletion of the Sss1 protein rapidly results in accumulation of multiple secretory or membrane proteins devoid of post-translational modifications. SSS1 overexpression restores translocation in sec61 mutants.	YDR086C	S000002493
SST2		GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family	GTPase activating protein (GAP)	Null mutants are viable and exhibit increased sensitivity to mating factors	YLR452C	S000004444
SSU1	LPG16	Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein			YPL092W	S000006013
SSU3		sensitive to sulfite		ssu3 mutants are sensitive to sulfite		S000029512
SSU4		sensitive to sulfite				S000029513
SSU72		Transcription/RNA-processing factor that associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 of the RNA polymerase II C-terminal domain; affects start site selection in vivo			YNL222W	S000005166
SSX1				Suppresses the swi6 requirement for HO transcription		S000029514
SSX2				Suppresses the swi6 requirement for HO transcription		S000029515
SSX3				Suppresses the swi6 requirement for HO transcription		S000029516
SSX4				Suppresses the swi6 requirement for HO transcription		S000029517
SSX5				Suppresses the swi6 requirement for HO transcription		S000029518
SSX6				Suppresses the swi6 requirement for HO transcription		S000029519
SSX7				Suppresses the swi6 requirement for HO transcription		S000029520
SSY1	SHR10	Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes		Null mutant is viable, resistant to 30 mM histidine, and synthetically lethal in combination with leu2 on complex media. Sensitive to sulfonylurea herbicides in complex media (YPD)	YDR160W	S000002567
SSY4				Sensitive to sulfonylurea herbicides on complex media (YPD)		S000029521
SSY5		Probable serine protease of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that regulate expression of amino acid permease genes		Sensitive to sulfonylurea herbicides on complex media (YPD)	YJL156C	S000003692
SSZ1	PDR13	Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP		Null mutant is viable, cold sensitive; SSZ1 overexpression causes increased expression of some PDR genes	YHR064C	S000001106
STA1	DEX2|MAL5		glucan 1,4-alpha-glucosidase|glucoamylase			S000029522
STA10		Involved in repression of starch hydrolysis genes				S000029523
STA2		allows yeast to degrade starch	glucan 1,4-alpha-glucosidase|glucoamylase			S000029524
STA3		Starch hydrolysis				S000029525
STB1		Protein with a role in regulation of MBF-specific transcription at Start, phosphorylated by Cln-Cdc28p kinases in vitro; unphosphorylated form binds Swi6p and binding is required for Stb1p function; expression is cell-cycle regulated			YNL309W	S000005253
STB2		Protein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p			YMR053C	S000004657
STB3		Protein that binds Sin3p in a two-hybrid assay			YDR169C	S000002576
STB4		Protein that binds Sin3p in a two-hybrid assay; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins		Null mutant is viable, hypersensitive to caffeine	YMR019W	S000004621
STB5		Activator of multidrug resistance genes, forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a PDRE (pleotropic drug resistance element) in vitro; binds Sin3p in a two-hybrid assay			YHR178W	S000001221
STB6		Protein that binds Sin3p in a two-hybrid assay			YKL072W	S000001555
STB8						S000029526
STD1	MSN3|SFS3	Protein involved in control of glucose-regulated gene expression; interacts with protein kinase Snf1p, glucose sensors Snf3p and Rgt2p, and TATA-binding protein Spt15p; acts as a regulator of the transcription factor Rgt1p		Null mutant is viable, no defects in mating or sporulation. Suppressor of TBP deletion; multicopy suppressor of SNF; std1-mth1 has defective glucose derepression and sporulation	YOR047C	S000005573
STE11		Signal transducing MEK kinase involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p			YLR362W	S000004354
STE12		Transcription factor that is activated by a MAP kinase signaling cascade, activates genes involved in mating or pseudohyphal/invasive growth pathways; cooperates with Tec1p transcription factor to regulate genes specific for invasive growth	transcription factor	Null mutant is viable but sterile; homozygous mutant diploids exhibit defects in pseudohyphal growth	YHR084W	S000001126
STE13	YCI1	Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor	dipeptidyl aminopeptidase|yscIV	Null mutant is viable, sporulation proficient	YOR219C	S000005745
STE14		Farnesyl cysteine-carboxyl methyltransferase, mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum, localizes to the ER membrane	farnesyl cysteine-carboxyl methyltransferase	Null mutant is viable, MAT a ste14 mutants are sterile	YDR410C	S000002818
STE18		G protein gamma subunit, forms a dimer with Ste4p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste4p to dampen signaling; C-terminus is palmitoylated and farnesylated, which are required for normal signaling	G protein gamma subunit	The null mutant is viable but sterile. Sst1 sst2 double mutants and scg1 mutants can be suppressed by a null allele of ste18.	YJR086W	S000003846
STE2		Receptor for alpha-factor pheromone; seven transmembrane-domain GPCR that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells	G protein coupled receptor (GPCR)|alpha-factor pheromone receptor		YFL026W	S000001868
STE20		Signal transducing kinase of the PAK (p21-activated kinase) family, involved in pheromone response and pseudohyphal/invasive growth pathways, activated by Cdc42p; binds Ste4p at a GBB motif present in noncatalytic domains of PAK kinases			YHL007C	S000000999
STE23		Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; member of the insulin-degrading enzyme family		effects a-factor secretion and mating by a cells	YLR389C	S000004381
STE24	AFC1|PIO2	Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans	zinc metalloprotease	Null mutant is viable, exhibits a mating efficiency of ~5% that of a wild-type strain and an a-factor processing defect	YJR117W	S000003878
STE3	DAF2	Receptor for a factor receptor, transcribed in alpha cells and required for mating by alpha cells, couples to MAP kinase cascade to mediate pheromone response; ligand bound receptors are endocytosed and recycled to the plasma membrane; GPCR	G protein coupled receptor (GPCR)|a-factor receptor	The null mutant is viable. Alpha cells lacking STE3 are sterile, but a cells lacking STE3 can mate.	YKL178C	S000001661
STE4	HMD2	G protein beta subunit, forms a dimer with Ste18p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste18p to dampen signaling; may recruit Rho1p to the polarized growth site during mating; contains WD40 repeats	G protein beta subunit		YOR212W	S000005738
STE5	HMD3|NUL3	Pheromone-responsive scaffold protein; shuttles from the nucleus to the plasma membrane and assembles kinases Ste11p, Ste7p, and Fus3p into a specific signaling complex; active oligomeric form interacts with Ste4p-Ste18p complex		Null mutant is viable but sterile. Overexpression of STE5 suppresses the temperature sensitivity of a cdc25 allele.	YDR103W	S000002510
STE50		Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction	protein kinase regulator	Null mutant is viable, sterile, has a modulated sensitivity to alpha-pheromone	YCL032W	S000000537
STE6		ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport, contains 12 transmembrane domains and two ATP binding domains, expressed only in MATa cells	mating pheromone transporter	sterility of MATa cells, failure to export a-factor	YKL209C	S000001692
STE7		Signal transducing MAP kinase kinase involved in pheromone response, where it phosphorylates Fus3p, and in the pseudohyphal/invasive growth pathway, through phosphorylation of Kss1p; phosphorylated by Ste11p, degraded by ubiquitin pathway	MAP kinase kinase (MEK)		YDL159W	S000002318
STF1	AIS2	Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein			YDL130W-A	S000007232
STF2		Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein			YGR008C	S000003240
STH1	NPS1	ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p		sth1 mutants exhibit altered centromeric and centromere-proximal chromatin structure and increased missegregation of authentic chromosomes; conditional mutants arrest at large bud stage with a single nucleus; null is inviable.	YIL126W	S000001388
STI1		Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones; activates the ATPase activity of Ssa1p; homolog of mammalian Hop protein	co-chaperone	Null mutant is viable but shows slow growth at high or low temperatures; shows synthetic interactions with hsp82, cpr7, kin28 and sba1	YOR027W	S000005553
STL1		Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock		Null mutant is viable, no growth defects on galactose, mannose, maltose, or glycerol.	YDR536W	S000002944
STM1	MPT4	Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations	purine motif triplex-binding protein	Null mutant is viable; overexpression of STM1 suppresses some phenotypes of pop2 null mutations and the temperature sensitivity of tom1 and htr1 mutants. Cells lacking Stm1 display deficiency in the apoptosis-like cell death process induced by treatment with low concentrations of H2O2. Survival is increased when Stm1 is completely missing from the cells or when inhibition of Stm1 synthesis permits proteasomal degradation to decrease its amount in the cell. Stm1 accumulation induces cell death.	YLR150W	S000004140
STN1		Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping			YDR082W	S000002489
STO1	CBC1|CBP80|GCR3|SUT1	Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80	Large subunit of the nuclear cap-binding protein complex	defective growth on fermentable carbon sources and supression of top1-hpr1	YMR125W	S000004732
STP1	BAP1|SSY2	Transcription factor, activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing		null is viable, but causes reduced efficiency of SUP4-mediated suppression, and is also sensitive to sulfonylurea herbicides on complex media (YPD); multiple copies enhance the suppression of SUP4(G37)	YDR463W	S000002871
STP2		Transcription factor, activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes			YHR006W	S000001048
STP22	VPS23	Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype			YCL008C	S000000514
STP3		Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids			YLR375W	S000004367
STP4		Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p			YDL048C	S000002206
STP52				Ste pseudorevertants		S000029527
STR2		Cystathionine gamma-synthase, converts cysteine into cystathionine	cystathionine gamma-synthase	Null mutant is viable but unable to turn cysteine into homocysteine. Grows when supplied with cystathionine.	YJR130C	S000003891
STR3		Cystathionine beta-lyase, converts cystathionine into homocysteine	cystathionine beta-lyase	Null mutant is viable but unable to turn cysteine into homocysteine. No growth when supplied with cystathionine.	YGL184C	S000003152
STRP		Transmembrane protein with a highly basic C-terminal region				S000029679
STS1	DBF8|SSM5	Protein that interacts with the karyopherin Srp1p; may have a role with Srp1p in ubiquitin-mediated protein degradation			YIR011C	S000001450
STT3		Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; forms a subcomplex with Ost3p and Ost4p and is directly involved in catalysis		Null mutant is inviable. sst3 mutants are defective in protein glycosylation, sensitive to hygromycin B, and resistant to sodium orthovanadate. Depletion of the STT3 protein results in loss of oligosaccharyl transferase activity in vivo and a deficiency in the assembly of oligosaccharyl transferase complex.	YGL022W	S000002990
STT4		Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization	phosphatidylinositol 4-kinase	Null mutant is viable, has an osmoremedial phenotype, staurosporine sensitive, stt4 mutations can be suppressed by overexpression of PKC1/STT1 or MSS4, Bleomycin sensitive	YLR305C	S000004296
STU1		Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles		Null mutant shows defects in spindle assembly.	YBL034C	S000000130
STU2		Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p			YLR045C	S000004035
STV1		Subunit of vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole	V-ATPase V0 sector subunit a	Null mutant is viable, displays additive phenotypes in combination with vph1 null mutations	YMR054W	S000004658
SUA2		Suppressor of upstream AUG		sua2 mutations suppress an aberrant ATG codon in the leader region of cyc1		S000029528
SUA3		Suppressor of upstream AUG		sua3 mutations suppress an aberrant ATG codon in the leader region of cyc1		S000029529
SUA4		Suppressor of upstream AUG		sua4 mutations suppress an aberrant ATG codon in the leader region of cyc1		S000029530
SUA5		Protein required for respiratory growth; null mutation suppresses the Cyc1p translation defect caused by the presence of an aberrant ATG codon upstream of the correct start		Null mutant is viable, lack cytochrome a/a3, suppresses a cyc1 mutation and confers slow growth, fails to grow on lactate or glycerol	YGL169W	S000003137
SUA7	SOH4	Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II	TFIIB		YPR086W	S000006290
SUB1	TSP1	Transcriptional coactivator, facilitates elongation by influencing enzymes that modify RNAP II, acts in a peroxide resistance pathway involving Rad2p; suppressor of TFIIB mutations	transcriptional coactivator	Null mutant is viable, auxotrophic for inositol; high copy suppressor of SUA7 (TFIIB) mutations. Overexpression of SUB1 stimulates transcription by some types of activators in vivo	YMR039C	S000004642
SUB2		Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56	ATP-dependent RNA helicase	Null mutant is inviable; sub2 allele suppresses cold-sensitive snRNP phenotype of brr1-1	YDL084W	S000002242
SUC1		Invertase, sucrose hydrolyzing enzyme; six closely related but non-identical invertase genes have been described in yeast (SUC1-5, 7) but only SUC2 is in the reference strain (S288C)	invertase	Sucrose fermentation		S000029531
SUC2		Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively	invertase	Null mutant is viable but cannot ferment sucrose	YIL162W	S000001424
SUC3		Invertase, sucrose hydrolyzing enzyme; six closely related but non-identical invertase genes have been described in yeast (SUC1-5, 7) but only SUC2 is in the reference strain (S288C)	invertase			S000029532
SUC4	SUC6	Invertase, sucrose hydrolyzing enzyme; six closely related but non-identical invertase genes have been described in yeast (SUC1-5, 7) but only SUC2 is in the reference strain (S288C)	invertase			S000029533
SUC5		Invertase, sucrose hydrolyzing enzyme; six closely related but non-identical invertase genes have been described in yeast (SUC1-5, 7) but only SUC2 is in the reference strain (S288C)	invertase	Sucrose fermentation		S000029534
SUC7		Invertase, sucrose hydrolyzing enzyme; six related but non-identical invertase genes have been described in yeasat (SUC1-5, 7) but only SUC2 is in strain S288C; unlike the other forms of invertase, Suc7p is unable to hydrolyze raffinose	invertase	Sucrose fermentation		S000029535
SUE1		Mitochondrial protein required for degradation of unstable forms of cytochrome c		Null: Lack of degradation of abnormal cytochrome c.	YPR151C	S000006355
SUF1		tRNA-Gly	tRNA-Gly	suppression of frameshift mutation		S000006592
SUF10		tRNA-Pro		suppression of frameshift mutation		S000006679
SUF11		tRNA-Pro	tRNA-Pro	suppression of frameshift mutation		S000006688
SUF15				suppression of frameshift mutation		S000029536
SUF16		tRNA-Gly	tRNA-Gly	suppression of frameshift mutation		S000006575
SUF17		tRNA-Gly	tRNA-Gly	suppression of frameshift mutation		S000006587
SUF18				suppression of frameshift mutation		S000029537
SUF19				suppression of frameshift mutation		S000029538
SUF2		tRNA-Pro		suppression of frameshift mutation		S000006678
SUF20		tRNA-Gly	tRNA-Gly	suppression of frameshift mutation		S000006579
SUF21				suppression of frameshift mutation		S000029539
SUF22				suppression of frameshift mutation		S000029540
SUF23				suppression of frameshift mutation		S000029541
SUF24				suppression of frameshift mutation		S000029542
SUF25				suppression of frameshift mutation		S000029543
SUF3		tRNA-Gly	tRNA-Gly	suppression of frameshift mutation		S000006572
SUF4		tRNA-Gly	tRNA-Gly	suppression of frameshift mutation		S000006590
SUF5		tRNA-Gly	tRNA-Gly	suppression of frameshift mutation		S000006573
SUF6		tRNA-Gly	tRNA-Gly	suppression of frameshift mutation		S000006591
SUF7		tRNA-Pro	tRNA-Pro	suppression of frameshift mutation		S000006684
SUF76				suppression of frameshift mutation		S000029544
SUF8		tRNA-Pro	tRNA-Pro	suppression of frameshift mutation		S000006682
SUF9		tRNA-Pro	tRNA-Pro	suppression of frameshift mutation		S000006681
SUH1				suppression of his2-1		S000029545
SUH2				suppression of his2-1		S000029546
SUI1	MOF2|RFR1	Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase	translation initiation factor eIF1		YNL244C	S000005188
SUI2		Alpha subunit of the translation initiation factor eIF2, involved in the identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP	translation initiation factor eIF-2 alpha subunit	suppression of initiator codon mutations	YJR007W	S000003767
SUI3		Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding	translation initiation factor eIF-2 beta subunit	suppression of initiator codon mutations	YPL237W	S000006158
SUL1	SFP2	High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates		Null mutant unable to grow on media containing less than 5 mM sulfate.	YBR294W	S000000498
SUL2		High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates	sulfate permease		YLR092W	S000004082
SUL3		Sulfate uptake		selenate resistant		S000029547
SUM1		Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; involved in telomere maintenance, regulated by the pachytene checkpoint		Restores silencing at HML and HMR in presence of sir2, sir3 and sir4 mutants	YDR310C	S000002718
SUN4	SCW3	Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family			YNL066W	S000005010
SUP-1A				high copy number suppressor of amber nonsense mutations		S000029700
SUP11		tRNA-Tyr		suppression of nonsense mutations		S000006779
SUP111				recessive omnipotent nonsense repressor		S000029548
SUP112				recessive omnipotent nonsense repressor		S000029549
SUP113				recessive omnipotent nonsense repressor		S000029550
SUP139				suppression of nonsense mutations		S000029551
SUP15				suppression of nonsense mutations		S000029552
SUP150				suppression of nonsense mutations		S000029553
SUP154				suppression of nonsense mutations		S000029554
SUP155				suppression of nonsense mutations		S000029555
SUP16	SUQ5	tRNA-Ser		suppression of ochre nonsense mutations		S000006736
SUP160				suppression of nonsense mutations		S000029557
SUP165				suppression of nonsense mutations		S000029558
SUP17		tRNA-Ser		suppression of UGA nonsense mutations		S000006735
SUP19	SUP20	tRNA-Ser	tRNA-Ser	suppression of UGA nonsense mutations		S000006734
SUP2		tRNA-Tyr				S000006778
SUP22				suppression of nonsense mutations		S000029559
SUP25				suppression of nonsense mutations		S000029560
SUP26				suppression of nonsense mutations		S000029561
SUP27				suppression of nonsense mutations		S000029562
SUP28			leucine-inserting UAA suppressors	suppression of nonsense mutations		S000029563
SUP29	SUP30			suppression of nonsense mutations		S000029564
SUP3		tRNA-Tyr	tRNA-Tyr	suppression of nonsense mutations		S000006785
SUP33				suppression of nonsense mutations		S000029565
SUP35	GST1|PNM2|SAL3|SUF12|SUP2|SUP36|[PSI(+)]|[PSI]	Translation termination factor eRF3; altered protein conformation creates the [PSI(+)] prion, a dominant cytoplasmically inherited protein aggregate that alters translational fidelity and creates a nonsense suppressor phenotype	translation termination factor eRF3	accumulation of large budded cells and substantial arrest of DNA synthesis at the nonpermissive temperature (arrests at G(sub)1/S transition); omnipotent suppressor of nonsense mutations	YDR172W	S000002579
SUP37				suppression of nonsense mutations		S000029566
SUP4		tRNA-Tyr	tRNA-Tyr	Many alleles suppress ochre (UAA) nonsense mutations		S000006782
SUP40				suppression of nonsense mutations		S000029567
SUP42				suppression of nonsense mutations		S000029568
SUP43				suppression of nonsense mutations		S000029569
SUP45	SAL4|SUP1|SUP47	Polypeptide release factor involved in translation termination; mutant form acts as a recessive omnipotent suppressor	eRF1	The null mutant is inviable. Other mutant alleles produce a variety of phenotypes which can include: omnipotent nonsense suppression, osmotic sensitivity, benomyl sensitivity, paromomycin sensitivity, and novobiocin resistance.	YBR143C	S000000347
SUP5		tRNA-Tyr		suppression of nonsense mutations		S000006783
SUP50				suppression of nonsense mutations		S000029570
SUP51	SUP52	tRNA-Leu	tRNA-Leu	suppression of amber nonsense mutations		S000006650
SUP53		tRNA-Leu	tRNA-Leu	suppression of amber nonsense mutations		S000006637
SUP54		tRNA-Leu	tRNA-Leu	suppression of amber nonsense mutations		S000006640
SUP56		tRNA-Leu	tRNA-Leu	suppression of nonsense mutations		S000006636
SUP57				suppression of nonsense mutations		S000029571
SUP58				suppression of nonsense mutations		S000029572
SUP6		tRNA-Tyr	tRNA-Tyr	suppression of ochre nonsense mutations		S000006780
SUP61		tRNA-Ser	tRNA-Ser	suppression of nonsense mutations		S000006730
SUP7		tRNA-Tyr		suppression of nonsense mutations		S000006781
SUP71				suppression of nonsense mutations		S000029573
SUP72				suppression of nonsense mutations		S000029574
SUP73				suppression of nonsense mutations		S000029575
SUP74				suppression of nonsense mutations		S000029576
SUP75				suppression of nonsense mutations		S000029577
SUP76				suppression of nonsense mutations		S000029578
SUP77	SUP166			suppression of nonsense mutations		S000029579
SUP78				suppression of nonsense mutations		S000029580
SUP79				suppression of nonsense mutations		S000029581
SUP8		tRNA-Tyr	tRNA-Tyr	suppression of nonsense mutations		S000006784
SUP80				suppression of nonsense mutations		S000029582
SUP85				suppression of nonsense mutations		S000029583
SUP86				suppression of nonsense mutations		S000029584
SUP87				suppression of nonsense mutations		S000029585
SUP88				suppression of nonsense mutations		S000029586
SUPX						S000029587
SUPY						S000029588
SUR1	BCL21|CSG1|LPE15	Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p		Null mutant is viable, calcium sensitive at 37 degrees C on YPD but calcium tolerant at 26 degrees C, accumulates greatly reduced levels of several mannosylated sphingolipids; sur1 mutations have been isolated based on their ability to suppress certain phenotype of rvs161 mutants including reduced viability upon starvation and sensitivies to unrelated drugs; SUR1 is a high copy suppressor of the calcium sensitivity of csg2 mutants	YPL057C	S000005978
SUR2	SYR2	Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis	sphingosine hydroxylase	Null mutant has altered phospholipid levels; suppressor of rvs161 and rvs167 mutations.	YDR297W	S000002705
SUR3		Suppressor of rvs161 and rvs167 mutations		sur3 mutants exhibit dumbell-like morphology in stationary phase, and an overall decrease of the phospholipid amounts and modifications in the relative contents of some phospholipid classes		S000029589
SUR4	APA1|ELO3|SRE1|VBM1	Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis	elongase	Null mutants is viable, not sensitive to UV or gamma radiation. sur4 mutants suppress rad3, rvs161 delta, and rvs167 mutations. sur4 fen1 mutants and sur4 elo2 mutants are inviable.	YLR372W	S000004364
SUR7		Putative integral membrane protein; component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants		Null mutant is viable, exhibits no growth defects on non-fermentable carbon sources or sensitivites to 3-AT or high salt	YML052W	S000004516
SUS1		Protein involved in mRNA export coupled transcription activation; component of the SAGA histone acetylase complex			YBR111W-A	S000028510
SUT1		Transcription factor of the Zn[II]2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression			YGL162W	S000003130
SUT2		Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p			YPR009W	S000006213
SUV3	LPB2	ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs		Deletion of SUV3 leads to a variety of disturbances in mtRNA metabolism and results in respiratory incompetence.	YPL029W	S000005950
SVF1	SGI1	Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis		Null: Mutants with insertion of a mini transposon near the start codon in the ORF are viable and suppress growth inhibion caused by cellular phosphorylated sphingoid bases.	YDR346C	S000002754
SVL1		Styryl dye vacuolar localization				S000029591
SVL10		Styryl dye vacuolar localization		svl10 mutants contain very large vacuoles and mislocalize vacuolar vital dyes		S000029592
SVL11		Styryl dye vacuolar localization		svl11 mutants contain very large vacuoles and mislocalize vacuolar vital dyes		S000029593
SVL12		Styryl dye vacuolar localization		the svl12 mutant exhibits a exhibits a temperature sensitive vacuolar staining defect in which there is punctuate and diffuse staining of the vacuolar vital dye FM4-64		S000029594
SVL13		Styryl dye vacuolar localization				S000029595
SVL3		Protein of unknown function, mutant phenotype suggests a potential role in vacuolar function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck		the svl3 mutant has large vacuoles and exhibits a temperature sensitive vacuolar staining defect	YPL032C	S000005953
SVL4		Styryl dye vacuolar localization		the svl4 mutant contains very large vacuoles and mislocalizes vacuolar vital dyes		S000029596
SVL5		Styryl dye vacuolar localization		svl5 mutants exhibit punctuate and diffuse staining of the vacuolar vital dye FM4-64		S000029597
SVL8		Styryl dye vacuolar localization		svl8 mutants exhibit punctuate and diffuse staining of the vacuolar vital dye FM4-64 and exhibits defects in uptake and sorting of phosphatidylcholine and phosphatidylethanolamine		S000029598
SVL9		Styryl dye vacuolar localization		svl9 mutants have fragmented vacuoles and mislocalize vacuolar vital dyes		S000029599
SVP26	ERV26	Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment			YHR181W	S000001224
SVS1		Cell wall and vacuolar protein, required for wild-type resistance to vanadate		Null mutant is viable, shows increased sensitivity to vanadate, but not other metallic ions or drugs	YPL163C	S000006084
SWA2	AUX1|BUD24	Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles		Null mutant is viable but exhibits endocytosis and late Golgi defects.	YDR320C	S000002728
SWC3	SWC1	Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae			YAL011W	S000000009
SWC4	EAF2|GOD1	Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex			YGR002C	S000003234
SWC5	AOR1	Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A		Null: Cold-sensitive; Benomyl hypersensitive; Latrunculin-A hypersensitive	YBR231C	S000000435
SWC7	AWS1	Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin			YLR385C	S000004377
SWD1	CPS50|FUN16|SAF49	Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7	COMPASS (complex proteins associated with Set1p) component	Null: defective in silencing of expression of genes located near telomeres; hydroxyurea sensitive.	YAR003W	S000000064
SWD2	CPS35|SAF37	Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination	COMPASS (complex proteins associated with Set1p) component		YKL018W	S000001501
SWD3	CPS30|SAF35	Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5	COMPASS (complex proteins associated with Set1p) component	Null: defective in silencing of expression of genes located near telomeres; hydroxyurea sensitive.	YBR175W	S000000379
SWE1	WEE1	Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate	tyrosine kinase	Null mutant is viable. <br>Defective for morphogenesis checkpoint	YJL187C	S000003723
SWF1	PSL10	Palmitoyltransferase that acts on the SNAREs Snc1p, Syn8p, Tlg1p and likely on all SNAREs; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion		Profilin synthetic lethal	YDR126W	S000002533
SWH1	OSH1|YAR044W	Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction			YAR042W	S000000081
SWI1	ADR6|GAM3|LPA1	Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2	transcription factor	null mutants are deficient in homothallic switching, unable to fully derepress ADH2 expression	YPL016W	S000005937
SWI3	TYE2	Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2	transcription factor		YJL176C	S000003712
SWI4	ART1	DNA binding component of the SBF complex (Swi4p-Swi6p), a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair	transcription factor	Null mutant is viable, deficient in homothallic switching, and temperature sensitive	YER111C	S000000913
SWI5		Transcription factor that activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase	transcriptional activator	homothallic switching deficient	YDR146C	S000002553
SWI6	PSL8|SDS11	Transcription cofactor, forms complexes with DNA-binding proteins Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; localization regulated by phosphorylation; potential Cdc28p substrate	transcription factor	Null mutant is viable and deficient in homothallic switching	YLR182W	S000004172
SWM1		Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation		Null mutant completes meiotic nuclear division but does not show spore wall maturation	YDR260C	S000002668
SWP1		Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum	oligosaccharyl transferase glycoprotein complex, delta subunit	lethal	YMR149W	S000004757
SWP82		Member of the SWI/SNF chromatin remodeling complex in which it plays an as yet unidentified role; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p			YFL049W	S000001845
SWR1		Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A		Null: Null mutant is viable and shows no growth defects; swr1 rat8-2 and swr1 rsc9-1double mutants has a slow growth phenotype; SWR1 is a partial High copy suppressor of pse1-1 kap123	YDR334W	S000002742
SWS2		Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency		Null mutant is viable but causes slight growth defect, sporulation defect; similar to S. pombe 40S mitochondrial ribosomal protein; expression of GFP fusion increases on YPGE.	YNL081C	S000005025
SWT1		Putative protein of unknown function; predicted to contain a PINc domain (PilT N terminus)			YOR166C	S000005692
SXM1	KAP108	Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1		Null mutant is viable, does not exhibit growth defects at any temperature examined or exhibit marked defects in tRNA processing	YDR395W	S000002803
SYC1		Subunit of the APT subcomplex of cleavage and polyadenylation factor, may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs			YOR179C	S000005705
SYF1	NTC90	Component of the spliceosome complex involved in pre-mRNA splicing; involved in regulation of cell cycle progression; similar to Drosophila crooked neck protein			YDR416W	S000002824
SYF2	NTC31	Component of the spliceosome complex involved in pre-mRNA splicing; involved in regulation of cell cycle progression			YGR129W	S000003361
SYG1		Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency			YIL047C	S000001309
SYL39		Protein synthetically lethal to Cdc12p				S000029600
SYM1		Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17		Null: fails to grow on ethanol or acetaldehyde at 37 degrees. Other phenotypes: partiallay respiration-defective at 37 degrees	YLR251W	S000004241
SYN8	SLT2|UIP2	Endosomal SNARE related to mammalian syntaxin 8			YAL014C	S000000012
SYP1	YCR029C-A	Protein with a potential role in actin cytoskeletal organization; overexpression suppresses a pfy1 (profilin) null mutation			YCR030C	S000000626
SYS1		Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation		Null mutant is viable. sys1 ypt6 double mutant displays enhanced defects in vacuolar sorting and cell growth	YJL004C	S000003541
SYT1		Guanine nucleotide exchange factor (GEF) for Arf proteins; involved in vesicular transport; suppressor of ypt3 mutations; member of the Sec7-domain family			YPR095C	S000006299
TAD1		tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala	tRNA-specific adenosine deaminase		YGL243W	S000003212
TAD2		Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs	tRNA-specific adenosine deaminase subunit		YJL035C	S000003572
TAD3		Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs	tRNA-specific adenosine deaminase subunit		YLR316C	S000004308
TAF1	TAF130|TAF145	TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation, has histone acetyltransferase activity, involved in promoter binding and G1/S progression	TafII130|TafII145	Null mutant is inviable, taf145 (ts) mutants arrest as small unbudded cells with a G0 like morphology at the nonpermissive temperature|Mutations in region 4 (amino acid residues 199 to 303) confer both temperature-conditional (ts) growth phenotypes and transcription defects.	YGR274C	S000003506
TAF10	TAF23|TAF25	Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification	TFIID subunit|TafII25		YDR167W	S000002574
TAF11	TAF40	TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors	TFIID subunit|TafII40		YML015C	S000004477
TAF12	TAF61|TAF68	Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A	TFIID subunit|TafII61|TafII68		YDR145W	S000002552
TAF13	FUN81|TAF19	TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors	TFIID subunit|TafII19		YML098W	S000004564
TAF14	ANC1|SWP29|TAF30|TFG3	Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes, involved in RNA polymerase II transcription initiation and in chromatin modification; contains a YEATS domain	TafII30|transcription initiation factor TFIIF small subunit	Null mutant is viable but has a depolarized actin cytoskeleton.	YPL129W	S000006050
TAF2	TAF150|TSM1	TFIID subunit (150 kDa), involved in RNA polymerase II transcription initiation	TATA binding protein-associated factor|TafII150		YCR042C	S000000638
TAF3	TAF47	TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation	TAF(II) complex component|TafII47		YPL011C	S000005932
TAF4	MPT1|TAF48|TSG2	TFIID subunit (48 kDa), involved in RNA polymerase II transcription initiation; potential Cdc28p substrate	TFIID subunit|TafII48		YMR005W	S000004607
TAF5	TAF90	Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification	TafII90		YBR198C	S000000402
TAF6	TAF60	Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4	TATA-binding protein-associated-factor|TafII60		YGL112C	S000003080
TAF7	TAF67	TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation	TFIID subunit|TafII67		YMR227C	S000004840
TAF8	TAF65	TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation	TFIID subunit|TafII65		YML114C	S000004582
TAF9	TAF17	Subunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3	TFIID subunit|TafII17		YMR236W	S000004849
TAH1		HSP90 cofactor; interacts with Hsp82p, Pih1p, Rvb1 and Rvb2, contains a single TPR domain with at least two TPR motifs			YCR060W	S000000656
TAH11	CDT1|SID2	DNA replication licensing factor, required for pre-replication complex assembly		Mutants lose minichromosomes in ARS number-dependent manner. tah11-1 mutant hypersensitive to hydroxyurea, camptothecin when overexpressing wild-type TOP1. Cells partially depleted of TAH11 replicate DNA from fewer origins; fully-depleted cells fail to load Mcm2 on chromatin, fail to initiate but not elongate DNA synthesis.	YJR046W	S000003807
TAH18		Protein with a potential role in DNA replication; displays synthetic lethal genetic interaction with the pol3-13 allele of POL3, which encodes DNA polymerase delta		tah18-1 mutant is hypersensitive to hydroxyurea, camptothecin when overexpressing wild-type TOP1, and has a slow growth phenotype	YPR048W	S000006252
TAL1		Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate	transaldolase		YLR354C	S000004346
TAM41	MMP37	Mitochondrial protein involved in protein import into the mitochondrial matrix; maintains the functional integrity of the TIM23 protein translocator complex; viability of null mutant is strain-dependent; mRNA is targeted to the bud			YGR046W	S000003278
TAN1		Putative tRNA acetyltransferase, RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA			YGL232W	S000003201
TAO3	PAG1	Protein involved in cell morphogenesis and proliferation, associated with protein kinase Cbk1p; mutants activate OCH1 transcription		tao3 mutants activate OCH1 transcription and form aggregates. Null mutant is viable in the W303 background	YIL129C	S000001391
TAP42		Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits			YMR028W	S000004630
TAR1	YLR154W-A	Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand			YLR154W-C	S000028422
TAT1	VAP1	Amino acid transport protein for valine, leucine, isoleucine, and tyrosine, low-affinity tryptophan and histidine transporter; overexpression confers FK506 resistance	tyrosine transporter	overexpression confers resistance to the volatile anesthetic isoflurane.	YBR069C	S000000273
TAT2	LTG3|SAB2|SCM2|TAP2	High affinity tryptophan and tyrosine permease, overexpression confers FK506 resistance	tryptophan transporter	suppressor of chromosome segregation mutation	YOL020W	S000005380
TAX4		Protein involved in regulation of phosphatidylinositol 4,5-bisphosphate concentrations; Irs4p and Tax4p bind and activate the phosphatase Inp51p			YJL083W	S000003619
TAZ1		Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; similar to human tafazzin, which is implicated in Barth syndrome			YPR140W	S000006344
TBF1	LPI16	Telobox-containing general regulatory factor; binds to TTAGGG repeats within subtelomeric anti-silencing regions (STARs) and possibly throughout the genome and mediates their insulating capacity by blocking silent chromatin propagation	TTAGGG repeat binding factor	lethal	YPL128C	S000006049
TBS1		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YBR150C	S000000354
TCB1		Lipid-binding protein containing three calcium and lipid binding domains; non-tagged protein localizes to mitochondria and GFP-fusion protein localizes to the cell periphery; C-termini of Tcb1p, Tcb2p and Tcb3p interact			YOR086C	S000005612
TCB2		Bud-specific protein with a potential role in membrane trafficking; GFP-fusion protein migrates from the cell surface to intracellular vesicles near vacuole; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud via the mRNA transport system involving She2p			YNL087W	S000005031
TCB3		Lipid-binding protein, localized to the bud via specific mRNA transport; non-tagged protein localizes to mitochondria and GFP-fusion protein localizes to the cell periphery; C-termini of Tcb1p, Tcb2p and Tcb3p interact			YML072C	S000004537
TCM62		Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone		Null mutant is viable but cannot grow on minimal glycerol medium and exhibits slow growth on rich glycerol medium.	YBR044C	S000000248
TCO89		Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complex that regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin		Null: Caffeine Sensitivity.	YPL180W	S000006101
TCP1	CCT1	Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in maintenance of actin cytoskeleton; homolog to Drosophila melanogaster and mouse tailless complex polypeptide	chaperonin subunit alpha		YDR212W	S000002620
TDH1	GLD3	Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall	glyceraldehyde-3-phosphate dehydrogenase	Null mutant is viable, tdh1 tdh2 and tdh1 tdh3 double mutants grow at wild type rates when ethanol is used as a carbon source	YJL052W	S000003588
TDH2	GLD2	Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall	glyceraldehyde 3-phosphate dehydrogenase	Null mutant is viable, grow poorly on glucose, grow as well as wild-type on ethanol media, tdh2 tdh3 double deletion mutants are inviable	YJR009C	S000003769
TDH3	GLD1|HSP35|HSP36|SSS2	Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall	glyceraldehyde-3-phosphate dehydrogenase		YGR192C	S000003424
TDP1		Tyrosyl-DNA Phosphodiesterase I, hydrolyzes 3'-phosphotyrosyl bonds to generate 3'-phosphate DNA and tyrosine, involved in the repair of DNA lesions created by topoisomerase I			YBR223C	S000000427
TEA1		Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein		Diminished Ty1 expression	YOR337W	S000005864
TEC1	ROC1	Transcription factor required for full Ty1 epxression, Ty1-mediated gene activation, and haploid invasive and diploid pseudohyphal growth; TEA/ATTS DNA-binding domain family member	TEA/ATTS DNA-binding domain family transcription factor		YBR083W	S000000287
TEF1	EF-1 alpha	Translational elongation factor EF-1 alpha; also encoded by TEF2; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes	translation elongation factor EF-1 alpha		YPR080W	S000006284
TEF2	EF-1 alpha	Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes	translation elongation factor EF-1 alpha		YBR118W	S000000322
TEF4	EFC1	Translation elongation factor EF-1 gamma	translation elongation factor EF-1 gamma		YKL081W	S000001564
TEL1		Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; homolog of human ataxia telangiectasia (ATM) gene	phosphatidylinositol kinase		YBL088C	S000000184
TEL2		Essential DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect	telomere binding protein	point mutant has shorter-than-normal telomeres; there is a long (150 generation) lag time for phenotypic expression	YGR099W	S000003331
TEM1		GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis	GTP-binding protein	Null mutant is inviable; net1-1 can suppress the lethality of a tem1 deletion by enabling Clb2p degradation and Sic1p accumulation; tem1-3 temperature sensitive mutants arrest in late anaphase with large buds, an elongated spindle and separated DNA; overexpression of CDC15, CDC5, SIC1, SPO12, and CDC14 can suppress the ts growth defects of tem1-3; overexpression of CLB2 is toxic to tem1-3 mutants at permissive temperature; deletion of cfi1 suppresss the temperature sensitivity of tem1-1 mutants	YML064C	S000004529
TEN1		Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p			YLR010C	S000004000
TEP1		Homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 that has lipid phosphatase activity and is linked to the phosphatidylinositol signaling pathway; plays a role in normal sporulation			YNL128W	S000005072
TES1	PTE1	Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids	acyl-CoA thioesterase		YJR019C	S000003780
TEX1		Protein involved in mRNA export, component of the transcription export (TREX) complex			YNL253W	S000005197
TFA1		TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening	transcription factor tfIIE large subunit		YKL028W	S000001511
TFA2		TFIIE small subunit, involved in RNA polymerase II transcription initiation	transcription factor TFIIE subunit		YKR062W	S000001770
TFB1		Subunit of TFIIH and nucleotide excision repair factor 3 complexes, required for nucleotide excision repair, target for transcriptional activators	transcription initiation factor TFIIH subunit		YDR311W	S000002719
TFB2		Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH	transcription initiation factor TFIIH subunit	Null mutant is inviable; a c-terminal deletion mutant is associated with defects in nucleotide excision repair (as demonstrated by UV sensitivity	YPL122C	S000006043
TFB3	RIG2	Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit	transcription initiation factor TFIIH subunit		YDR460W	S000002868
TFB4		Subunit of TFIIH complex, involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p	transcription initiation factor TFIIH subunit		YPR056W	S000006260
TFB5		Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation; homolog of the Chlamydomonas reinhardtii REX1-S protein which is involved in DNA repair	transcription initiation factor TFIIH subunit		YDR079C-A	S000007603
TFC1		One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63	tau 95 subunit of transcription factor TFIIIC	lethal	YBR123C	S000000327
TFC3	FUN24|TSV115	Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding	tau 138 subunit of transcription factor TFIIIC		YAL001C	S000000001
TFC4	PCF1	One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102	tau 131 subunit of transcription factor TFIIIC		YGR047C	S000003279
TFC6		One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110	tau 91 subunit of transcription factor TFIIIC		YDR362C	S000002770
TFC7		One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes	tau 55 subunit of transcription factor TFIIIC		YOR110W	S000005636
TFC8		One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90	tau 60 subunit of transcription factor TFIIIC		YPL007C	S000005928
TFG1	RAP74|SSU71	TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74	transcription factor TFIIF large subunit	Mutating the Fcp1p-binding motif KEFGK in Tfg1p to EEFGE led to both synthetic phenotypes in certain fcp1tfg1 double mutants and a reduced ability of Fcp1p to activate transcription when it is artificially tethered to a promoter.	YGR186W	S000003418
TFG2		TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30	transcription initiation factor TFIIF middle subunit		YGR005C	S000003237
TFP1	CLS8|VMA1	Vacuolar ATPase V1 domain subunit A containing the catalytic nucleotide binding sites; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease	V-ATPase V1 sector subunit A	Null mutant is viable, resistant to trifluoperazine, grows slowly under non-acidic conditions and on glycerol and is cold, temperature, and cation-sensitive	YDL185W	S000002344
TFP3	CLS9|VMA11	Vacuolar ATPase V0 domain subunit c', involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen	V-ATPase V0 sector subunit c'	Null mutant is viable, defective in vacuolar acidification, high copy TFP3 confers resistance to trifluoperazine	YPL234C	S000006155
TFS1	DKA1	Carboxypeptidase Y inhibitor, function requires acetylation by the NatB N-terminal acetyltransferase; phosphatidylethanolamine-binding protein involved in protein kinase A signaling pathway	supressor of a cdc25 mutation		YLR178C	S000004168
TGA1		alanine tRNA				S000029601
TGL1	YKL5	Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes	cholesterol esterase|triglyceride lipase		YKL140W	S000001623
TGL2		Protein with lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli; role in yeast lipid degradation is unclear	triglyceride lipase	Null mutant is viable, exhibits no apparent phenotype	YDR058C	S000002465
TGL3		Triacylglycerol lipase of the lipid particle, responsible for all the TAG lipase activity of the lipid particle; contains the consensus sequence motif GXSXG, which is found in lipolytic enzymes	triacylglycerol lipase		YMR313C	S000004930
TGL4	STC1	Triacylglycerol lipase involved in triacylglycerol mobilization and degradation; found in lipid particles; potential Cdc28p substrate	triacylglycerol lipase		YKR089C	S000001797
TGL5	STC2	Triacylglycerol lipase involved in TAG mobilization; localizes to lipid particles; potential Cdc28p substrate	triacylglycerol lipase		YOR081C	S000005607
TGS1		Trimethyl guanosine synthase, conserved nucleolar methyl transferase responsible for conversion of the m(7)G cap structure of snRNAs and snoRNAs to m(2,2,7)G; also required for ribosome synthesis and nucleolar morphology			YPL157W	S000006078
THG1		tRNAHis guanylyltransferase, adds a guanosine residue to the 5' end of tRNAHis after transcription and RNase P cleavage; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotes			YGR024C	S000003256
THI11		Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13			YJR156C	S000003917
THI12		Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13			YNL332W	S000005276
THI13		Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13			YDL244W	S000002403
THI2	PHO6	Zinc finger protein of the Zn(II)2Cys6 type, probable transcriptional activator of thiamine biosynthetic genes	transcriptional activator	Null mutant is viable, demonstrates thiamine auxotrophy, reduced expression of thiamine biosynthetic genes	YBR240C	S000000444
THI20		Multifunctional protein with both hydroxymethylpyrimidine kinase and thiaminase activities; involved in thiamine biosynthesis and also in thiamine degradation; member of a gene family with THI21 and THI22; functionally redundant with Thi21p		null mutant is viable; the double deletion of YOL055c and YPL258c renders the cells auxotrophic for thiamine	YOL055C	S000005416
THI21		Hydroxymethylpyrimidine phosphate kinase, involved in the last steps in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p		null mutant is viable; the double deletion of YOL055c and YPL258c renders the cells auxotrophic for thiamine	YPL258C	S000006179
THI22		Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis			YPR121W	S000006325
THI3	KID1	Probable decarboxylase, required for expression of enzymes involved in thiamine biosynthesis; may have a role in catabolism of amino acids to long-chain and complex alcohols	alpha-ketoisocaproate decarboxylase		YDL080C	S000002238
THI4	ESP35|MOL1	Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability		Null mutant is viable, auxotrophic for thiamine	YGR144W	S000003376
THI5		Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13	thiamine regulated pyrimidine precursor biosynthesis enzyme	Null: null mutant viable, no phenotype; thi5, thi11,thi12, thi13 quadruple mutant shows hydroxymethyl pyrimidine auxotrophy	YFL058W	S000001836
THI6		Bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities, required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern	hydroxyethylthiazole kinase|thiamine-phosphate pyrophosphorylase		YPL214C	S000006135
THI7	THI10	Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia	thiamine transporter	Null mutant is viable, thi7 mutants are pyrithiamine resistant and cordycepin resistant	YLR237W	S000004227
THI71	YOR29-22	Transporter of thiamine or related compound; shares sequence similarity to Thi7p; proposed to be involved in 5-fluorocytosine sensitivity			YOR071C	S000005597
THI72		Transporter of thiamine or related compound; shares sequence similarity with Thi7p			YOR192C	S000005718
THI73		Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs			YLR004C	S000003994
THI74		Mitochondrial transporter repressible by thiamine			YDR438W	S000002846
THI80		Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate)	thiamin pyrophosphokinase		YOR143C	S000005669
THO1		Protein of unknown function; overproduction suppresses the transcriptional defect caused by an hpr1 mutation		Null mutant is viable; wild-type levels of transcription and recombination; overexpression of THO1 suppresses the temperature-sensitive phenotype of hpr1-delta mutants and their incapacity to transcribe lacZ sequences.	YER063W	S000000865
THP1	BUD29	Nuclear pore-associated protein, forms a complex with Sac3p that is involved in transcription and in mRNA export from the nucleus; contains a PAM domain implicated in protein-protein binding		Null mutant is viable and shows transcription-associated hyper-recombination and transcription elongation impairment, and is unable to transcribe the bacterial lacZ ORF	YOL072W	S000005433
THP2		Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance		null mutant is viable, hyper-recombination between direct repeats dependent on transcription elongation, transcription elongation impairment, inability to properly transcribe lacZ sequences	YHR167W	S000001210
THR1		Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway	homoserine kinase	Null mutant is viable, threonine auxotroph	YHR025W	S000001067
THR4		Threonine synthase, conserved protein that catalyzes formation of threonine from 0-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway	threonine synthase	threonine requiring	YCR053W	S000000649
THS1		Threonyl-tRNA synthetase, essential cytoplasmic protein	threonyl-tRNA synthetase		YIL078W	S000001340
TID3	HEC1|NDC80	Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering			YIL144W	S000001406
TIF1		Translation initiation factor eIF4A, identical to Tif2p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G	translation initiation factor eIF4A subunit	viable, tif1tif2 double mutant is lethal	YKR059W	S000001767
TIF11		Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3	translation initiation factor eIF1A		YMR260C	S000004873
TIF2		Translation initiation factor eIF4A, identical to Tif1p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G	translation initiation factor eIF4A subunit	viable, tif1tif2 double mutant is lethal	YJL138C	S000003674
TIF3	RBL3|STM1	Translation initiation factor eIF-4B, has RNA annealing activity; contains an RNA recognition motif and binds to single-stranded RNA	translation initiation factor eIF4B		YPR163C	S000006367
TIF34		Subunit of the core complex of translation initiation factor 3(eIF3), which is essential for translation	translation initiation factor eIF3 subunit		YMR146C	S000004754
TIF35		Subunit of the core complex of translation initiation factor 3(eIF3), which is essential for translation	translation initiation factor eIF3 subunit		YDR429C	S000002837
TIF4631		Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); homologous to Tif4632p	mRNA cap binding protein eIF-4F	Null mutant is viable, grows slowly and is cold-sensitive. tif4631 tif4632 double deletion mutants are inviable	YGR162W	S000003394
TIF4632		Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); homologous to Tif4631p	eIF-4F mRNA cap-binding complex subunit	Null mutant is viable; tif4631 tif4632 double disruption mutants are inviable	YGL049C	S000003017
TIF5	SUI5	Translation initiation factor eIF-5; N-terminal domain functions as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP; C-terminal domain is the core of ribosomal preinitiation complex formation	translation initiation factor eIF5		YPR041W	S000006245
TIF6	CDC95	Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits		Null mutant is inviable; cells are depleted of 60S ribosomal subunits, translation initiation is inhibited, and cells arrest in G1	YPR016C	S000006220
TIM11	ATP21	Subunit e of mitochondrial F1F0-ATPase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric state of ATP synthase	F1F0 ATP synthase subunit e		YDR322C-A	S000007255
TIM13		Mitochondrial intermembrane space protein, forms a complex with TIm8p that mediates import and insertion of a subset of polytopic inner membrane proteins; may prevent aggregation of incoming proteins in a chaperone-like manner			YGR181W	S000003413
TIM17	MIM17|MPI2|SMS1	Essential constituent of the mitochondrial inner membrane presequence translocase; interacts with Pam18p to recruit the presequence translocase-associated motor (PAM complex) and also required for protein sorting during import			YJL143W	S000003679
TIM18		Component of the mitochondrial Tim54p-Tim22p complex involved in insertion of polytopic proteins into the inner membrane; may function to stabilize the complex	translocase		YOR297C	S000005823
TIM21	FMP17	Constituent of the mitochondrial inner membrane presequence translocase (TIM23 complex); may regulate protein import by binding to both the translocase of the outer membrane (TOM) and presequence-associated motor (PAM) complexes			YGR033C	S000003265
TIM22		Component of the mitochondrial Tim54p-Tim22p complex involved in insertion of polytopic proteins into the inner membrane			YDL217C	S000002376
TIM44	ISP45|MIM44|MPI1	Peripheral mitochondrial membrane protein involved in mitochondrial protein import, tethers essential chaperone Ssc1p to the translocon channel at the matrix side of the inner membrane			YIL022W	S000001284
TIM50		Constituent of the mitochondrial inner membrane presequence translocase (TIM23 complex); may promote binding of incoming precursor proteins to the intermembrane space domain of Tom22p during translocation			YPL063W	S000005984
TIM54		Component of the mitochondrial Tim54p-Tim22p complex involved in insertion of polytopic proteins into the inner membrane		Null mutant is inviable; the tim54-1 allele is temperature-sensitive and at the nonpermissive temperature is defective in the insertion of proteins into the mitochondrial inner membrane.	YJL054W	S000003590
TIM8		Mitochondrial intermembrane space protein mediating import and insertion of polytopic inner membrane proteins; homolog of human DDP1 (deafness dystonia peptide 1) which is mutated in the X-linked Mohr-Tranebjaerg syndrome			YJR135W-A	S000007348
TIM9		Mitochondrial intermembrane space protein, forms a complex with Mrs11p/Tim10p that mediates import and insertion of a subset of polytopic inner membrane proteins; may prevent aggregation of incoming proteins in a chaperone-like manner			YEL020W-A	S000007256
TIP1		Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins	cell wall mannoprotein	Null mutant is viable; exhibits increased sensitivity to calcoflour white and congo red	YBR067C	S000000271
TIP20	TIP1	Peripheral membrane protein required for fusion of COPI vesicles with the ER, prohibits back-fusion of COPII vesicles with the ER, may act as a sensor for vesicles at the ER membrane	transport protein that interacts with Sec20p; required for protein transport from the endoplasmic reticulum to the golgi apparatus		YGL145W	S000003113
TIP41		Protein that interacts physically and genetically with Tap42p, which regulates protein phosphatase 2A; component of the TOR (target of rapamycin) signaling pathway		Homozygous null mutants did not sporulate, showed resistance to benomyl; homozygous and haploid deletants were sensitive to thiabendazol	YPR040W	S000006244
TIR1	SRP1	Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking			YER011W	S000000813
TIR2	SRP2	Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis			YOR010C	S000005536
TIR3	YIB1	Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth	cell wall mannoprotein	inviable under unaerobic conditions	YIL011W	S000001273
TIR4		Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock	cell wall mannoprotein	inviable under anaerobic conditions	YOR009W	S000005535
TIS11	CTH2	mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis		Null mutant is viable but alters metabolism that is reflected by a pH change on YPD plates.	YLR136C	S000004126
TKL1		Transketolase, similar to Tkl2p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids	transketolase	tkl1 tkl2 mutants are auxotrophic for aromatic amino acids	YPR074C	S000006278
TKL2		Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids	transketolase	tkl1 tkl2 mutants are auxotrophic for aromatic amino acids	YBR117C	S000000321
TLC1	TER1	TLC1 RNA contains a template sequence that Est2p uses to add irregular repeats of TG(1-3) residues onto a DNA end; RNA template component of telomerase	RNA template component of telomerase	when wild-type is expressed at high copy, suppresses telomeric silencing		S000006657
TLG1		Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p	tSNARE that affects a late Golgi compartment	Endocytosis defect and loss of Kex2p in SEY6210 background; Deletion may be lethal in some genetic backgrounds	YDR468C	S000002876
TLG2		Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation	tSNARE that affects a late Golgi compartment	Null mutant is viable in SEY6210, exhibits endocytosis defect and loss of Kex2p	YOL018C	S000005378
TMA10	RBF9	Protein of unknown function that associates with ribosomes			YLR327C	S000004319
TMA108	RBF108	Protein that associates with ribosomes; putative metalloprotease			YIL137C	S000001399
TMA16	RBF17	Protein of unknown function that associates with ribosomes			YOR252W	S000005778
TMA17		Protein of unknown function that associates with ribosomes			YDL110C	S000002268
TMA19	MMI1|RBF18	Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress			YKL056C	S000001539
TMA20	RBF20	Protein of unknown function that associates with ribosomes and has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1			YER007C-A	S000002957
TMA22	RBF22	Protein of unknown function that associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; has homology to human protein DRP1, which interacts with human Tma20p homolog MCT-1			YJR014W	S000003775
TMA23	YMR268W-A	Nucleolar protein of unknown function implicated in ribosome biogenesis; TMA23 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes		null has both reduced growth and reduced protein synthesis rates	YMR269W	S000004882
TMA29		NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments			YMR226C	S000004839
TMA46	RBF46	Protein of unknown function that associates with ribosomes; interacts with GTPase Rbg1p			YOR091W	S000005617
TMA64	RBF64	Protein of unknown function that associates with ribosomes; has a putative RNA binding domain			YDR117C	S000002524
TMA7	RBF7	Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin			YLR262C-A	S000007246
TMN2		Multispanning membrane protein of unknown function			YDR107C	S000002514
TMN3		Non-essential golgi localized protein of unknown function; contains niine potential transmembrane domains and has similarity to the endosomal protein, Emp70p			YER113C	S000000915
TMR4		revertant of tom1 ts mutant				S000029602
TMR7		revertant of tom1 ts mutant				S000029603
TMS1		Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance			YDR105C	S000002512
TMT1	TAM1	Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle			YER175C	S000000977
TNA1		High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)	nicotinic acid permease	Null mutant is viable; the deletion of both YGR260W and YJR025C/BNA1 is lethal at low external nicotinic acid concentration	YGR260W	S000003492
TOA1		TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to largest and second largest subunits of human and Drosophila TFIIA	transcription factor IIA subunit alpha	Null mutant is inviable. Overexpression of TFIIA partially suppresses an spt3 delta mutation. toa1 mutants have Spt-phenotypes. spt3 delta toa1 double mutants are inviable.	YOR194C	S000005720
TOA2		TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA	transcription factor IIA subunit	Null mutant is inviable. Overexpression of TFIIA partially suppresses an spt3 delta mutation.	YKL058W	S000001541
TOF1		Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase			YNL273W	S000005217
TOF2		Nonessential mitochondrial protein of unknown function with sequence similarity to Net1p; identified as a topoisomerase I (Top1p) binding protein; displays synthetic genetic interactions with TOP1 and HPR1		Null mutant is viable and has no obvious phenotypes; tof2-hpr1 double mutant shows poor growth	YKR010C	S000001718
TOK1	DUK1|YKC1|YORK|YPK1	Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin	potassium channel	Null mutant is viable, lacks potassium current<br>resistant to K1 Killer Toxin	YJL093C	S000003629
TOM1		E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators		Null mutant is viable and temperature sensitive, and arrests at the G2/M boundary of the cell cycle	YDR457W	S000002865
TOM20	MAS20|MOM19	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins	20 kDa mitochondrial outer membrane protein import receptor		YGR082W	S000003314
TOM22	MAS17|MAS22|MOM22	Component of the TOM (translocase of outer membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between the TOM and TIM complexes	mitochondrial import receptor protein		YNL131W	S000005075
TOM40	ISP42|MOM38	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore		Null mutant is inviable; cells accumulate uncleaved mitochondrial precursor proteins	YMR203W	S000004816
TOM5	MOM8A	Small mitochondrial outer membrane protein crucial to a binding relay for the import of proteins into mitochondria; subunit on the outer mouth of the TOM channel that accepts precursors from the receptors Tom20p and Tom22p		Null mutant is viable but is temperature-sensitive and shows defects in import of mitochondrial preproteins; synthetically lethal with tom6, tom7, tom20, tom37, and tom70	YPR133W-A	S000006433
TOM6	ISP6|MOM8B	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex	protein translocation complex component	Null mutant is viable, associated with a delay of import of preproteins, stabilization of preprotein binding to receptors and the general insertion pore, and destabilization of the interaction between receptors and the general insertion pore; tom6 tom40 double mutants are inviable.	YOR045W	S000005571
TOM7	MOM7|YOK22	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex	translocase of the outer mitochondrial membrane		YNL070W	S000005014
TOM70	MAS70|MOM72|OMP1	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins	70 kDa mitochondrial specialized import receptor of the outer membrane	Null mutant is viable but exhibits defects in mitochondrial import	YNL121C	S000005065
TOM71	TOM72	Mitochondrial outer membrane protein with similarity to Tom70p; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins	protein translocase 71 kDa component of the outer membrane of mitochondria	Null mutant is viable, shows slight decrease in growth on non-fermentable carbon sources at 37C and minimal effects upon the import of Tom70-depenedent preproteins into mitochondria	YHR117W	S000001159
TOP1	MAK1|MAK17	Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination	topoisomerase I		YOL006C	S000005366
TOP2	TOR3|TRF3	Essential type II topoisomerase, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis	topoisomerase II	Null mutant is inviable; top2 mutants arrest at the mononucleate stage, Rec- mutants suppress the meiosis I block, suggesting TOP2 resolves recombinant chromosomes	YNL088W	S000005032
TOP3	EDR1	DNA Topoisomerase III, conserved protein that functions in a complex with Sgs1p and Rmi1p to relax single-stranded negatively-supercoiled DNA preferentially, involved in telomere stability and regulation of mitotic recombination	DNA topoisomerase III	Null mutant exhibits a genomic instability phenotype that includes slow growth, hyper-sensitivity to genotoxic agents, mitotic hyper-recombination, increased chromosome missegregation, and meiotic failure. top3 is RAD1-dependent hyper-Rec in mitosis, suggesting that top3 damage is channeled to the recombination repair pathway by RAD1; TOP3 is required for sporulation.	YLR234W	S000004224
TOR1	DRR1	PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis		Null mutant is viable, grows slowly; rapamycin resistance, tor1 tor2 double mutant is inviable	YJR066W	S000003827
TOR2	DRR2	PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis		Null mutant is inviable, exhibits disruption of the polarized distribution of the actin cytoskeleton during the cell cycle; tor2-1 allele confers rapamycin resistance	YKL203C	S000001686
TOS1		Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C			YBR162C	S000000366
TOS2		Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p			YGR221C	S000003453
TOS3		Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome			YGL179C	S000003147
TOS4		Transcription factor that binds to a number of promoter regions, particularly promoters of some genes involved in pheromone response and cell cycle; potential Cdc28p substrate; expression is induced in G1 by bound SBF			YLR183C	S000004173
TOS8		Homeodomain-containing transcription factor; SBF regulated target gene that in turn regulates expression of genes involved in G1/S phase events such as bud site selection, bud emergence and cell cycle progression; similarity to Cup9p			YGL096W	S000003064
TPA1		Protein of unknown function; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; has a role in translation termination efficiency, mRNA poly(A) tail length and mRNA stability			YER049W	S000000851
TPC1		Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family	thiamine pyrophosphate transporter		YGR096W	S000003328
TPD3	FUN32	Regulatory subunit A of the heterotrimeric protein phosphatase 2A, which also contains regulatory subunit Cdc55p and either catalytic subunit Pph21p or Pph22p; required for cell morphogenesis and for transcription by RNA polymerase III	protein phosphatase 2A regulatory subunit A	Null mutant is viable, defective in cytokinesis at reduced temperatures, defective in transcription by RNA polymerase III at elevated temperatures; nocodazole sensitive and exhibits phenotypes of previously identified kinetochore/spindle checkpoint mutants	YAL016W	S000000014
TPI1		Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region	triosephosphate isomerase		YDR050C	S000002457
TPK1	PKA1|SRA3	cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk2p and Tpk3p		multicopy suppression of ras mutant	YJL164C	S000003700
TPK2	PKA2|PKA3|YKR1	cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk1p and Tpk3p	cAMP-dependent protein kinase catalytic subunit	Null mutant haploids are defective for invasive growth; diploid homozygous null mutants are defective for pseudohyphal growth.	YPL203W	S000006124
TPK3		cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk1p and Tpk2p	cAMP-dependent protein kinase catalytic subunit	Null mutant is viable, tpk1 tpk2 tpk3 triple mutant is inviable	YKL166C	S000001649
TPM1		Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently	tropomyosin|tropomyosin I	Null mutant is viable, grows slowly, exhibits cell size heterogeneity, has delocalized deposition of chitin, mates poorly; exhibits loss of actin cables	YNL079C	S000005023
TPM2		Minor isoform of tropomyosin, binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p	tropomyosin|tropomyosin isoform II	Null mutant is viable, exhibits no detectable phenotype; tpm1 tpm2 double deletion mutants are inviable; TPM2 overexpression does not suppress tpm1 mutant phenotypes	YIL138C	S000001400
TPN1		Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p	pyridoxine transporter		YGL186C	S000003154
TPO1		Polyamine transporter that recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane			YLL028W	S000003951
TPO2		Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily			YGR138C	S000003370
TPO3		Polyamine transport protein specific for spermine; localizes to the plasma membrane; member of the major facilitator superfamily			YPR156C	S000006360
TPO4		Polyamine transport protein, recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane; member of the major facilitator superfamily			YOR273C	S000005799
TPO5		Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles			YKL174C	S000001657
TPP1		DNA 3'-phosphatase that functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; has similarity to the l-2-haloacid dehalogenase superfamily	DNA 3' phosphatase		YMR156C	S000004765
TPS1	BYP1|CIF1|FDP1|GGS1|GLC6|TSS1	Synthase subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway	trehalose-6-phosphate synthase/phosphatase complex 56 kDa synthase subunit	null is viable, but does not grow on glucose and/or fructose,and shows lack of trehalose	YBR126C	S000000330
TPS2	HOG2|PFK3	Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway	trehalose-6-phosphate phosphatase	Null mutant is viable, exhibits complete loss of trehalose-6-phosphate phosphatase activity, measured in vitro, and accumulation of excessive amounts of trehalose-6-phosphate instead of trehalose upon heat shock or entrance into stationary phase in vivo; null mutant is temperature sensitive, tps2 (pfk3) pfk1 double mutants are glucose negative	YDR074W	S000002481
TPS3		Regulatory subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway	trehalose-6-phosphate synthase/phosphatase complex 115 kDa regulatory subunit		YMR261C	S000004874
TPT1		tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide	tRNA 2'-phosphotransferase		YOL102C	S000005462
TRA1		Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation	NuA4 histone acetyltransferase subunit		YHR099W	S000001141
TRE1		Plasma membrane protein that binds to Bsd2p and regulates ubiquitylation and vacuolar degradation of the metal transporter Smf1p; function is redundant with that of Tre2p; has similarity to transferrin receptors			YPL176C	S000006097
TRE2		Protein that functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; has similarity to transferrin receptors; inviability of null mutant in systematic studies is due to proximity to CDC31			YOR256C	S000005782
TRF5		Poly (A) polymerase involved in nuclear RNA quality control based on: homology with Trf4p, genetic interactions with TRF4 mutants, physical interaction with Mtr4p (TRAMP subunit), and by direct assay; disputed role as a sigma DNA polymerase	DNA polymerase sigma		YNL299W	S000005243
TRI1		Protein of unknown function with similarity to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; YMR233W is not an essential gene			YMR233W	S000004846
TRK1		Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation	potassium transporter	Null mutant is viable, requires added potassium; trk1 trk2 double mutants are viable	YJL129C	S000003665
TRK2	RPD2	Component of the Trk1p-Trk2p potassium transport system	potassium transporter	Null mutant is viable, requires added potassium; trk1 trk2 double mutants are viable	YKR050W	S000001758
TRL1	LIG1|RLG1	tRNA ligase, required for tRNA splicing; composed of three essential domains containing the phosphodiesterase, polynucleotide kinase, and ligase activities required for ligation; localized at the inner membrane of the nuclear envelope	tRNA ligase		YJL087C	S000003623
TRM1		tRNA methyltransferase, localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments	N2,N2-dimethylguanosine-specific tRNA methyltransferase	An uncharacterized allele affects a specific base modification of both cytoplasmic and mitochondrial tRNA.	YDR120C	S000002527
TRM10		tRNA methyltransferase, methylates the N-1 position of guanosine in tRNAs			YOL093W	S000005453
TRM11		Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain	N2-monomethylguanosine-specific tRNA methyltransferase		YOL124C	S000005484
TRM112		Subunit of an adoMet-dependent tRNA methyltransferase (MTase) complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; putative zinc binding subunit of other MTase-related proteins			YNR046W	S000005329
TRM12	TYW2	S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA	tRNA methyltransferase		YML005W	S000004464
TRM13		2'-O-methyltransferase responsible for modification of tRNA at position 4; exhibits no obvious similarity to other known methyltransferases	tRNA 2'-O-methyltransferase		YOL125W	S000005485
TRM2	NUC2|NUD1|RNC1	tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair	tRNA methyltransferase		YKR056W	S000001764
TRM3		2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs	Gm18 tRNA methyltransferase	Null mutants are defective specifically for Gm18 tRNA ribose methylation	YDL112W	S000002270
TRM5		tRNA(m(1)G37)methyltransferase, methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; highly conserved across Archaea, Bacteria, and Eukarya			YHR070W	S000001112
TRM7		2'-O-ribose methyltransferase, methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop	2'-O-ribose tRNA anticodon loop methyltransferase	Null: slow-growth, translation is impaired, sensitive to paromomycin. Other phenotypes: Point mutation within the AdoMet-binding domain strongly affects the function of the enzyme	YBR061C	S000000265
TRM8		Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA			YDL201W	S000002360
TRM82		Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA			YDR165W	S000002572
TRM9		tRNA methyltransferase, catalyzes the esterification of modified uridine nucleotides in tRNAs, creating 5-methylcarbonylmethyluridine in tRNA(Arg3) and 5-methylcarbonylmethyl-2-thiouridine in tRNA(Glu); may have a role in stress response	mcm5U/mcm5s2U tRNA carboxyl methyltransferase		YML014W	S000004476
TRN1		tRNA-Pro	tRNA-Pro			S000006680
TRP1		Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)	N-(5'-phosphoribosyl)-anthranilate isomerase		YDR007W	S000002414
TRP2		Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p	anthranilate synthase component I	tryptophan requiring	YER090W	S000000892
TRP3		Bifunctional enzyme exhibiting both indole-3-glycerol-phosphate synthase and anthranilate synthase activities, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p	anthranilate synthase component II|indole-3-glycerol-phosphate synthase	Null mutant is viable, tryptophan auxotroph	YKL211C	S000001694
TRP4		Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis	anthranilate phosphoribosyl transferase	tryptophan requiring	YDR354W	S000002762
TRP5		Tryptophan synthase involved in tryptophan biosynthesis, regulated by the general control system of amino acid biosynthesis	tryptophan synthase	Null mutant is viable and requires tryptophan	YGL026C	S000002994
TRR1		Cytoplasmic thioredoxin reductase, key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress	thioredoxin reductase	Null mutant is viable but grow slowly; trr1 mutations are sensitive to hydrogen peroxide and activate Mlu1 cell cycle box (MCB)- and Swi4/Swi6 cell cycle box (SCB)-dependent reporter genes in swi6 null mutants.	YDR353W	S000002761
TRR2		Mitochondrial thioredoxin reductase involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p, contains active-site motif (CAVC) present in prokaryotic thioredoxin reductases, binds NADPH and FAD	thioredoxin reductase	Null mutant is viable, increased sensitivity to hydrogen peroxide	YHR106W	S000001148
TRR4		tRNA-Arg (Arg4), single essential nuclear tRNA gene containing the tDNA-anticodon CCG (presumably CCG in the mature tRNA), decodes CGG codons into arginine, one of 19 nuclear tRNAs for arginine	tRNA-Arg			S000006706
TRS120		One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic			YDR407C	S000002815
TRS130		One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1			YMR218C	S000004831
TRS20		One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; mutations in the human homolog cause the spondyloepiphyseal dysplasia tarda (SEDL) disorder			YBR254C	S000000458
TRS23		One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; human homolog is TRAPPC4			YDR246W	S000002654
TRS31		One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic			YDR472W	S000002880
TRS33		One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic			YOR115C	S000005641
TRT2		tRNA-Thr; tRNA threonine 2	tRNA-Thr			S000006748
TRX1	LMA1	Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against both oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance	thioredoxin reductase	Null mutant is viable; trx1-trx2 double mutant shows prolonged S phase, shortened G(sub)1 and methionine auxotrophy	YLR043C	S000004033
TRX2	LMA1	Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against both oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance	thioredoxin reductase	Null mutant is viable; trx1-trx2 double mutant shows prolonged S phase, shortened G(sub)1 and methionine auxotrophy	YGR209C	S000003441
TRX3		Mitochondrial thioredoxin, highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained by both Trr2p and Glr1p	thioredoxin	Null mutant is viable, normal sensitivity to hydrogen peroxide	YCR083W	S000000679
TRZ1		tRNase Z, involved in RNA processing, has two putative nucleotide triphosphate-binding motifs (P-loop) and a conserved histidine motif, homolog of the human candidate prostate cancer susceptibility gene ELAC2	tRNA 3' processing endoribonuclease		YKR079C	S000001787
TS225						S000029605
TS26		The data suggest that the primary defect of the ts26 mutation is at the initiation step of DNA synthesis		temperature sensitive lethal		S000029606
TS4572						S000029607
TSA1	TPX1|ZRG14	Ubiquitous housekeeping thioredoxin peroxidase, reduces reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; mediates redox regulation of the nuclear localization of Yap1p; deletion results in mutator phenotype	cTPxI|thioredoxin peroxidase	Null mutant is viable, grows slower than wild-type under aerobic conditions	YML028W	S000004490
TSA2		Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants	cTPxII		YDR453C	S000002861
TSC10		3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family	3-ketosphinganine reductase		YBR265W	S000000469
TSC11	AVO3	Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain			YER093C	S000000895
TSC13		Enoyl reductase that catalyzes the last step in each cycle of very long chain fatty acid elongation, localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions, coimmunoprecipitates with elongases Fen1p and Sur4p	enoyl reductase		YDL015C	S000002173
TSC3		Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis		Essential for cell viability only at elevated temperatures. Dominant mutations in Lcb2p subunit of serine palmitoyltransferase suppress temp-sensitive growth phenotype of tsc3 delta null mutant.	YBR058C-A	S000007521
TSF1				tsf1 mutations derepress expression from yeast CYC-GAL hybrid promoters (fused to lacZ) that harbor a variety of operator sequences, activate expression from GAL1 and CYC1 promoters (fused to lacZ) lacking upstream activating sequences.and cause pleiotropic defects in cell growth, mating, and sporulation.		S000029608
TSL1		Large subunit of trehalose 6-phosphate synthase (Tps1p)/phosphatase (Tps2p) complex, which converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose, homologous to Tps3p and may share function	trehalose-6-phosphate synthase/phosphatase complex 123 kDa regulatory subunit		YML100W	S000004566
TSM0039				temperature sensitive lethal		S000029609
TSM0070				temperature sensitive lethal		S000029610
TSM0080				temperature sensitive lethal		S000029611
TSM0111				temperature sensitive lethal		S000029612
TSM0119				temperature sensitive lethal		S000029613
TSM0120				temperature sensitive lethal		S000029614
TSM0139				temperature sensitive lethal		S000029615
TSM0151				temperature sensitive lethal		S000029616
TSM0186				temperature sensitive lethal		S000029617
TSM0225				temperature sensitive lethal		S000029618
TSM0800				temperature sensitive lethal		S000029619
TSM134				temperature sensitive lethal		S000029620
TSM437				temperature sensitive lethal		S000029621
TSM5				temperature sensitive lethal		S000029622
TSM5162				temperature sensitive lethal		S000029623
TSM8740						S000029624
TSR1		Protein required for processing of 20S pre-rRNA in the cytoplasm, associates with pre-40S ribosomal particles		essential	YDL060W	S000002218
TSR2		Protein with a potential role in pre-rRNA processing			YLR435W	S000004427
TTR2				triethyltin resistant, have increased intracellular cytochrome c concentration, increased respiration rate, decreased growth yield, increased growth sensitivity to several drugs inhibiting oxidative phosphorylation: namely, CCCP (permeabilizing inner mitochondrial membrane to protons), valinomycin (permeabilizing inner mitochondrial membrane to potassium) and oligomycin (inhibitor of mitochondrial ATPase), and increased sensitivity to carbon source starvation		S000029625
TTR3				triethyltin resistant, have increased intracellular cytochrome c concentration, increased respiration rate, decreased growth yield, increased growth sensitivity to several drugs inhibiting oxidative phosphorylation: namely, CCCP (permeabilizing inner mitochondrial membrane to protons), valinomycin (permeabilizing inner mitochondrial membrane to potassium) and oligomycin (inhibitor of mitochondrial ATPase), and increased sensitivity to carbon source starvation		S000029626
TUB1		Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules	alpha-tubulin	Null mutant is inviable; heterozygous tub1 null diploids are slow growing and sporulate poorly	YML085C	S000004550
TUB2	ARM10|SHE8	Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules	beta-tubulin	null is inviable; conditional mutants show block of mitotic nuclear migration and chromosome segregation and defects in spindle and/or cytoplasmic microtubules at non-permissive conditions; some mutants are benomyl-hypersensitive	YFL037W	S000001857
TUB3		Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p	alpha-tubulin	Null mutant is viable, hypersensitive to benomyl, exhibits poor spore viability	YML124C	S000004593
TUB4		Gamma-tubulin, involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body	gamma tubulin	Null mutant is inviable. Tub4p-depleted cells arrest during nuclear division; most arrested cells contain a large bud, replicated DNA, and a single nucleus. Immunofluorescence and nuclear staining experiments indicate that cells depleted of Tub4p contain defects in the organization of both cytoplasmic and nuclear microtubule arrays; such cells exhibit nuclear migration failure, defects in spindle formation, and/or aberrantly long cytoplasmic microtubule arrays.	YLR212C	S000004202
TUF1		Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans	Ef-Tu|mitochondrial translation elongation factor	Null mutant is viable, blocks mitochondrial translation and destabilizes mitochondrial genome.	YOR187W	S000005713
TUL1		Golgi-localized RING-finger ubiquitin ligase (E3), involved in ubiquitinating and sorting membrane proteins that contain polar transmembrane domains to multivesicular bodies for delivery to the vacuole for quality control purposes	RING-domain E3 ubiquitin ligase	Null: Blocks ubiquitin-dependent sorting of some proteins (e.g. Cps1p, Phm5p) into multivesicular bodies	YKL034W	S000001517
TUP1	AAR1|AER2|AMM1|CRT4|CYC9|FLK1|ROX4|SFL2|UMR7	General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes		Null mutant is viable; exhibits flocculent colony morphology	YCR084C	S000000680
TUP4				tup4 mutants are permeable to dTMP and display markedly elevated rates of inorganic phosphate transport		S000029627
TUS1	SOP10	Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate		Null mutant is viable; shows temperature sensitive growth above 37 degrees C, but no detectable secretory or endocytosis defect.	YLR425W	S000004417
TVP15		Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p		Null: no notable phenotype	YDR100W	S000002507
TVP18		Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments		Null: no notable phenotype	YMR071C	S000004675
TVP23		Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern		Null: no notable phenotype	YDR084C	S000002491
TVP38		Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern		Null: no notable phenotype	YKR088C	S000001796
TWF1		Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly	twinfilin A, an actin monomer sequestering protein	Null mutant is viable, twf1 null cof1-22 mutants exhibit synthetic lethality	YGR080W	S000003312
TYE1		Required for Ty mediated expression of ADH2		tye1 mutations suppresses transcription of ADH2 when associated with a Ty element, or when ADH2 is controlled by a polyA/T insertion mutation; tye1 mutants are defective in transcription of all Ty1 and Ty2 elements		S000029628
TYE5		Required for Ty mediated expression of ADH2		tye5 mutations suppresses transcription of ADH2 when associated with a Ty element, or when ADH2 is controlled by a polyA/T insertion mutation; tye5 mutants are defective in transcription of all Ty1 and Ty2 elements		S000029629
TYE7	SGC1	Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression		Null mutant is viable; expression of enolase genes is reduced three-fivefold in null mutant; gcr1 tye7 double deletion mutants exhibit additive defects in enolase expression. TYE7 was isolated as a dominant suppressor of gcr1 mutations	YOR344C	S000005871
TYR1		Prephenate dehydrogenase involved in tyrosine biosynthesis, expression is dependent on phenylalanine levels	prephenate dehydrogenase	tyrosine-requiring	YBR166C	S000000370
TYS1	TTS1|TyrRS	Cytoplasmic tyrosyl-tRNA synthetase, class I aminoacyl-tRNA synthetase that aminoacylates tRNA(Tyr), required for cytoplasmic protein synthesis, interacts with positions 34 and 35 of the anticodon of tRNATyr	tyrosyl-tRNA synthetase		YGR185C	S000003417
TYW1		Protein required for the synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions			YPL207W	S000006128
TYW3		Protein required for the synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions			YGL050W	S000003018
UAF30		Subunit of UAF (upstream activation factor), which is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate		Null mutant is viable but exhibits slow growth. A double mutant with top1 is inviable.	YOR295W	S000005821
UBA1		Ubiquitin activating enzyme, involved in ubiquitin-mediated protein degradation and essential for viability	ubiquitin activating enzyme e1		YKL210W	S000001693
UBA2	UAL1	Nuclear protein that acts as a heterodimer with Aos1p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability			YDR390C	S000002798
UBA3		Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern	ubiquitin-like protein activating enzyme	Null mutant is viable with no obvious phenotypes. Synthetically lethal with cdc34(ubc3) ts mutant	YPR066W	S000006270
UBA4	YHR1	Protein that activates Urm1p before its conjugation to proteins (urmylation); one target is the thioredoxin peroxidase Ahp1p, suggesting a role of urmylation in the oxidative stress response			YHR111W	S000001153
UBC1		Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response	ubiquitin-conjugating enzyme	Null mutant is viable but exhibit moderately slow growth.	YDR177W	S000002584
UBC11		Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2			YOR339C	S000005866
UBC12		Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes		Null mutant is viable with no obvious phenotypes. Synthetically lethal with cdc34(ubc3) ts mutant	YLR306W	S000004297
UBC13		Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus	ubiquitin-conjugating enzyme	Deletion results in elevated levels of the DNA damage recognition protein Rad4 and an increase in ubiquitylated Rad23.	YDR092W	S000002499
UBC4		Ubiquitin-conjugating enzyme that mediates degradation of short-lived and abnormal proteins; interacts with E3-CaM in ubiquitinating calmodulin; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response	ubiquitin conjugating enzyme e2	Overexpression confers resistance to methylmercury. The ubc4ubc5 double mutant is temperature sensitive, reduces turnover of short-lived proteins and canavanyl-peptides but not of long-lived proteins.	YBR082C	S000000286
UBC5		Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins, central component of the cellular stress response; expression is heat inducible	ubiquitin-conjugating enzyme	viable, ubc4/ubc5 double mutant is temperature sensitive	YDR059C	S000002466
UBC6	DOA2	Ubiquitin-conjugating enzyme involved in ER-associated protein degradation; located at the cytosolic side of the ER membrane; tail region contains a transmembrane segment at the C-terminus; substrate of the ubiquitin-proteasome pathway	ubiquitin-conjugating enzyme		YER100W	S000000902
UBC8	GID3	Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro	ubiquitin-conjugating enzyme		YEL012W	S000000738
UBC9		SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC)	SUMO-conjugating enzyme		YDL064W	S000002222
UBI4	SCD2|UB14	Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response	poly-ubiquitin|ubiquitin	Null mutant is viable, grows at wild-type rates and contains wild-type levels of free ubiquitin under exponential growth conditions, hypersensitive to high temperatures, starvation and amino acid analogs; although ubi4/UBI4 diploids form initially viable spores, the two ubi4 spores lose viability extremely rapidly; homozygous ubi4/ubi4 diploids are sporulation defective	YLL039C	S000003962
UBP1		Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains	ubiquitin-specific protease	Null mutant is viable. Null yuh1 ubp1 ubp2 ubp3 quadruple mutants are viable and retain the ability to deubiquitinate ubiquitin fusions. UBP1 is a dosage dependent suppressor of rsp5 mutations	YDL122W	S000002280
UBP10	DOT4	Ubiquitin-specific protease that deubiquitinates ubiquitin-protein moieties; may regulate silencing by acting on Sir4p; involved in posttranscriptionally regulating Gap1p and possibly other transporters; primarily located in the nucleus		Null mutant is viable, exhibits decreased telomeric silencing; UBP10(DOT4) overexpression reduces silencing at the HM, rDNA, and telomeric loci	YNL186W	S000005130
UBP11		Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins	ubiquitin-specific protease		YKR098C	S000001806
UBP12		Ubiquitin-specific protease present in the nucleus and cytoplasm that cleaves ubiquitin from ubiquitinated proteins	ubiquitin carboxyl-terminal hydrolase		YJL197W	S000003733
UBP13		Putative ubiquitin-specific protease	ubiquitin carboxyl-terminal hydrolase		YBL067C	S000000163
UBP14	GID6	Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T	ubiquitin-specific protease	Null mutant is viable but show accumulation of free ubiquitin chains, which correlates with defects in ubiquitin-dependent proteolysis; overexpression of mutant or wild-type Ubp14p can inhibit protein degration too	YBR058C	S000000262
UBP15		Ubiquitin-specific protease that may play a role in ubiquitin precursor processing			YMR304W	S000004920
UBP16		Deubiquitinating enzyme anchored to the outer mitochondrial membrane, probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria			YPL072W	S000005993
UBP2		Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins, cleaves at the C terminus of ubiquitin fusions; capable of cleaving polyubiquitin and possesses isopeptidase activity	ubiquitin-specific protease	Null mutant is viable. Null yuh1 ubp1 ubp2 ubp3 quadruple mutants are viable and retain the ability to deubiquitinate ubiquitin fusions.	YOR124C	S000005650
UBP3		Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between endoplasmic reticulum and Golgi compartments; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin	ubiquitin-specific protease	Null mutant is viable. Null yuh1 ubp1 ubp2 ubp3 quadruple mutants are viable and retain the ability to deubiquitinate ubiquitin fusions. Deletion of the UBP3 gene results in markedly improved silencing of genes inserted either near a telomere or at one of the silent mating type loci.	YER151C	S000000953
UBP5		Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neck			YER144C	S000000946
UBP6		Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; deletion causes hypersensitivity to cycloheximide and other toxic compounds			YFR010W	S000001906
UBP7		Ubiquitin-specific protease that cleaves ubiquitin-protein fusions	ubiquitin-specific protease		YIL156W	S000001418
UBP8		Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B			YMR223W	S000004836
UBP9		Ubiquitin-specific protease that cleaves ubiquitin-protein fusions	ubiquitin carboxyl-terminal hydrolase		YER098W	S000000900
UBR1	PTR1	Ubiquitin-protein ligase (E3) that interacts with Rad6p/Ubc2p to ubiquitinate substrates of the N-end rule pathway; binds to the Rpn2p, Rpt1p, and Rpt6p proteins of the 19S particle of the 26S proteasome	ubiquitin-protein ligase	Null mutant is viable, unable to degrade substrates of the N-end rule pathway, partially defective in sporulation	YGR184C	S000003416
UBR2		Cytoplasmic ubiquitin-protein ligase (E3)	ubiquitin-protein ligase (E3)		YLR024C	S000004014
UBS1		Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity		Null mutant is viable but exhibits a synthetic phenotype with temperature-sensitive alleles of cdc34.	YBR165W	S000000369
UBX3		UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern			YDL091C	S000002249
UBX4	CUI1	UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p			YMR067C	S000004671
UBX5		UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p			YDR330W	S000002738
UBX6	CUI2	UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline			YJL048C	S000003584
UBX7	CUI3	UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p			YBR273C	S000000477
UDT1		Involved in transcription of HEM12		Slight accumulation in levels of uroporphyrogen		S000029630
UFD1		Protein that interacts with Cdc48p and Npl4p, involved in recognition of polyubiquitinated proteins and their presentation to the 26S proteasome for degradation; involved in transporting proteins from the ER to the cytosol		Homozygous ufd1-1 mutant diploids exhibit sporulation defects. loss of Ufd1 blocks ER-associated protein degradation at a post-ubiquitination but pre-proteasome step.	YGR048W	S000003280
UFD2		Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3	ubiquitin conjugating factor e4	Null mutant is viable but exhibits increased sensitivity to ethanol stress.	YDL190C	S000002349
UFD4		Ubiquitin-protein ligase (E3) that interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins	ubiquitin ligase e3	Null is viable; defective in proteolysis of fusion proteins containing a 'nonremovable' N-terminal ubiquitin moiety	YKL010C	S000001493
UFE1	YOR29-26	t-SNARE required for ER membrane fusion and vesicular traffic, integral membrane protein that constitutes with Sec20p and Use1p the trimeric acceptor for R/v-SNAREs on Golgi-derived vesicles at the ER; part of Dsl1p complex	t-SNARE (ER)		YOR075W	S000005601
UFO1		F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation	F-box protein	Null mutant is viable and UV sensitive	YML088W	S000004553
UGA1		Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization	4-aminobutyrate aminotransferase|gamma-aminobutyrate (GABA) transaminase		YGR019W	S000003251
UGA2	UGA5	Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm	succinate semialdehyde dehydrogenase	Null mutant is viable but cannot grow with GABA as the only nitrogen source.	YBR006W	S000000210
UGA3		Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus	transcription factor	Null mutant is viable but exhibits defects in activation of UGA1 and UGA4.	YDL170W	S000002329
UGA4		Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane	gamma-aminobutyric acid transporter		YDL210W	S000002369
UGO1		Protein of unknown function; outer membrane component of the mitochondrial fusion machinery; Ugo1p bind directly to Fzo1p and Mgm1p and thereby link these two GTPases during mitochondrial fusion		Null mutant is viable but defective in mitochondrial fusion. Null mutant also exhibits fragmentation of mitochondria, loss of mtDNA, and inviability on nonfermentable carbon sources.	YDR470C	S000002878
UGP1		UDP-glucose pyrophosphorylase (UGPase), catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p	uridinephosphoglucose pyrophosphorylase	Null mutant is inviable, probably due to inability to properly form the cell wall	YKL035W	S000001518
UGX2		Protein of unknown function, transcript accumulates in response to any combination of stress conditions			YDL169C	S000002328
UIP3		Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family			YAR027W	S000000075
UIP4		Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates			YPL186C	S000006107
UIP5		Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates			YKR044W	S000001752
ULA1	ENR2	Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation		Null mutant is viable with no obvious mutant phenotype, is synthetically lethal with cdc34(ubc3) ts mutant, and enhances the phenotypes of cdc4, cdc53, and skp1 mutants	YPL003W	S000005924
ULP1	NIB1	Ubl (ubiquitin-like protein)-specific protease that cleaves Smt3p protein conjugates; specifically required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase	Smt3-specific protease	Null mutant is lethal. Temperature-sensitive mutants accumulate in G2/M at the restrictive temperature|The ulp1-I615N allele results in an accumulation of Smt3-conjugated proteins, shows severe growth defects at permissive temperatures together with a strong hyperrecombination phenotype and is impaired in meiosis.	YPL020C	S000005941
ULP2	SMT4	Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate			YIL031W	S000001293
UME1	WTM3	Negative regulator of meiosis, required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p, Wtm2p	transcriptional modulator	Null mutant is viable, expression of the meiotic gene IME2 in null haploid	YPL139C	S000006060
UME6	CAR80|NIM2|RIM16	Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p	C6 zinc finger URS1-binding protein	Null mutant is viable. Exhibits defects in IME1-dependent activation and repression through URS1 sites. ume6 does not require Mata/Matalpha, starvation, IME1, or IME2 for derepressed expression in mitosis and is epistatic to lethality of IME1 overexpression in haploids.	YDR207C	S000002615
UMP1		Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly	20S proteasome maturation factor	Null mutant is viable, grows slower than wild-type, is hypersensitive to cadmium ions and canavanine, accumulates Ub-protein conjugates; ump1 null homozygous diploids fail to sporulate	YBR173C	S000000377
UNG1		Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus	uracil DNA glycosylase	Null mutant is viable. Strains containing an ung1 mutation have an increased sensitivity to sodium bisulfite and sodium nitrite but a wild-type sensitivity to methyl methanesulfonate, UV light, and drugs that cause depletion of the thymidylate pool.	YML021C	S000004483
UPC2	MOX4	Sterol regulatory element binding protein, induces transcription of sterol transport and biosynthetic genes; involved in the anaerobic induction of DAN/TIR mannoproteins and seripauperins; binucleate zinc cluster protein; Ecm22p homolog	transcription factor	Null mutant is viable; upc2-1 allele shows altered sterol uptake	YDR213W	S000002621
UPF3	SUA6	Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance		Null mutant is viable but shows increased accumulation of mRNA containing a premature stop codon due to mRNA stabilization	YGR072W	S000003304
UPS1		Mitochondrial intermembrane space protein that regulates alternative processing and sorting of Mgm1p and other proteins; required for normal mitochondrial morphology; ortholog of human PRELI			YLR193C	S000004183
URA1		Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid	dihydroorotate dehydrogenase	uracil requiring	YKL216W	S000001699
URA10		One of two orotate phosphoribosyltransferase isozymes (see also URA5) that catalyze the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate	orotate phosphoribosyltransferase		YMR271C	S000004884
URA2		Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP	aspartate transcarbamylase|carbamoyl phosphate synthetase|glutamine amidotransferase	uracil requiring	YJL130C	S000003666
URA3		Orotidine-5'-phosphate (OMP) decarboxylase, catalyzes the sixth enzymatic step in the de novo biosynthesis of pyrimidines, converting OMP into uridine monophosphate (UMP); converts 5-FOA into 5-fluorouracil, a toxic compound	orotidine-5'-phosphate decarboxylase	Null mutant is viable, uracil auxotroph	YEL021W	S000000747
URA4		Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate	dihydroorotase	Null mutant is viable and requires uracil	YLR420W	S000004412
URA5	PYR5	One of two orotate phosphoribosyltransferase isozymes (see also URA10) that catalyze the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate	orotate phosphoribosyltransferase		YML106W	S000004574
URA6	SOC8	Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)	uridylate kinase	uracil requiring	YKL024C	S000001507
URA7		Major CTP synthase isozyme (see also URA8), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis	CTP synthase	Null mutant is viable; ura7 ura8 double deletion mutants are inviable	YBL039C	S000000135
URA8		Minor CTP synthase isozyme (see also URA7), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis	CTP synthase	Null mutant is viable. Double deletion of URA7, which also encodes CTP synthetase, and URA8 is lethal	YJR103W	S000003864
URB1	NPA1	Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit			YKL014C	S000001497
URB2	NPA2	Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis			YJR041C	S000003802
URC2						S000122335
URE2	[URE3]	Nitrogen catabolite repression regulator that acts by inhibition of GLN3 transcription in good nitrogen source; altered form of Ure2p creates [URE3] prion	prion|transcriptional regulator	Null mutant is viable but exhibits defects in nitrogen catabolite repression (NCR), and null mutant diploids are defective in pseudohyphal growth and display an increased incidence of random bud patterns.	YNL229C	S000005173
URH1		Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in recycling pyrimidine deoxy- and ribonucleosides via the pyrimidine salvage pathway	uridine ribohydrolase		YDR400W	S000002808
URK1		Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP	uridine kinase		YNR012W	S000005295
URM1		Ubiquitin-like protein with only weak sequence similarity to ubiquitin; depends on the E1-like activating enzyme Uba4p; molecular function of the Urm1p pathway is unknown, but it is required for normal growth, particularly at high temperature		Null mutant is viable and has temperature-sensitive growth defect at 37 degrees C	YIL008W	S000001270
URN1		Pre-mRNA splicing factor associated with the U2-U5-U6 snRNPs, the RES complex, and the Prp19-associated complex (NTC); null mutation displays synthetic genetic interactions with mutations affecting U2 snRNA and pre-mRNA splicing factors			YPR152C	S000006356
URR1			transcriptional repressor	urr1 mutations suppress snf1 mutations		S000029631
URR3			transcriptional repressor	urr3 mutations suppress snf1 mutations		S000029632
URR4			transcriptional repressor	urr4 mutations suppress snf1 mutations		S000029633
USA1		Protein involved in ER-associated protein degradation (ERAD); component of the Hrd1p complex; interacts with the U1 snRNP-specific protein, Snp1p			YML029W	S000004491
USE1	SLT1	Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p			YGL098W	S000003066
USO1	INT1	Essential protein involved in intracellular protein transport, coiled-coil protein necessary for transport from ER to Golgi; required for assembly of the ER-to-Golgi SNARE complex			YDL058W	S000002216
UTH1		Mitochondrial outer membrane and cell wall localized SUN family member required for mitochondrial autophagy; involved in the oxidative stress response, life span during starvation, mitochondrial biogenesis, and cell death		extension of yeast lifespan	YKR042W	S000001750
UTP10		Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA	U3 snoRNP protein		YJL109C	S000003645
UTP11		Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA	U3 snoRNP protein		YKL099C	S000001582
UTP13		Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA	U3 snoRNP protein		YLR222C	S000004212
UTP14		Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA	U3 snoRNP protein		YML093W	S000004558
UTP15		Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA	U3 snoRNP protein		YMR093W	S000004699
UTP18		Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data	U3 snoRNP protein	Null: lethal. Other phenotypes: required for 18S RNA production	YJL069C	S000003605
UTP20		Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA	U3 snoRNP protein		YBL004W	S000000100
UTP21		Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data	U3 snoRNP protein		YLR409C	S000004401
UTP22		Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data			YGR090W	S000003322
UTP23		Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function	SSU processome protein		YOR004W	S000005530
UTP30		Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data			YKR060W	S000001768
UTP4		Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA	U3 snoRNP protein		YDR324C	S000002732
UTP5		Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA	U3 snoRNP protein		YDR398W	S000002806
UTP6		Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA	U3 snoRNP protein		YDR449C	S000002857
UTP7	KRE31	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA	U3 snoRNP protein	Heterozygous diploid mutant exhibit haploinsufficiency K1 killer toxin resistance	YER082C	S000000884
UTP8		Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA	U3 snoRNP protein		YGR128C	S000003360
UTP9		Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA	U3 snoRNP protein		YHR196W	S000001239
UTR1		ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p)			YJR049C	S000003810
UTR2	CRH2	Cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; putative chitin transglycosidase; glycosylphosphatidylinositol (GPI)-anchored protein localized to the bud neck; has a role in cell wall maintenance			YEL040W	S000000766
UTR4		Protein of unknown function, found in both the cytoplasm and nucleus			YEL038W	S000000764
UTR5		Protein of unknown function; transcription may be regulated by Gcr1p			YEL035C	S000000761
VAB2	VAB31	Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern			YEL005C	S000000731
VAC14		Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p	Activator of Fab1p	Null mutant has extremely enlarged vacuoles, is defective in vacuole membrane scission, has a vacuole acidification defect, and is defective in phosphatidylinositol 3,5 bisphosphate synthesis	YLR386W	S000004378
VAC17	YCL062W	Protein involved in vacuole inheritance; acts as a vacuole-specific receptor for myosin Myo2p	the vacuole-specific receptor of Myo2p, a class V myosin	Null: defective in vacuole inheritance	YCL063W	S000000568
VAC6				Vacuolar segregation defect		S000029634
VAC7		Integral vacuolar membrane protein involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock		Null mutant is viable but shows severely swollen vacuoles, figure-eight morphology, and slow growth at 24 degrees	YNL054W	S000004999
VAC8	YEB3	Phosphorylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions		Defective in vacuole inheritance and aminopeptidase I targeting to the vacuole	YEL013W	S000000739
VAL1			tRNA-Val			S000029635
VAM10	YOR29-19	Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering		Null: Fragmented vacuoles.	YOR068C	S000005594
VAM3	PTH1	Syntaxin-related protein required for vacuolar assembly; functions with Vam7p in vacuolar protein trafficking; member of the syntaxin family of proteins		Null mutant is viable, defective in processing of vacuolar hydrolases.	YOR106W	S000005632
VAM6	CVT4|VPL18|VPL22|VPS39	Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p		Null mutant is viable but exhibits defects in processing vacuolar proteases and in maturation of vacuolar alkaline phosphatase. Mutants also exhibit a defective vacuolar morphology; they contain several small vesicles that stain with vacuolar markers.	YDL077C	S000002235
VAM7	VPS43	Component of the vacuole SNARE complex involved in vacuolar morphogenesis; SNAP-25 homolog; functions with a syntaxin homolog Vam3p in vacuolar protein trafficking		Null mutant is viable, exhibits prominent large vacuoles	YGL212W	S000003180
VAN1	LDB13|VRG7|VRG8	Component of the mannan polymerase I; forms a complex with Mnn9p, which is involved in in mannan synthesis; mutants are vanadate-resistant	dolichyl phosphate-D-mannose:protein O-D-mannosyltransferase	vanadate resistant. van1 is lethal in combination with chs3.	YML115C	S000004583
VAR1	VARI	Mitochondrial ribosomal protein of the small subunit, mitochondrially-encoded; polymorphic in different strains due to variation in number of AAT (asparagine) codons; translated near the mitochondrial inner membrane	mitochondrial ribosomal small subunit component		Q0140	S000007275
VAS1		Mitochondrial and cytoplasmic valyl-tRNA synthetase	mitochondrial valyl-tRNA synthetase|valyl-tRNA synthetase		YGR094W	S000003326
VBA1		Permease of basic amino acids in the vacuolar membrane			YMR088C	S000004694
VBA2		Permease of basic amino acids in the vacuolar membrane			YBR293W	S000000497
VBA3		Permease of basic amino acids in the vacuolar membrane			YCL069W	S000000574
VCX1	HUM1|MNR1	Vacuolar H+/Ca2+ exchanger involved in control of cytosolic Ca2+ concentration; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter	H+/Ca2+ exchanger	Null mutant is viable, sensitive to high Ca2+ conditions	YDL128W	S000002286
VDE	VDE1|YDL184w-a|YDL185W2	Vma1p derived endonuclease;a 50 kDa intein derived from the self-splicing of the Tfp1/Vma1 gene product; has endonuclease activity and cleaves at the TFP1/VMA1 gene to stimulate gene conversion during meiosis.	PI-SceI			S000029636
VEL1		Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants			YGL258W	S000003227
VHR1		Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations	transcription factor		YIL056W	S000001318
VHS1		Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p			YDR247W	S000002655
VHS2		Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p			YIL135C	S000001397
VHS3	YOR29-05	Functionally redundant (see also SIS2) inhibitory subunit of Ppz1p, a PP1c-related ser/thr protein phosphatase Z isoform; synthetically lethal with sis2; putative phosphopantothenoylcysteine decarboxylase involved in coenzyme A biosynthesis			YOR054C	S000005580
VHT1		High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin	H(+)-biotin symporter	reduced biotin uptake, reduced levels of protein biotinylation	YGR065C	S000003297
VID1		vacuolar import and degradation				S000029637
VID21	EAF1	Component of the NuA4 histone acetyltransferase complex			YDR359C	S000002767
VID22		Glycosylated integral membrane protein localized to the plasma membrane; plays a role in fructose-1,6-bisphosphatase (FBPase) degradation; involved in FBPase transport from the cytosol to Vid (vacuole import and degradation) vesicles		Null mutant is viable but exhibits vacuole degradation of cytosolic proteins	YLR373C	S000004365
VID24	GID4	Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; involved in proteasome-dependent catabolite degradation of FBPase		Null mutant is viable, defective in fructose-1,6-bisphosphatase dergadation	YBR105C	S000000309
VID27		Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth		Null mutant is viable but exhibits vacuole degradation of cytosolic proteins	YNL212W	S000005156
VID28	GID5|YIL017W	Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm			YIL017C	S000001279
VID30	GID1	Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); shifts the balance of nitrogen metabolism toward the production of glutamate; localized to the nucleus and the cytoplasm		Null mutant is viable but exhibits vacuolar degradation of cytosolic proteins; mutants are also sensitive to starvation.	YGL227W	S000003196
VIK1		Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion; has similarity to Cik1p		Null mutant is viable and resistant to benomyl	YPL253C	S000006174
VIP1		Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of IP7 by Vip1p is important for phosphate signaling; likely involved in cortical actin cytoskeleton function, by analogy with S. pombe ortholog asp1	inositol pyrophosphate synthase		YLR410W	S000004402
VMA10	YHR039BC|YHR039C-B	Vacuolar H+ ATPase subunit G of the catalytic (V1) sector, involved in vacuolar acidification	V-ATPase V1 sector subunit G	Null mutant is viable, fails to grow on media buffered at pH 7.5, fails to accumulate quinacrine in its vacuole	YHR039C-A	S000002100
VMA13	CLS11	Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase	V-ATPase V1 sector subunit H	Null mutant is viable, V-ATPase complex from null mutants is less stable than from wild-type strains	YPR036W	S000006240
VMA2	ATPSV|VAT2	Subunit B of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; contains nucleotide binding sites; also detected in the cytoplasm	V-ATPase V1 sector subunit B	Null mutant is viable, severely defective for growth in medium buffered at neutral pH	YBR127C	S000000331
VMA21		Integral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)		Null mutant is viable but grows slowly and exhibits increased calcium sensitivity. Null mutants also cannot grow on glycerol or at pH 7.5	YGR105W	S000003337
VMA22	CEV1|VPH6	Integral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)		Null mutant is viable but is defective in vacuolar H(+)-ATPase activity, sensitive to calcium, cyclosporin A, and FK506, and requires calcineurin for viability	YHR060W	S000001102
VMA4		Subunit E of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane	V-ATPase V1 sector subunit E	Null mutant is viable, slow growing, cold-sensitive, thermo-sensitive, and exhibits poor growth on glycerol; fails to grow on media supplemented with 100 mM CaCl2 or ZnCl2	YOR332W	S000005859
VMA42		Required for V-ATPase activity		An uncharacterized mutant allele exhibits pH-conditional growth, increased calcium sensitivity, and the inability to grow on glycerol. In addition, the mutant allele does not accumulate the lysosomotropic dye quinacrine in their vacuoles.		S000029638
VMA43		Required for V-ATPase activity		An uncharacterized mutant allele exhibits pH-conditional growth, increased calcium sensitivity, and the inability to grow on glycerol. In addition, the mutant allele does not accumulate the lysosomotropic dye quinacrine in their vacuoles.		S000029639
VMA44		Required for V-ATPase activity		An uncharacterized mutant allele exhibits pH-conditional growth, increased calcium sensitivity, and the inability to grow on glycerol. In addition, the mutant allele does not accumulate the lysosomotropic dye quinacrine in their vacuoles.		S000029640
VMA5	CSL5|VAT3	Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane	V-ATPase V1 sector subunit C	Null mutant is viable; certain vma5 mutations show allele-specific synthetic lethality with cdc24-ls mutants	YKL080W	S000001563
VMA6		Subunit d of the five-subunit V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found in the endomembrane system; stabilizes VO subunits; required for V1 domain assembly on the vacuolar membrane	V-ATPase V0 sector subunit d	Null mutant is viable, sensitive to media buffered at neutral pH or media containing 100 mM Ca2+	YLR447C	S000004439
VMA7		Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane	V-ATPase V1 sector subunit F	Null mutant is viable, unable to grow on media buffered at pH 7.5, fails to accumulate quinacrine into vacuoles, other subunits of the catalytic sector are not assembled onto the vacuolar membrane	YGR020C	S000003252
VMA8		Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis	V-ATPase V1 sector subunit D	Null mutant is viable, does not grow on media buffered at pH 7.5 and does not show accumulation of quinacrine into its vacuoles; grows slowly, fails to grow on non-fermentable carbon sources	YEL051W	S000000777
VMA9	CWH36|LDB10	Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis	V-ATPase V0 sector subunit e		YCL005W-A	S000028508
VMR1		Protein of unknown function that may interact with ribosomes, based on co-purification experiments; member of the ATP-binding cassette (ABC) family; potential Cdc28p substrate; detected in purified mitochondria in high-throughput studies		Null: multidrug and cadmium sensitivity	YHL035C	S000001027
VPH1		Subunit a of vacuolar-ATPase V0 domain, one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes	V-ATPase V0 sector subunit a	Null mutant is viable, deficient in assembly of vacuolar H(+) ATPase and acidification of the vacuole	YOR270C	S000005796
VPH2	CLS10|VMA12	Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER)		Null mutant is viable, zinc sensitive, defective in vacuolar acidification, calcium-sensitive, respiratory deficient	YKL119C	S000001602
VPS1	GRD1|LAM1|SPO15|VPL1|VPT26	Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, late Golgi-retention of some proteins, regulating peroxisome biogenesis		Null mutant is viable, but is sporulation defective, fails to grow at high temperature and shows abnormal organization of intracellular membranes	YKR001C	S000001709
VPS13	SOI1|VPT2	Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; homologous to human COH1; involved in sporulation, vacuolar protein sorting and protein-Golgi retention			YLL040C	S000003963
VPS15	GRD8|VAC4|VPL19	Myristoylated serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p	serine/threonine protein kinase	defective vacuolar protein localization	YBR097W	S000000301
VPS16	SVL6|VAM9|VPT16	Subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; part of the Class C Vps complex essential for membrane docking and fusion at both the Golgi-to-endosome and endosome-to-vacuole stages of protein transport		Null mutant is viable, has a severe defect in vacuolar protein sorting, is temperature sensitive for growth, displays grossly abnormal vacuolar morphology, and possesses a defect in alpha-factor processing	YPL045W	S000005966
VPS17	PEP21	Subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation		Null mutant is viable, exhibits defect in vacuolar morphology and protein sorting	YOR132W	S000005658
VPS20	CHM6|VPL10|VPT20	Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes			YMR077C	S000004682
VPS21	VPS12|VPT12|YPT21|YPT51	GTPase required for transport during endocytosis and for correct sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog	small GTP-binding protein	Null mutant is viable, temperature-sensitive, missorts multiple vacuolar proteins, accumulate 40-50 nm vesicles, and contain a large vacuole	YOR089C	S000005615
VPS24	DID3	One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway			YKL041W	S000001524
VPS25	VPT25	Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome		Null mutant is viable but a class E vps mutant (missorts vacuolar hydrolases and accumulates late endosomal compartment vacuolar hydrolases and accumulates a late endosomal compartment).	YJR102C	S000003863
VPS27	DID7|GRD11|SSV17|VPL23|VPT27	Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)		required for membrane traffic to the vacuole	YNR006W	S000005289
VPS28	VPT28	Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; involved in transport of precursors for soluble vacuolar hydrolases from the late endosome to the vacuole		Null mutant is viable, shows moderate defects in both biosynthetic traffic and endocytic traffic destined for the vacuole	YPL065W	S000005986
VPS29	PEP11	Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval		Defective for sorting of soluble hydrolases to the vacuole. Mislocalisation of the vacuolar hydrolase sorting receptor Vps10p.	YHR012W	S000001054
VPS3	PEP6|VPL3|VPT17	Cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase		Null mutant is viable, grows slower than wild-type, exhibits altered vacuolar morphology and defects in vacuolar segregation	YDR495C	S000002903
VPS30	APG6|ATG6|VPT30	Protein that forms a membrane-associated complex with Apg14p that is essential for autophagy; involved in a retrieval step of the carboxypeptidase Y receptor, Vps10p, to the late Golgi from the endosome; involved in vacuolar protein sorting		Vacuolar hydrolases sorting receptor Vps10p is mislocalized in vps30 mutants.	YPL120W	S000006041
VPS33	CLS14|MET27|PEP14|SLP1|VAM5|VPL25|VPT33	ATP-binding protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at both the Golgi-to-endosome and endosome-to-vacuole stages of protein transport		temperature sensitive, defective vacuolar morphology and protein localization, methionine auxotroph	YLR396C	S000004388
VPS34	END12|PEP15|VPL7|VPT29	Phosphatidylinositol 3-kinase responsible for the synthesis of phosphatidylinositol 3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p	phosphatidylinositol 3-kinase	temperature sensitive, defective vacuolar protein sorting	YLR240W	S000004230
VPS35	GRD9|VPT7	Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval	retromer complex component	Null mutant is viable, exhibits defects in sorting of vacuolar carboxypeptidase Y, proteinase A, proteinase B, and alkaline phosphatase	YJL154C	S000003690
VPS36	GRD12|VAC3|VPL11	Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome			YLR417W	S000004409
VPS38	VPL17	Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity			YLR360W	S000004352
VPS4	CSC1|DID6|END13|GRD13|VPL4|VPT10	AAA-type ATPase required for efficient late endosome to vacuole transport; catalyzes the release of an endosomal membrane-associated class E VPS protein complex; regulates cellular sterol metabolism; cytoplasmic and endosomal localization	AAA ATPase	Null mutant is viable, exhibits protein sorting and morphological defects	YPR173C	S000006377
VPS41	CVT8|FET2|SVL2|VAM2|VPL20	Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport		Null mutant is viable, associated with fragmented vacuoles, exhibits defective high affinity transport due to impaired Fet3p activity and also exhibits defects in the processing and sorting of multiple vacuolar hydrolases	YDR080W	S000002487
VPS45	STT10|VPL28	Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment		Null mutant is viable, defective in the segregation of vacuolar material into the developing daughter cell, has large central vacuoles	YGL095C	S000003063
VPS5	GRD2|PEP10|VPT5|YOR29-20	Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p		Null mutant missorts and secretes soluble vacuolar proteins, contains fragmented vacuoles, and mislocalizes carboxypeptidase and Vps10p.	YOR069W	S000005595
VPS51	API3|VPS67|WHI6	Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP)  complex to the SNARE Tlg1p		Null: small critical cell size	YKR020W	S000001728
VPS52	SAC2	Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin		Null mutant is viable, cold-sensitive growth phenotype, suppressor of actin mutation; aberrant organization of intracellular actin and deposition of chitin at the cell surface	YDR484W	S000002892
VPS53		Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting		Null mutant is viable but is defective for growth at 37^*C. vps53 null mutants have fragmented vacuoles, missort and secrete CPY, and mislocalize late Golgi membrane proteins to the vacuole.	YJL029C	S000003566
VPS54	CGP1|LUV1|TCS3	Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; potentially phosphorylated by Cdc28p		Null mutant exhibits disrupted vacuole and conditional defects in microtubule assembly and cell growth; accumulates 20-50 acidic vesicles per cell that contain CPY, ALP and VMA subunits; sensitive to Mn, Zn, Cu, high pH, hygromycin, Cd, high temp (37C), low temp (14C) and FK506.	YDR027C	S000002434
VPS55		Late endosomal protein involved in late endosome to vacuole trafficking; functional homolog of human obesity receptor gene-related protein (OB-RGRP)		Null: Defect in maturation of carboxypeptidase Y	YJR044C	S000003805
VPS60	CHM5|MOS10	Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport; required for normal filament maturation during pseudohyphal growth; may function in targeting specific cargo proteins for degradation		Null mutant is viable but a class E vps mutant (missorts vacuolar hydrolases and accumulates late endosomal compartment).	YDR486C	S000002894
VPS61		Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect		Null: CPY secretion	YDR136C	S000002543
VPS62		Vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins			YGR141W	S000003373
VPS63		Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect		Null mutant secretes CPY.	YLR261C	S000004251
VPS64	FAR9	Cytoplasmic protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p, Far7p, Far10p, and Far11p that is involved in pheromone-induced cell cycle arrest; also localized to the endoplasmic reticulum membrane		Null mutant secretes CPY.	YDR200C	S000002608
VPS65		Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 75% of ORF overlaps the verified gene SFH1; deletion causes a vacuolar protein sorting defect		Null mutant secretes CPY.	YLR322W	S000004314
VPS66		Cytoplasmic protein of unknown function involved in vacuolar protein sorting.		Null mutant secretes CPY.	YPR139C	S000006343
VPS68		Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria		Null mutant secretes CPY.	YOL129W	S000005489
VPS69		Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene SRP54; deletion causes a vacuolar protein sorting defect		Null mutant secretes CPY.	YPR087W	S000006291
VPS70		Protein of unknown function involved in vacuolar protein sorting		Null mutant secretes CPY.	YJR126C	S000003887
VPS71	SWC6	Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting		Null mutant secretes CPY.	YML041C	S000004505
VPS72	SWC2	Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting		Null mutant secretes CPY.	YDR485C	S000002893
VPS73		Mitochondrial protein of unknown function involved in vacuolar protein sorting		Null mutant secretes CPY.	YGL104C	S000003072
VPS74	API1	Non-essential protein of unknown function involved in vacuolar protein sorting; belongs to a family of cytosolic Golgi-associated proteins suggesting that it may play a role in secretion; also detected in the nucleus		Null mutant secretes CPY.	YDR372C	S000002780
VPS75		NAP family histone chaperone; binds to histone H3-H4 tetramers and to histone acetyltransferase RTT109; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting		Null mutant secretes CPY.	YNL246W	S000005190
VPS8	FUN15|VPT8	Membrane-associated hydrophilic protein that interacts with the small GTPase, Vps21p, to facilitate soluble vacuolar protein localization; required for localization and trafficking of the CPY sorting receptor; contains a RING finger motif		Null mutant is viable, missorts and secretes vacuolar hydrolases, overexpression of VPS21 partially suppresses vps8 null	YAL002W	S000000002
VPS9	VPL31|VPT9	A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin		Null mutant is viable, exhibits severe vacuolar protein sorting defects and is temperature sensitive	YML097C	S000004563
VPT15		vacuolar protein targeting		An uncharacterized mutant allele exhibits defects in vacuolar protein sorting.		S000029641
VPT3		vacuolar protein targeting		Null mutant is viable but is temperature-sensitive and exhibits defects in vacuolar protein sorting. In addition, null mutants do not acidify the vacuole.		S000029642
VRG4	GOG5|LDB3|VAN2|VIG4	Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi		Null mutant is inviable; mutants exist with defects in Golgi-specific glycosylation, resistance to vanadate, sensitivity to aminoglycosides, and sporulation defects	YGL225W	S000003193
VRP1	END5|MDP2|YLR337W	Proline-rich actin-associated protein involved in cytoskeletal organization and cytokinesis; related to mammalian Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP)	proline-rich protein verprolin	Null mutant is viable but is both temperature and pH sensitive and cannot grow on minimal medium. Null mutant also exhibits depolarization of the actin cytoskeleton.	YLR337C	S000004329
VTA1		Multivesicular body (MVB) protein involved in endosomal protein sorting; binds to Vps20p and Vps4p; may regulate Vps4p function; bindsVps60p and may act at a late step in MVB formation; mutants show class E vacuolar-protein sorting defects		Null: Class E defect in vacuolar protein sorting (accumulates FM4-64, Ste3, Vph1, Pep12 in the class E compartment)	YLR181C	S000004171
VTC1	NRF1|PHM4	Vacuolar transporter chaperon (VTC) involved in distributing V-ATPase and other membrane proteins; together with other VTC proteins, forms a heterotetrameric complex that associates with the SNARE Nyv1p and the V0 sector of the V-ATPase		Null mutant is viable, but exhibits both reduced V-ATPase in the vacuolar membrane and reduced H(+)-ATPase(Pma1p) in the plasma membrane	YER072W	S000000874
VTC2	PHM1	Vacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in protein localization and non-autophagic vacuolar fusion		Null nutant is viable; no polyphosphate accumulation in a vtc2(phm1)/vtc3(phm2) double disruptant	YFL004W	S000001890
VTC3	PHM2	Vacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in non-autophagic vacuolar fusion		Null nutant is viable; no polyphosphate accumulation in a vtc2(phm1)/vtc3(phm2) double disruptant	YPL019C	S000005940
VTC4	PHM3|YJL012C-A	Vacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in non-autophagic vacuolar fusion		Null mutant has been shown to be either inviable, or viable while exhibiting no polyphosphate accumulation	YJL012C	S000003549
VTH1		Putative membrane glycoprotein with strong similarity to Vth2p and Pep1p/Vps10p, may be involved in vacuolar protein sorting		Null mutant is viable; overexpression partially suppresses the sorting defect of a pep1 null mutant.	YIL173W	S000001435
VTH2		Putative membrane glycoprotein with strong similarity to Vth1p and Pep1p/Vps10p, may be involved in vacuolar protein sorting		Null mutant is viable; overexpression of the nearly identical Vth1 partially suppresses the sorting defect of a pep1 null mutant strain.	YJL222W	S000003758
VTI1		Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways	v-SNARE		YMR197C	S000004810
VTP1						S000029643
VTS1		Post-transcriptional gene regulator, RNA-binding protein containing a SAM domain; shows genetic interactions with Vti1p, which is a v-SNARE involved in cis-Golgi membrane traffic		Null is viable and healthy	YOR359W	S000005886
WAR1		Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively			YML076C	S000004541
WBP1		Beta subunit of the oligosaccharyl transferase (OST) glycoprotein complex; required for N-linked glycosylation of proteins in the endoplasmic reticulum	oligosaccharyl transferase glycoprotein complex, beta subunit	lethal	YEL002C	S000000728
WHI2		Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression			YOR043W	S000005569
WHI3		RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci; cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start		Null mutant is viable and defective in filamentous growth	YNL197C	S000005141
WHI4		Putative RNA binding protein and partially redundant Whi3p homolog that regulates the cell size requirement for passage through Start and commitment to cell division		Null mutant increases severity of the Whi phenotype of whi3.	YDL224C	S000002383
WHI5		Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1	transcriptional repressor	Null: small critical cell size	YOR083W	S000005609
WRS1	HRE342	Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA	tryptophanyl-tRNA synthetase		YOL097C	S000005457
WSC2	STA3	Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response		Null mutant is viable and shows no phenotypes; slg1 (wsc1)-null wsc2-null double mutant shows a lysis defect on YPD at room temperature and heat shock sensitivity; overexpression of WSC genes suppresses heat shock sensitivity of hyperactivated ras mutant; heat shock sensitivity of wsc mutant strain is suppressed by deletion of ras2	YNL283C	S000005227
WSC3		Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity; involved in the response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis		Null mutant is viable and shows no phenotypes; slg1 (wsc1)-null WSC3-null double mutant shows a lysis defect on YPD at room temperature and heat shock sensitivity; overexpression of WSC genes suppresses heat shock sensitivity of hyperactivated ras mutant; heat shock sensitivity of wsc mutant strain is suppressed by deletion of ras2	YOL105C	S000005465
WSC4	YFW1|YHC8	ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3			YHL028W	S000001020
WSS1		Sumoylated protein of unknown function, identified based on genetic interactions with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response, processing stalled or collapsed replication forks			YHR134W	S000001176
WTM1		Transcriptional repressor involved in regulation of meiosis and silencing, required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats	transcriptional modulator		YOR230W	S000005756
WTM2		Transcriptional repressor involved in regulation of meiosis and silencing; contains WD repeats	transcriptional modulator		YOR229W	S000005755
WWM1		WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes Gi phase growth arrest and clonal death that is suppressed by overexpression of MCA1		Other phenotypes: overexpression inhibits growth	YFL010C	S000001884
XBP1		Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate	transcriptional repressor		YIL101C	S000001363
XCM2				suppressor of cmd1-1 mutation		S000029644
XCM3				suppressor of cmd1-1 mutation		S000029645
XDJ1		Putative chaperone, homolog of E. coli DnaJ, closely related to Ydj1p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies		Null mutant is viable, displays no detectable phenotype	YLR090W	S000004080
XHO1						S000029646
XKS1		Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains	xylulokinase	Null mutant is viable and cannot grow on media containing xylulose as the sole carbon source	YGR194C	S000003426
XPT1		Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine	xanthine phosphoribosyl transferase	Cannot utilize xanthine as a source of GMP	YJR133W	S000003894
XRS2		Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling	DNA repair protein	X-ray sensitive, spores inviable, xrs2 is rescued by spo13 and is epistatic to rad52	YDR369C	S000002777
XSP18		extragenic suppressor of pdc2		dominant mutation suppresses pdc2 deletion		S000029647
XSP37		extragenic suppressor of pdc2		mutation suppresses pdc2 deletion		S000029648
XYL2		Xylitol dehydrogenase, converts xylitol to D-xylulose in the endogenous xylose utilization pathway	xylitol dehydrogenase		YLR070C	S000004060
YAE1		Essential protein of unknown function			YJR067C	S000003828
YAF9		Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain			YNL107W	S000005051
YAH1		Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin			YPL252C	S000006173
YAK1		Serine-threonine protein kinase that is part of a glucose-sensing system involved in growth control in response to glucose availability; translocates from the cytoplasm to the nucleus and phosphorylates Pop2p in response to a glucose signal		viable, confers growth to strains deleted for tpk1, tpk2, tpk3 (genes encoding the catalytic subunit of the cAMP-dependent kinase)	YJL141C	S000003677
YAP1	PAR1|SNQ3	Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance; mediates pleiotropic drug and metal resistance; localized to the nucleus in response to the presence of oxidants	jun-like transcription factor		YML007W	S000004466
YAP1801		Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1802p, member of the AP180 protein family			YHR161C	S000001204
YAP1802		Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1801p, member of the AP180 protein family			YGR241C	S000003473
YAP3		Basic leucine zipper (bZIP) transcription factor			YHL009C	S000001001
YAP5		Basic leucine zipper (bZIP) transcription factor	transcription factor		YIR018W	S000001457
YAP6	HAL7	Putative basic leucine zipper (bZIP) transcription factor; overexpression increases sodium and lithium tolerance			YDR259C	S000002667
YAP7		Putative basic leucine zipper (bZIP) transcription factor	basic leucine zipper (bZIP) transcription factor		YOL028C	S000005388
YAR1		Cytoplasmic ankyrin-repeat containing protein of unknown function, proposed to link the processes of 40S ribosomal subunit biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock		Null mutant is viable, grow slowly at low temperature. YAR1 overexpression has no phenotype	YPL239W	S000006160
YAT1		Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix	carnitine acetyltransferase	Null mutant is viable, yields no obvious phenotype on any carbon source	YAR035W	S000000080
YAT2		Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane	carnitine acetyltransferase	Null: viable. Other phenotypes: The cit2yat2 double mutant does not grow on ethanol, glycerol and acetate in the presence of carnitine.	YER024W	S000000826
YBP1		Protein required for oxidation of specific cysteine residues of the transcription factor Yap1p, resulting in the nuclear localization of Yap1p in response to stress			YBR216C	S000000420
YBP2		Protein with a role in resistance to oxidative stress; has similarity to Ybp1p, which is involved in regulation of the transcription factor Yap1p via oxidation of specific cysteine residues			YGL060W	S000003028
YBT1	BAT1	Transporter of the ATP-binding cassette (ABC) family involved in bile acid transport; similar to mammalian bile transporters			YLL048C	S000003971
YCF1		Vacuolar glutathione S-conjugate transporter of the ATP-binding cassette family, has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin; similar to human cystic fibrosis protein CFTR		Null mutant is viable, hypersensitive to cadmium	YDR135C	S000002542
YCG1	TIE1|YCS5	Non-SMC subunit of the condensin complex (Smc2p-Smc4p-Ycs4p-Brn1p-Ycg1p); required for establishment and maintenance of chromosome condensation, chromosome segregation and for chromatin binding of the condensin complex	condensin	High-copy suppressor of brn1	YDR325W	S000002733
YCK1	CKI2	Palmitoylated, plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck2p		Null mutant is viable; yck1 yck2 double deletion mutants are inviable; yck1 point mutants suppress defective Snf1p kinase activity in snf4 strains	YHR135C	S000001177
YCK2		Palmitoylated, plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck1p		Null mutant is viable; yck1 yck2 double deletion mutant is inviable	YNL154C	S000005098
YCK3	CKI3	Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of the HOPS complex subunit, Vps41p; shares overlapping essential functions with Hrr25p		Null mutant is viable; multiple copies suppress gcs1-induced blockage of cell proliferation from stationary phase	YER123W	S000000925
YCP4		Protein of unknown function, has sequence and structural similarity to flavodoxins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YCR004C	S000000597
YCS4	LOC7	Non-SMC subunit of the condensin complex (Smc2p-Smc4p-Ycs4p-Brn1p-Ycg1p); required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin and silencing at the mating type locus		Null mutant is viable but exhibits defects in sister chromatid separation and segregation.	YLR272C	S000004262
YCT1		High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene	cysteine transporter		YLL055W	S000003978
YDC1		Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity	alkaline dihydroceramidase		YPL087W	S000006008
YDJ1	HSP40|MAS5	Protein chaperone involved in regulation of the HSP90 and HSP70 functions; involved in protein translocation across membranes; member of the DnaJ family	heat shock protein	slow growth at 23 degrees, inviable at 37 degrees; modest mitochondrial import defect at 23 degrees, substantial import defect at 37 degrees	YNL064C	S000005008
YEA4		Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER			YEL004W	S000000730
YEA6	NDT2	Putative mitochondrial NAD+ transporter, member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog	NAD+ transporter		YEL006W	S000000732
YEF1		ATP-NADH kinase; phosophorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; sequence similarity to Utr1p and Pos5p; overexpression complements certain pos5 phenotypes			YEL041W	S000000767
YEF3	TEF3	Translational elongation factor, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal complex; contains two ABC cassettes; binds and hydrolyses ATP	translation elongation factor 2 (EF-2)		YLR249W	S000004239
YEH1		Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes	steryl ester hydrolase		YLL012W	S000003935
YEH2		Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism	steryl ester hydrolase		YLR020C	S000004010
YEL1		Non-essential protein proposed to be a nucleotide exchange factor for Arf3			YBL060W	S000000156
YEN1		Protein of unknown function, has similarity to endonuclease Rth1p; potentially phosphorylated by Cdc28p			YER041W	S000000843
YET1		Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein			YKL065C	S000001548
YET2		Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein			YMR040W	S000004643
YET3		Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein			YDL072C	S000002230
YFH1		Frataxin, regulates mitochondrial iron accumulation; interacts with Isu1p which promotes Fe-S cluster assembly; interacts with electron transport chain components and may influence respiration; human homolog involved in Friedrich's ataxia		Null mutant is viable, grows poorly on glucose, fails to grown on respiratory substrates	YDL120W	S000002278
YGK3		Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation	protein kinase		YOL128C	S000005488
YGP1		Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p			YNL160W	S000005104
YHB1	YHB4	Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses	flavohemoglobin	Null mutant is viable. A rho+ strain carrying a yhb1(-) deletion has normal levels of both cyanide-sensitive and cyanide-insensitive respiration. Cells that carry a yhb1(-) deletion are sensitive to conditions that promote oxidative stress.	YGR234W	S000003466
YHC1		Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site	U1-C|U1C		YLR298C	S000004289
YHC3	BTN1	Vacuolar membrane protein involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; homolog of human CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis)		Null mutant is viable. btn1delta suppresses both the canavanine sensitivity and the elevated rate of uptake of arginine displayed by btn2delta strains.	YJL059W	S000003595
YHI9		Protein of unknown function that is a member of the PhzF superfamily, although unlike its bacterial homolog, is most likely not involved in phenazine production; possibly involved in a membrane regulation metabolic pathway			YHR029C	S000001071
YHM2		Mitochondrial DNA-binding protein, component of the mitochondrial nucleoid structure, involved in mtDNA replication and segregation of mitochondrial genomes; member of the mitochondrial carrier protein family	DNA binding protein	Null mutant is viable but shows slow growth in the presence of non-fermentable carbon sources; mutant shows mitochondrial genome unstability	YMR241W	S000004854
YHP1		One of two homeobox transcriptional repressors (see also Yox1p), that bind to Mcm1p and to early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval			YDR451C	S000002859
YIA6	NDT1	Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs	NAD+ transporter		YIL006W	S000001268
YIF1		Integral membrane protein required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles			YNL263C	S000005207
YIG1		Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol			YPL201C	S000006122
YIH1		Protein that inhibits activation of Gcn2p, an eIF2 alpha subunit protein kinase, by competing for Gcn1p binding, thus impacting gene expression in response to starvation; has sequence and functional similarity to the mouse IMPACT gene		Null mutant is viable and exhibits no growth defects; derepression of PMN in rich medium.	YCR059C	S000000655
YIM1		Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YMR152W	S000004760
YIM2		Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1			YMR151W	S000004759
YIP1		Integral membrane protein required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles			YGR172C	S000003404
YIP3		Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p			YNL044W	S000004989
YIP4		Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport			YGL198W	S000003166
YIP5		Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport			YGL161C	S000003129
YJU2	CWC16	Essential nuclear protein; putative spliceosomal component involved in mRNA splicing, based on computational analysis of large-scale protein-protein interaction data			YKL095W	S000001578
YJU3		Serine hydrolase with sequence similarity to monoglyceride lipase (MGL), localizes to lipid particles			YKL094W	S000001577
YKE2	GIM1|PFD6	Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin	prefoldin complex subunit		YLR200W	S000004190
YKE4		Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family	zinc transporter		YIL023C	S000001285
YKT6		Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus	v-SNARE	Null mutant is inviable. Depletion of Ykt6p results in the accumulation of the p1 precursor (endoplasmic reticulum form) of the vacuolar enzyme carboxypeptidase Y and morphological abnormalities consistent with a defect in secretion.	YKL196C	S000001679
YKU70	HDF1|KU70|NES24	Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair	DNA binding protein		YMR284W	S000004897
YKU80	HDF2	Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair		Null mutant is viable, methylmethane sulfonate sensitive, exhibits DNA joining defects; temperature sensitive, bleomycin sensitive	YMR106C	S000004712
YLF2	YLF1	Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YHL014C	S000001006
YLH47		Mitochondrial inner membrane protein exposed to the mitochondrial matrix, associates with mitochondrial ribosomes, NOT required for respiratory growth; homolog of human Letm1, a protein implicated in Wolf-Hirschhorn syndrome			YPR125W	S000006329
YMC1		Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc2p			YPR058W	S000006262
YMC2		Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc1p			YBR104W	S000000308
YMD8		Putative nucleotide sugar transporter, has similarity to Vrg4p			YML038C	S000004502
YME1	OSD1|YTA11	Subunit, with Mgr1p, of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; mutation causes an elevated rate of mitochondrial turnover		Null mutant is viable, exhibits an elevation in the rate at which copies of TRP1 and ARS1, integrated into the mitochondrial genome, escape to the nucleus; a heat-sensitive respiratory-growth defect; a cold-sensitive growth defect on rich glucose medium; and synthetic lethality in rho- (cytoplasmic petite) cells; yme1 (osd1) mutants fail to degrade newly synthesized subunits of cytochrome c	YPR024W	S000006228
YME2	PRP12|RNA12	Integral inner mitochondrial membrane protein with similarity to exonucleases; mutants exhibit an increased rate of mitochondrial DNA escape		Null mutant is viable but shows increased rate of DNA escape from mitochondria to the nucleus and, in some strains, shows a growth defect on nonfermentable carbon sources; rna12-1 is a dominant, thermosensitive allele that results in defects in RNA maturation at the restrictive temperature; yme1 cold sensitivity is suppressed by prp1; yme1 prp12 double mutant has synthetic growth defect on ethanol-glycerol medium at 30 degrees	YMR302C	S000004917
YML6		Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins			YML025C	S000004487
YMR1		Phosphatidylinositol 3-phosphate [PI(3)P] phosphatase, regulates the localization and levels of PI(3)P; involved in cytoplasm to vacuole (CVT) transport; has similarity to the conserved myotubularin dual specificity phosphatase family			YJR110W	S000003871
YMR31		Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36	mitochondrial ribosomal small subunit component		YFR049W	S000001945
YND1	YEJ5	Apyrase with wide substrate specificity, involved in preventing the inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates which are inhibitors of glycotransferases; partially redundant with Gda1p	NDPase/NTPase|apyrase	Null mutant is viable but vanadate-resistant and hygromycin-sensitive. The double mutant ynd1 gda1 exhibits slow growth and substantial defects in protein glycosylation and cell morphology.	YER005W	S000000807
YNG1	YOR29-15	Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3, has similarity to the human tumor suppressor ING1	histone acetyltransferase complex component	carbon source sensitive, heat shock sensitive	YOR064C	S000005590
YNG2	EAF4|NBN1	Subunit of the NuA4 histone acetyltransferase complex that acetylates histone H4 and H2A; has similarity to the human tumor suppressor ING1	NuA4 histone acetyltransferase subunit	carbon source-, heat shock-, temperature-, and caffeine-sensitive, abnormal morphology, reduced histone H4 acetylation; BEM and RAD phenotypes; haploid yng2 mutants do not tolerate mutations in genes important for nonhomologous end joining repair yet remain proficient for homologous recombination.	YHR090C	S000001132
YNK1	NDK1	Nucleoside diphosphate kinase, catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate	nucleoside diphosphate kinase		YKL067W	S000001550
YOP1	YIP2	Membrane protein that interacts with Yip1p to mediate membrane traffic; overexpression results in cell death and accumulation of internal cell membranes; regulates vesicular traffic in stressed cells			YPR028W	S000006232
YOR1	YRS1	Plasma membrane transporter of the ATP-binding cassette (ABC) family, mediates export of many different organic anions including oligomycin	multidrug transporter	Null mutant is viable but exhibits a slight growth defect; null mutant is hypersensitive to reveromycin A and fumonisin B1. Overexpression increases resistance to fumonisin B, sphingosine, and reveromycin A.	YGR281W	S000003513
YOS1		Integral membrane protein required for ER to Golgi transport; localized to the Golgi, the ER, and COPII vesicles; interacts with Yip1p and Yif1p			YER074W-A	S000007651
YOS9		ER quality-control lectin; integral subunit of the HRD ligase; serves as a receptor for misfolded N-glycosylated proteins, participates in their targeting to ERAD; member of the OS-9 protein family		Accelerates Gas1 transport and processing in cells overexpressing YOS9. Gas1 processing is slowed in cells bearing a deletion in YOS9.	YDR057W	S000002464
YOX1		Homeodomain-containing transcriptional repressor, binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate			YML027W	S000004489
YPC1		Alkaline ceramidase that also has reverse (CoA-independent) ceramide synthase activity, catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance	alkaline ceramidase	Null mutant is viable and two times more heat resistant than the wild-type parental strain.	YBR183W	S000000387
YPD1		Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus	two-component phosphorelay intermediate	Null mutant is inviable due to the persistent activation of HOG1 MAP kinase cascade. The ypd1 lethality can be suppressed by overexpression of the tyrosine phosphatase gene PTP2, or by inactivation of either one of SSK1, SSK2, PBS2, or HOG1 genes.	YDL235C	S000002394
YPI1		Inhibitor of the type I protein phosphatase Glc7p, which is involved in regulation of a variety of metabolic processes; overproduction causes decreased cellular content of glycogen	protein phosphatase 1 inhibitor		YFR003C	S000001899
YPK1	SLI2	Serine/threonine protein kinase required for receptor-mediated endocytosis; involved in sphingolipid-mediated and cell integrity signaling pathways; localized to the bud neck, cytosol and plasma membrane; homolog of mammalian kinase SGK	serine/threonine protein kinase	Null mutant is viable, slow growing, ypk1 ypk2 double deletion mutants are defective for vegetative growth	YKL126W	S000001609
YPK2	YKR2	Protein kinase with similarityto serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK	serine/threonine protein kinase		YMR104C	S000004710
YPP1		Cargo-transport protein involved in endocytosis; may interact with ribosomes, based on co-purification experiments; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene			YGR198W	S000003430
YPR1		2-methylbutyraldehyde reductase, may be involved in isoleucine catabolism			YDR368W	S000002776
YPS1	YAP3	Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor	aspartic protease	Null mutant is viable, defective in expression of somatostatin-28; yps1 mkc7 double disruptants are temperature sensitive; yps1 mkc7 kex2 mutants are profoundly temperature sensitive and are cold sensitive	YLR120C	S000004110
YPS3	YPS4	Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor	aspartic protease		YLR121C	S000004111
YPS5		Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p	aspartic protease		YGL259W	S000003228
YPS6		Putative GPI-anchored aspartic protease	aspartic protease		YIR039C	S000001478
YPS7		Putative GPI-anchored aspartic protease, located in the cytoplasm and endoplasmic reticulum	GPI-anchored aspartic protease		YDR349C	S000002757
YPT1	YP2	Ras-like small GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)	GTP-binding protein	Null mutant is inviable, at non-permissive temp, ts and cs mutants accumulate ER membranes and small vesicles, fail to process invertase and other secreted proteins, and show cytoskeletal defects; ypt1 causes lethality during nitrogen starvation	YFL038C	S000001856
YPT10		GTP binding protein that contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles			YBR264C	S000000468
YPT11		Rab-type small GTPase that interacts with the C-terminal tail domain of Myo2p to mediate distribution of mitochondria to daughter cells		Deletion of YPT11 induced partial delay of mitochondrial transmission to the bud, and overexpression of YPT11 resulted in mitochondrial accumulation in the bud.	YNL304W	S000005248
YPT31	YPT8	GTPase of the Ypt/Rab family, very similar to Ypt32p; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi	GTPase	ypt31 ypt32 double deletion mutants are inviable	YER031C	S000000833
YPT32		GTPase of the Ypt/Rab family, very similar to Ypt31p; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi	GTPase	ypt31 ypt32 double deletion mutants are inviable	YGL210W	S000003178
YPT35		Endosomal protein of unknown function that contains a phox (PX) homology domain and binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transport			YHR105W	S000001147
YPT52		GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis		Null mutant is viable; ypt51 ypt52 double deletion exacerbates the temperature sensitivity and vacuolar protein sorting defects of ypt51 deletion	YKR014C	S000001722
YPT53		GTPase, similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis	GTP-binding protein		YNL093W	S000005037
YPT6		GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6		Null mutant is viable, temperature sensitive; suppressed by ssd1 and imh1 mutations	YLR262C	S000004252
YPT7	AST4|VAM4	GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion, similar to mammalian Rab7	GTP-binding protein	Null mutant is viable, characterized by highly fragmented vacuoles and differential defects of vacuolar transport and maturation	YML001W	S000004460
YRA1	SHE11	Nuclear protein that binds to RNA and to Mex67p, required for export of poly(A)+ mRNA from the nucleus; member of the REF (RNA and export factor binding proteins) family; another family member, Yra2p, can substitute for Yra1p function	RNA-binding RNA annealing protein	Null mutant is inviable; overexpression causes growth arrest	YDR381W	S000002789
YRA2		Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus			YKL214C	S000001697
YRB1	CST20|HTN1|SFO1	Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1		yrb1 (ts) mutants are defective in protein import and nuclear export	YDR002W	S000002409
YRB2		Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential			YIL063C	S000001325
YRB30		RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes		Overproduction of the full-length protein and complete deletion of the open reading frame reveal no obvious phenotype. <br>Overproduction of C-term truncated forms of the protein inhibits yeast vegetative growth.	YGL164C	S000003132
YRF1-1	YRF1	Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p	DNA helicase		YDR545W	S000002953
YRF1-2	YRF1	Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p	DNA helicase		YER190W	S000000992
YRF1-3	YRF1	Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p	DNA helicase		YGR296W	S000003528
YRF1-4	YRF1	Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p	DNA helicase		YLR466W	S000004458
YRF1-5	YRF1	Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p	DNA helicase		YLR467W	S000004459
YRF1-6	YRF1	Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p	DNA helicase		YNL339C	S000005283
YRF1-7	YRF1	Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p	DNA helicase		YPL283C	S000006204
YRF1-8		One of several telomeric Y' element-encoded DNA helicases, known as Y'-Help1 (Y'-HELicase Protein 1)			YOR396W	S000007526
YRM1		Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes	transcription factor		YOR172W	S000005698
YRO2		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p			YBR054W	S000000258
YRR1	PDR2	Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes	transcription factor	Null mutant is viable; hypersensitive to calcofluor white; hypersensitive to 4-nitroquinoline oxide (4-NQO); cannot utilize glycerol and lactate as sole carbon source; the YRR1-1 allele confers resistance to 4-NQO, reveromycin-A and oligomycin	YOR162C	S000005688
YSA1	RMA2	Nudix hydrolase family member with ADP-ribose pyrophosphatase activity			YBR111C	S000000315
YSC83		Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83			YHR017W	S000001059
YSC84	LSB4	Protein involved in the organization of the actin cytoskeleton; contains SH3 domain similar to Rvs167p			YHR016C	S000001058
YSF3	RCP10	Component of the U2 snRNP, associated with the SF3b complex; conserved in Ashbya gossypii	U2 snRNP subunit, SF3b associated	metabolic depletion results in splicing arrest	YNL138W-A	S000028509
YSH1	BRR5	Putative endonuclease, subunit of the mRNA cleavage and polyadenylation specificity complex required for 3' processing of mRNAs	cleavage factor II (CF II) component|polyadenylation factor I (PF I)		YLR277C	S000004267
YSN1		Sortilin homolog, interacts with proteins of the endocytic machinery			YNR065C	S000005348
YSP1		Mitochondrial protein with a potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone			YHR155W	S000001198
YSP2		Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification			YDR326C	S000002734
YSP3		Putative precursor to the subtilisin-like protease III			YOR003W	S000005529
YSR3	LBP2	Dihydrosphingosine 1-phosphate phosphatase, membrane protein involved in sphingolipid metabolism; has similarity to Lcb3p	DHS-1-P phosphatase	Null mutant is viable and accumulates of dihydrosphingosine-1-P	YKR053C	S000001761
YSW1		Protein expressed specifically in spores			YBR148W	S000000352
YSY6		Protein whose expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion			YBR162W-A	S000002158
YTA12	RCA1	Component, with Afg3p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes	ATPase	Null mutant is viable, petite grossly deficient in mitochondrial respiratory and ATPase complexes, yet synthesizes all proteins encoded by mitochondrial DNA	YMR089C	S000004695
YTA6		Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family, localized to the cortex of mother cells but not to daughter cells	AAA ATPase		YPL074W	S000005995
YTA7		Protein of unknown function, member of CDC48/PAS1/SEC18 family of ATPases, potentially phosphorylated by Cdc28p			YGR270W	S000003502
YTH1		Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation	polyadenylation factor subunit	null is inviable; other mutations result in polyadenylation deficiency	YPR107C	S000006311
YTM1		Constituent of 66S pre-ribosomal particles, required for maturation of the large ribosomal subunit			YOR272W	S000005798
YTP1		Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins			YNL237W	S000005181
YUH1		Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p	ubiquitin hydrolase		YJR099W	S000003860
YUR1		Mannosyltransferase of the KTR1 family, involved in protein N-glycosylation; located in the Golgi apparatus	dolichyl phosphate-D-mannose:protein O-D-mannosyltransferase		YJL139C	S000003675
YVC1	YOR088W	Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock			YOR087W	S000005613
YVH1		Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; transcription induced by low temperature and nitrogen starvation; member of the dual-specificity family of protein phosphatases	protein tyrosine phosphatase		YIR026C	S000001465
ZAP1	ZRG10	Zinc-regulated transcription factor, binds to zinc-responsive promoter elements to induce transcription of certain genes in the presence of zinc; regulates its own transcription; contains seven zinc-finger domains		High level expression of ZRT1 and ZRT2 in both zinc-limited and zinc-replete cells	YJL056C	S000003592
ZDS1	CES1|CKM1|NRC1|OSS1	Protein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; has a role in localization of Bcy1p, a regulatory subunit of protein kinase A; implicated in mRNA nuclear export		High-copy suppressor of ceg-ts mutations	YMR273C	S000004886
ZDS2	CES4	Protein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; paralog of Zds1p		Null mutant is viable; zds1 zds2 double deletion causes slow growth and defects in bud morphology and cell cycle progression	YML109W	S000004577
ZEO1		Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p		Null mutant is viable and exhibits slow growth in galactose	YOL109W	S000005469
ZIM17	FMP28|HEP1|TIM15	Heat shock protein with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix			YNL310C	S000005254
ZIP1		Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate		Null mutant is viable and shows defects in meiosis	YDR285W	S000002693
ZIP2		Meiosis-specific protein involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis		Null mutant is viable but is defective in chromosome synapsis, but not chromosome pairing, and causes meiosis I non-disjunction and reduced homologous recombination	YGL249W	S000003218
ZOD1		Locus of unknown function, located upstream of UFO1, that is associated with components of the Pol III machinery: Tfc4p, Brf1p, Bdp1, and Rpc34p				S000077071
ZPR1		Essential protein with two zinc fingers, present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 (Tef1p)			YGR211W	S000003443
ZPS1		Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH			YOL154W	S000005514
ZRC1	OSR1	Vacuolar membrane zinc transporter, transports zinc from the cytosol into the vacuole for storage; also has a role in resistance to zinc shock resulting from a sudden influx of zinc into the cytoplasm		Null mutant is viable and sensitive to zinc	YMR243C	S000004856
ZRG17		Endoplasmic reticulum protein of unknown function, transcription is induced under conditions of zinc deficiency; mutant phenotype suggests a role in uptake of zinc			YNR039C	S000005322
ZRG8		Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency			YER033C	S000000835
ZRT1		High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor		disruption viable	YGL255W	S000003224
ZRT2		Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor	zinc transporter	Null mutant is viable; ZRT2 overexpression increases rate of zinc uptake	YLR130C	S000004120
ZRT3		Vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency			YKL175W	S000001658
ZSP1		Protein of unknown function; mutation results in a zinc sensitive phenotype			YBR287W	S000000491
ZTA1		Zeta-crystallin homolog, found in the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin, which has quinone oxidoreductase activity			YBR046C	S000000250
ZUO1		Cytosolic ribosome-associated chaperone that acts, together with Ssz1p and the Ssb proteins, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p	zuotin		YGR285C	S000003517
ZWF1	MET19|POS10	Glucose-6-phosphate dehydrogenase (G6PD), catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia	glucose-6-phosphate dehydrogenase		YNL241C	S000005185